一个反转录转座子在一个奇怪的数字丢失案例中被当场抓获

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-07-09 DOI:10.1038/s41588-025-02147-9

Youjia Guo, Andrew J. Modzelewski

引用次数: 0

摘要

一个新发现的机制显示了逆转录病毒起源的单个转座因子如何能够采用邻近基因的表达模式。这导致病毒样颗粒的产生，当表观遗传沉默被破坏时，这些颗粒会破坏器官的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A retrotransposon caught red-handed in a curious case of missing digits

查看原文本刊更多论文

A retrotransposon caught red-handed in a curious case of missing digits

A newly uncovered mechanism shows how a single transposable element of retroviral origin can adopt the expression pattern of a neighboring gene. This leads to the production of viral-like particles that disrupt organ formation when epigenetic silencing is compromised.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution