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Imageological analysis of upper airway in noninvasive ventilation with bi-level positive airway pressure 双水平气道正压无创通气的上气道影像学分析
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-12-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.06.012
林治川, 温晓晖, 余革, 陈苓, 林翰菲
{"title":"Imageological analysis of upper airway in noninvasive ventilation with bi-level positive airway pressure","authors":"林治川, 温晓晖, 余革, 陈苓, 林翰菲","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.06.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.06.012","url":null,"abstract":"目的 应用多层螺旋CT对患者不同通气状态下上呼吸道放射性成像,证实在全身麻醉无自主呼吸的条件下,双相气道正压(bi-level positive airway pressure,BiPAP)无创机械通气能克服上呼吸道阻力,实施有效的机械通气.方法 选择拟实施全身麻醉的择期手术患者10例,分别对患者清醒自主呼吸、麻醉诱导后自主呼吸停止、BiPAP无创通气时头颈部正位和侧位作螺旋CT扫描.监测扫描过程的无创血压(NIBP)、脉搏氧饱和度(SpO2)、心率(HR)、自主呼吸频率(RR).测量上呼吸道各软组织区(软腭后区RP、舌根后区RG、会厌区EPG)的最窄气道横截面左右径、前后径线长度及相应横截面积.结果 头部正位麻醉诱导后各软组织区的最窄横截面左右径、前后径线长度及相应横截面积均比清醒时缩小(P＜0.05),BiPAP通气时各截面径线和面积与清醒期比较差异仍有统计学意义(P＜0.05,P＜0.01).头部侧位BiPAP通气时各径线和截面积与清醒时比较,差异无统计学意义.EPG区和RG区在BiPAP通气期的侧位截面积明显比正位时增大(P＜0.05,P＜0.01).诱导期正、侧位SpO2均明显下降(P＜0.01);头部正位BiPAP通气时与诱导期的SpO2比较虽有改善,但差异无统计学意义(P＞0.05);头部侧位BiPAP通气时SpO2较诱导期明显升高(P＜0.01),基本恢复到清醒期水平(P＞0.05).结论 麻醉诱导后上呼吸道的通气面积明显减少,气道通畅度下降;头颈部侧位时上呼吸道各软组织区最狭窄处的通气截面积比正位时显著改善,以会厌区最明显.无明显上呼吸道梗阻性病史的成年患者全身麻醉时,头部侧位BiPAP无创通气能克服上呼吸道阻力,实施有效的机械通气,保证通气和氧合正常。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116116271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of irbesartan on cardiac hypertrophy and MHC gene expression induced by angiotensin II inrat 厄贝沙坦对血管紧张素ⅱ诱导大鼠心肌肥大及MHC基因表达的影响
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-12-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.06.007
陈爱兰, 陈敏生, 何兆初, 刘启才, 董颀
{"title":"Effect of irbesartan on cardiac hypertrophy and MHC gene expression induced by angiotensin II inrat","authors":"陈爱兰, 陈敏生, 何兆初, 刘启才, 董颀","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.06.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.06.007","url":null,"abstract":"目的 观察伊贝沙坦对血管紧张素Ⅱ(AngⅡ)所致心肌细胞中蛋白质合成速率及肌球蛋白重链(MHC)基因表达改变的影响.方法 以AngⅡ及伊贝沙坦分别或同时作用于培养的细胞.采用放射性同位素[3H]-leu掺入法检测培养心肌细胞蛋白质合成速率.应用荧光定量PCR方法检测心肌细胞心房利钠肽因子(ANF)以及α-MHC、β-MHC的表达.结果 AngⅡ处理使心肌细胞中[3H]-Leu掺人增加(P＜0.05),同时ANF mRNA的表达明显高于正常(P＜0.05);α-MHC mRNA的表达显著低于正常(P＜0.05),而β-MHC mRNA的表达显著高于正常(P＜0.05),α-MHC/β-MHC的比值下降(P＜0.05).当伊贝沙坦与AngⅡ共同作用于培养的心肌细胞时,与AngⅡ组比较,[3H]-Leu的掺入明显下降(P＜0.05),与正常组比无统计学意义(P＞0.05);同时ANF的表达下降,与正常组比无统计学意义(P＞0.05);心肌细胞中α-MHC的表达明显增高(P＜0.05),而β-MHCmRNA的表达显著降低(P＜0.05),α-MHC/β-MHC的比值上升(P＜0.05).结论 伊贝沙坦能抑制AngⅡ所致的心肌细胞肥大和细胞中α-MHC向β-MHC表达的转换。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122920070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppression of established melanoma in mice by a humanized single-chain Fv antibody/human interleukin-2 fusion protein therapy 人源化单链Fv抗体/人白细胞介素-2融合蛋白治疗对小鼠黑色素瘤的抑制作用
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.007
沈粤春, 王晓明, 赵超尘, 黄刚, 刘安重, 李君
{"title":"Suppression of established melanoma in mice by a humanized single-chain Fv antibody/human interleukin-2 fusion protein therapy","authors":"沈粤春, 王晓明, 赵超尘, 黄刚, 刘安重, 李君","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.007","url":null,"abstract":"目的 评价人源化抗Her2/neu单链抗体及人白细胞介素2(hIL-2)双功能融合蛋白H520C9scFv-hIL-2治疗Her2/neu阳性肿瘤的效果.方法 将构建的表达载体转染293细胞,G418筛选阳性克隆建立稳定表达细胞系.免疫印迹法(Western blotting)、酶联免疫吸附试验(ELISA)及[3H]脱氧胸苷(3H-TdR)渗入法检测融合蛋白浓度和生物学活性.建立荷瘤小鼠肿瘤模型,静脉给药,观测肿瘤体积变化判断治疗效果.结果 细胞培养上清中融合蛋白浓度达(1.2±0.23)mmol/L,5μl上清即可在46 000处见到清晰蛋白条带.纯化后的融合蛋白两个功能单位活性良好,在荷瘤小鼠肿瘤模型治疗实验中显示了明确的治疗效果.结论 哺乳动物细胞可高效表达生物活性良好的融合蛋白H520C9scFv-hIL-2,该蛋白在体内实验中有明显的抑瘤作用,显示了较好的应用前景。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121066592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The measurement of dielectric response of normal human platelets in the radio frequency range 正常人血小板在射频范围内介电响应的测量
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.013
丁方, 何学影, 张红波, 马青
{"title":"The measurement of dielectric response of normal human platelets in the radio frequency range","authors":"丁方, 何学影, 张红波, 马青","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.013","url":null,"abstract":"目的 在射频段测量正常人血小板介电谱,建立血小板对交流电场介电响应的数据特征.方法 利用频域阻抗技术测量人血小板交流阻抗,经过介电谱、Cole-Cole图、介电损耗因子△e\"、导电率虚部△κ\"、介电损耗角正切△tgδ等频谱,明确人血小板介电频响的数据特征.结果 在射频电场中,人血小板的介电常数和电导率具有频率依赖性;血小板介电响应具有两个中心特征频率:第一中心特征频率fC1=6.66 MHz,第二中心特征频率fC2=9.81 MHz.结论 交流阻抗技术能够测量血小板射频段介电响应。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131767415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
4-hydroxynonenal induces the apoptosis of bronchial epithelial cells 4-羟基壬烯醛诱导支气管上皮细胞凋亡
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.009
于亮, 冉丕鑫
{"title":"4-hydroxynonenal induces the apoptosis of bronchial epithelial cells","authors":"于亮, 冉丕鑫","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.009","url":null,"abstract":"目的 探讨4-羟基壬烯醛(4-HNE)对支气管上皮细胞(16-HBE)凋亡的诱导作用及其机制.方法 将支气管上皮细胞(16-HBE)分为空白对照组、10 μmol/L、30 μmol/L、50 μmol/L4-HNE作用4 h组,观察4-HNE作用4 h后的细胞凋亡情况.Western印迹方法检测磷酸化(p-)SAPK-JNK和caspase-3蛋白表达的情况.结果 细胞经30 μmol/L、50 μmol/L 4-HNE作用后,姬姆萨染色可见明显细胞凋亡改变.对照组、10 μmol/L、30 μmol/L、50μmol/L 4-HNE组的AnnexinV-PI染色凋亡细胞数分别为1.94±1.03,2.03±1.04,43.36±1.3,65.92±3.45.30 μmol/L和50 μmol/L 4-HNE组与对照组及10 μmol/L 4-HNE组比较,差异有统计学意义(P＜0.01).各组p-SAPK-JNK蛋白表达差异无统计学意义(P＞0.05).30 μmol/L、50 μmol/L 4-HNE刺激组caspase-3的表达较对照组和10 μmol/L4-HNE组差异有统计学意义(P＜0.01).结论 30、50 μmol/L 4-HNE可通过caspase-3的激活引起支气管上皮细胞的凋亡。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"114 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116006331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
血压变异性分析及其在重力生理学中的应用前景 血压变异性分析及其在重力生理学中的应用前景
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.018
汪德生, 袁明, 李志利
{"title":"血压变异性分析及其在重力生理学中的应用前景","authors":"汪德生, 袁明, 李志利","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.018","url":null,"abstract":"航天后立位耐力、运动能力和加速度耐力降低均与心血管自主神经调节功能变化关系密切[1,2 ].重力生理学研究中心血管自主神经调节功能评价对于明确航天微重力环境所致的人体生理功能影响机理的认识很关键。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122590038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of plastic embedding technique in bone tissue examination 塑料埋置技术在骨组织检查中的应用
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.014
张双燕, 谢幼专, 薛文东, 汤亭亭, 戴尅戎
{"title":"The application of plastic embedding technique in bone tissue examination","authors":"张双燕, 谢幼专, 薛文东, 汤亭亭, 戴尅戎","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.014","url":null,"abstract":"目的 研究塑料包埋技术制作的不脱钙硬组织切片,确定制作的关键步骤及用于骨组织研究的优点.方法 选取狗胫骨节段或带有金属种植体的骨材料塑料包埋,LeicaSP1600切片机(德国)切片,用苦味酸品红染色观察,并与常规石蜡包埋相比较.结果 不脱钙骨组织经塑料包埋技术处理后,可清楚地观察类骨质形成、多孔材料及种植体周围骨组织的整合程度.与常规石蜡包埋相比,染色层次分明,组织移位形变小.结论 应用规范塑料包埋技术制作不脱钙硬组织切片,更有利于行骨形态计量分析以及材料与骨整合的研究。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130025749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical research of arsenic trioxide (As2O3 )continuous regional hepatic arterial infusion in the treatment of primary hepatic carcinoma 三氧化二砷(As2O3)连续肝动脉灌注治疗原发性肝癌的临床研究
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.015
崔书中, 吴印兵, 王嘉康, 唐云强, 汤日杰, 王斌, 巴明臣
{"title":"Clinical research of arsenic trioxide (As2O3 )continuous regional hepatic arterial infusion in the treatment of primary hepatic carcinoma","authors":"崔书中, 吴印兵, 王嘉康, 唐云强, 汤日杰, 王斌, 巴明臣","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.015","url":null,"abstract":"目的 探讨三氧化二砷(As2O3)注射液单药连续区域动脉灌注化疗原发性肝癌的临床疗效.方法 55例手术不能切除的非晚期原发性肝癌患者,随机分为两组:(1)As2O3治疗组26例:患者采用经股动脉肝动脉碘油栓塞后埋置皮下化疗泵,予以连续区域灌注As2O3化疗,20 mg/d,每天1次,共7 d,间隔4周重复,共5疗程.(2)对照组29例:采用经股动脉肝动脉栓塞化疗(TACE),2次TACE15例,3次TACE14例.结果 As2O3治疗组总有效率为34.6%(9/26)、肿瘤复发率为15.4%(4/26)、1年生存率为80.7%(21/26);TACE组分别是31.0%(9/29)、37.9%(11/29)、51.7%(15/29).统计学分析表明,两组的总有效率差异无统计学意义,P＞0.05;肿瘤复发率和1年生存率差异有统计学意义,P＜0.05.As2O3治疗组较对照组不良反应轻微,未见不可逆不良反应.结论 经股动脉肝动脉碘油栓塞后埋置皮下化疗泵予以连续区域灌注As2O3化疗用于治疗原发性肝癌不良反应轻微、疗效确切,具有一定的临床应用前景。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129182916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An improvement of 11 C-acetate synthesis and its biodistribution 11 - c -乙酸酯合成及其生物分布的改进
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.011
何山震, 王淑侠, 徐卫平, 唐安戊, 陈立光, 王朋
{"title":"An improvement of 11 C-acetate synthesis and its biodistribution","authors":"何山震, 王淑侠, 徐卫平, 唐安戊, 陈立光, 王朋","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.011","url":null,"abstract":"目的 建立快速、有效合成正电子发射体层摄影(PET)示踪剂11C-乙酸的方法并研究其生物分布,满足临床PET的用药需要.方法 以11C-CO2为原料,与CH3 MgBr反应后再用17%的H3PO4酸解,产物通过加热的方法蒸出,同时通过控制11C-CO2的释放速度和适当延长11C-CO2与CH3MgBr的反应时间,提高反应产率.小鼠给药后不同时间处死,分别取不同器官称重并测放射线计数.结果 从加速器生产出11C-CO2到产物11C-乙酸的蒸出完毕,需15 min,放化纯度大于98%,化学纯度大于99%,平均产率为34.6%(未经衰变校正).注射11C-乙酸后,放射线主要集中在肝脏及肾脏.结论 改进反应条件后的合成方法具有快速、高效的特点,为PET日常耗材节省了成本,提高了用药的质量。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116812721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human signals and medical ultrasonic signals 人体信号和医用超声信号
Journal of Modern Clinical Medical Bioengineering Pub Date : 2006-10-15 DOI: 10.3760/CMA.J.ISSN.1008-634X.2006.05.001
王威琪, 周国辉, 汪源源, 他得安, 余建国
{"title":"Human signals and medical ultrasonic signals","authors":"王威琪, 周国辉, 汪源源, 他得安, 余建国","doi":"10.3760/CMA.J.ISSN.1008-634X.2006.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-634X.2006.05.001","url":null,"abstract":"一、引言 疾病的危险程度可以分为高、中、低三等.目前临床检查手段又可分为侵入及损伤、微侵入及微损伤、非侵入及无损伤,显然非侵入及无损伤的检查手段受到各种患者和健康检查者的欢迎.见表1。","PeriodicalId":189947,"journal":{"name":"Journal of Modern Clinical Medical Bioengineering","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130420137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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