用于微创手术和传感的磁驱动多模态生物电子导管

IF 38.5 1区 材料科学 Q1 CHEMISTRY, PHYSICAL
Jingbo Yang, Yuanxi Zhang, Zhengjie Liu, Shuang Huang, Xinshuo Huang, Yunuo Wang, Mingqiang Li, Shantao Zheng, Fuqian Chen, Jing Liu, Yu Tao, Tong Wu, Lizhi Xu, Huijiuan Chen, Lelun Jiang, Xi Xie
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引用次数: 0

摘要

具有远程主动导航功能的小型磁致导尿管在微创手术中具有广阔的应用前景。然而,现有的制造技术阻碍了它们与多模态传感元件的集成,特别是因为在导管内嵌入刚性电子元件可能会降低导管的灵活性和可控性。在这里,我们报告了一种磁驱动的生物电子导管,可以同时对多种类型的代谢物或离子进行原位多路生物传感。我们使用四维多通道打印技术制造了一种柔性多通道铁磁导管,该导管具有多通道护套结构,由六个嵌入聚合物基质的液态金属微通道组成,用于导电。该导管可以通过磁控主动转向在血管和肠道中导航,用于肾静脉或肠道介入手术,并在兔和猪模型上进行原位多代谢物传感。总的来说,磁驱动的生物电子导管是一种很有前途的工具,用于远程控制生物传感和微创手术中难以触及的病变的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing

Magnetically actuated multimodal bioelectronic catheter for minimally invasive surgery and sensing

Small-scale magnetically actuated catheters capable of remote active navigation have promising applications in minimally invasive surgeries. However, existing fabrication techniques hinder their integration with multimodal sensing components, especially since embedding rigid electronic components within the catheters may diminish their flexibility and controllability. Here we report a magnetically actuated bioelectronic catheter with the in situ multiplexed biosensing of multiple types of metabolite or ion simultaneously. We use four-dimensional multichannel printing to fabricate a flexible multichannel ferromagnetic catheter with a multichannel-sheath structure, comprising six liquid metal microchannels embedded in a polymer matrix for electrical conduction. The catheter can navigate through blood vessels and intestines using magnetically controlled active steering, being used for renal vein or intestines interventional surgeries and in situ multimetabolite sensing on rabbit and porcine models. Overall, the reported magnetically actuated bioelectronic catheter is a promising tool for remotely controlled biosensing and therapies on hard-to-reach lesions during minimally invasive surgery.

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来源期刊
Nature Materials
Nature Materials 工程技术-材料科学:综合
CiteScore
62.20
自引率
0.70%
发文量
221
审稿时长
3.2 months
期刊介绍: Nature Materials is a monthly multi-disciplinary journal aimed at bringing together cutting-edge research across the entire spectrum of materials science and engineering. It covers all applied and fundamental aspects of the synthesis/processing, structure/composition, properties, and performance of materials. The journal recognizes that materials research has an increasing impact on classical disciplines such as physics, chemistry, and biology. Additionally, Nature Materials provides a forum for the development of a common identity among materials scientists and encourages interdisciplinary collaboration. It takes an integrated and balanced approach to all areas of materials research, fostering the exchange of ideas between scientists involved in different disciplines. Nature Materials is an invaluable resource for scientists in academia and industry who are active in discovering and developing materials and materials-related concepts. It offers engaging and informative papers of exceptional significance and quality, with the aim of influencing the development of society in the future.
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