Nature Medicine最新文献

PD-L1 and the dawn of modern cancer immunotherapy PD-L1与现代癌症免疫治疗的曙光

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-05-05 DOI: 10.1038/s41591-025-03698-4

引用次数: 0

Targeting blood pressure to protect the brain 以血压为目标来保护大脑

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-05-02 DOI: 10.1038/s41591-025-03694-8

Josef Coresh, Salim S. Virani, Rebecca F. Gottesman

引用次数: 0

The quandary of high-quality evaluation in complex child welfare systems 复杂儿童福利体系中高质量评估的困境

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-05-01 DOI: 10.1038/s41591-025-03643-5

Bethany Kotlar, Henning Tiemeier

引用次数: 0

Infant mental health services for birth and foster families of maltreated pre-school children in foster care (BeST?): a cluster-randomized phase 3 clinical effectiveness trial 对受虐待学龄前儿童的出生和寄养家庭的婴儿心理健康服务（BeST?）：一项集群随机3期临床有效性试验

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-05-01 DOI: 10.1038/s41591-025-03534-9

Karen Crawford, Robin Young, Philip Wilson, Manuela Deidda, Matt Forde, Susanne Millar, Alex McConnachie, Kathleen Boyd, Emma McIntosh, Dennis Ougrin, Marion Henderson, Christopher Gillberg, Gary Kainth, Fiona Turner, Edmund J. S. Sonuga-Barke, Bridie Fitzpatrick, Helen Minnis

{"title":"Infant mental health services for birth and foster families of maltreated pre-school children in foster care (BeST?): a cluster-randomized phase 3 clinical effectiveness trial","authors":"Karen Crawford, Robin Young, Philip Wilson, Manuela Deidda, Matt Forde, Susanne Millar, Alex McConnachie, Kathleen Boyd, Emma McIntosh, Dennis Ougrin, Marion Henderson, Christopher Gillberg, Gary Kainth, Fiona Turner, Edmund J. S. Sonuga-Barke, Bridie Fitzpatrick, Helen Minnis","doi":"10.1038/s41591-025-03534-9","DOIUrl":"https://doi.org/10.1038/s41591-025-03534-9","url":null,"abstract":"Children entering foster care are at high risk of poor mental health. In this single-blind, cluster-randomized phase 3 trial, 382 families with 488 0–5-year-old children, entering foster care, were randomized to the New Orleans Intervention Model (NIM) or social work services as usual (SAU). NIM offers infant mental health assessment (~3 months) and treatment (6–9 months) to children and to their birth and foster families, aiming to improve child mental health and recommend return home or adoption. The principal outcome was child mental health, as measured by the Strengths and Difficulties Questionnaire Total Difficulties (SDQ-TD) scale at 2.5 years after study entry. In total, 286 families (149 NIM and 137 SAU, 367 children) were followed-up (79.4%). Intention-to-treat analysis found no intervention effect of NIM: mean (s.d.) SDQ-TD NIM, 11.5 (7.6); SAU, 11.1 (7.2); adjusted mean difference (NIM − SAU), 1.4; 95% confidence interval (−0.63, 3.53); P = 0.17. No within-trial effects for primary or secondary outcomes were observed. Despite its components being delivered to a high standard, the UK legal context surrounding NIM led to it being impossible to deliver to all eligible families, and less than 70% of families received the intervention to which they were randomized. Future research will be required to evaluate NIM in more favorable social and legal contexts. ClinicalTrials.gov registration: NCT02653716.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"25 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks 模拟疫苗运动对基孔肯雅病毒暴发流行传播动态的影响

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-05-01 DOI: 10.1038/s41591-025-03684-w

Pastor E. Pérez-Estigarribia, Gabriel Ribeiro dos Santos, Simon Cauchemez, Cynthia Vazquez, Ana Karina Ibarrola-Vannucci, Guillermo Sequera, Shirley Villalba, María José Ortega, Jose Luis Di Fabio, Danny Scarponi, Christinah Mukandavire, Arminder Deol, Águeda Cabello, Elsi Vargas, Cyntia Fernández, Liz León, Henrik Salje

{"title":"Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks","authors":"Pastor E. Pérez-Estigarribia, Gabriel Ribeiro dos Santos, Simon Cauchemez, Cynthia Vazquez, Ana Karina Ibarrola-Vannucci, Guillermo Sequera, Shirley Villalba, María José Ortega, Jose Luis Di Fabio, Danny Scarponi, Christinah Mukandavire, Arminder Deol, Águeda Cabello, Elsi Vargas, Cyntia Fernández, Liz León, Henrik Salje","doi":"10.1038/s41591-025-03684-w","DOIUrl":"https://doi.org/10.1038/s41591-025-03684-w","url":null,"abstract":"A licensed chikungunya vaccine now exists; however, it remains unclear whether it could be deployed during outbreaks to reduce the health burden. We used an epidemic in Paraguay as a case study. We conducted a seroprevalence study and used models to reconstruct epidemic transmission dynamics, providing a framework to assess the theoretical impact of a vaccine had it been available. We estimated that 33.0% (95% confidence interval (CI) 30.1–36.0%) of the population became infected during the outbreak. Of these individuals, 6.3% (95% CI 5.8–6.9%) were detected by the surveillance system, with a mean infection fatality ratio of 0.013% (95% CI 0.012–0.014%). A disease-blocking vaccine with 75% efficacy deployed in 40% of individuals aged ≥12 years over a 3-month period would have prevented 34,200 (95% CI 30,900–38,000) cases, representing 23% of all cases, and 73 (95% CI 66–81) deaths. If the vaccine also leads to infection blocking, 88% of cases would have been averted. These findings suggest that the vaccine is an important new tool to control outbreaks.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"72 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmission through a heavy-tailed sexual contact network explains the New York City mpox outbreak 通过重尾性接触网络的传播解释了纽约市痘的爆发

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-04-30 DOI: 10.1038/s41591-025-03695-7

引用次数: 0

Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury 作者更正：条件消融Stat3或Socs3揭示了脊髓损伤后反应性星形胶质细胞的双重作用

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-04-30 DOI: 10.1038/s41591-025-03737-0

Seiji Okada, Masaya Nakamura, Hiroyuki Katoh, Tamaki Miyao, Takuya Shimazaki, Ken Ishii, Junichi Yamane, Akihiko Yoshimura, Yukihide Iwamoto, Yoshiaki Toyama, Hideyuki Okano

引用次数: 0

Progress with stem cell therapy in Parkinson’s disease 干细胞治疗帕金森病的进展

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-04-30 DOI: 10.1038/d41591-025-00029-5

引用次数: 0

Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial 低压区消融治疗持续性心房颤动：一项随机对照试验

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-04-30 DOI: 10.1038/s41591-025-03674-y

Masaharu Masuda, Akihiro Sunaga, Nobuaki Tanaka, Tetsuya Watanabe, Hitoshi Minamiguchi, Yasuyuki Egami, Takafumi Oka, Tomoko Minamisaka, Takashi Kanda, Masato Okada, Masato Kawasaki, Yasuhiro Matsuda, Koji Tanaka, Tomomi Yamada, Shungo Hikoso, Tomoharu Dohi, Koichi Inoue, Yohei Sotomi, Yasushi Sakata

{"title":"Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial","authors":"Masaharu Masuda, Akihiro Sunaga, Nobuaki Tanaka, Tetsuya Watanabe, Hitoshi Minamiguchi, Yasuyuki Egami, Takafumi Oka, Tomoko Minamisaka, Takashi Kanda, Masato Okada, Masato Kawasaki, Yasuhiro Matsuda, Koji Tanaka, Tomomi Yamada, Shungo Hikoso, Tomoharu Dohi, Koichi Inoue, Yohei Sotomi, Yasushi Sakata","doi":"10.1038/s41591-025-03674-y","DOIUrl":"https://doi.org/10.1038/s41591-025-03674-y","url":null,"abstract":"Low-voltage areas (LVAs) in the left atrium may promote atrial fibrillation (AF), but the efficacy of LVA ablation for preventing arrhythmia has not been determined. In the present study, we carried out a multicenter, randomized controlled trial (SUPPRESS-AF) to investigate the efficacy of LVA ablation in patients with persistent AF who had left atrial LVAs. Patients with persistent AF and left atrial LVAs that covered ≥5 cm2 of the left atrial surface on a voltage map after pulmonary vein isolation (PVI) were randomized to undergo LVA ablation (PVI + LVA-ABL group) or not (PVI-alone group) in a 1:1 fashion. Recurrence of AF or atrial tachycardia (AT) was monitored using 24-h Holter electrocardiography (ECG) and twice-daily portable ECG recordings. The primary endpoint was freedom from AF or AT recurrence without antiarrhythmic drug use during 1 year of follow-up. Of 1,347 patients (1,003 males and 344 females) who underwent initial ablation for AF, patients with left atrial LVAs were assigned to the PVI + LVA-ABL (n = 170) or the PVI-alone group (n = 171). Although the PVI + LVA-ABL group demonstrated a numerically higher rate of freedom from AF or AT recurrence compared with the PVI-alone group (61% (95% confidence interval (CI) = 53–68%) versus 50% (95% CI = 42–57%)), this difference did not reach statistical significance (P for log(rank) test = 0.127). There was no difference in the procedure-related serious adverse events between the two groups (1.7% versus 1.8%, P < 0.0001). In conclusion, LVA ablation in addition to PVI did not significantly reduce 1-year AF or AT recurrence in patients with persistent AF with left atrial LVAs. Future studies are needed to identify patients who may receive greater benefit from LVA ablation.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"223 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision nutrition for cardiometabolic diseases 心脏代谢疾病的精准营养

IF 82.9 1区医学

Nature Medicine Pub Date : 2025-04-30 DOI: 10.1038/s41591-025-03669-9

Marta Guasch-Ferré, Clemens Wittenbecher, Marie Palmnäs, Orly Ben-Yacov, Ellen E. Blaak, Christina C. Dahm, Tove Fall, Berit L. Heitmann, Tine R. Licht, Marie Löf, Ruth Loos, Chirag J. Patel, Carmelo Quarta, Leanne M. Redman, Eran Segal, Nicola Segata, Michael Snyder, Qi Sun, Deirdre K. Tobias, Frank B. Hu, Paul W. Franks, Rikard Landberg, Jennifer L. Sargent, Jordi Merino

{"title":"Precision nutrition for cardiometabolic diseases","authors":"Marta Guasch-Ferré, Clemens Wittenbecher, Marie Palmnäs, Orly Ben-Yacov, Ellen E. Blaak, Christina C. Dahm, Tove Fall, Berit L. Heitmann, Tine R. Licht, Marie Löf, Ruth Loos, Chirag J. Patel, Carmelo Quarta, Leanne M. Redman, Eran Segal, Nicola Segata, Michael Snyder, Qi Sun, Deirdre K. Tobias, Frank B. Hu, Paul W. Franks, Rikard Landberg, Jennifer L. Sargent, Jordi Merino","doi":"10.1038/s41591-025-03669-9","DOIUrl":"https://doi.org/10.1038/s41591-025-03669-9","url":null,"abstract":"Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that expands the understanding of within- and between-person variability in responses to diet. These studies illustrate the promise of precision nutrition to complement the traditional ‘one size fits all’ dietary guidelines, which, while considering broad life-stage and disease-specific nutritional requirements, often lack the granularity to account fully for individual variations in nutritional needs and dietary responses. Despite these developments, however, considerable challenges remain before precision nutrition can be implemented on a broader scale. This Review examines the current state of precision nutrition research, with a focus on its application to reducing the incidence and burden of cardiometabolic diseases. We critically examine the evidence base, explore the potential benefits and discuss the challenges and opportunities ahead.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"35 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0