Nature Medicine最新文献

{"title":"An international treaty to regulate misuse of alcohol and cannabis","authors":"Cyprian M. Mostert, Agustin Ibanez, Zul Merali, Florence Jaguga, Chinedu Udeh-Momoh","doi":"10.1038/s41591-025-03764-x","DOIUrl":"https://doi.org/10.1038/s41591-025-03764-x","url":null,"abstract":"As alcohol and cannabis consumption rise around the world, we call for a global treaty to regulate misuse, inspired by the WHO Tobacco Control Framework.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"88 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training physician-scientists, a view from inside","authors":"Cynthia Y. Tang, Alex D. Waldman, Lawrence F. Brass","doi":"10.1038/s41591-025-03786-5","DOIUrl":"https://doi.org/10.1038/s41591-025-03786-5","url":null,"abstract":"<p>Physician-scientists are essential for translating research into clinical practice, yet recent US policy changes, combined with a protracted training path, threaten the stability of the current workforce and the ability to train their successors. As physician-scientist trainees (C.Y.T. and A.D.W.) and a director of physician-scientist training (L.F.B.), we have seen the US investment in biomedical research rapidly shift from a shared public value to a source of division. Cuts to research funding risk stalling breakthrough discoveries, and the suspension of pipeline training programs raises barriers to entry^1,2,3,4. In less than 6 weeks, over US$1.8 billion of National Institutes of Health (NIH) grant funding was terminated, and 20% of these grants were for training, fellowship, and career development awards⁵. Without urgent intervention, these abrupt policy shifts will compromise medical advances, drive away talented individuals, and move medical discoveries, new drug identification, and therapeutic advances overseas. Here, we examine barriers across the training continuum, concluding with a call to action.</p><p>Historically, federal funding supported crucial entry points for prospective physician-scientists. Competitive programs such as the NIH Summer Internship Program and the National Science Foundation (NSF) Research Experiences for Undergraduates offered early research exposure and mentorship. Suspending these programs disproportionately affects those who rely on structured pathways to enter physician-scientist training, weakening efforts to cultivate a biomedical workforce with diverse perspectives.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"16 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-based large-scale screening of gastric cancer from noncontrast CT imaging","authors":"Can Hu, Yingda Xia, Zhilin Zheng, Mengxuan Cao, Guoliang Zheng, Shangqi Chen, Jiancheng Sun, Wujie Chen, Qi Zheng, Siwei Pan, Yanqiang Zhang, Jiahui Chen, Pengfei Yu, Jingli Xu, Jianwei Xu, Zhongwei Qiu, Tiancheng Lin, Boxiang Yun, Jiawen Yao, Wenchao Guo, Chen Gao, Xianghui Kong, Keda Chen, Zhengle Wen, Guanxia Zhu, Jinfang Qiao, Yibo Pan, Huan Li, Xijun Gong, Zaisheng Ye, Weiqun Ao, Lei Zhang, Xing Yan, Yahan Tong, Xinxin Yang, Xiaozhong Zheng, Shufeng Fan, Jielu Cao, Cheng Yan, Kangjie Xie, Shengjie Zhang, Yao Wang, Lin Zheng, Yingjie Wu, Zufeng Ge, Xiyuan Tian, Xin Zhang, Yan Wang, Ruolan Zhang, Yizhou Wei, Weiwei Zhu, Jianfeng Zhang, Hanjun Qiu, Miaoguang Su, Lei Shi, Zhiyuan Xu, Ling Zhang, Xiangdong Cheng","doi":"10.1038/s41591-025-03785-6","DOIUrl":"https://doi.org/10.1038/s41591-025-03785-6","url":null,"abstract":"<p>Early detection through screening is critical for reducing gastric cancer (GC) mortality. However, in most high-prevalence regions, large-scale screening remains challenging due to limited resources, low compliance and suboptimal detection rate of upper endoscopic screening. Therefore, there is an urgent need for more efficient screening protocols. Noncontrast computed tomography (CT), routinely performed for clinical purposes, presents a promising avenue for large-scale designed or opportunistic screening. Here we developed the Gastric Cancer Risk Assessment Procedure with Artificial Intelligence (GRAPE), leveraging noncontrast CT and deep learning to identify GC. Our study comprised three phases. First, we developed GRAPE using a cohort from 2 centers in China (3,470 GC and 3,250 non-GC cases) and validated its performance on an internal validation set (1,298 cases, area under curve = 0.970) and an independent external cohort from 16 centers (18,160 cases, area under curve = 0.927). Subgroup analysis showed that the detection rate of GRAPE increased with advancing T stage but was independent of tumor location. Next, we compared the interpretations of GRAPE with those of radiologists and assessed its potential in assisting diagnostic interpretation. Reader studies demonstrated that GRAPE significantly outperformed radiologists, improving sensitivity by 21.8% and specificity by 14.0%, particularly in early-stage GC. Finally, we evaluated GRAPE in real-world opportunistic screening using 78,593 consecutive noncontrast CT scans from a comprehensive cancer center and 2 independent regional hospitals. GRAPE identified persons at high risk with GC detection rates of 24.5% and 17.7% in 2 regional hospitals, with 23.2% and 26.8% of detected cases in T1/T2 stage. Additionally, GRAPE detected GC cases that radiologists had initially missed, enabling earlier diagnosis of GC during follow-up for other diseases. In conclusion, GRAPE demonstrates strong potential for large-scale GC screening, offering a feasible and effective approach for early detection. ClinicalTrials.gov registration: NCT06614179.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"639 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial","authors":"Corby K. Martin, Owen T. Carmichael, Susan Carnell, Robert V. Considine, David A. Kareken, Ulrike Dydak, Richard D. Mattes, David Scott, Sergey Shcherbinin, Hiroshi Nishiyama, Alastair Knights, Shweta Urva, Lukasz Biernat, Edward Pratt, Axel Haupt, Mark Mintun, Diana Otero Svaldi, Zvonko Milicevic, Tamer Coskun","doi":"10.1038/s41591-025-03774-9","DOIUrl":"https://doi.org/10.1038/s41591-025-03774-9","url":null,"abstract":"<p>Tirzepatide induces weight reduction but the underlying mechanisms are unknown. This 6-week phase 1 study investigated early effects of tirzepatide on energy intake. Male and female adults without diabetes (<i>n</i> = 114) and a body mass index from 27 to 50 kg per m² were randomized 1:1:1 to blinded once-weekly tirzepatide or placebo, or open-label once-daily liraglutide. The primary outcome was change from baseline to week 3 in energy intake during an ad libitum lunch with tirzepatide versus placebo. Secondary outcomes assessed self-reported ingestive behavior and blood-oxygenation-level-dependent functional magnetic resonance imaging with food photos. Tirzepatide reduced energy intake versus placebo at week 3 (estimated treatment difference −524.6 kcal (95% confidence interval −648.1 to −401.0), <i>P</i> &lt; 0.0001). With regard to secondary outcomes versus placebo, tirzepatide decreased overall appetite, food cravings, tendency to overeat, perceived hunger and reactivity to foods in the environment but did not impact volitional restriction of dietary intake. At week 3 versus placebo, tirzepatide did not statistically significantly impact blood-oxygenation-level-dependent activation to highly palatable food photos (aggregated category of high-fat, high-sugar foods and high-fat, high-carbohydrate foods) but decreased activation to high-fat, high-sugar food photos in the medial frontal and cingulate gyri, orbitofrontal cortex and hippocampus. Our results suggest tirzepatide reduces food intake, potentially by impacting ingestive behavior. ClinicalTrials.gov registration: NCT04311411.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"17 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated community-based HIV and sexual and reproductive health services for youth: a cluster-randomized trial","authors":"Rashida A. Ferrand, Ethel Dauya, Chido Dziva Chikwari, Tsitsi Bandason, Sarah Bernays, Constance Mackworth-Young, Aoife M. Doyle, Chris Grundy, Pitchaya Indravudh, Fern Terris-Presholt, Constancia Vimbayi Mavodza, Owen Mugurungi, Tsitsi Apollo, Getrude Ncube, Leyla Larsson, Ona McCarthy, Victoria Simms, Mandikudza Tembo, Katharina Kranzer, Richard J. Hayes","doi":"10.1038/s41591-025-03762-z","DOIUrl":"https://doi.org/10.1038/s41591-025-03762-z","url":null,"abstract":"<p>Human immunodeficiency virus (HIV) viral suppression rates are disproportionately worse in youth compared to other age groups, and improving this will require addressing the whole HIV cascade, including HIV testing, linkage to care and support to maintain viral suppression. We conducted a cluster-randomized trial of community-based services incorporating HIV testing, treatment and adherence support integrated with sexual and reproductive health (SRH) services for youth (16–24 years) in Zimbabwe. Our hypothesis was that integrated services in community-based settings would increase demand and access. In total, 24 clusters (geographically demarcated areas) were randomized 1:1 to intervention or control (existing services). Primary outcome was virological suppression (defined as HIV viral load &lt;1,000 copies per ml) among youth with HIV (YWH), ascertained through a population-level outcome survey of 17,682 youth (18–24 years). Secondary outcomes, corresponding to UNAIDS 90-90-90 targets, were the proportion of YWH who knew their HIV status, the proportion of YWH who knew their HIV status who were taking antiretroviral therapy (ART) and the proportion of YWH taking ART who achieved viral suppression (HIV viral load &lt;1,000 copies per ml). There was no difference by arm in primary outcome (mean cluster prevalence—41.3% (intervention) versus 38.3% (control); risk ratio (RR)—1.07 (95% confidence interval (CI), 0.88–1.30)) or in proportion of YWH who were diagnosed. In the intervention arm, a lower proportion of diagnosed YWH were taking treatment (RR = 0.91 (95% CI, 0.83–0.99)), but a higher proportion of those on ART had viral suppression (RR = 1.18 (95% CI, 1.02–1.37)). The intervention did not impact the proportion of youth with undiagnosed HIV, which explains the lack of effect on the primary outcome. Among those taking treatment, the intervention improved viral suppression. Delivery of integrated HIV and SRH services was feasible and facilitated uptake by youth of essential services beyond HIV, addressing an important programmatic gap. Trial registration number: NCT03719521.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"6 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many flavors of flavonoids are good for health","authors":"","doi":"10.1038/d41591-025-00040-w","DOIUrl":"https://doi.org/10.1038/d41591-025-00040-w","url":null,"abstract":"Greater diversity of dietary flavonoid intake correlated with reduced all-cause mortality risk and chronic disease incidence among UK Biobank participants.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"52 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality sports to tackle pediatric obesity","authors":"Sol Vidal-Almela, Cristina Cadenas-Sanchez, Francisco B. Ortega","doi":"10.1038/s41591-025-03757-w","DOIUrl":"https://doi.org/10.1038/s41591-025-03757-w","url":null,"abstract":"Virtual reality sports offer a novel and effective strategy to reduce fat mass and holistically promote metabolic, physical, psychological and cognitive health in adolescents with excess body weight, yielding similar, and at times superior, benefits compared with conventional real-world sports.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"8 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial","authors":"Jihong Wang, Yiming Qin, Qian Wu, Dian Zeng, Xiaojing Gao, Qinyi Wang, Zhen Li, Yueqiong Ni, Haoxuan Li, Ping Zhang, Jingyi Guo, Weizhi Ma, Mamatkasim Maitusun, Xufeng Jin, Minghong Chen, Liping Zhu, Qin Lu, Qiandi Chen, Yuna Wu, Chengxiang Lin, Rui Han, Di Cheng, Jiacheng Ni, Xiaochun Wang, Fangshu Yao, Jie Zhuang, Jun Xia, Dan Liu, Yuwei Lu, Piao Kang, Shujie Yu, Anran Chen, Ying Zhang, Qian Li, Wenli Ge, Xiaoxue Long, Zehua Jiang, Zhouyu Guan, Zihao Jin, Pengfei Jin, Tingyao Li, Jia Shu, Jiale Yang, Jinyang Wang, Nan Jiang, Jing Qian, Younhyun Jung, Han Zhang, Qing Yang, Lifei Ma, Xiaomeng Wu, Xiaojun Huang, Dongyang Si, Jie Ren, Hui Qiao, Yuchen Guo, Zhifeng Huang, Wenxiao Wang, Weihong Deng, Lei Bi, Danyue Zhao, Yuehua Li, Rynson W. H. Lau, Yih-Chung Tham, Xindong Ma, Jing Ma, Dinggang Shen, Songhai Zhang, Haibing Guan, Weiwen Zou, Minyi Guo, Xinping Guan, Xiaokang Yang, Aimin Xu, Jiarui Wu, Gianni Panagiotou, Michael Andrew Tse, Jinman Kim, Enhua Wu, Daniel Thalmann, Nadia Magnenat Thalmann, Felipe Fregni, Tien Yin Wong, Weiping Jia, Rong Zeng, Chwee Teck Lim, Bin Sheng, Huating Li","doi":"10.1038/s41591-025-03724-5","DOIUrl":"https://doi.org/10.1038/s41591-025-03724-5","url":null,"abstract":"<p>Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), which used deep reinforcement learning to train transformer-based virtual coaching agents, offering immersive and effective sports guidance, with biomechanical performance comparable to real-world physical sports. We integrated REVERIE into a randomized controlled trial involving an 8-week intervention in adolescents with excess body weight (<i>n</i> = 227). Participants were randomized (1:1:1:1:1) to physical table tennis, physical soccer, REVERIE table tennis, REVERIE soccer or control. REVERIE sports intervention was effective in reducing primary outcome fat mass (mean −4.28 kg (95% confidence interval (CI) −6.35 to −2.22), relative to control), with no significant difference compared with physical sports (mean −5.06 kg (95% CI −7.13 to −2.98), relative to control). For secondary outcomes, decreases in liver enzymes and low-density lipoprotein cholesterol levels were found in physical and REVERIE sports groups compared to control. Physical and REVERIE sports showed improvements in physical fitness, psychological well-being and sports willingness after an 8-week intervention, which remained at the 6-month follow-up in the REVERIE sports group. REVERIE sports demonstrated superior cognitive enhancements compared to physical sports in exploratory analyses, as evidenced by olfactory tests (total score: mean 2.84 (95% CI 1.15 to 4.53)) and working memory paradigm (2-back accuracy: mean 10.88% (95% CI 1.19% to 20.56%)). Functional magnetic resonance imaging exhibited that REVERIE sports enhanced neural efficiency and neuroplasticity. Multi-omics analyses revealed distinct changes induced by REVERIE sports that were closely associated with cognitive improvement. Minimal injury rates were 7.69% for REVERIE and 13.48% for physical sports, with no serious adverse events. Collectively, this study demonstrates that the virtual reality sports therapy could provide an empathetic approach to addressing adolescent obesity, offering comprehensive improvements in physical, psychological and cognitive health beyond mere weight loss. Clinical Trial registration: ChiCTR2300068786.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"6 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses","authors":"Steven Laurie, Wouter Steyaert, Elke de Boer, Kiran Polavarapu, Nika Schuermans, Anna K. Sommer, German Demidov, Kornelia Ellwanger, Ida Paramonov, Coline Thomas, Stefan Aretz, Jonathan Baets, Elisa Benetti, Gemma Bullich, Patrick F. Chinnery, Jill Clayton-Smith, Enzo Cohen, Daniel Danis, Jean-Madeleine de Sainte Agathe, Anne-Sophie Denommé-Pichon, Jordi Diaz-Manera, Stephanie Efthymiou, Laurence Faivre, Marcos Fernandez-Callejo, Mallory Freeberg, José Garcia-Pelaez, Lena Guillot-Noel, Tobias B. Haack, Mike Hanna, Holger Hengel, Rita Horvath, Henry Houlden, Adam Jackson, Lennart Johansson, Mridul Johari, Erik-Jan Kamsteeg, Melanie Kellner, Tjitske Kleefstra, Didier Lacombe, Hanns Lochmüller, Estrella López-Martín, Alfons Macaya, Anna Marcé-Grau, Aleš Maver, Heba Morsy, Francesco Muntoni, Francesco Musacchia, Isabelle Nelson, Vincenzo Nigro, Catarina Olimpio, Carla Oliveira, Jaroslava Paulasová Schwabová, Martje G. Pauly, Borut Peterlin, Sophia Peters, Rolph Pfundt, Giulio Piluso, Davide Piscia, Manuel Posada, Selina Reich, Alessandra Renieri, Lukas Ryba, Karolis Šablauskas, Marco Savarese, Ludger Schöls, Leon Schütz, Verena Steinke-Lange, Giovanni Stevanin, Volker Straub, Marc Sturm, Morris A. Swertz, Marco Tartaglia, Iris B. A. W. te Paske, Rachel Thompson, Annalaura Torella, Christina Trainor, Bjarne Udd, Liedewei Van de Vondel, Bart van de Warrenburg, Jeroen van Reeuwijk, Jana Vandrovcova, Antonio Vitobello, Janet Vos, Emílie Vyhnálková, Robin Wijngaard, Carlo Wilke, Doreen William, Jishu Xu, Burcu Yaldiz, Luca Zalatnai, Birte Zurek, Anthony J. Brookes, Teresinha Evangelista, Christian Gilissen, Holm Graessner, Nicoline Hoogerbrugge, Stephan Ossowski, Olaf Riess, Rebecca Schüle, Matthis Synofzik, Alain Verloes, Leslie Matalonga, Han G. Brunner, Katja Lohmann, Richarda M. de Voer, Ana Töpf, Lisenka E.L.M. Vissers, Sergi Beltran, Alexander Hoischen","doi":"10.1038/s41591-025-03754-z","DOIUrl":"https://doi.org/10.1038/s41591-025-03754-z","url":null,"abstract":"<p>Correction to: <i>Nature Medicine</i> https://doi.org/10.1038/s41591-024-03420-w, published online 17 January 2025.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"36 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal mental health is declining in the USA","authors":"","doi":"10.1038/d41591-025-00039-3","DOIUrl":"https://doi.org/10.1038/d41591-025-00039-3","url":null,"abstract":"Analysis of national survey data reveals large declines in self-reported mental well-being among female parents, which suggests that maternal mental health should be a focal point of public health efforts.","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"15 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}