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Targeting NK2R reverses cardiometabolic dysfunction 靶向NK2R逆转心脏代谢功能障碍
IF 26.8 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01334-z
Jennifer Haskell
{"title":"Targeting NK2R reverses cardiometabolic dysfunction","authors":"Jennifer Haskell","doi":"10.1038/s41551-024-01334-z","DOIUrl":"10.1038/s41551-024-01334-z","url":null,"abstract":"An agonist of the neurokinin 2 receptor induced weight loss and increased energy expenditure in obese mice and monkeys with diabetes.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"8 12","pages":"1510-1510"},"PeriodicalIF":26.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone 促肾上腺皮质激素释放激素介导的机械重塑增强人造血干细胞的植入
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01316-1
Mingming Wu, Haoxiang Yang, Senquan Liu, Lai Jiang, Tingting Liang, Yan Wang, Mingming Zhu, Xian Song, Hao Liu, Jinghao Shen, Shuangzi Wang, Xiaoyu Zhu, Cheng-Kui Qu, Linzhao Cheng, Hongyuan Jiang, Fang Ni
{"title":"Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone","authors":"Mingming Wu, Haoxiang Yang, Senquan Liu, Lai Jiang, Tingting Liang, Yan Wang, Mingming Zhu, Xian Song, Hao Liu, Jinghao Shen, Shuangzi Wang, Xiaoyu Zhu, Cheng-Kui Qu, Linzhao Cheng, Hongyuan Jiang, Fang Ni","doi":"10.1038/s41551-024-01316-1","DOIUrl":"https://doi.org/10.1038/s41551-024-01316-1","url":null,"abstract":"<p>The engraftment of haematopoietic stem and progenitor cells (HSPCs), particularly in cord-blood transplants, remains challenging. Here we report the role of the corticotropin-releasing hormone (CRH) in enhancing the homing and engraftment of human-cord-blood HSPCs in bone marrow through mechanical remodelling. By using microfluidics, intravital two-photon imaging and long-term-engraftment assays, we show that treatment with CRH substantially enhances HSPC adhesion, motility and mechanical remodelling, ultimately leading to improved bone-marrow homing and engraftment in immunodeficient mice. CRH induces Ras homologue gene family member A (RhoA)-dependent nuclear translocation of the yes-associated protein (YAP), which upregulates the expression of genes encoding extracellular-matrix proteins (notably, thrombospondin-2 (THBS2)). This process guides the mechanical remodelling of HSPCs via modulation of the actin cytoskeleton and the extracellular matrix, with THBS2 interacting with the integrin αvβ3 and coordinating the nuclear translocation of YAP upon CRH/CRH-receptor-1 (CRH/CRHR1) signalling. Overall, the CRH/CRHR1/RhoA/YAP/THBS2/αvβ3 axis has a central role in modulating HSPC behaviour via a mechanical feedback loop involving THBS2, αvβ3, the actin cytoskeleton and YAP signalling. Our findings may suggest avenues for optimizing the transplantation of HSPCs.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"92 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin independence from stem-cell-derived islets 干细胞来源胰岛的胰岛素独立性
IF 26.8 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01331-2
Alessandra Griffo
{"title":"Insulin independence from stem-cell-derived islets","authors":"Alessandra Griffo","doi":"10.1038/s41551-024-01331-2","DOIUrl":"10.1038/s41551-024-01331-2","url":null,"abstract":"An autologous transplant of islets derived from chemically induced pluripotent stem cells allowed an individual with type 1 diabetes to forgo insulin.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"8 12","pages":"1507-1507"},"PeriodicalIF":26.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoprobes for X-ray-mediated theranostics 用于x射线介导治疗的纳米探针
IF 26.8 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01333-0
Jennifer Haskell
{"title":"Nanoprobes for X-ray-mediated theranostics","authors":"Jennifer Haskell","doi":"10.1038/s41551-024-01333-0","DOIUrl":"10.1038/s41551-024-01333-0","url":null,"abstract":"Organic nanoprobes facilitate the imaging of small deep-seated tumours in mice via the X-ray-mediated generation of long-lasting luminescence.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"8 12","pages":"1511-1511"},"PeriodicalIF":26.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FAS-less allogeneic CAR T cells 无fas异体CAR - T细胞
IF 26.8 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01319-y
Keith P. Eidell, Michael T. Hemann
{"title":"FAS-less allogeneic CAR T cells","authors":"Keith P. Eidell,&nbsp;Michael T. Hemann","doi":"10.1038/s41551-024-01319-y","DOIUrl":"10.1038/s41551-024-01319-y","url":null,"abstract":"In immunocompetent hosts, the ablation of FAS and CD3 in allogeneic chimeric antigen receptor T cells confers them with partial protection from rejection by T cells and natural killer cells.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"8 12","pages":"1518-1520"},"PeriodicalIF":26.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue 声压驱动超声激活机械敏感受体RET和结肠组织细胞增殖
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01300-9
Laura Zamfirov, Ngoc-Minh Nguyen, Maria Elena Fernández-Sánchez, Paula Cambronera Ghiglione, Eliott Teston, Alexandre Dizeux, Thomas Tiennot, Emmanuel Farge, Charlie Demené, Mickael Tanter
{"title":"Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue","authors":"Laura Zamfirov, Ngoc-Minh Nguyen, Maria Elena Fernández-Sánchez, Paula Cambronera Ghiglione, Eliott Teston, Alexandre Dizeux, Thomas Tiennot, Emmanuel Farge, Charlie Demené, Mickael Tanter","doi":"10.1038/s41551-024-01300-9","DOIUrl":"https://doi.org/10.1038/s41551-024-01300-9","url":null,"abstract":"<p>Ultrasound generates both compressive and shear mechanical forces in soft tissues. However, the specific mechanisms by which these forces activate cellular processes remain unclear. Here we show that low-intensity focused ultrasound can activate the mechanosensitive RET signalling pathway. Specifically, in mouse colon tissues ex vivo and in vivo, focused ultrasound induced RET phosphorylation in colonic crypts cells, which correlated with markers of proliferation and stemness when using hours-long insonication. The activation of the RET pathway is non-thermal, is linearly related to acoustic pressure and is independent of radiation-force-induced shear strain in tissue. Our findings suggest that ultrasound could be used to regulate cell proliferation, particularly in the context of regenerative medicine, and highlight the importance of adhering to current ultrasound-safety regulations for medical imaging.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"93 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing breast cancer risk stratification using multimodal AI 使用多模式人工智能推进乳腺癌风险分层
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01304-5
{"title":"Advancing breast cancer risk stratification using multimodal AI","authors":"","doi":"10.1038/s41551-024-01304-5","DOIUrl":"https://doi.org/10.1038/s41551-024-01304-5","url":null,"abstract":"A modular model integrating clinical metadata and mammography and tri-modal ultrasound images from patients presenting to the clinic with breast cancer symptoms performs similarly or better than experienced human experts at differential diagnosis and tumour classification.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"54 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours 同时消耗调节性T细胞和激活肿瘤中的细胞毒性T细胞
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01305-4
{"title":"Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours","authors":"","doi":"10.1038/s41551-024-01305-4","DOIUrl":"https://doi.org/10.1038/s41551-024-01305-4","url":null,"abstract":"An anti-4-1BB antibody fused to interleukin-15 via a peptide that is sensitive to tumour proteases concurrently depletes regulatory T cells and expands cytotoxic T cells in the tumour microenvironment. This fusion protein augments tumour inhibition without increasing systemic toxicity.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"23 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The analgesic potential of heavy water 重水的镇痛潜力
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-19 DOI: 10.1038/s41551-024-01325-0
Michael J. M. Fischer
{"title":"The analgesic potential of heavy water","authors":"Michael J. M. Fischer","doi":"10.1038/s41551-024-01325-0","DOIUrl":"https://doi.org/10.1038/s41551-024-01325-0","url":null,"abstract":"The influx of deuterated water through the TRPV1 channel reduces pain-related behaviour.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"12 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulating localizable sensations 刺激局部感觉
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-18 DOI: 10.1038/s41551-024-01321-4
Marc H. Schieber
{"title":"Stimulating localizable sensations","authors":"Marc H. Schieber","doi":"10.1038/s41551-024-01321-4","DOIUrl":"https://doi.org/10.1038/s41551-024-01321-4","url":null,"abstract":"Overlapping projected fields from multiple intracortical electrodes produce sensations on the hand that are more easily localizable, as shown in three participants with cervical spinal cord injury.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"259 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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