Ending the taboo on periods and period problems

IF 58.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hilary O. D. Critchley, Ian Roberts, Ally Murji, Michelle Lavin, Lesley Regan, Michael K. Georgieff, Malcolm G. Munro
{"title":"Ending the taboo on periods and period problems","authors":"Hilary O. D. Critchley, Ian Roberts, Ally Murji, Michelle Lavin, Lesley Regan, Michael K. Georgieff, Malcolm G. Munro","doi":"10.1038/s41591-025-03778-5","DOIUrl":null,"url":null,"abstract":"<p>Heavy menstrual bleeding (HMB), reflecting excessive menstrual volume, affects quality of life in up to half of all menstruating girls and women<sup>2,3</sup>. The blood loss associated with HMB may induce iron deficiency that, when severe, results in iron deficiency anemia (IDA). Iron deficiency, with or without IDA, can adversely affect physical, cognitive and even cardiac function. In pregnancy, anemia can have an adverse effect on both the mother and her fetus, with increased risks of antepartum hemorrhage, prematurity, stillbirth, neonatal death, post-partum hemorrhage (PPH), and maternal mortality. Furthermore, peri-conceptional and prenatal iron deficiency is linked to impaired fetal neurodevelopment and adverse neuro-behavioral effects for the child that persist into adulthood<sup>4</sup>.</p><p>Some 30% of the world’s non-pregnant women are anemic, increasing to over 40% in South Asia, the Eastern Mediterranean and sub-Saharan Africa (WHO Anaemia Action Alliance), with iron deficiency the most common contributory factor. During ‘normal’ periods, approximately 1 mg of iron is lost monthly, but in women with HMB, iron loss may be 5–6 times higher. As a result, independent of culture or geographic location, HMB is the most common cause of iron deficiency and IDA (<u>&gt;</u>50%) in nonpregnant reproductive-aged girls and women. The extent of iron loss associated with HMB can make it impossible for dietary replacement (even with supplementation) before the next period starts, thus establishing a progressive deterioration of iron status.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"18 1","pages":""},"PeriodicalIF":58.7000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-025-03778-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Heavy menstrual bleeding (HMB), reflecting excessive menstrual volume, affects quality of life in up to half of all menstruating girls and women2,3. The blood loss associated with HMB may induce iron deficiency that, when severe, results in iron deficiency anemia (IDA). Iron deficiency, with or without IDA, can adversely affect physical, cognitive and even cardiac function. In pregnancy, anemia can have an adverse effect on both the mother and her fetus, with increased risks of antepartum hemorrhage, prematurity, stillbirth, neonatal death, post-partum hemorrhage (PPH), and maternal mortality. Furthermore, peri-conceptional and prenatal iron deficiency is linked to impaired fetal neurodevelopment and adverse neuro-behavioral effects for the child that persist into adulthood4.

Some 30% of the world’s non-pregnant women are anemic, increasing to over 40% in South Asia, the Eastern Mediterranean and sub-Saharan Africa (WHO Anaemia Action Alliance), with iron deficiency the most common contributory factor. During ‘normal’ periods, approximately 1 mg of iron is lost monthly, but in women with HMB, iron loss may be 5–6 times higher. As a result, independent of culture or geographic location, HMB is the most common cause of iron deficiency and IDA (>50%) in nonpregnant reproductive-aged girls and women. The extent of iron loss associated with HMB can make it impossible for dietary replacement (even with supplementation) before the next period starts, thus establishing a progressive deterioration of iron status.

结束对经期和经期问题的禁忌
月经大量出血(HMB),反映月经量过多,影响多达一半的经期女孩和妇女的生活质量。与HMB相关的失血可引起缺铁,严重时可导致缺铁性贫血(IDA)。缺铁,不论有无IDA,都会对身体、认知甚至心功能产生不利影响。在怀孕期间,贫血可对母亲和胎儿产生不利影响,增加产前出血、早产、死产、新生儿死亡、产后出血(PPH)和孕产妇死亡率的风险。此外,围孕期和产前缺铁与胎儿神经发育受损和持续到成年的儿童的不良神经行为影响有关4。世界上约30%的非孕妇患有贫血症,在南亚、东地中海和撒哈拉以南非洲(世卫组织贫血行动联盟)这一比例上升至40%以上,缺铁是最常见的导致贫血的因素。在“正常”时期,每月大约损失1毫克的铁,但在患有HMB的女性中,铁的损失可能会高出5-6倍。因此,与文化或地理位置无关,HMB是导致未怀孕育龄女童和妇女缺铁和IDA(50%)的最常见原因。与HMB相关的铁流失程度可能使在下一个月经期开始之前无法通过饮食替代(即使是补充),从而导致铁状态的逐渐恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Nature Medicine
Nature Medicine 医学-生化与分子生物学
CiteScore
100.90
自引率
0.70%
发文量
525
审稿时长
1 months
期刊介绍: Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信