Mathematical modeling of nonlinear coupling mechanisms of gastric slow wave propagation and its SIMULINK simulation for investigating gastric dysrhythmia and pacing

Abstract

Gastric electrical activity controls gastric peristalsis and plays an important role in the digestive process of the stomach. Gastric dysrhythmia has been reported to be associated with gastric functional diseases. The aim of this paper is to understand possible mechanisms involved in the generation of gastric electrical dysrhythmia and the feasibility of gastric pacing for the normalization of gastric dysrhythmia. First, a mathematical model is established to stimulate normal and abnormal gastric electrical activities, and then its SIMULINK circuit implementation is applied to simulate the effect of gastric pacing for the normalization of gastric dysrhythmia.