发布求助
文献互助 智能选刊 最新文献

Nederlands tijdschrift voor geneeskunde最新文献

筛选
英文 中文
[Fluctuating hormones, fluctuating mood? Depression in perimenopause]. 荷尔蒙波动，情绪波动？围绝经期抑郁症[j]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-10-01
Jade M Castelijn, Marijn Schipper, Yadira Roggeveen, Birit F P Broekman
{"title":"[Fluctuating hormones, fluctuating mood? Depression in perimenopause].","authors":"Jade M Castelijn, Marijn Schipper, Yadira Roggeveen, Birit F P Broekman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Perimenopause is characterized by fluctuating and ultimately declining estrogen and progesterone levels and is associated with an increased risk of depression. Approximately 35% of women experience depressive symptoms, and up to 24% may develop a depression during the perimenopause. The etiology is multifactorial, involving both psychosocial and biological factors such as an individual vulnerability to hormonal fluctuations ('hormonal mood sensitivity'). Neurobiological mechanisms include interactions between the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, as well as modulation of GABAergic signalling by allopregnanolone. Genetic and epigenetic factors may further contribute. Diagnosis is primarily clinical; routine hormone measurements are not recommended. Management includes psychoeducation, lifestyle interventions, and consideration of menopausal hormone therapy in selected cases, alongside standard treatment for depression when indicated. Increased awareness and targeted assessment of perimenopausal mood symptoms may improve recognition and care for this population.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The floating kidney: a rare cause of abdominal pain]. 【浮肾：引起腹痛的罕见原因】。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-30
Johnatan M S Martis, Bin K Kroon
{"title":"[The floating kidney: a rare cause of abdominal pain].","authors":"Johnatan M S Martis, Bin K Kroon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 25-year-old woman presented with a mobile mass in the lower right abdomen, accompanied by pain and nausea. Ultrasound and renogram imaging revealed nephroptosis, a rare condition typically seen in young, slender women. The patient underwent a robot-assisted laparoscopic nephropexy, after which the nephroptosis resolved.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Consequences of celiac disease in an unaccompanied minor Eritrean refugee: severe intramedullary hemolytic anemia due to vitamin B12deficiency]. [一名无人陪伴的厄立特里亚未成年难民的乳糜泻后果：维生素b12缺乏导致的严重髓内溶血性贫血]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-30
Milou M Cruijsen, Hendrikus J M Pullens, Monique H Suijker, Tom Versteege, Albertine Baauw, Ruud W H Meijneke
{"title":"[Consequences of celiac disease in an unaccompanied minor Eritrean refugee: severe intramedullary hemolytic anemia due to vitamin B12deficiency].","authors":"Milou M Cruijsen, Hendrikus J M Pullens, Monique H Suijker, Tom Versteege, Albertine Baauw, Ruud W H Meijneke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Unaccompanied minor refugees (UMRs), particularly from regions like Syria, Eritrea, and Iraq, face significant healthcare challenges in the Netherlands. Their unique medical and psychosocial needs necessitate a culturally sensitive diagnostic approach and coordinated care. Chronic conditions linked to nutritional deficiencies, such as celiac disease, are of particular concern. Celiac disease is an immune-mediated disorder triggered by gluten, leading to inflammation and malabsorption in the intestines. We present a case of a 16-year-old Eritrean UMR who, after a lengthy migration, arrived with anemia, gastrointestinal issues, and nutritional deficiencies. Diagnostic tests revealed anemia, intramedullary hemolysis, and vitamin B12 deficiency, with endoscopy confirming celiac disease and chronic gastritis. Treatment included a blood transfusion, vitamin B12 supplementation, a gluten-free diet, and multidisciplinary follow-up, resulting in significant clinical improvement within weeks. This case highlights the necessity of culturally sensitive, comprehensive care for chronic conditions in UMRs.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Idiopathic normal pressure hydrocephalus: diagnosis or dilemma?] 特发性常压性脑积水：诊断还是困境？］
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-28
Rahman Fakhry, Edo Richard, Harmke A Polinder-Bos, Ruben Dammers, Martine W T van Bilsen
{"title":"[Idiopathic normal pressure hydrocephalus: diagnosis or dilemma?]","authors":"Rahman Fakhry, Edo Richard, Harmke A Polinder-Bos, Ruben Dammers, Martine W T van Bilsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Idiopathic normal pressure hydrocephalus is a condition that predominantly affects older adults and is subject to considerable controversy because symptoms and radiological features are commonly found in the general elderly population. Additionally, the diagnosis can only be definitively made after assessing the treatment response (improvement following shunt placement). Reliable tests to predict the effect of shunting are lacking.Recently, the PENS trial provided the first level I evidence for the effectiveness of shunting in idiopathic normal pressure hydrocephalus after three months. Although the study has high internal validity, the generalizability and longevity of the results is limited. It remains a challenge to select the appropriate patients for shunt treatment.In the Netherlands, there is currently significant variation in the treatment of idiopathic normal pressure hydrocephalus across hospitals. Therefore, a national guideline to standardize the multidisciplinary approach to this condition and identify knowledge gaps, could improve diagnostics and care.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"70 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Multidisciplinary Management of Bone Metastases in Clinical Practice]. [临床实践中骨转移的多学科管理]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-24
Edwin F Dierselhuis, Paulien G Westhoff, Joris J W Ploegmakers, Jacco J de Haan
{"title":"[Multidisciplinary Management of Bone Metastases in Clinical Practice].","authors":"Edwin F Dierselhuis, Paulien G Westhoff, Joris J W Ploegmakers, Jacco J de Haan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bone metastases occur in approximately two-thirds of patients with advanced cancer and are associated with pain, fractures, and neurological complications. The recently revised Dutch multidisciplinary guideline on bone metastases emphasizes early diagnosis, personalized treatment, and coordinated multidisciplinary care. We present three clinical cases highlighting key aspects of management: delayed diagnosis leading to femoral destruction and loss of mobility; a missed opportunity for prophylactic fixation in a patient with limited prognosis; and curative-intent stereotactic radiotherapy for a solitary bone metastasis. These cases illustrate the importance of timely imaging, appropriate surgical and radiotherapeutic interventions, and the use of bone-strengthening agents where indicated. Patients with bone metastases are a heterogeneous group; treatment decisions should take tumor type, extent of disease, patient condition,prognosis, and the preferences of patients into account. Implementation of the guideline requires collaboration across specialties to improve outcomes and quality of life for patients with bone metastases.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How residents develop virtues: A qualitative longitudinal study]. [居民如何培养美德：一项定性纵向研究]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-23
Pleuntje M B Verstegen, Jos J Kole, A Stef Groenewoud, Frank J A van den Hoogen
{"title":"[How residents develop virtues: A qualitative longitudinal study].","authors":"Pleuntje M B Verstegen, Jos J Kole, A Stef Groenewoud, Frank J A van den Hoogen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Medical specialists in training not only develop competencies, but also virtues (positive personal qualities). Literature generally assumes that people develop virtues and character, yet, how this process takes place during postgraduate medical education has hardly been investigated.</p><p><strong>Objective: </strong>To provide an empirically informed account of virtue development during medical specialty training.</p><p><strong>Method: </strong>A qualitative, longitudinal study of fifteen otolaryngology residents and thirteen educators. Residents were interviewed twice with in between participant observations, followed by a group member check. A virtue ethics framework was used in combination with a thematic analysis.</p><p><strong>Results: </strong>Residents appear to develop virtues in phases, moving from cardinal and intellectual virtues to professional and moral virtues. Role models, context, and culture influence this development. Also, residents' professional goals evolve over time.</p><p><strong>Conclusion: </strong>This study of residents' phase-based virtue development raises important educational questions and provides new insights. For instance, supporting discussions about formative experiences, motivations and purposes with peers and surgeons can improve residents' education.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Medical evacuations from conflict areas; practice and politics]. [从冲突地区的医疗后送；实践和政治]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-21
Cosette Molijn
{"title":"[Medical evacuations from conflict areas; practice and politics].","authors":"Cosette Molijn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The debate over whether to admit critically ill and wounded people from Gaza, as occurred in The Netherlands, raises broader questions of how medical evacuations are established. This article examines the origins, political and practical realities associated with medical evacuations ('medevacs') from conflict areas. Medevacs constitute a form of humanitarian assistance and part of the obligation to protect civilians during armed conflict, as set out in the Geneva Conventions. A brief overview of involved actors and organizations is provided, after which it discusses the challenges encountered during the preparatory and operational phases. Experiences from the former Yugoslavia, Ukraine and Gaza demonstrate that, despite the protection of healthcare under both international humanitarian and customary law, medevacs are often systematically targeted and obstructed. Finally, several objections against or risks coming with this practice are discussed, as is the political relevance of universal access to and protection of healthcare worldwide.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A new era in the treatment ofStaphylococcus aureusbacteremia: cefazolin becomes first choice]. 【治疗金黄色葡萄球菌血症的新时代：头孢唑林成为首选】。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-16
Nynke G L Jager, Marjolein P M Hensgens
{"title":"[A new era in the treatment ofStaphylococcus aureusbacteremia: cefazolin becomes first choice].","authors":"Nynke G L Jager, Marjolein P M Hensgens","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Investigate whether cefazolin is as effective as flucloxacillin in the treatment of Staphylococcus aureus bacteremia (SAB). In the Netherlands, SAB is typically treated with flucloxacillin, with cefazolin as an alternative.</p><p><strong>Design: </strong>The international adaptive platform trial SNAP compared cefazolin to (flu)cloxacillin in adults with methicillin-susceptible S. aureus (MSSA) bacteremia.</p><p><strong>Methods: </strong>Primary outcome was 90-day all-cause mortality; secondary outcomes included acute kidney injury (AKI).</p><p><strong>Results: </strong>Between February 2022 and June 2024, 1,287 patients from eight countries were enrolled. Ninety-day mortality was 15.0% with cefazolin versus 17.0% with (flu)cloxacillin (aOR 0.81; 95%CrI 0.59-1.12; probability of non-inferiority 99.2%). AKI occurred in 13.9% versus 19.6% of patients, respectively (aOR 0.67; 95%CrI 0.50-0.89; probability of superiority 99.7%).</p><p><strong>Conclusion: </strong>Cefazolin is non-inferior to flucloxacillin in the treatment of MSSA bacteremia and is associated with less AKI.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute abdomen in a neonate due to meconium peritonitis]. 胎便性腹膜炎引起的新生儿急腹症。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-16
Chantal D Tan, Aukje C Bos
{"title":"[Acute abdomen in a neonate due to meconium peritonitis].","authors":"Chantal D Tan, Aukje C Bos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fitness to drive]. [适合开车]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2026-09-15
Ragnhild J Davidse, Mahlet Beyene, Renske Leistra, Marieke Perry
{"title":"[Fitness to drive].","authors":"Ragnhild J Davidse, Mahlet Beyene, Renske Leistra, Marieke Perry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this article, we answer questions from doctors and other healthcare providers regarding the evaluation of fitness to drive. We describe who decides on medical fitness to drive and which diseases, medical conditions, and medications may affect fitness to drive. Additionally, we discuss the role of doctors and pharmacists in fitness-to-drive evaluations and how, as a healthcare provider, to deal with clients who continue to drive despite an advice to stop. Whether or not to breach confidentiality is also addressed.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"170 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书