Mycopathologia最新文献

{"title":"Extensive Recalcitrant Tinea Corporis Caused by Trichophyton indotineae.","authors":"Lanyu Sun, João Ferreira, Bruno Vidal, Cristina Veríssimo, Raquel Sabino, Tiago Marques, Luís Soares-de-Almeida, Paulo Filipe","doi":"10.1007/s11046-024-00927-1","DOIUrl":"10.1007/s11046-024-00927-1","url":null,"abstract":"","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"20"},"PeriodicalIF":3.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Draft Genome of Naganishia uzbekistanensis from a Clinical Pulmonary Infection.","authors":"Rong-Chen Dai, Xin-Fei Chen, Xin Fan, Li Gu, Li Zhang, Dan Guo, Ying-Chun Xu, Meng Xiao","doi":"10.1007/s11046-025-00931-z","DOIUrl":"10.1007/s11046-025-00931-z","url":null,"abstract":"<p><p>This study presents the first high-quality assembled genome of Naganishia uzbekistanensis, derived from a clinical isolate CY11558 obtained from a patient with a postoperative pulmonary infection. This work provides an improved reference assembly for downstream research and diagnosis of infections caused by this species.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"19"},"PeriodicalIF":3.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clioquinol 3% Cream Improves Clinical Symptoms and Restores the Skin Microbiome in Interdigital Tinea Pedis.","authors":"Lingzhi Zhong, Tingting Li, Xiaoyue Zhang, Houmin Li","doi":"10.1007/s11046-024-00923-5","DOIUrl":"10.1007/s11046-024-00923-5","url":null,"abstract":"<p><strong>Background: </strong>Interdigital tinea pedis is a common type of tinea pedis that occurs between toes and is easy to recur. Recently, the skin microbiome analysis of interdigital tinea pedis showed changes in bacterial microbiome in addition to fungal infection.</p><p><strong>Objectives: </strong>To investigate the efficacy and safety of clioquinol 3% cream in treating interdigital tinea pedis as well as characterize changes in the skin microbiome during treatment.</p><p><strong>Methods: </strong>The clinical characteristics and skin microbiome of patients with interdigital tinea pedis were investigated in a longitudinal prospective study. In total 28 participants were rcruited to use the clioquinol 3% cream topically to the target skin lesions twice a day for 1 week. Disease severity evaluation, fungal microscopic examination, and sample collection for skin microbiome analysis were performed at baseline, after treatment, and 1 week post-treatment.</p><p><strong>Results: </strong>Compared with baseline, the disease severity, lesion score, pruritus score, and malodor score of the patients significantly decreased after treatment and at 1 week post-treatment (P < 0.05). The fungal profiles after treatment and 1 week post-treatment revealed significantly decreased abundance of Trichophyton and significantly increased abundances of Cladosporium, Alternaria, and Aspergillus, which led to higher fungal diversity than pretreatment samples. The bacterial profiles after treatment and 1 week post-treatment revealed significantly decreased abundances of Brevibacterium, Finegoldia, and Facklamia. The abundance of Streptococcus and bacterial diversity were also significantly decreased at 1 week post-treatment. The disease severity was positively associated with the abundance of Trichophyton, Arthroderma, Finegoldia, Facklamia, Brevibacterium, Corynebacterium, and Porphyromonas.</p><p><strong>Conclusions: </strong>The clioquinol 3% cream was efficient on treating interdigital tinea pedis by decreasing the abundance of pathogenic fungus, recovering the normal balance of the fungal and bacterial communities, and restore species diversity.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"18"},"PeriodicalIF":3.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Kerion Caused by Trichophyton tonsurans.","authors":"Yu Peng, Bilin Dong, Bin Hu, Jing Yang, Zhong Liu, Zhongsheng Tong","doi":"10.1007/s11046-024-00911-9","DOIUrl":"10.1007/s11046-024-00911-9","url":null,"abstract":"<p><p>Adult tinea capitis, especially kerion, caused by Trichophyton tonsurans is relatively rare in China. Here, we report a case caused by the agent in an old woman with normal immune function. Fungal microscopic examination and culture were positive. The isolate was further identified as Trichophyton tonsurans by internal transcribed spacer (ITS) sequencing. Skin biopsy and histopathological examination suggested diffuse inflammatory cell infiltration in the dermis and subcutaneous tissue. Notably, fungal spores were observed within the dermis by Periodic acid-Schiff (PAS) staining. After eight weeks of treatment with oral griseofulvin and topical luliconazole, the patient's abscess subsided, hair regrowth occurred without scarring, and the mycologic examination returned negative.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"17"},"PeriodicalIF":3.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Coronavirus Disease 2019-Associated Fungal Infections in the Intensive Care Unit: A Single-Center Retrospective Study.","authors":"Jessica S Little, Gerald McGwin, Lisa Tushla, Kaitlin Benedict, Meghan M Lyman, Mitsuru Toda, John W Baddley, Peter G Pappas","doi":"10.1007/s11046-025-00928-8","DOIUrl":"10.1007/s11046-025-00928-8","url":null,"abstract":"<p><strong>Introduction: </strong>Invasive fungal disease (IFD) is a morbid superinfection that can arise in critically ill patients with COVID-19 infection. Studies evaluating the full spectrum of COVID-19-associated fungal infections remain limited.</p><p><strong>Methods: </strong>Single-center retrospective study assessing IFD in patients with COVID-19, hospitalized for ≥ 72 h in the intensive care unit (ICU) between 02/25/20 and 02/28/22 (n = 1410). IFD was assessed using consensus criteria (EORTC/MSGERC or ISHAM/ECMM criteria). T- and chi-square tests compared demographic/clinical characteristics between IFD and non-IFD patients. Cox proportional hazards regression estimated risk factors for in-hospital mortality.</p><p><strong>Results: </strong>Of 1410 patients with severe COVID-19, 70 (5%) had a diagnosis of COVID-19-associated fungal infection with invasive candidiasis occurring in 3%, and invasive aspergillosis in 2%. Other fungal infections were rare. Patients with IFD had longer ICU stays (26 vs. 13 days; p < 0.001); increased rates of mechanical ventilation (99% vs. 70%; p < 0.001); and a higher risk of in-hospital death (69% vs. 36%; p < 0.001). On multivariable analysis, COVID-associated fungal infections were associated with an increased risk of in-hospital mortality.</p><p><strong>Conclusions: </strong>This real-world study of critically ill patients with COVID-19 demonstrated a low incidence of COVID-19-associated fungal infections with invasive candidiasis occurring most frequently. Fungal infections were associated with an increased risk of in-hospital mortality in this population.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"16"},"PeriodicalIF":3.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malassezia polysorbatinonusus sp. nov., a Novel Isolate from a Japanese Patient with Seborrheic Dermatitis.","authors":"Junichiro Hiruma, Honoka Nojo, Masataro Hiruma, Takashi Sugita, Koich Makimura, Kazutoshi Harada, Rui Kano","doi":"10.1007/s11046-024-00926-2","DOIUrl":"10.1007/s11046-024-00926-2","url":null,"abstract":"<p><p>We describe a novel Malassezia species named Malassezia polysorbatinonusus, isolated from a Japanese patient with seborrheic dermatitis. The internal transcribed spacer (ITS) region of the isolate (LSEM 4845^T) were only 94.7% identical to those of M. yamatoensis. A phylogenetic analysis of D1/D2 domain of 26S rDNA and β-TUB-encoding gene sequences also revealed that the novel isolate was distinct from the cluster formed by other Malassezia species. Notably, morphological characteristics and molecular analysis indicated that the novel species is most closely related to M. yamatoensis isolated from a Japanese patient with seborrheic dermatitis, although the two species exhibit different physiological characteristics. In contrast to M. yamatoensis, the novel isolate does not metabolize Tweens and can grow at 40 °C. These characteristics have historically distinguished animal Malassezia isolates from those isolated from humans. Therefore, we conclude the novel isolate constitutes a new species, which we designate M. polysorbatinonusus.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"15"},"PeriodicalIF":3.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Epidemiology and Clinical Aspects of Dermatophytosis in Guiyang, Southwest China (2017-2023): A Single-Institution Retrospective Study.","authors":"Songgan Jia, Jiali Zhu, Zhan Zhou, Wanglan Luo, Zhengling Shang, Yinhui Jiang, Clement K M Tsui, Di Che, Yanping Jiang","doi":"10.1007/s11046-024-00922-6","DOIUrl":"10.1007/s11046-024-00922-6","url":null,"abstract":"<p><p>Epidemiological studies combining taxonomic and clinical data have been limited globally, particularly Guiyang, the most under-developed economic provincial capital city in southwestern China. A retrospective analysis was performed of dermatophyte epidemiology involving all culture-positive cases received between May 2017 and May 2023 at the Affiliated Hospital of Guizhou Medical University. Phylogenetic analysis was conducted on 391 dermatophyte isolates collected from patients using the rDNA internal transcribed spacer sequences. Clinical relevance information was analyzed statistically using T-test, one-way ANOVA, Kruskal-Wallis H test, and Chi-square test. Eight species were recognized, and their identity was confirmed on the basis of phylogenetics. Trichophyton rubrum (n = 308, 78.77%) ranked first, followed by T. mentagrophytes (n = 39, 9.97%) and Microsporum canis (n = 32, 8.18%). Tinea unguium (48.56%) was the most common type of dermatophytosis in this study, rates of detection being impacted by the host population's attention for dermatophyte infections. The hypothesized patterns of evolution in the M. canis series, T. mentagrophytes series and T. rubrum series, i.e. from zoophilic to a preponderantly anthropophilic nature, was reflected in clinical parameters such as host age, occupational background, infection pattern, degree of skin involvement and site preference. To the best of our knowledge, we provide the first detailed analysis of epidemiological characteristics and pathogenic patterns of dermatophytosis in Guiyang.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"14"},"PeriodicalIF":3.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole Genome Sequence Analysis of Terbinafine Resistant and Susceptible Trichophyton Isolates from Human and Animal Origin.","authors":"Sheetal Thakur, Bram Spruijtenburg, Abhishek, Dipika Shaw, Theun de Groot, Eelco F J Meijer, Tarun Narang, Sunil Dogra, Arunaloke Chakrabarti, Jacques F Meis, Shivaprakash M Rudramurthy","doi":"10.1007/s11046-024-00920-8","DOIUrl":"10.1007/s11046-024-00920-8","url":null,"abstract":"<p><p>Trichophyton indotineae, first identified in India, has increasingly been reported in Asia, the Middle East, Europe, and recently in the USA. The global spread of terbinafine-resistant T. indotineae underscores the urgency of the issue. With its ability for human-to-human transmission, it can be considered anthropophilic. However, its highly virulent nature suggests a possible link to zoophilic species, raising the potential for disease transmission from animals. In this study, we have performed whole genome sequencing (WGS) of terbinafine susceptible and resistant Trichophyton species from animal and human origin to understand transmission dynamics of this species. Thirteen isolates of Trichophyton spp. from human (n = 9) and canine (n = 4) origin, respectively from Chandigarh and Bareilly, India, were included in this study. Isolate identification based on ITS extracted from WGS data identified six T. indotineae (ITS genotype VIII) and seven T. interdigitale (ITS genotype II) isolates. WGS single nucleotide polymorhpism (SNP) analysis separated the isolates into two distinct groups, T. indotineae and T. interdigitale and showed the clonal nature of both species. For both species, low SNP differences between isolates from humans and dogs were observed as well as low differences between isolates from Chandigarh and Bareilly, cities >350 km apart from each other. These findings suggest zoonotic transmission, next to fast spread across large distances. The T. indotineae terbinafine-resistant strains exhibited the SQLE^F397L substitution while susceptible strains had the SQLE^S395P substitution or demonstrated a wild-type (WT) SQLE sequence. However, all T. interdigitale strains displayed a WT SQLE sequence despite terbinafine minimum inhibitory concentrations (MICs) ranging between 0.031 to 64 µg/mL.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"13"},"PeriodicalIF":3.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy.","authors":"Ramzi Kechaou, Denis Magne, Yaye Senghor, Cécile Brin, Karine Louvion, Laurene Parrot, Marjolaine Morgand, Céline Nourrisson, Philippe Poirier, Jeanne Bigot, Christophe Hennequin, Alicia Moreno-Sabater","doi":"10.1007/s11046-024-00918-2","DOIUrl":"10.1007/s11046-024-00918-2","url":null,"abstract":"<p><p>We present Enterocytozoon bieneusi infection in four patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Two patients suffered from inflammatory bowel disease and received anti-TNF therapies, whereas two other patients suffered from systemic lupus erythematosus with renal involvement and received anti-CD20 or anti-BLyS protein therapies. Three out of four patients consulted for diarrhea with abdominal pain without intestinal inflammation or bleeding at the time of sampling. The fourth patient did not declare intestinal troubles. Microsporidia genotype detected in this study were S9, C, Wildboard3 with one patient harboring 2 genotypes S6 and EBCMAP-038. Management of microsporidia infection included albendazole and reduction of immunosuppression treatment, but no specific treatment was implemented in two other patients. In conclusion, microsporidia infection occurs in patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Diagnosis should be carefully assessed in this population and a thorough benefit-risk analysis is essential prior to initiating therapeutic interventions.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"12"},"PeriodicalIF":3.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Patient Advocacy in Mycology: Cultivating Collaboration in Education, Research, and Policy.","authors":"Rob Purdie, Rasha Kuran, Ana Alastruey-Izquierdo, Hatim Sati, Juan Luis Rodriguez-Tudela, Martin Hoenigl, John Perfect, Rita Oladele, Thomas J Walsh, Tom Chiller","doi":"10.1007/s11046-024-00906-6","DOIUrl":"10.1007/s11046-024-00906-6","url":null,"abstract":"<p><p>In the healthcare landscape, diseases such as cancer and HIV/AIDS have benefited from the patient's perspective. For fungal diseases, the patient voice remains absent in critical areas such as policy formulation, funding decisions, and research priorities. Patients affected by fungal disease, along with their caregivers and advocacy groups, possess invaluable insights into the challenges and unmet needs they face. By elevating their voices and experiences, policymakers, funding agencies, and researchers can gain a more comprehensive understanding of the multifaceted nature of fungal disease and the urgency of addressing them. This paper addresses the pressing need for a coordinated effort to elevate the patient voice in advocating for improved policies, increased funding, and enhanced research initiatives regarding fungal disease.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"190 1","pages":"11"},"PeriodicalIF":3.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}