Nature Medicine最新文献

{"title":"The silent battle to address the health crisis of conflict-induced air pollution","authors":"Karen J. Cloete, Goran Bandov, Samer Abuzerr","doi":"10.1038/s41591-025-03594-x","DOIUrl":"https://doi.org/10.1038/s41591-025-03594-x","url":null,"abstract":"Conflict zones are plagued by air pollution from warfare-related activities, which exacerbates public health challenges, especially for vulnerable populations and the environments they live in.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"9 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global call to action for disability inclusion in health research","authors":"Anna M. Anderson, Rachelle A. Martin, Willyanne DeCormier Plosky, Lieketseng Ned, Bonnielin K. Swenor, Jodie Bailie, Kaaren Mathias, Jasjot K. Maggo, Mildred A. Omino, Amy M. Russell, Anna M. M. Lawson, Anna E. Brown, Barbara E. Bierer, Sameed Shariq, Mrisho Mwifadhi, Katherine H. O. Deane, Sharad Philip, Victoria Shepherd, Nicola E. Walsh, Gretl A. McHugh","doi":"10.1038/s41591-025-03587-w","DOIUrl":"https://doi.org/10.1038/s41591-025-03587-w","url":null,"abstract":"Despite bringing great strengths and facing substantial health inequities, disabled people remain underserved by health research; addressing this requires multi-level actions spanning all areas of research.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"99 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial","authors":"Lin Shen, Yanqiao Zhang, Ziyu Li, Xiaotian Zhang, Xiangyu Gao, Bo Liu, Yusheng Wang, Yi Ba, Ning Li, Ruixing Zhang, Jingdong Zhang, Ye Chen, Jian Chen, Mingzhu Huang, Yang Fu, Mulin Liu, Zheng Liu, Jun Zhao, Wei Li, Jia Wei, Changzheng Li, Nong Xu, Zengqing Guo, Bangwei Cao, Lian Liu, Peng Nie, Lixin Wan, Lili Sheng, Zhenyang Liu, Yifu He, Kangsheng Gu, Guowu Wu, Weibo Wang, Futong Zhang, Wensheng Qiu, Jun Guo, Jieer Ying, Hongming Pan, Huiting Xu, Yuan Yuan, Yuansong Bai, Zhenghua Wang, Jiye Xu, Xuehong Zhao, Hao Liu, Xizhi Zhang, Wenxiang Dai, Hongyan Xu, Ming Liu, Lin Xie, Yong Tang, Jianying Jin, Xiujuan Qu, Xuefeng Fang, Mingwei Huang, Hao Chen, Zhendong Zheng, Ying Wang, Daqing Wang, Xiaoqin Li, Guohua Yu, Haiyan Liu, Yongjian Zhou, Diansheng Zhong, Shan Zeng, Mafei Kang, Meiqing Wang, Yong Gao, Wenxin Li, Zejun Wang, Minghui Zhang, Jinghua Zhang, Qingshan Li, Shujuan Sun, Aimin Zang, Lizhu Lin, Ming Xie, Zhixiang Zhuang, Tao Zhang, Zhifang Yao, Dongmei Lu, Wei Liu, Mingxiu Hu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Jiajia Zhang, Xiangji Ying, Drew M. Pardoll, Jiafu Ji","doi":"10.1038/s41591-025-03666-y","DOIUrl":"https://doi.org/10.1038/s41591-025-03666-y","url":null,"abstract":"<p>Correction to: <i>Nature Medicine</i> https://doi.org/10.1038/s41591-024-03450-4, published online 22 January 2025.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"33 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community","authors":"Giulia Grande, Martina Valletta, Debora Rizzuto, Xin Xia, Chengxuan Qiu, Nicola Orsini, Matilda Dale, Sarah Andersson, Claudia Fredolini, Bengt Winblad, Erika J. Laukka, Laura Fratiglioni, Davide L. Vetrano","doi":"10.1038/s41591-025-03605-x","DOIUrl":"https://doi.org/10.1038/s41591-025-03605-x","url":null,"abstract":"<p>Evidence regarding the clinical validity of blood biomarkers of Alzheimer’s disease (AD) in the general population is limited. We estimated the hazard and predictive performance of six AD blood biomarkers for incident all-cause and AD dementia—the ratio of amyloid-β 42 to amyloid-β 40 and levels of tau phosphorylated at T217 (p-tau217), tau phosphorylated at T181 (p-tau181), total tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP)—in a cohort of 2,148 dementia-free older adults from Sweden, who were followed for up to 16 years. In multi-adjusted Cox regression models, elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia, displaying a non-linear dose–response relationship. Elevated concentrations of p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia, with negative predictive values exceeding 90% but low positive predictive values (PPVs). Combining p-tau217 with NfL or GFAP further improved prediction, with PPVs reaching 43%. Our findings suggest that these biomarkers have the potential to rule out impending dementia in community settings, but they might need to be combined with other biological or clinical markers to be used as screening tools.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"29 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharma companies collaborate on secure data sharing for AI","authors":"","doi":"10.1038/d41591-025-00021-z","DOIUrl":"https://doi.org/10.1038/d41591-025-00021-z","url":null,"abstract":"Using a novel federated learning approach, organizations can pool resources to develop better drug-discovery AI models — without sharing any private data.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"15 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rwanda’s science-led response to Marburg virus holds lessons for other outbreaks in Africa","authors":"Faraan O. Rahim, Mosoka Fallah, Claude Mambo Muvunyi, Loko Abraham, Sabin Nsanzimana, Jean Kaseya","doi":"10.1038/s41591-025-03551-8","DOIUrl":"https://doi.org/10.1038/s41591-025-03551-8","url":null,"abstract":"<p>On 27 September 2024, Rwanda triggered international alarms when the country announced its first confirmed case of Marburg virus disease (MVD), a severe hemorrhagic fever similar to Ebola, with a case fatality rate as high as 88%. By 3 October, the number of confirmed cases had risen to 36, with over 70% occurring among healthcare workers, and 11 fatalities reported across 7 of Rwanda’s 30 districts. In response, Rwanda’s Ministry of Health, collaborating with multiple international organizations, launched a comprehensive national program that included widespread public health awareness campaigns, promotion of hygiene practices, strict monitoring of transmissions, isolation of potential cases, effective treatment protocols for confirmed cases and the distribution of vaccines for frontline workers¹.</p><p>Through swift action, Rwanda maintained control over the number of MVD cases. The last confirmed case was reported on 30 October, which maintained the total number of cases at 66, with 53 recoveries. By 20 December, the Ministry of Health declared the outbreak over. Despite the typically high case fatality rate of MVD, in Rwanda, this has been less than 25%. This effective management stands as a notable global health success. Strengthened by its robust healthcare infrastructure², Rwanda’s handling of the situation has so far prevented the virus from spreading to neighboring countries with lower case fatality rates than those of previous MVD outbreaks in the Africa. We believe that there are some key lessons from this response that offer valuable lessons for preparing for and responding to global health emergencies.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"215 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder","authors":"Nicole R. Provenza, Sandesh Reddy, Anthony K. Allam, Sameer V. Rajesh, Nabeel Diab, Gabriel Reyes, Rose M. Caston, Kalman A. Katlowitz, Ajay D. Gandhi, Raphael A. Bechtold, Huy Q. Dang, Ricardo A. Najera, Nisha Giridharan, Katherine E. Kabotyanski, Faiza Momin, Mohammed Hasen, Garrett P. Banks, Brian J. Mickey, Brent M. Kious, Ben Shofty, Benjamin Y. Hayden, Jeffrey A. Herron, Eric A. Storch, Ankit B. Patel, Wayne K. Goodman, Sameer A. Sheth","doi":"10.1038/s41591-025-03667-x","DOIUrl":"https://doi.org/10.1038/s41591-025-03667-x","url":null,"abstract":"<p>Correction to: <i>Nature Medicine</i> https://doi.org/10.1038/s41591-024-03125-0, published online 12 July 2024.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"49 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance","authors":"Guo Hua","doi":"10.1038/s41591-025-03595-w","DOIUrl":"https://doi.org/10.1038/s41591-025-03595-w","url":null,"abstract":"The Hospital Research Integrity Alliance was founded to improve the academic integrity of doctors in China.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"21 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors","authors":"Areeba Patel, Kirsten Göbel, Sebastian Ille, Felix Hinz, Natalie Schoebe, Henri Bogumil, Jochen Meyer, Michelle Brehm, Helin Kardo, Daniel Schrimpf, Artem Lomakin, Michael Ritter, Pauline Göller, Paul Kerbs, Lisa Pfeifer, Stefan Hamelmann, Christina Blume, Franziska M. Ippen, Natalie Berghaus, Philipp Euskirchen, Leonille Schweizer, Claus Hultschig, Nadine Van Roy, Jo Van Dorpe, Joni Van der Meulen, Siebe Loontiens, Franceska Dedeurwaerdere, Henning Leske, Skarphéðinn Halldórsson, Graeme Fox, Simon Deacon, Inswasti Cahyani, Nadine Holmes, Satrio Wibowo, Rory Munro, Dan Martin, Abid Sharif, Mark Housley, Robert Goldspring, Sebastian Brandner, Somak Roy, Jürgen Hench, Stephan Frank, Andreas Unterberg, Violaine Goidts, Natalie Jäger, Simon Paine, Stuart Smith, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Einar O. Vik-Mo, Andreas von Deimling, Sandro Krieg, David TW Jones, Matthew Loose, Matthias Schlesner, Martin Sill, Felix Sahm","doi":"10.1038/s41591-025-03562-5","DOIUrl":"https://doi.org/10.1038/s41591-025-03562-5","url":null,"abstract":"<p>Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We previously reported the development of Rapid-CNS², an adaptive-sampling-based nanopore sequencing workflow. Here we comprehensively validated and further developed Rapid-CNS² for intraoperative use. It now offers real-time methylation classification and DNA copy number information within a 30-min intraoperative window, followed by comprehensive molecular profiling within 24 h, covering the complete spectrum of diagnostically and therapeutically relevant information for the respective entity. We validated Rapid-CNS² in a multicenter setting on 301 archival and prospective samples including 18 samples sequenced intraoperatively. To broaden the utility of methylation-based CNS tumor classification, we developed MNP-Flex, a platform-agnostic methylation classifier encompassing 184 classes. MNP-Flex achieved 99.6% accuracy for methylation families and 99.2% accuracy for methylation classes with clinically applicable thresholds across a global validation cohort of more than 78,000 frozen and formalin-fixed paraffin-embedded samples spanning five different technologies. Integration of these tools has the potential to advance CNS tumor diagnostics by providing broad access to rapid, actionable molecular insights crucial for personalized treatment strategies.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"71 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial","authors":"Tarek K. Rajji, Sheriza N. Baksh, David M. Shade, Zahinoor Ismail, Amer M. Burhan, Hamid R. Okhravi, Prasad R. Padala, Paul B. Rosenberg, Lon S. Schneider, Anton P. Porsteinsson, Constantine G. Lyketsos","doi":"10.1038/s41591-025-03569-y","DOIUrl":"https://doi.org/10.1038/s41591-025-03569-y","url":null,"abstract":"<p>Citalopram is effective in treating agitation in Alzheimer’s dementia (AD), but it is associated with cognitive and cardiac risks, likely due to its <i>R</i>-enantiomer. Escitalopram, the <i>S</i>-enantiomer, may be an alternative. In this double-masked randomized (1:1) placebo-controlled trial, we assessed the efficacy and safety of escitalopram in treating agitation in AD after failure of a psychosocial intervention (PSI). Assessments occurred at enrollment, post-PSI (baseline) and at 3, 6, 9 and 12 weeks post-baseline. Settings were 27 community-based centers. The target randomization sample was 392 participants. Participants were adults with AD, a Mini-Mental State Examination Telephone score of 3–20 and significant agitation. PSI non-responders received escitalopram (up to 15 mg per day) or placebo for 12 weeks while continuing PSI. The outcome was the proportion of participants with clinically significant improvement in agitation from baseline at 12 weeks. In total, 173 participants were randomized (84 escitalopram versus 89 placebo; mean ± s.d. age = 78.4 ± 8.7 years; 90 men (52.0%); 127 White (73.4%)). The unadjusted risk difference at 12 weeks was 0.08 (95% confidence interval: −0.21, 0.06). Drug-related QT interval prolongation was observed. Although the randomized sample was smaller than planned, escitalopram was not effective in treating agitation in AD and was associated with cardiac conduction delays. Clinicians need to be cautious in recommending escitalopram as an alternative to citalopram for this condition. ClincialTrials.gov identifier: NCT03108846.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"65 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}