Nature Materials最新文献_第3页

Resonant osmotic diodes for voltage-induced water filtration across composite membranes 用于电压诱导水跨复合膜过滤的共振渗透二极管

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-11 DOI: 10.1038/s41563-025-02257-z

Soufiane Abdelghani-Idrissi, Lucie Ries, Geoffrey Monet, Javier Perez-Carvajal, Zacharie Pilo, Paulina Sarnikowski, Alessandro Siria, Lydéric Bocquet

引用次数: 0

Instant assembly of collagen for tissue engineering and bioprinting 用于组织工程和生物打印的胶原蛋白的即时组装

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-06 DOI: 10.1038/s41563-025-02241-7

Xiangyu Gong, Zhang Wen, Zixie Liang, Hugh Xiao, Sein Lee, Alejandro Rossello‐Martinez, Qinzhe Xing, Thomas Wright, Ryan Y. Nguyen, Michael Mak

{"title":"Instant assembly of collagen for tissue engineering and bioprinting","authors":"Xiangyu Gong, Zhang Wen, Zixie Liang, Hugh Xiao, Sein Lee, Alejandro Rossello‐Martinez, Qinzhe Xing, Thomas Wright, Ryan Y. Nguyen, Michael Mak","doi":"10.1038/s41563-025-02241-7","DOIUrl":"https://doi.org/10.1038/s41563-025-02241-7","url":null,"abstract":"Engineering functional cellular tissue components holds great promise in regenerative medicine. Collagen I, a key scaffolding material in bodily tissues, presents challenges in controlling its assembly kinetics in a biocompatible manner in vitro, restricting its use as a primary scaffold or adhesive in cellular biofabrication. Here we report a collagen fabrication method termed as tunable rapid assembly of collagenous elements that leverages macromolecular crowding to achieve the instant assembly of unmodified collagen. By applying an inert crowder to accelerate the liquid–gel transition of collagen, our method enables the high-throughput creation of physiological collagen constructs across length scales—from micro to macro—and facilitates cell self-assembly and morphogenesis through the generation of tunable multiscale architectural cues. With high biocompatibility and rapid gelation kinetics, the tunable rapid assembly of collagenous elements method also offers a versatile bioprinting approach for collagen over a wide concentration range, enabling the direct printing of cellular tissues using pH-neutral, bioactive collagen bioinks and achieving both structural complexity and biofunctionality. This work broadens the scope of controllable multiscale biofabrication for tissues across various organ systems using unmodified collagen.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"25 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the glassy state in nanoparticles by transmission electron microscopy 用透射电子显微镜鉴定纳米颗粒的玻璃态

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-06 DOI: 10.1038/s41563-025-02260-4

Francis M. Alcorn, Prashant K. Jain

引用次数: 0

Detecting interference of lattice vibrations 检测晶格振动的干扰

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-06 DOI: 10.1038/s41563-025-02251-5

Elke Scheer, Paul Leiderer

引用次数: 0

Publisher Correction: High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics 出版者更正：高密度的刷状聚合物脂质减少了重复给药mRNA治疗的抗peg抗体结合

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-04 DOI: 10.1038/s41563-025-02270-2

Yufen Xiao, Xizhen Lian, Yehui Sun, Yun-Chieh Sung, Amogh Vaidya, Zexiang Chen, Ankit Gupta, Sumanta Chatterjee, Lining Zheng, Erick Guerrero, Xu Wang, Lukas Farbiak, Yangyang Yang, Marc I. Diamond, Cecilia Leal, Jeffrey G. McDonald, Daniel J. Siegwart

引用次数: 0

A stable home 一个稳定的家

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-03 DOI: 10.1038/s41563-025-02190-1

J. Will Medlin

引用次数: 0

Symmetry-protected electronic metastability in an optically driven cuprate ladder 光驱动铜阶梯中对称保护的电子亚稳态

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-03 DOI: 10.1038/s41563-025-02254-2

Hari Padma, Filippo Glerean, Sophia F. R. TenHuisen, Zecheng Shen, Haoxin Wang, Luogen Xu, Joshua D. Elliott, Christopher C. Homes, Elizabeth Skoropata, Hiroki Ueda, Biaolong Liu, Eugenio Paris, Arnau Romaguera, Byungjune Lee, Wei He, Yu Wang, Seng Huat Lee, Hyeongi Choi, Sang-Youn Park, Zhiqiang Mao, Matteo Calandra, Hoyoung Jang, Elia Razzoli, Mark P. M. Dean, Yao Wang, Matteo Mitrano

{"title":"Symmetry-protected electronic metastability in an optically driven cuprate ladder","authors":"Hari Padma, Filippo Glerean, Sophia F. R. TenHuisen, Zecheng Shen, Haoxin Wang, Luogen Xu, Joshua D. Elliott, Christopher C. Homes, Elizabeth Skoropata, Hiroki Ueda, Biaolong Liu, Eugenio Paris, Arnau Romaguera, Byungjune Lee, Wei He, Yu Wang, Seng Huat Lee, Hyeongi Choi, Sang-Youn Park, Zhiqiang Mao, Matteo Calandra, Hoyoung Jang, Elia Razzoli, Mark P. M. Dean, Yao Wang, Matteo Mitrano","doi":"10.1038/s41563-025-02254-2","DOIUrl":"https://doi.org/10.1038/s41563-025-02254-2","url":null,"abstract":"Optically excited quantum materials exhibit non-equilibrium states with remarkable emergent properties, but these phenomena are usually transient, decaying on picosecond timescales and limiting practical applications. Advancing the design and control of non-equilibrium phases requires the development of targeted strategies to achieve long-lived, metastable phases. Here we report the discovery of symmetry-protected electronic metastability in the model cuprate ladder Sr14Cu24O41. Using femtosecond resonant X-ray scattering and spectroscopy, we show that this metastability is driven by a transfer of holes from chain-like charge reservoirs into the ladders. This ultrafast charge redistribution arises from the optical dressing and activation of a hopping pathway that is forbidden by symmetry at equilibrium. Relaxation back to the ground state is, hence, suppressed after the pump coherence dissipates. Our findings highlight how dressing materials with electromagnetic fields can dynamically activate terms in the electronic Hamiltonian, and provide a rational design strategy for non-equilibrium phases of matter.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"246 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncertain times 不确定的时期

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-06-03 DOI: 10.1038/s41563-025-02267-x

引用次数: 0

Superconductivity and normal-state transport in compressively strained La2PrNi2O7 thin films 压缩应变La2PrNi2O7薄膜的超导性和正态输运

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-05-29 DOI: 10.1038/s41563-025-02258-y

Yidi Liu, Eun Kyo Ko, Yaoju Tarn, Lopa Bhatt, Jiarui Li, Vivek Thampy, Berit H. Goodge, David A. Muller, Srinivas Raghu, Yijun Yu, Harold Y. Hwang

{"title":"Superconductivity and normal-state transport in compressively strained La2PrNi2O7 thin films","authors":"Yidi Liu, Eun Kyo Ko, Yaoju Tarn, Lopa Bhatt, Jiarui Li, Vivek Thampy, Berit H. Goodge, David A. Muller, Srinivas Raghu, Yijun Yu, Harold Y. Hwang","doi":"10.1038/s41563-025-02258-y","DOIUrl":"https://doi.org/10.1038/s41563-025-02258-y","url":null,"abstract":"The discovery of superconductivity under high pressure in Ruddlesden–Popper phases of bulk nickelates has sparked great interest in stabilizing ambient-pressure superconductivity in the thin-film form using epitaxial strain. Recently, signs of superconductivity have been observed in compressively strained bilayer nickelate thin films with an onset temperature exceeding 40 K, although with broad, two-step-like transitions. Here we report the intrinsic superconductivity and normal-state transport properties in compressively strained La2PrNi2O7 thin films, achieved through a combination of isovalent Pr substitution, growth optimization and precision ozone annealing. The superconducting onset occurs above 48 K, with zero resistance reached above 30 K, and the critical current density at 1.4 K is 100-fold larger than previous reports. The normal-state resistivity exhibits quadratic temperature dependence indicative of Fermi liquid behaviour, and other phenomenological similarities to transport in overdoped cuprates suggest parallels in their emergent properties.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"2674 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity 聚羧基甜菜碱脂质提高mRNA治疗效果，降低其免疫原性

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-05-29 DOI: 10.1038/s41563-025-02240-8

Sijin Luozhong, Pingchuan Liu, Ruoxin Li, Zhefan Yuan, Erica Debley, Yu Chen, Yuping Hu, Zeyu Cao, Meng Cui, Kay McIlhenny, Caleb McCurdy, Dani Bhashyam, Stephan Wilkens, Prince Zhang, Austin Kwan, Mark Grossman, Rachel Lai, Yufei Ma, Steven Lipkin, Shaoyi Jiang

{"title":"Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity","authors":"Sijin Luozhong, Pingchuan Liu, Ruoxin Li, Zhefan Yuan, Erica Debley, Yu Chen, Yuping Hu, Zeyu Cao, Meng Cui, Kay McIlhenny, Caleb McCurdy, Dani Bhashyam, Stephan Wilkens, Prince Zhang, Austin Kwan, Mark Grossman, Rachel Lai, Yufei Ma, Steven Lipkin, Shaoyi Jiang","doi":"10.1038/s41563-025-02240-8","DOIUrl":"https://doi.org/10.1038/s41563-025-02240-8","url":null,"abstract":"Messenger RNA (mRNA) therapeutics are a promising strategy to combat diverse diseases. Traditional lipid nanoparticle (LNP) formulations for mRNA delivery contain poly(ethylene) glycol (PEG), a polymer widely used in drug delivery carriers but that recently has been associated with efficacy and immunogenicity concerns. Here we report poly(carboxybetaine) (PCB) lipids as surrogates for PEG-lipids used in mRNA formulations. In vitro studies with immortalized and primary cells show that PCB-containing LNPs have higher mRNA transfection efficiency than PEG-containing LNPs across different formulations. Moreover, primary cell engineering and in vivo immunization studies in mice further demonstrate greater therapeutic efficacy of PCB-containing LNPs over their PEG counterparts. Mechanistic assays show that this improvement is attributed to enhanced endosomal escape of PCB-containing LNPs. These formulations exhibit a safe immunotoxicity profile and effectively mitigate the accelerated blood clearance effect that has been observed for PEG-containing LNPs, enabling repeated administrations without efficacy loss. Overall, these findings highlight PCB-containing LNPs as a potent and safe mRNA delivery platform for clinical applications.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"5 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0