Nature genetics最新文献

{"title":"The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project","authors":"Lingzhao Fang, Jinyan Teng, Qing Lin, Zhonghao Bai, Shuli Liu, Dailu Guan, Bingjie Li, Yahui Gao, Yali Hou, Mian Gong, Zhangyuan Pan, Ying Yu, Emily L. Clark, Jacqueline Smith, Konrad Rawlik, Ruidong Xiang, Amanda J. Chamberlain, Michael E. Goddard, Mathew Littlejohn, Greger Larson, David E. MacHugh, John F. O’Grady, Peter Sørensen, Goutam Sahana, Mogens Sandø Lund, Zhihua Jiang, Xiangchun Pan, Wentao Gong, Haihan Zhang, Xi He, Yuebo Zhang, Ning Gao, Jun He, Guoqiang Yi, Yuwen Liu, Zhonglin Tang, Pengju Zhao, Yang Zhou, Liangliang Fu, Xiao Wang, Dan Hao, Lei Liu, Siqian Chen, Robert S. Young, Xia Shen, Charley Xia, Hao Cheng, Li Ma, John B. Cole, Ransom L. Baldwin, Cong-jun Li, Curtis P. Van Tassell, Benjamin D. Rosen, Nayan Bhowmik, Joan Lunney, Wansheng Liu, Leluo Guan, Xin Zhao, Eveline M. Ibeagha-Awemu, Yonglun Luo, Lin Lin, Oriol Canela-Xandri, Martijn F. L. Derks, Richard P. M. A. Crooijmans, Marta Gòdia, Ole Madsen, Martien A. M. Groenen, James E. Koltes, Christopher K. Tuggle, Fiona M. McCarthy, Dominique Rocha, Elisabetta Giuffra, Marcel Amills, Alex Clop, Maria Ballester, Gwenola Tosser-Klopp, Jing Li, Chao Fang, Ming Fang, Qishan Wang, Zhuocheng Hou, Qin Wang, Fuping Zhao, Lin Jiang, Guiping Zhao, Zhengkui Zhou, Rong Zhou, Hehe Liu, Juan Deng, Long Jin, Mingzhou Li, Delin Mo, Xiaohong Liu, Yaosheng Chen, Xiaolong Yuan, Jiaqi Li, Shuhong Zhao, Yi Zhang, Xiangdong Ding, Dongxiao Sun, Hui-Zeng Sun, Cong Li, Yu Wang, Yu Jiang, Dongdong Wu, Wenwen Wang, Xinzhong Fan, Qin Zhang, Kui Li, Hao Zhang, Ning Yang, Xiaoxiang Hu, Wen Huang, Jiuzhou Song, Yang Wu, Jian Yang, Weiwei Wu, Claudia Kasper, Xinfeng Liu, Xiaofei Yu, Leilei Cui, Xiang Zhou, Seyoung Kim, Wei Li, Hae Kyung Im, Edward S. Buckler, Bing Ren, Michael C. Schatz, Jingyi Jessica Li, Abraham A. Palmer, Laurent Frantz, Huaijun Zhou, Zhe Zhang, George E. Liu","doi":"10.1038/s41588-025-02121-5","DOIUrl":"https://doi.org/10.1038/s41588-025-02121-5","url":null,"abstract":"<p>Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype–Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context. This Perspective provides an overview of the priorities of FarmGTEx and advocates for coordinated strategies of data analysis and resource-sharing initiatives. FarmGTEx aims to serve as a platform for investigating context-specific regulatory effects, which will deepen our understanding of molecular mechanisms underlying complex phenotypes. The knowledge and insights provided by FarmGTEx will contribute to improving sustainable agriculture-based food systems, comparative biology and eventual human biomedicine.</p>","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"19 1","pages":""},"PeriodicalIF":30.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement","authors":"Weilong Kong, Xiangrui Kong, Zhongqiang Xia, Xiaofeng Li, Fang Wang, Ruiyang Shan, Zhihui Chen, Xiaomei You, Yuanyan Zhao, Yanping Hu, Shiqin Zheng, Sitong Zhong, Shengcheng Zhang, Yanbing Zhang, Kaixing Fang, Yinghao Wang, Hui Liu, Yazhen Zhang, Xinlei Li, Hualing Wu, Guo-Bo Chen, Xingtan Zhang, Changsong Chen","doi":"10.1038/s41588-025-02135-z","DOIUrl":"https://doi.org/10.1038/s41588-025-02135-z","url":null,"abstract":"<p>The tea plant stands as a globally cherished nonalcoholic beverage crop, but the genetic underpinnings of important agronomic and metabolomic traits remain largely unexplored. Here we de novo deep resequenced 802 tea plants and their relative accessions globally. By integrating public <i>Camellia</i> accessions, we constructed a comprehensive genome-wide genetic variation map and annotated deleterious mutations for 1,325 accessions. Population genetic analyses provided insights into genetic divergence from its relatives, different evolutionary bottlenecks, interspecific introgression and conservation of wild relatives. Our findings suggest the pivotal role of southwest China as the origin of tea plants, revealing the genetic diversity and domestication status of ancient tea plants. Genome-wide association studies herein identified thousands of substantial associations with leaf shape and metabolite traits, pinpointing candidate genes for crucial agronomic and flavor traits. This study illuminates the tea plant’s evolution and provides references for tea plant design breeding.</p>","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"55 1","pages":""},"PeriodicalIF":30.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A telomere-to-telomere genome assembly of cotton provides insights into centromere evolution and short-season adaptation","authors":"Guanjing Hu, Zhenyu Wang, Zunzhe Tian, Kai Wang, Gaoxiang Ji, Xingxing Wang, Xianliang Zhang, Zhaoen Yang, Xuan Liu, Ruoyu Niu, De Zhu, Yuzhi Zhang, Lian Duan, Xueyuan Ma, Xianpeng Xiong, Jiali Kong, Xianjia Zhao, Ya Zhang, Junjie Zhao, Shoupu He, Corrinne E. Grover, Junji Su, Keyun Feng, Guangrun Yu, Jinlei Han, Xinshan Zang, Zhiqiang Wu, Weihua Pan, Jonathan F. Wendel, Xiongfeng Ma","doi":"10.1038/s41588-025-02130-4","DOIUrl":"https://doi.org/10.1038/s41588-025-02130-4","url":null,"abstract":"<p>Cotton (<i>Gossypium hirsutum</i> L.) is a key allopolyploid crop with global economic importance. Here we present a telomere-to-telomere assembly of the elite variety Zhongmian 113. Leveraging technologies including PacBio HiFi, Oxford Nanopore Technology (ONT) ultralong-read sequencing and Hi-C, our assembly surpasses previous genomes in contiguity and completeness, resolving 26 centromeric and 52 telomeric regions, 5S rDNA clusters and nucleolar organizer regions. A phylogenetically recent centromere repositioning on chromosome D08 was discovered specific to <i>G. hirsutum</i>, involving deactivation of an ancestral centromere and the formation of a unique, satellite repeat-based centromere. Genomic analyses evaluated favorable allele aggregation for key agronomic traits and uncovered an early-maturing haplotype derived from an 11 Mb pericentric inversion that evolved early during <i>G. hirsutum</i> domestication. Our study sheds light on the genomic origins of short-season adaptation, potentially involving introgression of an inversion from primitively domesticated forms, followed by subsequent haplotype differentiation in modern breeding programs.</p>","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"24 1","pages":""},"PeriodicalIF":30.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes","authors":"Yuan Ji, Nana Liu, Yunjun Yang, Meiyun Wang, Jingliang Cheng, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Wen Qin, Feng Liu, Meng Liang, Sijia Wang, Qiang Xu, Jiayuan Xu, Jilian Fu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia-Hong Gao, Xiaochu Zhang, Kai Xu, Xi-Nian Zuo, Longjiang Zhang, Zhaoxiang Ye, Mulin Jun Li, Junfang Xian, Bing Zhang, Chunshui Yu","doi":"10.1038/s41588-025-02136-y","DOIUrl":"https://doi.org/10.1038/s41588-025-02136-y","url":null,"abstract":"<p>The amygdala is a small but critical multi-nucleus structure for emotion, cognition and neuropsychiatric disorders. Although genetic associations with amygdala volumetric traits have been investigated in sex-combined European populations, cross-ancestry and sex-stratified analyses are lacking. Here we conducted cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in 6,923 Chinese and 48,634 European individuals. We identified 191 variant–trait associations (<i>P</i> &lt; 2.38 × 10⁻⁹), including 47 new associations (12 new loci) in sex-combined univariate analyses and seven additional new loci in sex-combined and sex-stratified multivariate analyses. We identified 12 ancestry-specific and two sex-specific associations. The identified genetic variants include 16 fine-mapped causal variants and regulate amygdala and fetal brain gene expression. The variants were enriched for brain development and colocalized with mood, cognition and neuropsychiatric disorders. These results indicate that cross-ancestry and sex-stratified genetic association analyses may provide insight into the genetic architectures of amygdala and subnucleus volumes.</p>","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"499 1","pages":""},"PeriodicalIF":30.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding immune escape in lung cancer","authors":"Safia Danovi","doi":"10.1038/s41588-025-02144-y","DOIUrl":"10.1038/s41588-025-02144-y","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"486-486"},"PeriodicalIF":31.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput screening identifies modulators of gene bursting","authors":"Chiara Anania","doi":"10.1038/s41588-025-02143-z","DOIUrl":"10.1038/s41588-025-02143-z","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"486-486"},"PeriodicalIF":31.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell mapping of HTT somatic repeat expansions","authors":"Kyle Vogan","doi":"10.1038/s41588-025-02142-0","DOIUrl":"10.1038/s41588-025-02142-0","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"486-486"},"PeriodicalIF":31.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperactive histone genes fuel cancer","authors":"Tiago Faial","doi":"10.1038/s41588-025-02145-x","DOIUrl":"10.1038/s41588-025-02145-x","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"486-486"},"PeriodicalIF":31.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the role of succinyl-CoA in tumor immunity","authors":"","doi":"10.1038/s41588-025-02076-7","DOIUrl":"10.1038/s41588-025-02076-7","url":null,"abstract":"The study highlights the crucial role of succinyl-CoA in tumor immunity by inducing the succinylation of PD-L1. We identified the succinyltransferase CPT1A as a potential therapeutic target. CPT1A could be a valuable biomarker for evaluating the efficacy of anti-PD-1 therapy and suggests a promising treatment strategy.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"496-497"},"PeriodicalIF":31.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the distinct genomic features of Japanese soybeans","authors":"","doi":"10.1038/s41588-025-02114-4","DOIUrl":"https://doi.org/10.1038/s41588-025-02114-4","url":null,"abstract":"Japanese soybeans have been bred for centuries for traditional soy-based food production. A pangenome study using genome data from 462 soybeans worldwide revealed distinct genomic features in Japanese soybeans, as well as several quantitative trait loci alleles that are important for breeding cultivars suited to traditional soy-based foods.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"87 1","pages":""},"PeriodicalIF":30.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}