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Systems education can train the next generation of scientists and clinicians 系统教育可以培养下一代科学家和临床医生
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-17 DOI: 10.1038/s41591-024-03315-w
Péter Hegyi, András Varró
{"title":"Systems education can train the next generation of scientists and clinicians","authors":"Péter Hegyi, András Varró","doi":"10.1038/s41591-024-03315-w","DOIUrl":"https://doi.org/10.1038/s41591-024-03315-w","url":null,"abstract":"<p>In recent years, there has been growing concern about waning interest in science, as despite advances in research and technology, fewer young people seem to be pursuing careers in these fields<sup>1</sup>. This decline can be attributed to various factors, including a lack of early engagement, inadequate integration of practical experience and insufficient alignment between educational stages. To address this issue, the National Academy of Scientist Education (NASE) and Academia Europaea (AE) propose the concept of ‘multigenerational systems education’, a comprehensive approach that draws inspiration from systems biology and systems medicine.</p><p>The traditional methods of teaching science have failed to keep pace with the rapid advancements of the twenty-first century. Evidence of declining interest is reflected in the decreasing number of students enrolling in science courses at both the high school level and the university level<sup>1</sup>. According to recent studies, fewer students are choosing to specialize in life sciences, with many perceiving these fields as inaccessible or irrelevant to real-world applications<sup>2,3</sup>.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"1 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to prepare for the next inevitable Ebola outbreak: lessons from West Africa 如何应对下一次不可避免的埃博拉疫情爆发：西非的经验教训
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-17 DOI: 10.1038/s41591-024-03295-x
Henry Kyobe Bosa, Neema Kamara, Merawi Aragaw, Misaki Wayengera, Patrick D. M. C. Katoto, Chikwe Ihekweazu, Mosoka P. Fallah, Moussa Douno, Robert Kwame Agyarko, Placide Mbala, Mamadou Souncalo Traoré, Ambrose Talisuna, James Bangura, Henry G. Mwebesa, Abdoulaye Bousso, Obasanya Joshua, James Sylvester Squire, Tolbert Nyenswah, Thelma V. Nelson, Justin Maeda, Olushayo Oluseun Olu, Yonas Tegegn Woldemariam, Benjamin Djoudalbaye, Alain Ngashi Ngongo, Tajudeen Raji, Francis Chisaka Kasolo, Ibrahima Socé Fall, Ahmed Ouma Ogwell, Jane Ruth Aceng, Jean Kaseya
{"title":"How to prepare for the next inevitable Ebola outbreak: lessons from West Africa","authors":"Henry Kyobe Bosa, Neema Kamara, Merawi Aragaw, Misaki Wayengera, Patrick D. M. C. Katoto, Chikwe Ihekweazu, Mosoka P. Fallah, Moussa Douno, Robert Kwame Agyarko, Placide Mbala, Mamadou Souncalo Traoré, Ambrose Talisuna, James Bangura, Henry G. Mwebesa, Abdoulaye Bousso, Obasanya Joshua, James Sylvester Squire, Tolbert Nyenswah, Thelma V. Nelson, Justin Maeda, Olushayo Oluseun Olu, Yonas Tegegn Woldemariam, Benjamin Djoudalbaye, Alain Ngashi Ngongo, Tajudeen Raji, Francis Chisaka Kasolo, Ibrahima Socé Fall, Ahmed Ouma Ogwell, Jane Ruth Aceng, Jean Kaseya","doi":"10.1038/s41591-024-03295-x","DOIUrl":"https://doi.org/10.1038/s41591-024-03295-x","url":null,"abstract":"Many lessons have been learned 10 years after the Ebola virus disease outbreak in West Africa, but urgent work is now needed to prevent another outbreak.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"18 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori, gastric cancer and the screening conundrum 幽门螺杆菌、胃癌和筛查难题
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-17 DOI: 10.1038/d41591-024-00075-5
{"title":"Helicobacter pylori, gastric cancer and the screening conundrum","authors":"","doi":"10.1038/d41591-024-00075-5","DOIUrl":"https://doi.org/10.1038/d41591-024-00075-5","url":null,"abstract":"A large study failed to show a reduction in gastric cancer incidence or mortality when Helicobacter pylori screening was added to standard colon cancer screening.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"11 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative immunotherapy for bladder cancer 膀胱癌围手术期免疫疗法
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-16 DOI: 10.1038/d41591-024-00074-6
{"title":"Perioperative immunotherapy for bladder cancer","authors":"","doi":"10.1038/d41591-024-00074-6","DOIUrl":"https://doi.org/10.1038/d41591-024-00074-6","url":null,"abstract":"In the NIAGARA trial, the addition of perioperative durvalumab to standard treatment for muscle-invasive bladder cancer improved event-free and overall survival, marking a new treatment option for this condition.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"13 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial 出版商更正：异基因CD5特异性CAR-T疗法治疗复发/难治性T-ALL：1期试验
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-16 DOI: 10.1038/s41591-024-03348-1
Jing Pan, Yue Tan, Lingling Shan, Samuel Seery, Biping Deng, Zhuojun Ling, Jinlong Xu, Jiajia Duan, Zelin Wang, Kai Wang, Xinjian Yu, Qinlong Zheng, Xiuwen Xu, Guang Hu, Taochao Tan, Ying Yuan, Zhenglong Tian, Fangrong Yan, Yajing Han, Jiecheng Zhang, Xiaoming Feng
{"title":"Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial","authors":"Jing Pan, Yue Tan, Lingling Shan, Samuel Seery, Biping Deng, Zhuojun Ling, Jinlong Xu, Jiajia Duan, Zelin Wang, Kai Wang, Xinjian Yu, Qinlong Zheng, Xiuwen Xu, Guang Hu, Taochao Tan, Ying Yuan, Zhenglong Tian, Fangrong Yan, Yajing Han, Jiecheng Zhang, Xiaoming Feng","doi":"10.1038/s41591-024-03348-1","DOIUrl":"https://doi.org/10.1038/s41591-024-03348-1","url":null,"abstract":"<p>Correction to: <i>Nature Medicine</i> https://doi.org/10.1038/s41591-024-03282-2, published online 1 October 2024.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"231 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health AI needs meaningful human involvement: lessons from war 医疗人工智能需要有意义的人类参与：战争的教训
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-16 DOI: 10.1038/s41591-024-03311-0
James M. Hillis, Kenneth Payne
{"title":"Health AI needs meaningful human involvement: lessons from war","authors":"James M. Hillis, Kenneth Payne","doi":"10.1038/s41591-024-03311-0","DOIUrl":"https://doi.org/10.1038/s41591-024-03311-0","url":null,"abstract":"<p>Artificial intelligence (AI) continues to show its potential for innovation in healthcare. As this transformation occurs, robust methods are needed to assess when and how AI should function autonomously. The scalability of AI use in healthcare will often conflict with the maintenance of human oversight, and an appropriate balance must be sought. We draw on ongoing debates in the military domain to explain why the key to effective AI lies in ‘meaningful human involvement’ and key considerations in attaining it.</p><p>The goals of combat contrast sharply with the goals of healthcare. There are nonetheless salient parallels for shared approaches to weighing autonomy. The fundamental questions in both domains are, “When, how and by whom should decisions be made?”. Both arenas demand judgement of acceptable risk to life; the careful delineation of responsibility and accountability; and, ultimately, a decision about how much autonomy should be afforded to nonhuman systems.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"6 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell therapy for neurological disorders 神经系统疾病的细胞疗法
IF 58.7 1区 医学
Nature Medicine Pub Date : 2024-10-15 DOI: 10.1038/s41591-024-03281-3
Soshana P. Svendsen, Clive N. Svendsen
{"title":"Cell therapy for neurological disorders","authors":"Soshana P. Svendsen,&nbsp;Clive N. Svendsen","doi":"10.1038/s41591-024-03281-3","DOIUrl":"10.1038/s41591-024-03281-3","url":null,"abstract":"Cell therapies for neurological disorders are entering the clinic and present unique challenges and opportunities compared with conventional medicines. They have the potential to replace damaged nervous tissue and integrate into the brain or spinal cord to produce functional effects for the lifetime of the patient, which could revolutionize the way clinicians treat debilitating neurological disorders. The major challenge has been cell sourcing, which historically relied mainly on fetal brain tissue. This has largely been overcome with the advent of pluripotent stem cell technology and the ability to make almost any cell of the nervous system at scale. Furthermore, advances in gene editing now allow the generation of genetically modified cells that could perform better and evade the immune system. With all the remarkable new approaches to treat neurological disorders, we take a critical look at the state of current clinical trials and how challenges may be overcome with the evolving technology and innovation occurring in the stem cell field. This Review summarizes the state of clinical research on cell replacement therapy for neurological conditions, and discusses the challenges facing the field, from immunosuppression and therapeutic delivery to cost issues.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"30 10","pages":"2756-2770"},"PeriodicalIF":58.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A chatbot changes the minds of conspiracy theorists 聊天机器人改变阴谋论者的想法
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-14 DOI: 10.1038/d41591-024-00073-7
{"title":"A chatbot changes the minds of conspiracy theorists","authors":"","doi":"10.1038/d41591-024-00073-7","DOIUrl":"https://doi.org/10.1038/d41591-024-00073-7","url":null,"abstract":"A study of over 2,000 people shows that interacting with a large language model reduced belief in conspiracy theories — including some related to COVID-19 — by providing tailored, one-on-one interactions and compelling evidence.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"11 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to make cardiology clinical trials more inclusive 如何使心脏病学临床试验更具包容性
IF 58.7 1区 医学
Nature Medicine Pub Date : 2024-10-14 DOI: 10.1038/s41591-024-03273-3
Faiez Zannad, Otavio Berwanger, Stefano Corda, Martin R. Cowie, Habib Gamra, C. Michael Gibson, Alexandra Goncalves, Thomas Hucko, Kamlesh Khunti, Maciej Kostrubiec, Bettina Johanna Kraus, Cecilia Linde, Thomas F. Lüscher, Marion Mafham, Richard Mindham, Rebecca F. Ortega, Eva Prescott, Lehana Thabane, Clyde Yancy, André Ziegler, Harriette G. C. Van Spall
{"title":"How to make cardiology clinical trials more inclusive","authors":"Faiez Zannad,&nbsp;Otavio Berwanger,&nbsp;Stefano Corda,&nbsp;Martin R. Cowie,&nbsp;Habib Gamra,&nbsp;C. Michael Gibson,&nbsp;Alexandra Goncalves,&nbsp;Thomas Hucko,&nbsp;Kamlesh Khunti,&nbsp;Maciej Kostrubiec,&nbsp;Bettina Johanna Kraus,&nbsp;Cecilia Linde,&nbsp;Thomas F. Lüscher,&nbsp;Marion Mafham,&nbsp;Richard Mindham,&nbsp;Rebecca F. Ortega,&nbsp;Eva Prescott,&nbsp;Lehana Thabane,&nbsp;Clyde Yancy,&nbsp;André Ziegler,&nbsp;Harriette G. C. Van Spall","doi":"10.1038/s41591-024-03273-3","DOIUrl":"10.1038/s41591-024-03273-3","url":null,"abstract":"Cardiovascular clinical trials continue to under-represent children, older adults, females and people from ethnic minority groups relative to population disease distribution. Here we describe strategies to foster trial representativeness, with proposed actions at the levels of trial funding, design, conduct and dissemination. In particular, trial representativeness may be increased through broad recruitment strategies and site selection criteria that reflect the diversity of patients in the catchment area, as well as limiting unjustified exclusion criteria and using pragmatic designs that minimize research burden on patients (including embedded and decentralized trials). Trial communications ought to be culturally appropriate; engaging diverse people with lived experience in the co-design of some trial elements may foster this. The demographics of trialists themselves are associated with participant demographics; therefore, trial leadership must be actively diversified. Funding bodies and journals increasingly require the reporting of sociodemographic characteristics of trial participants, and regulatory bodies now provide guidance on increasing trial diversity; these steps may increase the momentum towards change. Although this Perspective focuses on the cardiovascular trial context, many of these strategies could be applied to other fields. Cardiology trials continue to under-represent certain population groups relative to disease distribution; this Perspective outlines strategies to foster representativeness and create a research enterprise that meets the needs of people living with cardiovascular disease.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"30 10","pages":"2745-2755"},"PeriodicalIF":58.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41591-024-03273-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lassa vaccines to save lives, spare economies and assist in pandemic preparedness 拉萨疫苗可拯救生命、挽救经济并协助大流行病防备工作
IF 82.9 1区 医学
Nature Medicine Pub Date : 2024-10-11 DOI: 10.1038/s41591-024-03332-9
{"title":"Lassa vaccines to save lives, spare economies and assist in pandemic preparedness","authors":"","doi":"10.1038/s41591-024-03332-9","DOIUrl":"https://doi.org/10.1038/s41591-024-03332-9","url":null,"abstract":"Lassa fever is a cryptic viral disease that is spread predominantly from rodents to humans in West Africa. We estimated the health-economic burden associated with Lassa fever, highlighting the gains to population health and economies that could be afforded by Lassa vaccines, several of which are currently in development.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"37 3 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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