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Nature Reviews. Drug Discovery最新文献

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A translational framework for extrahepatic oligonucleotide delivery. 肝外寡核苷酸递送的翻译框架。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-09 DOI: 10.1038/d41573-026-00125-2
Łukasz Jan Kiełpiński, Felix Franz Schumacher
{"title":"A translational framework for extrahepatic oligonucleotide delivery.","authors":"Łukasz Jan Kiełpiński, Felix Franz Schumacher","doi":"10.1038/d41573-026-00125-2","DOIUrl":"https://doi.org/10.1038/d41573-026-00125-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Un-siloed biomedical opportunities 非孤立的生物医学机会。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-07 DOI: 10.1038/d41573-026-00148-9
Asher Mullard
{"title":"Un-siloed biomedical opportunities","authors":"Asher Mullard","doi":"10.1038/d41573-026-00148-9","DOIUrl":"10.1038/d41573-026-00148-9","url":null,"abstract":"Edith Heard, CEO of the Francis Crick Institute, discusses the need to break down biomedical boundaries.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"750-751"},"PeriodicalIF":91.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengthening muscle for healthy ageing: innovative treatments for sarcopenia. 增强肌肉健康老化：创新治疗肌肉减少症。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-07 DOI: 10.1038/s41573-026-01514-3
Sara Ancel, Emmeran Le Moal, Yu Xin Wang, Helen M Blau
{"title":"Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.","authors":"Sara Ancel, Emmeran Le Moal, Yu Xin Wang, Helen M Blau","doi":"10.1038/s41573-026-01514-3","DOIUrl":"https://doi.org/10.1038/s41573-026-01514-3","url":null,"abstract":"<p><p>Millions of people worldwide suffer from sarcopenia, a clinically recognized syndrome that is defined as the age-related loss of skeletal muscle mass and strength. Sarcopenia reduces mobility, leads to falls and fractures, and increases the risk of death, posing an ever-increasing health-care and economic burden to society. There are currently no approved therapies for the syndrome, partly owing to its multifactorial aetiology, highlighting the need for therapies with pleiotropic beneficial effects on muscle function. Increased understanding of the cellular, metabolic and molecular mechanisms that drive muscle wasting with ageing is informing pharmacological interventions to increase muscle strength by promoting mitochondrial function (NAD<sup>+</sup>-related molecules, urolithin A), restoring impaired autophagy (mTORC1 inhibitors), promoting anabolic signalling (myostatin inhibitors), acting as selective androgen receptor modulators, maintaining vascularization (VEGF, apelin), reducing inflammageing (inhibitors of cytokine signalling), and restoring innervation, anabolism and regeneration (inhibitors of the gerozyme 15-PGDH). The recent surge in clinical trials combining weight loss-inducing GLP1RA therapies with drugs that preserve muscle tissue suggests that treatments that promote both healthspan and lifespan, or 'healthy ageing', are on the horizon.</p>","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newest glue degrader nabs multiple myeloma approval 最新的胶水降解剂获得多发性骨髓瘤批准。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-04 DOI: 10.1038/d41573-026-00147-w
Asher Mullard
{"title":"Newest glue degrader nabs multiple myeloma approval","authors":"Asher Mullard","doi":"10.1038/d41573-026-00147-w","DOIUrl":"10.1038/d41573-026-00147-w","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"748-748"},"PeriodicalIF":91.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Click chemistry platform enhances ADC tumour targeting 点击化学平台增强ADC肿瘤靶向。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-02 DOI: 10.1038/d41573-026-00146-x
Alex Eccleston
{"title":"Click chemistry platform enhances ADC tumour targeting","authors":"Alex Eccleston","doi":"10.1038/d41573-026-00146-x","DOIUrl":"10.1038/d41573-026-00146-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"754-754"},"PeriodicalIF":91.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solute carrier membrane transporters: emerging targets in CNS disorders. 溶质载体膜转运蛋白：中枢神经系统疾病的新靶点。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-09-01 DOI: 10.1038/s41573-026-01513-4
Yee Kwan Law, Selene Glück, Enrico Girardi, Ariel Bensimon, S Andreas Angermayr, Giulio Superti-Furga
{"title":"Solute carrier membrane transporters: emerging targets in CNS disorders.","authors":"Yee Kwan Law, Selene Glück, Enrico Girardi, Ariel Bensimon, S Andreas Angermayr, Giulio Superti-Furga","doi":"10.1038/s41573-026-01513-4","DOIUrl":"https://doi.org/10.1038/s41573-026-01513-4","url":null,"abstract":"<p><p>Prominent members of the solute carrier (SLC) superfamily of membrane transporters are established targets of central nervous system (CNS) drugs, including the blockbuster neurotransmitter reuptake inhibitors. Numerous other SLC transporters exhibit dysregulated expression in the CNS relative to other tissues, many of which have been genetically or functionally linked to neurological disorders and may therefore represent tractable therapeutic targets. As key regulators of metabolite and ion fluxes, SLCs shape developmental programmes and cellular states associated with epilepsy, neurodegeneration and autism spectrum disorders. Recent advances in assigning biochemical and cellular functions to previously uncharacterized SLCs, together with emerging chemical strategies to increase or decrease transporter abundance, are expanding the therapeutic landscape and positioning SLC biology at the forefront of next-generation CNS drug discovery.</p>","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serotonin receptor agonist suppresses colorectal cancer 血清素受体激动剂抑制结直肠癌。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00144-z
Sarah Crunkhorn
{"title":"Serotonin receptor agonist suppresses colorectal cancer","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00144-z","DOIUrl":"10.1038/d41573-026-00144-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"756-756"},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The landscape for in vivo CAR T cell therapies. 体内CAR - T细胞疗法的前景。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00140-3
Margot Bleys, Kelly Farley, Bonnie Walton, Minsoo Khang, John Wu
{"title":"The landscape for in vivo CAR T cell therapies.","authors":"Margot Bleys, Kelly Farley, Bonnie Walton, Minsoo Khang, John Wu","doi":"10.1038/d41573-026-00140-3","DOIUrl":"https://doi.org/10.1038/d41573-026-00140-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":" ","pages":""},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral protease-initiated pyroptosis 病毒蛋白酶引发的焦亡。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00141-2
Sarah Crunkhorn
{"title":"Viral protease-initiated pyroptosis","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00141-2","DOIUrl":"10.1038/d41573-026-00141-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"756-756"},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A metabolically activated molecular glue 一种代谢激活的分子胶。
IF 91.2 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2026-08-28 DOI: 10.1038/d41573-026-00143-0
Sarah Crunkhorn
{"title":"A metabolically activated molecular glue","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00143-0","DOIUrl":"10.1038/d41573-026-00143-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"25 10","pages":"756-756"},"PeriodicalIF":91.2,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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