Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000最新文献_第2页

Performing and optimizing individualized actuarial prediction of post-prostatectomy PSA control with a Clinical Outcome Prediction Expert (COPE) 应用临床预后预测专家(COPE)对前列腺切除术后PSA控制进行个体化精算预测并优化

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856885

R. Cheung, R. Whittington, M. Altschuler

{"title":"Performing and optimizing individualized actuarial prediction of post-prostatectomy PSA control with a Clinical Outcome Prediction Expert (COPE)","authors":"R. Cheung, R. Whittington, M. Altschuler","doi":"10.1109/CBMS.2000.856885","DOIUrl":"https://doi.org/10.1109/CBMS.2000.856885","url":null,"abstract":"Rational treatment decision requires accurate projection of the clinical course of a patient. Current methods in clinical outcome analysis mostly focus on population data. We investigated the applicability and optimization of the widely used actuarial method to project an individual's clinical outcome. We designed and implemented COPE (Clinical Outcome Prediction Expert), which performs, assesses and optimizes individualized actuarial prediction. The program was applied to analyze a post-prostatectomy database. Stratified actuarial curves are used to project individual outcomes. The area under the receiver operator characteristic (ROC) curve was used to measure predictive performance. We applied COPE to search for the optimal cut-off time and cut-off probability for prediction. The pre-treatment PSA (prostate-specific antigen), the Gleason score and the AJCC (American Joint Commission on Cancer) clinical T-stage were used as predictors. We found that the optimal range of the cut-off probability was 65% to 75% and the cut-off time was 44 to 52 months for all predictors. Optimization greatly simplifies the risk stratification and improves the predictive power of the Gleason score. The optimized multivariate risk score has the highest ROC area of 0.77 among all predictors. This study shows that ROC-optimized risk stratification improves the accuracy of clinical outcome prediction.","PeriodicalId":189930,"journal":{"name":"Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130848768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Integration of intelligent engines for a large scale medical image database 集成大型医学图像数据库的智能引擎

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856905

Lilian H. Y. Tang, R. Hanka, H. Ip, Kent K. T. Cheung, R. Lam

{"title":"Integration of intelligent engines for a large scale medical image database","authors":"Lilian H. Y. Tang, R. Hanka, H. Ip, Kent K. T. Cheung, R. Lam","doi":"10.1109/CBMS.2000.856905","DOIUrl":"https://doi.org/10.1109/CBMS.2000.856905","url":null,"abstract":"We present a semantic content representation scheme and the associated techniques for supporting (a) query by image examples or by natural language in a histological image database and (b) automatic annotation generation for images through image semantic analysis. In this research, various types of query are analysed by either a semantic analyser or a natural language analyser to extract high level concepts and histological information, which are subsequently converted into an internal semantic-content representation structure code-named \"Papillon\". Papillon serves not only as an intermediate representation scheme but also stores the semantic content of the image that will be used to match against the semantic index structure within the image database during query processing. During the image database population phase, all images that are going to be put into the database will go through the same processing so that every image would have its semantic content represented by a Papillon structure. Since the Papillon structure for an image contains high level semantic information of the image, it forms the basis of the technique that automatically generates textual annotation for the input images. Papillon bridges the gap between different media in the database, allows complicated intelligent browsing to be carried out efficiently and also provides a well-defined semantic content representation scheme for different content processing engines developed for content-based retrieval.","PeriodicalId":189930,"journal":{"name":"Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000","volume":"159 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122688023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Decision tree's induction strategies evaluated on a hard real world problem 决策树的归纳策略在现实世界难题上的评价

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856866

M. Zorman, V. Podgorelec, P. Kokol, Margaret G. E. Peterson, Joseph M. Lane

引用次数: 17

Mathematical modeling of nonlinear coupling mechanisms of gastric slow wave propagation and its SIMULINK simulation for investigating gastric dysrhythmia and pacing 胃慢波传播非线性耦合机制的数学建模及其SIMULINK仿真研究胃节律障碍和起搏

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856884

Z. Wang, Jing Chen

引用次数: 1

Segmentation of magnetic resonance images using a neuro-fuzzy algorithm 基于神经模糊算法的磁共振图像分割

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856901

R. Castellanos, S. Mitra

引用次数: 16

Linking clinical, research and administrative computer systems 连接临床、研究和行政计算机系统

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856914

M. Krol, H. Fong, Marcus Gauzza, D. Reich

引用次数: 3

Advanced signal processing methods for quantitation of resonances in magnetic resonance spectra 磁共振谱中共振定量的先进信号处理方法

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856877

Yu Wang, Sabine Van Huÿel, L. Vanhamme, N. Mastronardi, P. Hecke

引用次数: 1

Simulation of the Na/sup +/-Ca/sup ++/ exchanger response to electrical and ionic stimulation in spherical-type cells 球形电池中Na/sup +/-Ca/sup +/交换剂对电和离子刺激的响应模拟

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856883

V. González-Vélez, J. R. Godínez-Fernández

{"title":"Simulation of the Na/sup +/-Ca/sup ++/ exchanger response to electrical and ionic stimulation in spherical-type cells","authors":"V. González-Vélez, J. R. Godínez-Fernández","doi":"10.1109/CBMS.2000.856883","DOIUrl":"https://doi.org/10.1109/CBMS.2000.856883","url":null,"abstract":"The Na/sup +/-Ca/sup ++/ exchanger plays a fundamental role in the regulation of the intracellular calcium concentration (Ca/sub i/) in several animal cell types, like axons, heart muscle, cardiac cells and reconstituted vesicles. It shows a dual operation, extruding or introducing Ca/sup ++/ through the cell membrane, depending on the electrochemical gradients, which in turn applies a membrane potential and ionic concentrations both inside and outside of the cell. We are interested on the dependence of calcium movement through the cell as well as the reversible behaviour of the exchanger. With the aid of a Ca/sup ++/ regulation simulator for spherical-type cells, where we can apply the stimuli at the membrane level, we have been able to verify the presence of inward-outward exchanging currents. Our model includes the diffusion process as a function of time in the cell, and the presence of a Ca/sup ++/ buffer (parvalbumin), both collaborating with the Na/sup +/-Ca/sup ++/ exchanger. This is only a part of the complete model that we have developed, because we were interested only in verifying the role of the exchanger during the presence of different Na/sup +/ and Ca/sup ++/ concentrations.","PeriodicalId":189930,"journal":{"name":"Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130984070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CoMed: a real-time collaborative medicine system CoMed:实时协同医疗系统

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856902

M. Sung, Moon Suck Kim, Myung-Whun Sung, Eom Joon Kim, J. Yoo

引用次数: 39

Tissue mechanical attributes imaging: principles and methods 组织力学属性成像:原理和方法

Proceedings 13th IEEE Symposium on Computer-Based Medical Systems. CBMS 2000 Pub Date : 2000-06-23 DOI: 10.1109/CBMS.2000.856893

F. Kallel, J. Ophir

引用次数: 5