{"title":"用于微创手术和传感的磁驱动多模态生物电子导管","authors":"Jingbo Yang, Yuanxi Zhang, Zhengjie Liu, Shuang Huang, Xinshuo Huang, Yunuo Wang, Mingqiang Li, Shantao Zheng, Fuqian Chen, Jing Liu, Yu Tao, Tong Wu, Lizhi Xu, Huijiuan Chen, Lelun Jiang, Xi Xie","doi":"10.1038/s41563-025-02340-5","DOIUrl":null,"url":null,"abstract":"<p>Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously. We use four-dimensional multichannel printing to fabricate a flexible multichannel ferromagnetic catheter with a multichannel-sheath structure, comprising six liquid metal microchannels embedded in a polymer matrix for electrical conduction. The catheter can navigate through blood vessels and intestines using magnetically controlled active steering, being used for renal vein or intestines interventional surgeries and in situ multimetabolite sensing on rabbit and porcine models. Overall, the reported magnetically actuated bioelectronic catheter is a promising tool for remotely controlled biosensing and therapies on hard-to-reach lesions during minimally invasive surgery.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"30 1","pages":""},"PeriodicalIF":38.5000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing\",\"authors\":\"Jingbo Yang, Yuanxi Zhang, Zhengjie Liu, Shuang Huang, Xinshuo Huang, Yunuo Wang, Mingqiang Li, Shantao Zheng, Fuqian Chen, Jing Liu, Yu Tao, Tong Wu, Lizhi Xu, Huijiuan Chen, Lelun Jiang, Xi Xie\",\"doi\":\"10.1038/s41563-025-02340-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously. We use four-dimensional multichannel printing to fabricate a flexible multichannel ferromagnetic catheter with a multichannel-sheath structure, comprising six liquid metal microchannels embedded in a polymer matrix for electrical conduction. The catheter can navigate through blood vessels and intestines using magnetically controlled active steering, being used for renal vein or intestines interventional surgeries and in situ multimetabolite sensing on rabbit and porcine models. Overall, the reported magnetically actuated bioelectronic catheter is a promising tool for remotely controlled biosensing and therapies on hard-to-reach lesions during minimally invasive surgery.</p>\",\"PeriodicalId\":19058,\"journal\":{\"name\":\"Nature Materials\",\"volume\":\"30 1\",\"pages\":\"\"},\"PeriodicalIF\":38.5000,\"publicationDate\":\"2025-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1038/s41563-025-02340-5\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1038/s41563-025-02340-5","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing
Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously. We use four-dimensional multichannel printing to fabricate a flexible multichannel ferromagnetic catheter with a multichannel-sheath structure, comprising six liquid metal microchannels embedded in a polymer matrix for electrical conduction. The catheter can navigate through blood vessels and intestines using magnetically controlled active steering, being used for renal vein or intestines interventional surgeries and in situ multimetabolite sensing on rabbit and porcine models. Overall, the reported magnetically actuated bioelectronic catheter is a promising tool for remotely controlled biosensing and therapies on hard-to-reach lesions during minimally invasive surgery.
期刊介绍:
Nature Materials is a monthly multi-disciplinary journal aimed at bringing together cutting-edge research across the entire spectrum of materials science and engineering. It covers all applied and fundamental aspects of the synthesis/processing, structure/composition, properties, and performance of materials. The journal recognizes that materials research has an increasing impact on classical disciplines such as physics, chemistry, and biology.
Additionally, Nature Materials provides a forum for the development of a common identity among materials scientists and encourages interdisciplinary collaboration. It takes an integrated and balanced approach to all areas of materials research, fostering the exchange of ideas between scientists involved in different disciplines.
Nature Materials is an invaluable resource for scientists in academia and industry who are active in discovering and developing materials and materials-related concepts. It offers engaging and informative papers of exceptional significance and quality, with the aim of influencing the development of society in the future.