Nature Biomedical Engineering最新文献_第3页

A compact, wireless system for continuous monitoring of breast milk expressed during breastfeeding 一种紧凑的无线系统，用于持续监测母乳喂养期间分泌的乳汁

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-14 DOI: 10.1038/s41551-025-01393-w

Jihye Kim, Seyong Oh, Raudel Avila, Hee-Sup Shin, Matthew Banet, Jennifer Wicks, Anthony R. Banks, Yonggang Huang, Jae-Young Yoo, Daniel T. Robinson, Craig F. Garfield, John A. Rogers

{"title":"A compact, wireless system for continuous monitoring of breast milk expressed during breastfeeding","authors":"Jihye Kim, Seyong Oh, Raudel Avila, Hee-Sup Shin, Matthew Banet, Jennifer Wicks, Anthony R. Banks, Yonggang Huang, Jae-Young Yoo, Daniel T. Robinson, Craig F. Garfield, John A. Rogers","doi":"10.1038/s41551-025-01393-w","DOIUrl":"https://doi.org/10.1038/s41551-025-01393-w","url":null,"abstract":"Human milk is the ideal source of nutrition for infants. Most health organizations recommend direct breastfeeding from the first hour of life, extending throughout the first and second year. However, uncertainties regarding the volumes of milk ingested by the infant contribute to suboptimal rates of breastfeeding. Here we introduce a compact and unobtrusive device that gently interfaces to the breast via four electrodes and accurately measures expressed milk volume during breastfeeding through changes in the alternating current impedance. The data pass wirelessly to a smartphone continuously throughout each breastfeeding session for real-time graphical display. Comprehensive experimental and computational results establish the operating principles and guide engineering choices for optimized performance. Evaluations with 12 breastfeeding mothers over periods of as long as 17 weeks in the neonatal intensive care unit and in home settings illustrate the practical utility of this technology in addressing a critically important unmet need in maternal and neonatal care.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"68 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes 基于喹啉-丙二腈探针的活体大脑淀粉样蛋白-β斑块动力学的多重成像

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-13 DOI: 10.1038/s41551-025-01392-x

Jianfeng Dai, Weijun Wei, Chenxu Yan, Ding-Kun Ji, Caiqi Liu, Jialiang Huang, Chenyi Liang, Jianjun Liu, Zhiqian Guo, Wei-Hong Zhu

{"title":"Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes","authors":"Jianfeng Dai, Weijun Wei, Chenxu Yan, Ding-Kun Ji, Caiqi Liu, Jialiang Huang, Chenyi Liang, Jianjun Liu, Zhiqian Guo, Wei-Hong Zhu","doi":"10.1038/s41551-025-01392-x","DOIUrl":"https://doi.org/10.1038/s41551-025-01392-x","url":null,"abstract":"The dynamic behaviour of amyloid-β (Aβ) plaques in Alzheimer’s disease remains poorly understood, and accumulation and distribution of Aβ plaques must be inferred from in vitro pathological changes in brain tissue. In situ detection of Aβ plaques in live imaging is challenging because of the lack of adequate probes. Here we report the design of unimolecular quinoline-malononitrile-based Aβ probes, termed QMFluor integrative framework, that binds in vivo to Aβ plaques, making them detectable via near-infrared fluorescence imaging, magnetic resonance imaging, positron emission tomography and computed tomography. QMFluor probes are permeable to the blood–brain barrier, and, upon systematic injection, enable real-time magnetic resonance imaging and positron emission tomography–computed tomography imaging of the Aβ biodistribution in the hippocampus and cerebral cortex, and accurately differentiate the brains of living Alzheimer’s disease mouse models from wild-type controls. We further demonstrate the ability of QMFluor probes to reach the brain after intravenous injection in a large animal model. This strategy expands the toolbox of probes for in vivo visualization of amyloids in Alzheimer’s disease pathological analysis, drug screening and clinical applications.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"117 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations 聚焦超声微泡治疗可抑制脑海绵状畸形的生长和形成

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-13 DOI: 10.1038/s41551-025-01390-z

Delaney G. Fisher, Tanya Cruz, Matthew R. Hoch, Khadijeh A. Sharifi, Ishaan M. Shah, Catherine M. Gorick, Victoria R. Breza, Anna C. Debski, Joshua D. Samuels, Jason P. Sheehan, David Schlesinger, David Moore, James W. Mandell, John R. Lukens, G. Wilson Miller, Petr Tvrdik, Richard J. Price

{"title":"Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations","authors":"Delaney G. Fisher, Tanya Cruz, Matthew R. Hoch, Khadijeh A. Sharifi, Ishaan M. Shah, Catherine M. Gorick, Victoria R. Breza, Anna C. Debski, Joshua D. Samuels, Jason P. Sheehan, David Schlesinger, David Moore, James W. Mandell, John R. Lukens, G. Wilson Miller, Petr Tvrdik, Richard J. Price","doi":"10.1038/s41551-025-01390-z","DOIUrl":"https://doi.org/10.1038/s41551-025-01390-z","url":null,"abstract":"Cerebral cavernous malformations (CCMs) are vascular lesions within the central nervous system that cause debilitating neurological symptoms. Currently, surgical excision and stereotactic radiosurgery, the primary treatment options, pose risks to some patients. Here we tested whether pulsed, low intensity, focused ultrasound-microbubble (FUS-MB) treatments control CCM growth and formation in a clinically representative Krit1 null murine model. FUS-MB under magnetic resonance imaging (MRI) guidance opened the blood–brain barrier, with gadolinium contrast agent deposition most evident at perilesional boundaries. Longitudinal MRI revealed that, at 1 month after treatment, FUS-MB halted the growth of 94% of treated CCMs. In contrast, untreated CCMs grew ~7-fold in volume. FUS-MB-treated CCMs exhibited a marked reduction in Krit1 null endothelial cells. In mice receiving multiple FUS-MB treatments with fixed peak-negative pressures, de novo CCM formation was reduced by 81%, indicating a prophylactic effect. Our findings support FUS-MB as a minimally invasive treatment modality that can safely arrest murine CCM growth and prevent de novo CCM formation in mice. If proven safe and effective in clinical trials, FUS-MB treatment may enhance therapeutic options for CCM patients.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"31 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting inflammation with chimeric antigen receptor macrophages using a signal switch 利用信号开关靶向嵌合抗原受体巨噬细胞炎症

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-07 DOI: 10.1038/s41551-025-01387-8

Qi Cao, Yiping Wang, Jianwei Chen, Ruifeng Wang, Titi Chen, Brian Gloss, Scott A. Read, Xuerong Wang, Vincent W. S. Lee, Leighton Clancy, Natasha M. Rogers, Stephen I. Alexander, Guoping Zheng, Di Yu, David C. H. Harris

{"title":"Targeting inflammation with chimeric antigen receptor macrophages using a signal switch","authors":"Qi Cao, Yiping Wang, Jianwei Chen, Ruifeng Wang, Titi Chen, Brian Gloss, Scott A. Read, Xuerong Wang, Vincent W. S. Lee, Leighton Clancy, Natasha M. Rogers, Stephen I. Alexander, Guoping Zheng, Di Yu, David C. H. Harris","doi":"10.1038/s41551-025-01387-8","DOIUrl":"https://doi.org/10.1038/s41551-025-01387-8","url":null,"abstract":"Chimeric antigen receptor (CAR) T-cell immunotherapy has shown great success in clinical cancer, bringing hope to apply CAR strategies to other clinical settings. Here we developed a CAR macrophage (CAR-M) that recognizes the major inflammatory molecule tumour necrosis factor (TNF) and activates an intracellular IL-4 signalling pathway, thereby programming engineered macrophages for an anti-inflammatory function. CAR-M therapy has exhibited efficacy in mouse models of both acute and chronic inflammatory diseases. In kidney ischaemia reperfusion injury (IRI), infused CAR-Ms switched to an anti-inflammatory phenotype in inflamed kidney and attenuated kidney IRI. The anti-inflammatory phenotype of infused CAR-Ms switched off during the recovery phase of kidney IRI, coinciding with the disappearance of TNF. In Adriamycin-induced nephropathy, a model of chronic inflammatory disease, infused CAR-Ms maintained an anti-inflammatory phenotype for several weeks in response to sustained high levels of TNF and improved kidney function and structure. CAR-Ms also effectively reduced tissue injury in another organ, the liver. Human anti-TNF CAR-Ms exhibit anti-inflammatory phenotype and function in response to TNF. The CAR-M design, using signal switching, holds promise for the treatment of a broad range of acute and chronic inflammatory diseases.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"43 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial peptides boosted by ultrasound 超声增强抗菌肽

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-02 DOI: 10.1038/s41551-025-01388-7

Soraia Fernandes, Francesca Cavalieri

引用次数: 0

Enhanced nanoparticle delivery across vascular basement membranes of tumours using nitric oxide 利用一氧化氮增强肿瘤血管基底膜上纳米颗粒的传递

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-02 DOI: 10.1038/s41551-025-01385-w

Wei Jiang, Zixuan Guo, Qin Wang, Ziqi Chen, Wang Dong, Qirui Liang, Yinghong Hao, Huimin Pan, Cici Zeng, Hang Liu, Yucai Wang

{"title":"Enhanced nanoparticle delivery across vascular basement membranes of tumours using nitric oxide","authors":"Wei Jiang, Zixuan Guo, Qin Wang, Ziqi Chen, Wang Dong, Qirui Liang, Yinghong Hao, Huimin Pan, Cici Zeng, Hang Liu, Yucai Wang","doi":"10.1038/s41551-025-01385-w","DOIUrl":"https://doi.org/10.1038/s41551-025-01385-w","url":null,"abstract":"The delivery of nanoparticles (NPs) into solid tumours is challenged by the tumour vascular basement membrane (BM), a critical barrier beneath the endothelium with robust mechanical properties resistant to conventional treatments. Here we propose an approach that uses nitric oxide (NO) to induce the opening of endothelial junctions, creating gaps between endothelial cells and enabling the navigation of NPs through these gaps. Subsequently, NO orchestrates a transient degradation of the BM encasing NP pools in a precise, localized action, allowing the enhanced passage of NPs into the tumour interstitial space through explosive eruptions. We have engineered a NO nanogenerator tailored for near-infrared laser-triggered on-demand NO release at tumour sites. Through breaching the BM barrier, this system results in an increase of clinical nanomedicines within the tumour, boosting the tumour suppression efficacy in both mouse and rabbit models. This approach delicately manages BM degradation, avoiding excessive degradation that might facilitate cancer metastasis. Our NO nanogenerator serves as a precise spatial catalytic degradation strategy for breaching the tumour vascular BM barrier, holding promise for NP delivery into non-tumour diseases.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"22 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide 一种基于二苯丙氨酸的声敏广谱抗菌肽

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-02 DOI: 10.1038/s41551-025-01377-w

Xiaoguang Zhang, Xiaobo Feng, Liang Ma, Jie Lei, Gaocai Li, Weifeng Zhang, Huaizhen Liang, Bide Tong, Di Wu, Cao Yang, Lei Tan

{"title":"A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide","authors":"Xiaoguang Zhang, Xiaobo Feng, Liang Ma, Jie Lei, Gaocai Li, Weifeng Zhang, Huaizhen Liang, Bide Tong, Di Wu, Cao Yang, Lei Tan","doi":"10.1038/s41551-025-01377-w","DOIUrl":"https://doi.org/10.1038/s41551-025-01377-w","url":null,"abstract":"The antimicrobial effect of antimicrobial peptides is typically slow; they can be rapidly biodegraded and often have non-selective toxicity and elaborate sequences. Here we report a short peptide that is activated by ultrasound, that shows high broad-spectrum antibacterial efficiency (>99%) against clinically isolated methicillin-resistant bacteria (specifically, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Enterobacter cancerogenus and Pseudomonas aeruginosa) with 15 min of ultrasound irradiation, and that has negligible toxicity and low self-antibacterial activity. We selected the peptide, FFRKSKEK (a segment from the human host-defence LL-37 peptide), from a library of peptides with piezoelectric diphenylalanine (FF) sequences, low toxicity, hydrophobicity and net positive charge. We show via all-atom molecular dynamics simulations that ultrasound amplifies the membrane-penetrating ability of peptides with FF sequences and that its piezoelectric polarization generates reactive-oxygen species and disturbs bacterial electron-transport chains. In a goat model of hard-to-treat intervertebral infection, the sonosensitive peptide led to better outcomes than vancomycin. Antimicrobial peptides activated by ultrasound may offer a clinically relevant strategy for combating antibiotic-resistant infections.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"44 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically driven biohybrid blood hydrogel fibres for personalized intracranial tumour therapy under fluoroscopic tracking 磁驱动的生物混合血液凝胶纤维在透视跟踪下用于个性化颅内肿瘤治疗

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-05-01 DOI: 10.1038/s41551-025-01382-z

Ben Wang, Jie Shen, Chenyang Huang, Zhicheng Ye, Jiajun He, Xinyu Wu, Zhiguang Guo, Li Zhang, Tiantian Xu

{"title":"Magnetically driven biohybrid blood hydrogel fibres for personalized intracranial tumour therapy under fluoroscopic tracking","authors":"Ben Wang, Jie Shen, Chenyang Huang, Zhicheng Ye, Jiajun He, Xinyu Wu, Zhiguang Guo, Li Zhang, Tiantian Xu","doi":"10.1038/s41551-025-01382-z","DOIUrl":"https://doi.org/10.1038/s41551-025-01382-z","url":null,"abstract":"Small materials with pliability and untethered mobility are particularly suitable for minimally invasive medical interventions inside the body. However, the capabilities and applicability of such soft ‘robots’ are restricted by foreign-body responses to them and by the need to get them cleared from the body after the intervention. Here we report the development of biodegradable magnetized biohybrid blood hydrogel fibres that evade immune recognition, and their applicability for targeted intracranial tumour therapy with real-time tracking through X-ray fluoroscopy. The gel fibres can be made of the patient’s own blood mixed with a small amount of magnetic particles and can be produced in about 15 min. We show that the locomotion of intracranially injected gel fibres through cerebrospinal fluid can be remotely controlled under a magnetic field and fluoroscopically tracked, and that a drug encapsulated in the gels can be released on demand under magnetic control, as we show for the delivery of doxorubicin to intracranial tumours in the minipigs. Biodegradable soft actuatable materials that avoid foreign-body responses may aid the development of personalized targeted interventions.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"73 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A live bacteria enzyme assay for identification of human disease mutations and drug screening 用于鉴定人类疾病突变和药物筛选的活菌酶测定

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-04-30 DOI: 10.1038/s41551-025-01391-y

Donghui Choe, Bernhard O. Palsson

{"title":"A live bacteria enzyme assay for identification of human disease mutations and drug screening","authors":"Donghui Choe, Bernhard O. Palsson","doi":"10.1038/s41551-025-01391-y","DOIUrl":"https://doi.org/10.1038/s41551-025-01391-y","url":null,"abstract":"Advances in high-throughput sequencing have enabled the identification of genetic variations associated with human disease. However, deciphering the functional significance of these variations remains challenging. Here we propose an alternative approach that uses humanized Escherichia coli to study human genetic enzymopathies and to screen candidate drug effects on metabolic targets. By replacing selected E. coli metabolic enzymes with their human orthologues and their sequence variants, we demonstrate that the growth rate of E. coli reflects the in vivo activity of heterologously expressed human enzymes. This approach accurately reflected enzyme activities of known sequence variants, enabling rapid screening of causal sequence variations associated with human diseases. This approach bridges the gap between in vitro assays and cell-based assays. Our findings suggest that the proposed approach using a humanized E. coli strain holds promise for drug discovery, offering a high-throughput and cost-effective platform for identifying new compounds targeting human enzymes. Continued research and innovation in this field have the potential to impact the development and practice of precision medicine.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"35 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A highly mobile adeno-associated virus targeting vascular smooth muscle cells for the treatment of pulmonary arterial hypertension 一种高度移动的腺相关病毒靶向血管平滑肌细胞治疗肺动脉高压

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-04-29 DOI: 10.1038/s41551-025-01379-8

Yoojin Kim, Yeongju Yeo, Minju Kim, Yong-Wook Son, Joowon Kim, Koung Li Kim, Seohee Kim, Seokmin Oh, Yunha Kim, Hyowoo Lee, Hyun-Woo Park, Dongsoo Lee, Sung Jin Lee, Changmin Kang, Hongyoung Choi, Chan Soon Park, Seung-Pyo Lee, Wonhee Suh, Jae-Hyung Jang

{"title":"A highly mobile adeno-associated virus targeting vascular smooth muscle cells for the treatment of pulmonary arterial hypertension","authors":"Yoojin Kim, Yeongju Yeo, Minju Kim, Yong-Wook Son, Joowon Kim, Koung Li Kim, Seohee Kim, Seokmin Oh, Yunha Kim, Hyowoo Lee, Hyun-Woo Park, Dongsoo Lee, Sung Jin Lee, Changmin Kang, Hongyoung Choi, Chan Soon Park, Seung-Pyo Lee, Wonhee Suh, Jae-Hyung Jang","doi":"10.1038/s41551-025-01379-8","DOIUrl":"https://doi.org/10.1038/s41551-025-01379-8","url":null,"abstract":"In pulmonary arterial hypertension (PAH), a phenotypic switch in pulmonary arterial smooth muscle cells (PASMCs) that is primarily caused by aberrant gene regulatory networks can lead to dysregulated vascular remodelling, heart failure or death. No curative therapies for PAH are currently available, presumably because of a lack of viral vectors specifically targeting PASMCs. Here we show that a highly mobile and PASMC-tropic adeno-associated virus variant developed via directed evolution overcomes physical barriers that inhibit its transfer from bronchial airways to vascular layers, ultimately boosting therapeutic efficacy in murine models of PAH. Intratracheal administration of the adeno-associated virus variant carrying a transgene for fibroblast growth factor 12—a key factor regulating the PASMC phenotype—suppressed pulmonary vascular remodelling, prevented the development of PAH in mice and reversed established PAH in rats. The variant’s mobility and enhanced tropism for PASMCs may enable curative treatments for PAH.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"18 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0