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Nature Reviews. Drug Discovery最新文献

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Oncolytic virus drought continues, as Replimune fails to secure FDA cancer approval 溶瘤病毒干旱仍在继续，因为Replimune未能获得FDA的癌症批准
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-30 DOI: 10.1038/d41573-025-00132-9
Asher Mullard
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引用次数: 0
In vivo CAR T cells gain traction, with AbbVie’s US$2.1 billion acquisition of Capstan Therapeutics 随着艾伯维斥资21亿美元收购Capstan Therapeutics，体内CAR - T细胞获得关注
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-29 DOI: 10.1038/d41573-025-00131-w
Asher Mullard
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引用次数: 0
Neoantigen-targeting vaccine treats melanoma 新抗原靶向疫苗治疗黑色素瘤
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-28 DOI: 10.1038/d41573-025-00128-5
Sarah Crunkhorn
{"title":"Neoantigen-targeting vaccine treats melanoma","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00128-5","DOIUrl":"10.1038/d41573-025-00128-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 9","pages":"665-665"},"PeriodicalIF":101.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mimicking the health benefits of exercise 模仿运动对健康的益处
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-28 DOI: 10.1038/d41573-025-00127-6
Sarah Crunkhorn
{"title":"Mimicking the health benefits of exercise","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00127-6","DOIUrl":"10.1038/d41573-025-00127-6","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 9","pages":"665-665"},"PeriodicalIF":101.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDE5 inhibitor restores dendritic cell migration PDE5抑制剂恢复树突状细胞迁移
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-28 DOI: 10.1038/d41573-025-00130-x
Sarah Crunkhorn
{"title":"PDE5 inhibitor restores dendritic cell migration","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00130-x","DOIUrl":"10.1038/d41573-025-00130-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 9","pages":"665-665"},"PeriodicalIF":101.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De novo design of macrocycles 宏周期的从头设计
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-28 DOI: 10.1038/d41573-025-00129-4
Sarah Crunkhorn
{"title":"De novo design of macrocycles","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00129-4","DOIUrl":"10.1038/d41573-025-00129-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 9","pages":"665-665"},"PeriodicalIF":101.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The rise of China’s pharmaceutical industry from 2015–2024: a decade of innovation 2015-2024年中国医药产业崛起：创新的十年
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-21 DOI: 10.1038/d41573-025-00102-1
Sen Liu,  Hongxi Hu,  Chenghao Ge,  Shuona Yuan,  Jianhua Jiang,  Xiaoyuan Chen
{"title":"The rise of China’s pharmaceutical industry from 2015–2024: a decade of innovation","authors":"Sen Liu, \u0000 Hongxi Hu, \u0000 Chenghao Ge, \u0000 Shuona Yuan, \u0000 Jianhua Jiang, \u0000 Xiaoyuan Chen","doi":"10.1038/d41573-025-00102-1","DOIUrl":"10.1038/d41573-025-00102-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 10","pages":"738-739"},"PeriodicalIF":101.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41573-025-00102-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biased adrenergic receptor agonist tackles metabolic disease 偏肾上腺素能受体激动剂治疗代谢性疾病
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-17 DOI: 10.1038/d41573-025-00125-8
Sarah Crunkhorn
{"title":"Biased adrenergic receptor agonist tackles metabolic disease","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-025-00125-8","DOIUrl":"10.1038/d41573-025-00125-8","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 9","pages":"663-663"},"PeriodicalIF":101.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building on the momentum of N-of-1 base editor therapies for rare diseases 以N-of-1碱基编辑器治疗罕见疾病的势头为基础
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-15 DOI: 10.1038/d41573-025-00119-6
Katie Kingwell
{"title":"Building on the momentum of N-of-1 base editor therapies for rare diseases","authors":"Katie Kingwell","doi":"10.1038/d41573-025-00119-6","DOIUrl":"10.1038/d41573-025-00119-6","url":null,"abstract":"Rebecca Ahrens-Nicklas, a physician-scientist at the Children’s Hospital of Philadelphia, discusses her groundbreaking application of a gene-editing therapy for an ultra-rare urea cycle disorder. Rebecca Ahrens-Nicklas, a physician-scientist at the Children’s Hospital of Philadelphia, discusses her groundbreaking application of a gene-editing therapy for an ultra-rare urea cycle disorder.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 8","pages":"582-583"},"PeriodicalIF":101.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41573-025-00119-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA new drug approvals in Q2 2025 2025年第二季度FDA新药批准
IF 101.8 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2025-07-15 DOI: 10.1038/d41573-025-00124-9
Paul Verdin
{"title":"FDA new drug approvals in Q2 2025","authors":"Paul Verdin","doi":"10.1038/d41573-025-00124-9","DOIUrl":"10.1038/d41573-025-00124-9","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"24 8","pages":"579-579"},"PeriodicalIF":101.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41573-025-00124-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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