Liliana Halip, Sorin Avram, John P Overington, Bissan Al-Lazikani, Ramona Curpan, Suman Sirimulla, Alexei Pushechnikov, Andrea Rosario Beccari, Nikolay Savchuck, Tudor I Oprea
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引用次数: 0
Abstract
Since the turn of the century, drug discovery has been transformed by advances in genetics, genomics and proteomics, as well as automation, data science and the diversification of therapeutic modalities beyond synthetic small molecules and natural product derivatives. This transformation has led to the expansion of the drug target landscape, enabling advances in the treatment of many diseases, including some that previously lacked pharmacotherapies. In this Review, we map and quantify key elements of these changes over the past 25 years, such as trends in the number and type of targets through which drugs mediate their therapeutic effects, which now include 686 biomolecules modulated by 1,702 drugs. We also discuss trends we believe will continue or change, as target druggability continues to evolve with the emergence of new therapeutic modalities.
期刊介绍：
Nature Reviews Drug Discovery is a monthly journal aimed at everyone working in the drug discovery and development arena.
Each issue includes:
Highest-quality reviews and perspectives covering a broad scope.
News stories investigating the hottest topics in drug discovery.
Timely summaries of key primary research papers.
Concise updates on the latest advances in areas such as new drug approvals, patent law, and emerging industry trends and strategies.
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