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Genetics and dietary restriction impact lifespan 遗传和饮食限制影响寿命
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02005-0
Wei Li
{"title":"Genetics and dietary restriction impact lifespan","authors":"Wei Li","doi":"10.1038/s41588-024-02005-0","DOIUrl":"10.1038/s41588-024-02005-0","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Missense variation affects protein cellular localization 错义变异影响蛋白质的细胞定位
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02003-2
Michael Fletcher
{"title":"Missense variation affects protein cellular localization","authors":"Michael Fletcher","doi":"10.1038/s41588-024-02003-2","DOIUrl":"10.1038/s41588-024-02003-2","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal regulation of germline genes by piRNAs piRNA 对生殖基因的时空调控
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02004-1
Petra Gross
{"title":"Spatiotemporal regulation of germline genes by piRNAs","authors":"Petra Gross","doi":"10.1038/s41588-024-02004-1","DOIUrl":"10.1038/s41588-024-02004-1","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population survey of repeat expansion mutations 重复扩展突变的人群调查
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02007-y
Kyle Vogan
{"title":"Population survey of repeat expansion mutations","authors":"Kyle Vogan","doi":"10.1038/s41588-024-02007-y","DOIUrl":"10.1038/s41588-024-02007-y","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal optical pooled screening with CRISPRmap 利用 CRISPRmap 进行多模式集合光学筛选
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02010-3
Wei Li
{"title":"Multimodal optical pooled screening with CRISPRmap","authors":"Wei Li","doi":"10.1038/s41588-024-02010-3","DOIUrl":"10.1038/s41588-024-02010-3","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving reporting standards for genetic variants 改进基因变异报告标准
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02002-3
{"title":"Improving reporting standards for genetic variants","authors":"","doi":"10.1038/s41588-024-02002-3","DOIUrl":"10.1038/s41588-024-02002-3","url":null,"abstract":"The standardized naming of gene variants in both databases and publications is crucial to ensure their discoverability and clinical application. Efforts are underway in conjunction with the Human Genome Organization (HUGO) to develop a field standard for variant reporting through the use of validation software prior to publication.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41588-024-02002-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell 3D multi-omics during human brain development 人脑发育过程中的单细胞三维多组学研究
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02008-x
Chiara Anania
{"title":"Single-cell 3D multi-omics during human brain development","authors":"Chiara Anania","doi":"10.1038/s41588-024-02008-x","DOIUrl":"10.1038/s41588-024-02008-x","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing combination immunotherapy in lung cancer 优化肺癌联合免疫疗法
IF 31.7 1区 生物学
Nature genetics Pub Date : 2024-11-08 DOI: 10.1038/s41588-024-02011-2
Safia Danovi
{"title":"Optimizing combination immunotherapy in lung cancer","authors":"Safia Danovi","doi":"10.1038/s41588-024-02011-2","DOIUrl":"10.1038/s41588-024-02011-2","url":null,"abstract":"","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":31.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The kinase ZmCPK39 regulates foliar disease resistance in maize plants 激酶 ZmCPK39 调节玉米植物的叶面抗病性
IF 30.8 1区 生物学
Nature genetics Pub Date : 2024-11-07 DOI: 10.1038/s41588-024-01970-w
{"title":"The kinase ZmCPK39 regulates foliar disease resistance in maize plants","authors":"","doi":"10.1038/s41588-024-01970-w","DOIUrl":"https://doi.org/10.1038/s41588-024-01970-w","url":null,"abstract":"The calcium-dependent protein kinase ZmCPK39 is identified as a key immune component in maize infected with foliar pathogens. Its expression is lower in resistant maize lines than in susceptible lines, leading to stabilization of the transcription factor ZmDi19, elevated expression of the anti-microbial protein ZmPR10 and enhanced resistance to multiple foliar diseases.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":30.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A history of multiple Denisovan introgression events in modern humans 现代人的多次丹尼索瓦人引入事件史
IF 30.8 1区 生物学
Nature genetics Pub Date : 2024-11-05 DOI: 10.1038/s41588-024-01960-y
Linda Ongaro, Emilia Huerta-Sanchez
{"title":"A history of multiple Denisovan introgression events in modern humans","authors":"Linda Ongaro, Emilia Huerta-Sanchez","doi":"10.1038/s41588-024-01960-y","DOIUrl":"https://doi.org/10.1038/s41588-024-01960-y","url":null,"abstract":"<p>The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record consists of only a finger bone, jawbone, teeth and skull fragments. Leveraging the surviving Denisovan segments in modern human genomes has uncovered evidence of at least three introgression events from distinct Denisovan populations into modern humans in the past. Each of them presents different levels of relatedness to the sequenced Altai Denisovan, indicating a complex relationship between these sister lineages. Here we review the evidence suggesting that several Denisovan populations, who likely had an extensive geographical range, were adapted to distinct environments and introgressed into modern humans multiple times. We further discuss how archaic variants have been affected by demographic history, negative and positive selection and close by proposing possible new lines of future research.</p>","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":null,"pages":null},"PeriodicalIF":30.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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