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Nature Reviews. Drug Discovery最新文献

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J&J buys Intra-Cellular Therapies for US$14.6 billion, expanding its neuroscience portfolio 强生以146亿美元收购细胞内疗法，扩大其神经科学产品组合
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-22 DOI: 10.1038/d41573-025-00015-z
Asher Mullard
{"title":"J&J buys Intra-Cellular Therapies for US$14.6 billion, expanding its neuroscience portfolio","authors":"Asher Mullard","doi":"10.1038/d41573-025-00015-z","DOIUrl":"10.1038/d41573-025-00015-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 3","pages":"159-159"},"PeriodicalIF":122.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 FDA approvals exceed average number but have lower sales projections 2024年FDA批准的数量超过平均水平，但销售预期较低
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-17 DOI: 10.1038/d41573-025-00014-0
Mathias Baedeker,  Michael S. Ringel,  Clemens C. Möller
{"title":"2024 FDA approvals exceed average number but have lower sales projections","authors":"Mathias Baedeker, \u0000 Michael S. Ringel, \u0000 Clemens C. Möller","doi":"10.1038/d41573-025-00014-0","DOIUrl":"10.1038/d41573-025-00014-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"85-85"},"PeriodicalIF":122.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outlook for medicines development and use in 2025 2025年药物开发和使用展望
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-15 DOI: 10.1038/d41573-025-00012-2
Sarah Rickwood,  Helena Bayley,  Stefan Lutzmayer,  Meike Madelung,  Markus Gores
{"title":"Outlook for medicines development and use in 2025","authors":"Sarah Rickwood, \u0000 Helena Bayley, \u0000 Stefan Lutzmayer, \u0000 Meike Madelung, \u0000 Markus Gores","doi":"10.1038/d41573-025-00012-2","DOIUrl":"10.1038/d41573-025-00012-2","url":null,"abstract":"Oncology innovations, obesity medicines, an uptick for mergers and acquisitions, regulation for artificial intelligence applications and growing consumerization are expected to be key topics. Oncology innovations, obesity medicines, an uptick for mergers and acquisitions, regulation for artificial intelligence applications and growing consumerization are expected to be key topics.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"73-74"},"PeriodicalIF":122.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopharma dealmaking in 2024 2024年的生物制药交易
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-15 DOI: 10.1038/d41573-025-00013-1
Patricia Giglio,  Amanda Micklus
{"title":"Biopharma dealmaking in 2024","authors":"Patricia Giglio, \u0000 Amanda Micklus","doi":"10.1038/d41573-025-00013-1","DOIUrl":"10.1038/d41573-025-00013-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"86-87"},"PeriodicalIF":122.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting mitophagy in neurodegenerative diseases 靶向线粒体自噬在神经退行性疾病中的应用
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-14 DOI: 10.1038/s41573-024-01105-0
Odetta Antico, Paul W. Thompson, Nicholas T. Hertz, Miratul M. K. Muqit, Laura E. Parton
{"title":"Targeting mitophagy in neurodegenerative diseases","authors":"Odetta Antico, Paul W. Thompson, Nicholas T. Hertz, Miratul M. K. Muqit, Laura E. Parton","doi":"10.1038/s41573-024-01105-0","DOIUrl":"10.1038/s41573-024-01105-0","url":null,"abstract":"Mitochondrial dysfunction is a hallmark of idiopathic neurodegenerative diseases, including Parkinson disease, amyotrophic lateral sclerosis, Alzheimer disease and Huntington disease. Familial forms of Parkinson disease and amyotrophic lateral sclerosis are often characterized by mutations in genes associated with mitophagy deficits. Therefore, enhancing the mitophagy pathway may represent a novel therapeutic approach to targeting an underlying pathogenic cause of neurodegenerative diseases, with the potential to deliver neuroprotection and disease modification, which is an important unmet need. Accumulating genetic, molecular and preclinical model-based evidence now supports targeting mitophagy in neurodegenerative diseases. Despite clinical development challenges, small-molecule-based approaches for selective mitophagy enhancement — namely, USP30 inhibitors and PINK1 activators — are entering phase I clinical trials for the first time. Impaired mitophagy leading to the accumulation of damaged mitochondria is associated with the onset and progression of neurodegenerative diseases. This Review provides an overview of the molecular pathways of mitophagy regulation in neurons, discusses evidence implicating mitophagy impairment in the pathogenesis of neurodegenerative diseases and assesses small-molecule-based therapeutic approaches aimed at selective mitophagy enhancement.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 4","pages":"276-299"},"PeriodicalIF":122.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves next-generation triple therapy for cystic fibrosis FDA批准下一代三重治疗囊肿性纤维化
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00008-y
Asher Mullard
{"title":"FDA approves next-generation triple therapy for cystic fibrosis","authors":"Asher Mullard","doi":"10.1038/d41573-025-00008-y","DOIUrl":"10.1038/d41573-025-00008-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"83-83"},"PeriodicalIF":122.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting inherited mutations to prevent metastasis 靶向遗传突变以防止转移
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00009-x
M. Teresa Villanueva
{"title":"Targeting inherited mutations to prevent metastasis","authors":"M. Teresa Villanueva","doi":"10.1038/d41573-025-00009-x","DOIUrl":"10.1038/d41573-025-00009-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"90-90"},"PeriodicalIF":122.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DLL3 draws two antibody–drug conjugate deals DLL3获得了两笔抗体-药物结合物交易
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00011-3
Asher Mullard
{"title":"DLL3 draws two antibody–drug conjugate deals","authors":"Asher Mullard","doi":"10.1038/d41573-025-00011-3","DOIUrl":"10.1038/d41573-025-00011-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"84-84"},"PeriodicalIF":122.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-PKcs inhibitor causes genomic alterations DNA-PKcs抑制剂引起基因组改变
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-10 DOI: 10.1038/d41573-025-00004-2
Sarah Crunkhorn
{"title":"DNA-PKcs inhibitor causes genomic alterations","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00004-2","DOIUrl":"10.1038/d41573-025-00004-2","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"91-91"},"PeriodicalIF":122.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human brain organoids identify glioma inhibitors 人脑类器官识别神经胶质瘤抑制剂
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-01-10 DOI: 10.1038/d41573-025-00007-z
Sarah Crunkhorn
{"title":"Human brain organoids identify glioma inhibitors","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00007-z","DOIUrl":"10.1038/d41573-025-00007-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 2","pages":"91-91"},"PeriodicalIF":122.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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