Mycopathologia最新文献

{"title":"Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay.","authors":"Vanessa Brito de Souza Rabello, Marcus de Melo Teixeira, Fernando Almeida-Silva, Thiago Brasil de Moura Costa, Andrea Reis Bernardes-Engemann, Melissa Orzechowski Xavier, Rodrigo Almeida-Paes, María Cecilia López-Joffre, Cristina Elena Canteros, Lisandra Serra Damasceno, Isabella Dib Ferreira Gremião, José Guillermo Pereira Brunelli, Wieland Meyer, Rosely Maria Zancopé-Oliveira","doi":"10.1007/s11046-026-01113-1","DOIUrl":"10.1007/s11046-026-01113-1","url":null,"abstract":"<p><p>Sporothrix brasiliensis is the predominant etiological agent of sporotrichosis in Brazil and has been progressively expanding its geographic distribution to other countries in South America. The human patients infected with S. brasiliensis usually respond favorably to antifungal therapy. However, therapeutic failure may occur, and management may be particularly challenging in cases of severe disease. We recently reported that at least seven S. brasiliensis genotypes circulate across South America. However, their biological and clinical relevance of this genetic diversity remains poorly understood. In this study, we investigated whether distinct S. brasiliensis genotypes are associated with reduced susceptibility to the main antifungal agents used in the treatment of human and animal sporotrichosis. A total of 92 clinical, veterinary, and environmental S. brasiliensis strains from Brazil, Paraguay and Argentina, genotyping them using a four-gene MLST scheme. Mating type was assessed as well as antifungal susceptibility according to the M38-A2 CLSI guidelines. Results were interpreted according to the established epidemiological cutoff values for S. brasiliensis. The isolates are clustered into six distinct genotypes, with mating type showing a strong association with phylogenetic clades. Non-wild type strains were identified across four haplotypes (H1, H2, H3 and H4) for all antifungal drugs tested. These non-wild type strains were isolated from six distinct Brazilian states and were not associated to a specific genetic background. Nevertheless, non-wild-type strains were predominantly detected among feline isolates, most of which originated from Minas Gerais and belonged to haplotype H2. However, because only a limited number of H2 isolates were included in this study, additional isolates from this haplotype are need to confirm this association. Together, these findings suggest that decreased antifungal susceptibility in S. brasiliensis is not genotype-restricted but may be influenced by host-related or epidemiological factors, particularly in the context of feline sporotrichosis.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 6","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Terbinafine Contamination and Dermatophyte Resistance: A One Health Hypothesis in Need of Ecological Validation.","authors":"Aditya K Gupta, Elizabeth M Teasell, Tong Wang, Richard C Summerbell, Matthew C Fisher, Vincent Piguet","doi":"10.1007/s11046-026-01112-2","DOIUrl":"10.1007/s11046-026-01112-2","url":null,"abstract":"<p><p>Terbinafine resistance in dermatophytes is an increasing global concern, driven in part by the intercontinental spread of Trichophyton indotineae. The current epidemic of dermatophyte resistance is primarily attributed to clinical and community factors, including inappropriate antifungal use and fixed-dose corticosteroid-antifungal combinations. However, environmental antifungal contamination has emerged as a potential but largely unexplored contributor to resistance selection, as has been proposed for azole resistance in other fungal pathogens. Here, we examine whether environmental terbinafine contamination represents an overlooked One Health selection pressure or, alternatively, an exposure signal whose relevance to dermatophyte resistance remains ecologically constrained. Terbinafine is highly lipophilic, partitions into organic matter, and has been detected in wastewater, sludge, biosolids, surface water, groundwater, and sediment. Reported concentrations vary markedly by region and sample type, and in some cases exceed proposed resistance-selection thresholds. However, most clinically important dermatophytes, particularly anthropophilic Trichophyton lineages, are host-associated keratinophilic fungi rather than free-living environmental saprobes. Therefore, environmental terbinafine is unlikely to drive resistance unless viable dermatophyte propagules, keratinous substrates, and biologically active drug residues co-occur in the same ecological niche. Current evidence is insufficient to determine whether environmental terbinafine contamination contributes meaningfully to dermatophyte resistance selection. While infected wildlife and geophilic dermatophytes may serve as useful sentinel systems, they do not yet establish a causal environmental pathway for the emergence or spread of resistant T. indotineae. In order to address these knowledge gaps, we propose that future One Health surveillance should integrate terbinafine quantification with dermatophyte recovery, resistance-marker detection (i.e., SQLE screening), susceptibility testing, and experimental selection studies in biologically plausible reservoirs.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 6","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malassezia Species Isolated from Avian Carcasses in a Japanese Zoo, and the Description of Malassezia phoenicopteridarum sp. nov.","authors":"Ryuri Tachikawa, Yasuhiro Hori, Yu Nakayama, Dai Hirose","doi":"10.1007/s11046-026-01110-4","DOIUrl":"10.1007/s11046-026-01110-4","url":null,"abstract":"<p><p>Studies on the diversity of lipid-dependent Malassezia yeast that colonize avian hosts remain limited. In this study, we investigated Malassezia species diversity by sampling cerumen from 12 carcasses (representing 10 species across eight genera and four families) housed in a Japanese zoo. Using culture-based and molecular phylogenetic methods, four Malassezia strains were isolated from a lesser flamingo and a toco toucan. Molecular phylogenetic analyses based on the nucleotide sequences of the 26S rRNA D1/D2 domain, rRNA internal transcribed spacer region, and β-tubulin gene identified JCM 39679 and JCM 39681 as M. gallinae and M. furfur, respectively, and suggested that JCM 39680 and JCM 39682 represent a putative novel species closely related to M. psittaci, M. yamatoensis, and M. polysorbatinonusa. These novel strains exhibited physiological characteristics distinct from those of closely related species, specifically weak assimilation of Tween 80 and an inability to assimilate Cremophor EL. Accordingly, we propose the designation of the strains isolated from the lesser flamingo as the novel species M. phoenicopteridarum sp. nov.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 6","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeohyphomycosis in a Solid Organ Transplant Recipient: Case Report of a New Pathogenic Species of Kirschsteiniothelia.","authors":"Rihab Trabelsi, Melissa Zlobecki, Maxime Moniot, Natacha Mrozek, Victor Luzarraga, Michael Gras, Céline Nourrisson, Jacques Rouanet, Philippe Poirier","doi":"10.1007/s11046-026-01114-0","DOIUrl":"10.1007/s11046-026-01114-0","url":null,"abstract":"<p><p>Phaeohyphomycoses are rare infections caused by melanin-pigmented, saprophytic fungi commonly found in soil and on decaying plant matter. Infections typically affect immunocompromised individuals and present a wide clinical spectrum. Here, we report the case of a 63-year-old immunocompromised patient, with a history of combined heart-lung transplantation, who consulted in 2022 due to the appearance of a subcutaneous lesion on the thigh. A complete surgical debridement was performed and histopathological examination concluded the presence of a deep fungal infection. Three years later, relapse occurred. A spindle biopsy of the lesion was performed for microbiological and histopathological analysis. Mycological examination confirmed the diagnosis of phaeohyphomycosis caused by a dematiaceous fungus unknown as human pathogen before which belonged to the Kirschsteiniothelia genus. Retrospective analysis of formalin-fixed biopsies from 2022 found the same undescribed dematiaceous fungus, confirming the chronic and progressive nature of the fungal infection for 3 years. This case highlights how an integrated histological and mycological diagnosis improves patient care and outcomes.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 6","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug Resistance and Host Adaptation in Candida Auris: From Molecular Mechanisms to Emerging Therapeutic Frontiers.","authors":"Fenglin Shao, Tingru Wu, Jingjing Su","doi":"10.1007/s11046-026-01111-3","DOIUrl":"https://doi.org/10.1007/s11046-026-01111-3","url":null,"abstract":"<p><p>C. auris is an emerging multidrug-resistant (MDR) fungal pathogen that poses an urgent threat to global public health. It is characterized by rapid nosocomial transmission, persistent environmental survival, and extensive cross-resistance to conventional antifungal therapies. This comprehensive narrative review bridges the fundamental molecular mechanisms of intrinsic and acquired antifungal resistance with host adaptation strategies and emerging clinical interventions. C. auris resistance is driven by a highly sophisticated network of genetic mutations and metabolic reprogramming distributed across six geographically distinct clades (I-VI), including the newly identified Clade VI from the Indomalayan zone. Azole resistance primarily relies on clade-specific point mutations in the target gene ERG11, synergistically amplified by TAC1b-driven transcriptional upregulation of the CDR1 efflux pump. Echinocandin resistance is predominantly mediated by conformational reshaping across three distinct hotspot regions of the FKS1 gene, bolstered by Hsp90-mediated stress compensatory networks. For polyenes, while clinical resistance is frequently overestimated by commercial assays, true tolerance mechanisms involved the depletion of target ergosterol and profound non-sterol-dependent sphingolipid remodeling. Beyond genomic modifications, C. auris exhibits significant phenotypic plasticity, forming robust, polysaccharide-rich biofilms on indwelling medical devices that confer profound physical drug tolerance. Clinically, the fungus demonstrates a strong cutaneous tropism-predominantly colonizing the axilla and groin-which acts as the primary reservoir for hospital outbreaks. Furthermore, experimental models reveal that C. auris actively exploits host immune deficiencies, specifically subverting the IL-17A/neutrophil/S100A8 axis, to evade immune clearance and establish persistent colonization. To overcome these formidable MDR bottlenecks, therapeutic paradigms are rapidly evolving. The integration of next-generation antifungals such as the long-acting echinocandin rezafungin, fosmanogepix, and ibrexafungerp, synergistic combination therapies, quorum-sensing inhibitors such as farnesol, and experimental nanocarrier delivery systems could represent promising frontiers to effectively dismantle the complex defense networks of C. auris.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 6","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and Epidemiological Surveillance of Sporothrix spp. in Cats and Dogs from Southern Brazil.","authors":"Gabriela Ladeira Sanzo, Renata Osório de Faria, Juliana Tasende Ferrando, Marcela Brandão Costa, Isabela de Souza Morales, Giulia Batista Freitas, Lara Costa Grumann Michel, Luana Pereira Ramirez, Sergio Jorge, Kauê Rodriguez Martins, Rodrigo Casquero Cunha, Clairton Marcolongo Pereira, Angelita Dos Reis Gomes","doi":"10.1007/s11046-026-01107-z","DOIUrl":"10.1007/s11046-026-01107-z","url":null,"abstract":"<p><p>Sporotrichosis, a subcutaneous mycosis caused by Sporothrix spp., has emerged as a major zoonotic disease in Brazil, primarily driven by Sporothrix brasiliensis. The southern state of Rio Grande do Sul exhibits distinctive ecological and climatic conditions that may shape the persistence and distribution of this pathogen in this region. This study conducted molecular and epidemiological surveillance of feline and canine sporotrichosis in southern Rio Grande do Sul, Brazil. A total of 100 isolates from the culture collection of the Veterinary Mycology Laboratory at the Federal University of Pelotas (UFPel) were analyzed by PCR targeting the calmodulin (CAL) gene for species identification. Fourteen representative isolates were sequenced and subjected to phylogenetic analysis using the Maximum Likelihood method, including reference sequences from Brazil, Paraguay, and Argentina. Epidemiological and clinical variables, including host species, sex, lesion site, and morphology, were evaluated to characterize the epidemiological and clinical profiles of sporotrichosis in the study region. S. brasiliensis and S. schenckii were identified in 97% and 3% of the isolates, respectively. The CAL-based phylogeny confirmed the monophyly of S. brasiliensis and revealed low intraspecific variability with regional clustering among southern Brazilian isolates. When interpreted within the Southern Cone context, the topology indicated a close genetic affinity between isolates from Rio Grande do Sul and reference sequences from Argentina and Paraguay. These findings confirm the territorial expansion of S. brasiliensis across southern Brazil and emphasize the importance of molecular surveillance for detecting and tracking the circulating lineages. Continuous regional monitoring is crucial for strengthening One Health strategies and mitigating the zoonotic spread of sporotrichosis in the Southern Cone.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaporthe fructicola as a Cause of Subcutaneous Hyalohyphomycosis.","authors":"Hiromitsu Noguchi, Tadahiko Matsumoto, Masahide Kubo, Takashi Yaguchi","doi":"10.1007/s11046-026-01104-2","DOIUrl":"10.1007/s11046-026-01104-2","url":null,"abstract":"","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Perspective on Exophiala dermatitidis, A Systematic Review of Cases Reported Globally over 36 Years.","authors":"Tianyang Chen, Mingyuan Han, Ying Miao, Xinlin Zhu, Nan Hong, Xin Huang, Jianping Xu, Sybren de Hoog, Weihua Pan, Min Chen","doi":"10.1007/s11046-026-01109-x","DOIUrl":"10.1007/s11046-026-01109-x","url":null,"abstract":"<p><p>Exophiala dermatitidis is an opportunistic pathogen belonging to the so-called black yeasts, a group of fungi capable of causing a wide range of infections. Here we systematically reviewed 77 global cases of E. dermatitidis infections reported between 1989 and 2024. Most cases were reported from Japan (19/77), United States (16/77) and China (10/77), with 64.9% (50/77) cases reported since 2010, indicating an increasing global awareness of this fungus. Our results indicated that reported E. dermatitidis infections occurred in both immunocompromised (54.55%; 42/77) and apparently immunocompetent hosts (45.45%; 35/77), with deep-seated infections being the most common (76.62%; 59/77). Infections are associated with a high mortality rate, especially those affecting the central nervous system (63.63%; 7/11). Leukemia, nephropathy, diabetes, cystic fibrosis and CARD9 deficiency were identified as important predisposing factors for E. dermatitidis infection. All included cases were culture-confirmed, with a subset additionally supported by histopathological examination and/or molecular identification. Although there is currently no consensus about antifungal treatment for E. dermatitidis infections, our findings suggest that voriconazole was the most frequently used antifungal agent among the reviewed cases.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Genomic Insights into the Allodiploid Hybrid Pathogen Aspergillus latus: A Retrospective Case Series.","authors":"Yuqing Chen, Jieting Zhou, Lingjun Yuan, Mengxiao Xie, Jingchao Wang, Jieyuan Zheng, Linna Zhou, Dan Zhang, Dongsheng Han","doi":"10.1007/s11046-026-01108-y","DOIUrl":"10.1007/s11046-026-01108-y","url":null,"abstract":"<p><p>Aspergillus latus is an emerging cryptic allodiploid hybrid pathogen within Aspergillus section Nidulantes that closely resembles related species and therefore prone to misidentification by routine diagnostic methods. Therefore, its true clinical burden is likely underestimated. In this study, we retrospectively characterized five patients with A. latus infections identified by metagenomic next-generation sequencing (mNGS) at a tertiary hospital in China. Clinical manifestations varied according to host immune status, ranging from a subclinical pulmonary lesion in an immunocompetent individual to aggressive disease in highly immunocompromised patients. Conventional microbiological methods showed limited sensitivity and consistently misidentified the isolates as A. nidulans, whereas mNGS enabled accurate detection of A. latus together with complex co-infections. Three viable clinical isolates were recovered for morphological characterization, antifungal susceptibility testing, and whole-genome sequencing (WGS). All tested isolates demonstrated reduced susceptibility to echinocandins but remained susceptible to mold-active triazoles and amphotericin B. Furthermore, WGS and macrosynteny analyses confirmed their allodiploid hybrid nature, revealing a mosaic genome derived from A. spinulosporus and an A. quadrilineatus-related lineage. Collectively, these findings highlight that A. latus may be missed by routine diagnostic methods and may exhibit a distinct antifungal susceptibility profile. Molecular approaches such as mNGS and WGS may therefore help achieve accurate species-level identification and support targeted antifungal therapy. Given this small retrospective case series, larger prospective and multicenter studies are needed to validate these observations and better define the epidemiology, clinical spectrum, and therapeutic implications of this emerging allodiploid hybrid pathogen.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Genetic Clades and Frequent Zoonotic Transmission of Sporothrix brasiliensis with Reduced Itraconazole Susceptibility.","authors":"Mariana Rodrigues Trápaga, Bram Spruijtenburg, Jéssica Estefania Dávila Hidalgo, Bruna Jacomel, Isabel Martins Madrid, Daniela Isabel Brayer Pereira, Antonella Souza Mattei, Angelita Reis Gomes, Renata Osório de Faria, Flávio Silveira, Cecília Bittencourt Severo, Valério Rodrigues Aquino, Ana Paula Giolo Franz, Sonia de Ávila Botton, Rosely Maria Zancopé-Oliveira, Vanice Rodrigues Poester, Theun de Groot, Eelco F J Meijer, Melissa Orzechowski Xavier","doi":"10.1007/s11046-026-01101-5","DOIUrl":"10.1007/s11046-026-01101-5","url":null,"abstract":"<p><p>Sporothrix brasiliensis is driving a major zoonotic epidemic in Brazil, predominantly via cat-to-human transmission. In the late 1990s major outbreaks were reported in Rio de Janeiro (RJ) and Rio Grande do Sul (RS), the southernmost state. We characterized the antifungal susceptibility and genetic diversity of 450 S. brasiliensis isolates collected between 2009 and 2024 in RS to better understand treatment response, emergence and transmission.A bimodal distribution of the itraconazole minimum inhibitory concentration (MIC) was observed with 24% non-wild-type (NWT) isolates. Short tandem repeat genotyping revealed three main clades: One associated with RJ strains (Clade I) and two novel clades (Clades II and III). Clade II formed large transmission clusters with < 20% of isolates being NWT for itraconazole, similar to Clade I. Clade III demonstrated less clustering, higher genetic variation and NWT MICs for 89% of isolates. Finally, all NWT strains in human patients with cat-transmitted disease and available clinical data, appeared isolated prior to azole exposure.We report the emergence of genetically distinct S. brasiliensis clades in RS with different rates of reduced itraconazole susceptibility and evidence of zoonotic transmission of NWT isolates. Our findings highlight the urgent need for antifungal stewardship and surveillance in these endemic regions.</p>","PeriodicalId":19017,"journal":{"name":"Mycopathologia","volume":"191 5","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}