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Influenza Vaccination Coverage Among Nursing Home Residents and Health Care Personnel - United States, 2024-25 Influenza Season. 疗养院居民和卫生保健人员的流感疫苗接种覆盖率——美国,2024-25年流感季节
Morbidity and Mortality Weekly Report Pub Date : 2026-04-23 DOI: 10.15585/mmwr.mm7515a1
Jeneita M Bell,Kira Barbre,Lu Meng,Brynn Lape-Newman,Emily Wong,Austin Woods,Elizabeth J Kalayil,Heather Dubendris,Molly Stillions Prosper,Jonathan Edwards,Minn M Soe,David T Kuhar,Matthew J Stuckey,Megan C Lindley,Andrea Benin
{"title":"Influenza Vaccination Coverage Among Nursing Home Residents and Health Care Personnel - United States, 2024-25 Influenza Season.","authors":"Jeneita M Bell,Kira Barbre,Lu Meng,Brynn Lape-Newman,Emily Wong,Austin Woods,Elizabeth J Kalayil,Heather Dubendris,Molly Stillions Prosper,Jonathan Edwards,Minn M Soe,David T Kuhar,Matthew J Stuckey,Megan C Lindley,Andrea Benin","doi":"10.15585/mmwr.mm7515a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7515a1","url":null,"abstract":"Nursing home residents and health care personnel (HCP) are at increased risk for exposure to influenza; in addition, residents of nursing homes who acquire influenza are at increased risk for severe disease. The Advisory Committee on Immunization Practices recommends routine annual seasonal influenza vaccination for persons without contraindications, including HCP and those at increased risk for severe influenza. Nursing homes report influenza vaccination among residents and HCP to CDC's National Healthcare Safety Network. This report describes influenza vaccination coverage among nursing home residents and HCP working in nursing homes during the 2024-25 influenza season (October 1, 2024-March 31, 2025). At the end of the 2024-25 influenza season, influenza vaccination coverage was 61.3% among nursing home residents and 42.1% among HCP who work in nursing homes; coverage among HCP varied by employment type. This study is the first comprehensive, national assessment of influenza vaccination coverage among nursing home residents and HCP who work in nursing homes in the United States. Monitoring of influenza vaccination coverage in this population at high risk for influenza exposure and severe influenza disease, along with implementation of a combination of influenza vaccination, administration of influenza antiviral medications, and other recommended practices to control the spread and severity of influenza in nursing home settings, can help protect nursing home residents and HCP against severe influenza-associated outcomes.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"32 1","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notes from the Field: Contact Tracing for Monkeypox virus Clade I Cases Associated with Air Travel - United States, November 2024-January 2025. 现场记录:与航空旅行有关的猴痘病毒分支I病例的接触者追踪——美国,2024年11月至2025年1月。
Morbidity and Mortality Weekly Report Pub Date : 2026-04-23 DOI: 10.15585/mmwr.mm7515a2
Roberta Lugo Robles,Alida M Gertz,Francisco Alvarado-Ramy,Adelaide Asare,Kristen Pringle,Kara Adams,Yonette Hercules,Mayra Garcia Brown,Justice King,Linda C Pimentel,Faisal S Minhaj,Clive Brown,Sundari Mase,Shannon Gearhart
{"title":"Notes from the Field: Contact Tracing for Monkeypox virus Clade I Cases Associated with Air Travel - United States, November 2024-January 2025.","authors":"Roberta Lugo Robles,Alida M Gertz,Francisco Alvarado-Ramy,Adelaide Asare,Kristen Pringle,Kara Adams,Yonette Hercules,Mayra Garcia Brown,Justice King,Linda C Pimentel,Faisal S Minhaj,Clive Brown,Sundari Mase,Shannon Gearhart","doi":"10.15585/mmwr.mm7515a2","DOIUrl":"https://doi.org/10.15585/mmwr.mm7515a2","url":null,"abstract":"Monkeypox is a vesicular rash illness caused by Monkeypox virus (MPXV), which can be divided into clades (e.g., clade I and II), each of which includes subclades. MPXV is usually transmitted from person to person through close, sustained physical contact. Global spread of clade II MPXV began in 2022; to date, approximately 37,500 cases have been reported in the United States (provisional data), and domestic transmission is ongoing. CDC began conducting aircraft contact investigations for clade II MPXV in 2021. In February 2023, based on data showing no evidence of in-flight transmission of clade II MPXV, CDC discontinued routine aircraft contact investigations. Although outcome data were missing for approximately one third of identified aircraft contacts, a 2024 report describing data from 2021 to 2022 on clade II MPXV transmission risk during commercial air travel found no secondary cases reported among 1,538 persons who had contact with 113 infected travelers on 221 flights (1).","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"68 1","pages":"202-203"},"PeriodicalIF":0.0,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clusters of Invasive Haemophilus influenzae Type b Disease Among Adults Using Substances or Experiencing Homelessness or Housing Instability - Alaska, Oregon, and Washington, 2023─2025. 2023年─2025年阿拉斯加州、俄勒冈州和华盛顿州:使用药物或无家可归或住房不稳定的成年人中浸润性b型流感嗜血杆菌聚集性疾病
Morbidity and Mortality Weekly Report Pub Date : 2026-04-16 DOI: 10.15585/mmwr.mm7514a1
Jennifer P Collins,Heather M Scobie,Shalabh Sharma,Eric J Chow,Amy B Rubis,Tasha Martin,Nicholas R Graff,Matthew Redlinger,Saba Zewdie,Louisa Castrodale,Julia C Bennett,George A Conway,Chas DeBolt,Laurie Orell,Sarah Talia Himmelfarb,Kristen Moore,Ferric C Fang,Carolynn DeByle,Camerin A Rencken,Joe McLaughlin,Michael L Tran,Chi N Hua,Basanta Wagle,Jennifer Dolan Thomas,LeAnne M Fox,Jessica R MacNeil
{"title":"Clusters of Invasive Haemophilus influenzae Type b Disease Among Adults Using Substances or Experiencing Homelessness or Housing Instability - Alaska, Oregon, and Washington, 2023─2025.","authors":"Jennifer P Collins,Heather M Scobie,Shalabh Sharma,Eric J Chow,Amy B Rubis,Tasha Martin,Nicholas R Graff,Matthew Redlinger,Saba Zewdie,Louisa Castrodale,Julia C Bennett,George A Conway,Chas DeBolt,Laurie Orell,Sarah Talia Himmelfarb,Kristen Moore,Ferric C Fang,Carolynn DeByle,Camerin A Rencken,Joe McLaughlin,Michael L Tran,Chi N Hua,Basanta Wagle,Jennifer Dolan Thomas,LeAnne M Fox,Jessica R MacNeil","doi":"10.15585/mmwr.mm7514a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7514a1","url":null,"abstract":"","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"18 1","pages":"186-191"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notes from the Field: Tetanus in Four Children - Idaho, Minnesota, Missouri, and Wisconsin, 2024. 现场记录:四个孩子的破伤风——爱达荷州、明尼苏达州、密苏里州和威斯康星州,2024年。
Morbidity and Mortality Weekly Report Pub Date : 2026-04-16 DOI: 10.15585/mmwr.mm7514a2
Katherine L Campbell,Avnika B Amin,Jessica Goswitz,Rebecca Betz,Stacey Moyer,Jayne Griffith,Kris K Carter,Christine Hahn,Michelle M Hughes
{"title":"Notes from the Field: Tetanus in Four Children - Idaho, Minnesota, Missouri, and Wisconsin, 2024.","authors":"Katherine L Campbell,Avnika B Amin,Jessica Goswitz,Rebecca Betz,Stacey Moyer,Jayne Griffith,Kris K Carter,Christine Hahn,Michelle M Hughes","doi":"10.15585/mmwr.mm7514a2","DOIUrl":"https://doi.org/10.15585/mmwr.mm7514a2","url":null,"abstract":"","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"8 1","pages":"192-193"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergence of Extensively Drug-Resistant Shigellosis - United States, 2011-2023. 广泛耐药志贺氏菌病的出现-美国,2011-2023。
Morbidity and Mortality Weekly Report Pub Date : 2026-04-09 DOI: 10.15585/mmwr.mm7513a1
Naeemah Logan,Meseret G Birhane,Sharla L McDonald,Jemma Alarcón,Salette Amador,Madhu Anand,Laura H Bachmann,Kevin Bernard,Lindsay S Black,Angela N Chen,Laura A Cooley,Esther D Fortes,Marisa Gerard,Rachel H Jervis,Akiko C Kimura,Katherine Lamba,Julia Latash,Linlin Li,Grace Pederson,Carley Perez Kauffman,Jared L Reynolds,Richard Santiago,Ulrike Siemetzki-Kapoor,Sandra C Smole,Kaitlin A Tagg,Johanna Vostok,Hattie E Webb,Louise K Francois Watkins,
{"title":"Emergence of Extensively Drug-Resistant Shigellosis - United States, 2011-2023.","authors":"Naeemah Logan,Meseret G Birhane,Sharla L McDonald,Jemma Alarcón,Salette Amador,Madhu Anand,Laura H Bachmann,Kevin Bernard,Lindsay S Black,Angela N Chen,Laura A Cooley,Esther D Fortes,Marisa Gerard,Rachel H Jervis,Akiko C Kimura,Katherine Lamba,Julia Latash,Linlin Li,Grace Pederson,Carley Perez Kauffman,Jared L Reynolds,Richard Santiago,Ulrike Siemetzki-Kapoor,Sandra C Smole,Kaitlin A Tagg,Johanna Vostok,Hattie E Webb,Louise K Francois Watkins, ","doi":"10.15585/mmwr.mm7513a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7513a1","url":null,"abstract":"Shigellosis is a nationally notifiable diarrheal illness caused by gram-negative bacteria. Shigella infection is spread through fecal-oral transmission and sexual contact. Although most infections are self-limited, antibiotics are indicated for severe illness or to reduce transmission in settings with high risk for spread. Since 2015, a growing proportion of cases has been caused by extensively drug-resistant (XDR) Shigella species, defined as being resistant to ampicillin, azithromycin, ceftriaxone, ciprofloxacin, and trimethoprim-sulfamethoxazole. No Food and Drug Administration-approved oral antimicrobial agents are available to treat these XDR infections. To describe U.S. trends and epidemiologic characteristics of XDR shigellosis, CDC analyzed Shigella isolates submitted to PulseNet, CDC's molecular surveillance network for enteric pathogens, during January 1, 2011-October 20, 2023; antimicrobial resistance was characterized using whole-genome sequencing data and antimicrobial susceptibility testing. Among 16,788 isolates with resistance data during this period, 510 (3.0%) were XDR. The percentage of XDR isolates increased from 0% during 2011-2015 to 8.5% in 2023. Species information was available for 505 (99%) of 510 XDR isolates; among those, 333 (65.9%) were Shigella sonnei and 172 (34.1%) were Shigella flexneri. Among patients with XDR shigellosis, the median patient age was 41 years (IQR = 31-54 years) and 86.2% were men. Among patients with available travel history, 76.2% (173 of 227) reported no recent domestic travel and 82.4% (169 of 205) reported no recent international travel. Among 116 persons with available HIV status, 54 (46.6%) reported HIV co-infection. Strengthened surveillance, timely reporting, and targeted prevention strategies are needed to limit transmission of XDR Shigella strains.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"5 1","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Illness Associated with Eating Mushroom-Containing Chocolate Products - United States, January-October 2024. 与食用含蘑菇巧克力产品相关的严重疾病-美国,2024年1月至10月。
Morbidity and Mortality Weekly Report Pub Date : 2026-04-09 DOI: 10.15585/mmwr.mm7513a2
Jelonia T Rumph,Andrea Winquist,Alyssa N Troeschel,Skylar Pulver,Amy Helene Schnall,Joseph Ebersole,Michael Yeh,Brooke Burt,Sharon L Federman,Karl Klontz,Catherine Dasenbrock,Heather L Leahy,Shane Brady,Haylea Stuteville,Ketki Patel,Johnni Daniel,Arthur Chang
{"title":"Severe Illness Associated with Eating Mushroom-Containing Chocolate Products - United States, January-October 2024.","authors":"Jelonia T Rumph,Andrea Winquist,Alyssa N Troeschel,Skylar Pulver,Amy Helene Schnall,Joseph Ebersole,Michael Yeh,Brooke Burt,Sharon L Federman,Karl Klontz,Catherine Dasenbrock,Heather L Leahy,Shane Brady,Haylea Stuteville,Ketki Patel,Johnni Daniel,Arthur Chang","doi":"10.15585/mmwr.mm7513a2","DOIUrl":"https://doi.org/10.15585/mmwr.mm7513a2","url":null,"abstract":"In late spring 2024, CDC was alerted to an outbreak of poisoning potentially associated with eating Diamond Shruumz microdosing chocolate bars. Diamond Shruumz microdosing chocolate bars are edible products designed so that small doses of mushroom-derived psychoactive compounds and other psychoactive ingredients can be eaten in a presectioned serving. In response to this alert, CDC and the Food and Drug Administration coordinated a nationwide outbreak investigation to characterize the potential poisonings associated with eating Diamond Shruumz microdosing chocolate bars. A case of poisoning was defined as an illness with moderate or major clinical effects (i.e., symptoms) as defined by America's Poison Centers in a person who ate any Diamond Shruumz product or another mushroom-containing chocolate product during January-October 2024. In total, 180 cases were reported in 34 states. Among these, 73 persons were hospitalized, including 38 persons who required intensive care unit (ICU) admission, 29 who required endotracheal intubation, and two deaths. Eating Diamond Shruumz chocolate bars was associated with higher odds of hospitalization (odds ratio [OR] = 3.29; 95% CI = 1.51-7.40), ICU admission (OR = 6.30; 95% CI = 2.17-22.6), seizures (OR = 8.45; 95% CI = 3.00-27.9), and endotracheal intubation (OR = 8.04; 95% CI = 2.24-44.2), compared with eating other mushroom-containing chocolate products. Eating larger amounts of Diamond Shruumz chocolate bars was associated with an increased likelihood of hospitalization, ICU admission, and endotracheal intubation (p-value for trend tests [p-trend] = 0.023, 0.004, and <0.001, respectively). Diamond Shruumz products were recalled, and the public was advised not to eat, sell, or serve any Diamond Shruumz products and to discard any Diamond Shruumz products previously purchased. Testing of some Diamond Shruumz products identified substances present in psychoactive mushrooms, including muscimol, psilocin (a Schedule I controlled substance), kavalactones, and other substances in some, but not all, tested products. Consumers should be aware of the poisoning risk associated with eating Diamond Shruumz products and other mushroom-containing microdosing chocolate products due to variability in ingredient composition, the absence of standardized regulatory oversight for sampling and testing finished products, and the potential toxicity of compounds intended to produce psychoactive effects.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"62 1","pages":"179-184"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increase in Poison Center Reports Linked to Kratom-Containing Kava Products - National Poison Data System, United States, 2000-2025. 与含有kratom的Kava产品有关的毒物中心报告的增加-美国国家毒物数据系统,2000-2025。
Morbidity and Mortality Weekly Report Pub Date : 2026-04-02 DOI: 10.15585/mmwr.mm7512a1
Eleanor Blair Towers,Ivy L Williams,Christopher P Holstege,Rita Farah
{"title":"Increase in Poison Center Reports Linked to Kratom-Containing Kava Products - National Poison Data System, United States, 2000-2025.","authors":"Eleanor Blair Towers,Ivy L Williams,Christopher P Holstege,Rita Farah","doi":"10.15585/mmwr.mm7512a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7512a1","url":null,"abstract":"Kava (Piper methysticum), a central nervous system depressant derived from a plant in the pepper family native to the Pacific Islands, is traditionally consumed in religious, cultural, political, and social ceremonies. In the United States, kava emerged in the late 1990s and has experienced renewed growth and product diversification since the 2010s, with increasing availability of concentrated extracts and ready-to-drink beverages. These commercial products are commonly marketed as healthy alternatives to alcohol, sold near college campuses, and increasingly being combined with kratom, a psychoactive botanical with opioid-like effects, raising safety concerns. Data on kava-related use during January 2000-December 2025 that resulted in a report to the National Poison Data System (i.e., kava exposure report) were analyzed to assess trends by users' demographic characteristics, exposure type, and outcomes. Kava-related exposure reports declined sharply after a 2002 Food and Drug Administration advisory on kava-associated severe liver injury but have risen steadily since 2011, reaching 203 reported exposures in 2025. Reports primarily involved adults aged ≥20 years, but demographic characteristics have changed over time. During 2000-2001, reports primarily involved females and included more children aged ≤12 years, whereas exposure reports since 2013 have predominantly involved men; reports involving children have been rare. Since 2017, reports involving combined use of kava and kratom have increased, reaching 30% (61) of all kava reports in 2025. These increases have coincided with higher rates of serious reported clinical outcomes in recent years (32% in 2025 compared with 12% in 2000). These data indicate a resurgence of overall kava exposure reports to poison centers, as well as an increase in kratom-related kava reports, which has coincided with higher rates of serious clinical outcomes. The findings in this report suggest the need for enhanced surveillance for, clinical awareness of, and public education regarding commercial products containing kava.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"4 1","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel - United States, 2024-25 Respiratory Virus Season. 卫生保健人员的流感和COVID-19疫苗接种覆盖率-美国,2024-25呼吸道病毒季节
Morbidity and Mortality Weekly Report Pub Date : 2026-04-02 DOI: 10.15585/mmwr.mm7512a2
Mehreen Meghani,Zhuping Garacci,Hilda Razzaghi,Marie A de Perio,A Scott Laney,Jennifer L Kriss,Carla L Black
{"title":"Influenza and COVID-19 Vaccination Coverage Among Health Care Personnel - United States, 2024-25 Respiratory Virus Season.","authors":"Mehreen Meghani,Zhuping Garacci,Hilda Razzaghi,Marie A de Perio,A Scott Laney,Jennifer L Kriss,Carla L Black","doi":"10.15585/mmwr.mm7512a2","DOIUrl":"https://doi.org/10.15585/mmwr.mm7512a2","url":null,"abstract":"The Advisory Committee on Immunization Practices (ACIP) recommends that all health care personnel (HCP) receive an annual influenza vaccination to reduce the risk for influenza and influenza-related morbidity and mortality among themselves and their patients. For the 2024-25 respiratory virus season, ACIP also recommended that all HCP be vaccinated against COVID-19. During March 26-April 17, 2025, CDC conducted a nonprobability opt-in internet panel survey of 2,650 U.S. HCP to estimate influenza and COVID-19 vaccination coverage during the 2024-25 respiratory virus season. Overall, 76.3% of HCP reported having received an influenza vaccine and 40.2% reported receiving the 2024-25 COVID-19 vaccine. Influenza vaccination coverage was highest among pharmacists (94.6%), physicians (92.6%), and HCP who worked in hospital settings (88.3%). COVID-19 vaccination coverage was highest among physicians (46.7%), assistants or aides (46.7%), and HCP who worked in long-term care and home health care settings (44.5%). Both influenza and COVID-19 vaccination coverage rates were highest among HCP whose employer required or recommended the vaccines or offered them on-site. A multipronged approach, including educating HCP about benefits of vaccination and implementing workplace strategies (such as employer vaccination recommendations or offering on-site vaccination) might improve vaccination coverage and reduce influenza- and COVID-19-related morbidity among HCP.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"120 1","pages":"164-171"},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increases in Kratom-Related Reports to Poison Centers - National Poison Data System, United States, 2015-2025. 向中毒中心提交的克拉通相关报告的增加-美国国家中毒数据系统,2015-2025。
Morbidity and Mortality Weekly Report Pub Date : 2026-03-26 DOI: 10.15585/mmwr.mm7511a1
Eleanor Blair Towers,Ynhi T Thomas,Christopher P Holstege,Rita Farah
{"title":"Increases in Kratom-Related Reports to Poison Centers - National Poison Data System, United States, 2015-2025.","authors":"Eleanor Blair Towers,Ynhi T Thomas,Christopher P Holstege,Rita Farah","doi":"10.15585/mmwr.mm7511a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7511a1","url":null,"abstract":"Kratom, the leaves of a tropical evergreen tree (Mitragyna speciosa), is traditionally consumed in Southeast Asia for pain relief, mood enhancement, and to relieve symptoms of opioid withdrawal. Kratom contains psychoactive compounds that interact with opioid receptors and is widely available in various forms in the United States. Its evolution from natural leaf to high-potency alkaloid products has raised concerns about toxicity. Data on kratom-related use that resulted in a report to the National Poison Data System (NPDS) (i.e., kratom exposure report) during 2015-2025 were analyzed to assess trends by exposure report type, demographic characteristics of persons exposed, and outcomes. During the past 11 years, poison centers received a total of 14,449 kratom exposure reports; the record high 3,434 reports in 2025 represent an increase of approximately 1,200% compared with the 258 reports in 2015. Most reports involved males and young adults aged 20-39 years, but reports among adults aged 40-59 years increased most sharply, with rates nearly overlapping with those among young adults by 2025. Although single-substance exposure reports accounted for most reports (62%), multiple-substance reports occurred at higher rates (range = 467-5,442 per 1 million multiple-substance drug exposure reports versus 388-4,045 per 1 million single-substance drug exposure reports), were associated with more hospitalizations (44%-56% versus 24%-29% annually) and serious (life threatening, pronounced, prolonged, or systemic) outcomes (57%-66% versus 41%-49% annually), and accounted for the vast majority of kratom-associated deaths during the study period (184 of 233; 79%). NPDS data indicate that kratom-related reports to poison centers are increasing and expanding among demographic groups, underscoring the value of ongoing surveillance to identify high-risk patterns of kratom use and guide strategies to reduce risks from multiple-substance exposure reports.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"18 1","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Detection and Surveillance of the SARS-CoV-2 Variant BA.3.2 - Worldwide, November 2024-February 2026. SARS-CoV-2变体BA.3.2的早期发现和监测——全球范围内,2024年11月至2026年2月
Morbidity and Mortality Weekly Report Pub Date : 2026-03-19 DOI: 10.15585/mmwr.mm7510a1
Mila Shakya,Kevin C Ma,Laura J Hughes,Casey Smith,Lydia J Atherton,Alexandria B Boehm,Peter W Cook,Daniel M Cornforth,Meredith Gardner,Iryna V Goraichuk,Jennifer L Harcourt,Heather Hicks,Marc Johnson,Anna Kelleher,Heather E Reese,Susanna J Sabin,Teresa C Smith,Azaibi Tamin,Marlene K Wolfe,Benjamin J Silk,Clinton R Paden,Natalie Thornburg,Adam MacNeil
{"title":"Early Detection and Surveillance of the SARS-CoV-2 Variant BA.3.2 - Worldwide, November 2024-February 2026.","authors":"Mila Shakya,Kevin C Ma,Laura J Hughes,Casey Smith,Lydia J Atherton,Alexandria B Boehm,Peter W Cook,Daniel M Cornforth,Meredith Gardner,Iryna V Goraichuk,Jennifer L Harcourt,Heather Hicks,Marc Johnson,Anna Kelleher,Heather E Reese,Susanna J Sabin,Teresa C Smith,Azaibi Tamin,Marlene K Wolfe,Benjamin J Silk,Clinton R Paden,Natalie Thornburg,Adam MacNeil","doi":"10.15585/mmwr.mm7510a1","DOIUrl":"https://doi.org/10.15585/mmwr.mm7510a1","url":null,"abstract":"The SARS-CoV-2 variant BA.3.2 was first identified in South Africa on November 22, 2024. BA.3.2 has approximately 70-75 substitutions and deletions in the gene sequence of the spike protein relative to JN.1 and its descendant, LP.8.1, the antigens used in the 2025-26 COVID-19 vaccines. CDC is using a multimodal SARS-CoV-2 genomic surveillance approach to monitor the emergence and spread of BA.3.2 and other SARS-CoV-2 variants internationally and within the United States. The first U.S. BA.3.2 detection occurred on June 27, 2025, through CDC's Traveler-Based Genomic Surveillance program in a participant traveling to the United States from the Netherlands. The first U.S. detection of BA.3.2 in a clinical specimen collected from a patient was reported on January 5, 2026. As of February 11, 2026, BA.3.2 had been detected in voluntarily self-collected nasal swabs from four U.S. travelers, clinical samples from five patients, three airplane wastewater samples, and 132 wastewater surveillance samples from 25 states. BA.3.2 has been reported by at least 23 countries. SARS-CoV-2 continues to cause substantial morbidity and mortality worldwide. BA.3.2 mutations in the spike protein have the potential to reduce protection from a previous infection or vaccination. Continued genomic surveillance is needed to track SARS-CoV-2 evolution and determine its potential effect on public health.","PeriodicalId":18931,"journal":{"name":"Morbidity and Mortality Weekly Report","volume":"44 1","pages":"130-137"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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