Mucosal Immunology最新文献

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Maternal obesity associates with altered humoral immunity in blood and colostrum 产妇肥胖与血液和初乳体液免疫改变有关。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2025.01.007
Erick S. Sánchez-Salguero , Jessica Lakshmi Prieto-Chávez , Claudia Angélica García-Alonso , Anna-Maria Lampousi , Mario R. Alcorta-García , Víctor J. Lara-Diaz , Claudia N. López-Villaseñor , Marion E.G. Brunck
{"title":"Maternal obesity associates with altered humoral immunity in blood and colostrum","authors":"Erick S. Sánchez-Salguero ,&nbsp;Jessica Lakshmi Prieto-Chávez ,&nbsp;Claudia Angélica García-Alonso ,&nbsp;Anna-Maria Lampousi ,&nbsp;Mario R. Alcorta-García ,&nbsp;Víctor J. Lara-Diaz ,&nbsp;Claudia N. López-Villaseñor ,&nbsp;Marion E.G. Brunck","doi":"10.1016/j.mucimm.2025.01.007","DOIUrl":"10.1016/j.mucimm.2025.01.007","url":null,"abstract":"<div><div>Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5–25 or &gt; 30 kg/m<sup>2</sup> (21 and 16 mothers, respectively) were collected 24–48 h <em>postpartum</em>. B lymphocyte subpopulations were investigated using flow cytometry. IgG, IgA, and IgM concentrations, and antibody production from colostrum-resident B cells were quantified. Overall, naïve B lymphocytes were the most abundant subtype in peripheral blood, while CD27<sup>-</sup>IgD<sup>-</sup> double-negative B cells were the most frequent in colostrum. The colostrum from mothers with BMI &gt; 30 kg/m<sup>2</sup> contained significantly more IgG-secreting colostrum-resident B cells, more total IgG, and less total IgA. Mothers with BMI &gt; 30 kg/m<sup>2</sup> who had been vaccinated with the Pfizer BioNTech bivalent vaccine during the third trimester of pregnancy (n = 8) did not show higher IgA or IgG antibody responses against SARS-CoV-2 RBD in either tissue types compared to unvaccinated mothers, contrasting with mother of BMI between 18.5–25 kg/m<sup>2</sup> (n = 7). This is the first characterization of B lymphocyte subpopulations and antibodies in the colostrum of mothers with obesity. This work uncovers maternal obesity as a possible modifier of humoral immune components in colostrum.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 491-499"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells 通过调节肥大细胞中NGF的产生,早期生命微生物群定植计划伤害感受器敏感性。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.002
Nasser S. Abdullah , Amyaouch Bradaia , Manon Defaye , Christina Ohland , Kristofer Svendsen , Anabel Dickemann , Melissa Delanne-Cumenal , Ahmed Hassan , Mircea Iftinca , Kathy D. McCoy , Christophe Altier
{"title":"Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells","authors":"Nasser S. Abdullah ,&nbsp;Amyaouch Bradaia ,&nbsp;Manon Defaye ,&nbsp;Christina Ohland ,&nbsp;Kristofer Svendsen ,&nbsp;Anabel Dickemann ,&nbsp;Melissa Delanne-Cumenal ,&nbsp;Ahmed Hassan ,&nbsp;Mircea Iftinca ,&nbsp;Kathy D. McCoy ,&nbsp;Christophe Altier","doi":"10.1016/j.mucimm.2024.12.002","DOIUrl":"10.1016/j.mucimm.2024.12.002","url":null,"abstract":"<div><div>Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting the potential for microbiota-targeted pain interventions. During early life, both the microbiota and nociceptors are fine-tuned and respond to environmental factors, however, little is known about how they interact with each other. Using germ-free and gnotobiotic models, we demonstrate that microbiota colonization controls nociceptor sensitivity, partly by modulating mast cell production of nerve growth factor (NGF). We report that germ-free mice respond less to thermal and capsaicin-induced stimulation, which correlates with reduced trafficking of TRPV1 to the cell membrane of nociceptors. In germ-free mice, mast cells express lower levels of NGF. Hyposensitivity to thermal and capsaicin-induced stimulation, reduced TRPV1 trafficking, and decreased NGF expression are reversed when mice are colonized at birth, but not when colonization occurs after weaning. Inhibition of mast cell degranulation and NGF signaling during the first weeks of life in colonized mice leads to a hyposensitive phenotype in adulthood, demonstrating a role for mast cells and NGF signaling in linking early life colonization with nociceptor sensitivity. These findings implicate the early life microbiota in shaping mast cell NGF production and nociceptor sensitivity later in life.</div></div><div><h3>Significance Statement</h3><div>Nociceptors are specialized sensory neurons that detect and transduce painful stimuli. During the early postnatal period, nociceptors are influenced by sensory experiences and the environment. Our findings demonstrate that gut microbiota colonization is essential in setting the threshold of nociceptor responses to painful stimuli. We show that early-life bacterial colonization controls the production of nerve growth factor by mast cells, affecting our sensitivity to pain later in life. Our study highlights the potential for developing new pain treatments that target the gut microbiome.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 326-338"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly multiplexed cytokine analysis of bronchoalveolar lavage and plasma reveals age-related dynamics and correlates of inflammation in children 对支气管肺泡灌洗液和血浆进行高度多重细胞因子分析,揭示了与年龄相关的儿童炎症动态和相关因素。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.008
Shivanthan Shanthikumar , Liam Gubbels , Karen Davies , Hannah Walker , Anson Tsz Chun Wong , Eric Levi , Richard Saffery , Sarath Ranganathan , Melanie R. Neeland
{"title":"Highly multiplexed cytokine analysis of bronchoalveolar lavage and plasma reveals age-related dynamics and correlates of inflammation in children","authors":"Shivanthan Shanthikumar ,&nbsp;Liam Gubbels ,&nbsp;Karen Davies ,&nbsp;Hannah Walker ,&nbsp;Anson Tsz Chun Wong ,&nbsp;Eric Levi ,&nbsp;Richard Saffery ,&nbsp;Sarath Ranganathan ,&nbsp;Melanie R. Neeland","doi":"10.1016/j.mucimm.2024.12.008","DOIUrl":"10.1016/j.mucimm.2024.12.008","url":null,"abstract":"<div><div>Despite the central role of cytokines in mediating inflammation that underlies a range of childhood diseases, cytokine testing remains primarily limited to research settings and surrogate markers of inflammation are often used to inform clinical diagnostic and treatment decisions. There are currently no reference ranges available for cytokines in healthy children, either systemically (in blood) or at sites of disease (such as the lung). In our study, we aimed to develop an openly accessible dataset of cytokines in the airways and blood of healthy children spanning 1 to 16 years of age. We examined how cytokine concentration changes during childhood and assessed whether a core set of cytokine markers could be used to indirectly evaluate the response of a broad spectrum of inflammatory analytes. To develop our dataset, a total of 65 unique analytes were quantified in cell-free bronchoalveolar lavage (BAL) and plasma from 78 children. We showed that age profoundly impacts soluble immune analyte concentration in both sample types and identified a highly correlative core set of 10 analytes in BAL and 11 analytes in plasma capable of indirectly evaluating the response of up to 44 inflammatory mediators. This study addresses an urgent need to develop reference ranges for cytokines in healthy children to aid in diagnosis of disease, to determine eligibility for, and to monitor the effects of, cytokine-targeted monoclonal antibody therapy.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 380-389"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs 糖尿病损害肺中ifn γ依赖性抗菌防御。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.015
Facundo Fiocca Vernengo , Ivo Röwekamp , Léa Boillot , Sandra Caesar , Patrick Johann Dörner , Benjamin Tarnowski , Birgitt Gutbier , Geraldine Nouailles , Diana Fatykhova , Katharina Hellwig , Martin Witzenrath , Andreas C. Hocke , Ann-Brit Klatt , Bastian Opitz
{"title":"Diabetes impairs IFNγ-dependent antibacterial defense in the lungs","authors":"Facundo Fiocca Vernengo ,&nbsp;Ivo Röwekamp ,&nbsp;Léa Boillot ,&nbsp;Sandra Caesar ,&nbsp;Patrick Johann Dörner ,&nbsp;Benjamin Tarnowski ,&nbsp;Birgitt Gutbier ,&nbsp;Geraldine Nouailles ,&nbsp;Diana Fatykhova ,&nbsp;Katharina Hellwig ,&nbsp;Martin Witzenrath ,&nbsp;Andreas C. Hocke ,&nbsp;Ann-Brit Klatt ,&nbsp;Bastian Opitz","doi":"10.1016/j.mucimm.2024.12.015","DOIUrl":"10.1016/j.mucimm.2024.12.015","url":null,"abstract":"<div><div>Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including <em>Streptoccocus pneumoniae</em> and <em>Legionella pneumophila</em>, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal infection with <em>S. pneumoniae</em> or <em>L. pneumophila</em>, type 2 diabetic and prediabetic mice exhibited higher bacterial loads in their lungs compared to control animals. Single cell RNA sequencing, flow cytometry, and functional analyses revealed a compromised IFNγ production by natural killer cells in diabetic and prediabetic mice, which was associated with reduced IL-12 production by CD103<sup>+</sup> dendritic cells. Blocking IFNγ enhanced susceptibility of non-diabetic mice to <em>L. pneumophila</em>, while IFNγ treatment restored defense against this intracellular pathogen in diabetic animals. In contrast, IFNγ treatment did not increase resistance of diabetic mice to <em>S. pneumoniae</em>, suggesting that impaired IFNγ production is not the sole mechanism underlying the heightened susceptibility of these animals to pneumococcal infection. Thus, our findings uncover a mechanism that could help to explain how type 2 diabetes predisposes to pneumonia. We establish proof of concept for host-directed treatment strategies to reinforce compromised IFNγ-mediated antibacterial defense against atypical lung pathogens.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 431-440"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections 中性粒细胞NADPH氧化酶促进细菌根除,并通过NRF2信号调节尿路感染过程中NF-κ b介导的炎症。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.010
Israel Cotzomi-Ortega , Emily E. Rosowski , Xin Wang , Yuriko I. Sanchez-Zamora , Jeimy M. Lopez-Torres , Gamaliel Sanchez-Orellana , Rachel Han , Gabriela Vásquez-Martínez , Gabriel Mayoral Andrade , Gregory Ballash , Hanna Cortado , Birong Li , Yusuf Ali , Raul Rascon , Frank Robledo-Avila , Santiago Partida-Sanchez , Eduardo Pérez-Campos , Peter Olofsson-Sahl , Diana Zepeda-Orozco , John David Spencer , Juan de Dios Ruiz-Rosado
{"title":"Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections","authors":"Israel Cotzomi-Ortega ,&nbsp;Emily E. Rosowski ,&nbsp;Xin Wang ,&nbsp;Yuriko I. Sanchez-Zamora ,&nbsp;Jeimy M. Lopez-Torres ,&nbsp;Gamaliel Sanchez-Orellana ,&nbsp;Rachel Han ,&nbsp;Gabriela Vásquez-Martínez ,&nbsp;Gabriel Mayoral Andrade ,&nbsp;Gregory Ballash ,&nbsp;Hanna Cortado ,&nbsp;Birong Li ,&nbsp;Yusuf Ali ,&nbsp;Raul Rascon ,&nbsp;Frank Robledo-Avila ,&nbsp;Santiago Partida-Sanchez ,&nbsp;Eduardo Pérez-Campos ,&nbsp;Peter Olofsson-Sahl ,&nbsp;Diana Zepeda-Orozco ,&nbsp;John David Spencer ,&nbsp;Juan de Dios Ruiz-Rosado","doi":"10.1016/j.mucimm.2024.12.010","DOIUrl":"10.1016/j.mucimm.2024.12.010","url":null,"abstract":"<div><div>The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of NADPH oxidase 2 (NOX2)-derived ROS, as opposed to mitochondrial ROS, in facilitating neutrophil-mediated eradication of uropathogenic <em>Escherichia coli</em> (UPEC), the primary causative agent of UTI. Furthermore, NOX2-derived ROS regulate NF-κB-mediated inflammatory responses in neutrophils against UPEC by inducing the release of nuclear factor erythroid 2-related factor 2 (Nrf2) from its inhibitor, Kelch-like ECH-associated protein 1 (Keap1). Consistently, the absence of NOX2 (<em>Cybb<sup>-/-</sup></em>) in mice led to uncontrolled bacterial infection associated with increased NF-κB signaling, heightened neutrophilic inflammation, and increased bladder pathology during cystitis. These findings underscore a dual role for neutrophil NOX2 in both eradicating UPEC and mitigating neutrophil-mediated inflammation in the urinary tract, revealing a previously unrecognized effector and regulatory mechanism in the control of UTI.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 402-417"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD 吸烟对人和小鼠肠道菌群和短链脂肪酸的影响:对慢性阻塞性肺病的影响。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.006
Shiro Otake , Shotaro Chubachi , Junki Miyamoto , Yuri Haneishi , Tetsuya Arai , Hideto Iizuka , Takashi Shimada , Kaori Sakurai , Shinichi Okuzumi , Hiroki Kabata , Takanori Asakura , Jun Miyata , Junichiro Irie , Koichiro Asano , Hidetoshi Nakamura , Ikuo Kimura , Koichi Fukunaga
{"title":"Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD","authors":"Shiro Otake ,&nbsp;Shotaro Chubachi ,&nbsp;Junki Miyamoto ,&nbsp;Yuri Haneishi ,&nbsp;Tetsuya Arai ,&nbsp;Hideto Iizuka ,&nbsp;Takashi Shimada ,&nbsp;Kaori Sakurai ,&nbsp;Shinichi Okuzumi ,&nbsp;Hiroki Kabata ,&nbsp;Takanori Asakura ,&nbsp;Jun Miyata ,&nbsp;Junichiro Irie ,&nbsp;Koichiro Asano ,&nbsp;Hidetoshi Nakamura ,&nbsp;Ikuo Kimura ,&nbsp;Koichi Fukunaga","doi":"10.1016/j.mucimm.2024.12.006","DOIUrl":"10.1016/j.mucimm.2024.12.006","url":null,"abstract":"<div><div>We aimed to elucidate the dynamic changes in short-chain fatty acids (SCFA) produced by the gut microbiota following smoking exposure and their role in chronic obstructive pulmonary disease (COPD) pathogenesis. SCFA concentrations were measured in human plasma, comparing non-smokers (n = 6) and smokers (n = 12). Using a mouse COPD model induced by cigarette smoke exposure or elastase-induced emphysema, we modulated SCFA levels through dietary interventions and antibiotics to evaluate their effects on inflammation and alveolar destruction. Human smokers showed lower plasma SCFA concentrations than non-smokers, with plasma propionic acid positively correlating with forced expiratory volume in 1 s/forced vital capacity. Three-month smoking-exposed mice demonstrated altered gut microbiota and significantly reduced fecal SCFA concentrations compared to air-exposed controls. In these mice, a high-fiber diet increased fecal SCFAs and mitigated inflammation and alveolar destruction, while antibiotics decreased fecal SCFAs and exacerbated disease features. However, in the elastase-induced model, fecal SCFA concentration remained unchanged, and high-fiber diet or antibiotic interventions had no significant effect. These findings suggest that smoking exposure alters gut microbiota and SCFA production through its systemic effects. The anti-inflammatory properties of SCFAs may play a role in COPD pathogenesis, highlighting their potential as therapeutic targets.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 353-365"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus 母乳输送一种工程二聚体IgA可保护新生儿免受轮状病毒的侵害。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2025.01.002
Stephanie N. Langel , Claire E. Otero , Justin T. Steppe , Caitlin A. Williams , Tatiana Travieso , Jerry Chang , Helen Webster , Lauren E. Williamson , James E. Crowe Jr , Harry B. Greenberg , Huali Wu , Christoph P. Hornik , Katayoun Mansouri , Robert J. Edwards , Victoria Stalls , Priyamvada Acharya , Maria Blasi , Sallie R. Permar
{"title":"Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus","authors":"Stephanie N. Langel ,&nbsp;Claire E. Otero ,&nbsp;Justin T. Steppe ,&nbsp;Caitlin A. Williams ,&nbsp;Tatiana Travieso ,&nbsp;Jerry Chang ,&nbsp;Helen Webster ,&nbsp;Lauren E. Williamson ,&nbsp;James E. Crowe Jr ,&nbsp;Harry B. Greenberg ,&nbsp;Huali Wu ,&nbsp;Christoph P. Hornik ,&nbsp;Katayoun Mansouri ,&nbsp;Robert J. Edwards ,&nbsp;Victoria Stalls ,&nbsp;Priyamvada Acharya ,&nbsp;Maria Blasi ,&nbsp;Sallie R. Permar","doi":"10.1016/j.mucimm.2025.01.002","DOIUrl":"10.1016/j.mucimm.2025.01.002","url":null,"abstract":"<div><div>Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing antibodies directly into the infant intestine through breast milk could provide enhanced antimicrobial protection for neonates. Here, we developed a murine model of maternal protective transfer against human rotavirus (RV) using systemic administration of a dimeric IgA monoclonal antibody (mAb). First, we showed that systemically administered dIgA passively transferred into breast milk and the stomach of suckling pups in a dose-dependent manner. Next, we optimized the recombinant production of a potently RV-neutralizing, VP4-specific dIgA (mAb41) antibody. We then demonstrated that systemic administration of dIgA and IgG mAb41 in lactating dams conferred protection from RV-induced diarrhea in suckling pups, with dIgA resulting in lower diarrhea incidence from IgG. Systemic delivery of engineered antimicrobial dIgA mAbs should be considered as an effective strategy for sIgA delivery to the infant gastrointestinal tract via breast milk to increase protection against enteric pathogens.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 441-452"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glial-immune interactions in barrier organs 屏障器官中的神经胶质-免疫相互作用。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.012
Julia Karjalainen , Sofia Hain , Fränze Progatzky
{"title":"Glial-immune interactions in barrier organs","authors":"Julia Karjalainen ,&nbsp;Sofia Hain ,&nbsp;Fränze Progatzky","doi":"10.1016/j.mucimm.2024.12.012","DOIUrl":"10.1016/j.mucimm.2024.12.012","url":null,"abstract":"<div><div>Neuro-immune interactions within barrier organs, such as lung, gut, and skin, are crucial in regulating tissue homeostasis, inflammatory responses, and host defence. Our rapidly advancing understanding of peripheral neuroimmunology is transforming the field of barrier tissue immunology, offering a fresh perspective for developing therapies for complex chronic inflammatory disorders affecting barrier organs. However, most studies have primarily examined interactions between the peripheral nervous system and the immune system from a neuron-focused perspective, while glial cells, the nonneuronal cells of the nervous system, have received less attention. Glial cells were long considered as mere bystanders, only supporting their neuronal neighbours, but recent discoveries mainly on enteric glial cells in the intestine have implicated these cells in immune-regulation and inflammatory disease pathogenesis. In this review, we will highlight the bi-directional interactions between peripheral glial cells and the immune system and discuss the emerging immune regulatory functions of glial cells in barrier organs.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 271-278"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn’s disease patients with a severe disease course 在病程严重的克罗恩病患者亚群中,肠道归巢和肠道 TIGITnegCD38+ 记忆 T 细胞获得了 IL-12 诱导的外 Th17 致病表型。
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.11.008
Maud Heredia , Daniëlle M.H. Barendregt , Irma Tindemans , Renz C.W. Klomberg , Martine A. Aardoom , Beatriz Calado , Léa M.M. Costes , Maria E. Joosse , Daniëlle H. Hulleman-van Haaften , Bastiaan Tuk , Lisette A. van Berkel , Polychronis Kemos , Frank M. Ruemmele , Nicholas M. Croft , Johanna C. Escher , Lissy de Ridder , Janneke N. Samsom
{"title":"Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn’s disease patients with a severe disease course","authors":"Maud Heredia ,&nbsp;Daniëlle M.H. Barendregt ,&nbsp;Irma Tindemans ,&nbsp;Renz C.W. Klomberg ,&nbsp;Martine A. Aardoom ,&nbsp;Beatriz Calado ,&nbsp;Léa M.M. Costes ,&nbsp;Maria E. Joosse ,&nbsp;Daniëlle H. Hulleman-van Haaften ,&nbsp;Bastiaan Tuk ,&nbsp;Lisette A. van Berkel ,&nbsp;Polychronis Kemos ,&nbsp;Frank M. Ruemmele ,&nbsp;Nicholas M. Croft ,&nbsp;Johanna C. Escher ,&nbsp;Lissy de Ridder ,&nbsp;Janneke N. Samsom","doi":"10.1016/j.mucimm.2024.11.008","DOIUrl":"10.1016/j.mucimm.2024.11.008","url":null,"abstract":"<div><div>CD4<sup>+</sup> memory T cell (T<sub>M</sub>) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis. Defects driving loss of T<sub>M</sub> regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38<sup>+</sup>T<sub>M</sub> express co-inhibitory receptor T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). TIGIT<sup>+</sup>CD38<sup>+</sup>T<sub>M</sub> have regulatory function while TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> are enriched in IFN-γ-producing cells. We hypothesized TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> are inflammatory and drive disease in a subgroup of IBD patients. We characterized TIGIT<sup>+</sup>CD38<sup>+</sup>T<sub>M</sub> in a uniquely large cohort of pediatric IBD patients from time of diagnosis into adulthood. Circulating TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> frequencies were higher in a subgroup of therapy-naïve CD patients with high plasma IFN-γ and a more severe disease course. TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> were highly enriched in HLA-DR<sup>+</sup> and ex-Th17/Th1-like cells, high producers of IFN-γ. Cultures of healthy-adult-stimulated T<sub>M</sub> identified IL-12 as the only IBD-related inflammatory cytokine to drive the pathogenic ex-Th17-TIGIT<sup>neg</sup>CD38<sup>+</sup> phenotype. Moreover, <em>IL12RB2</em> mRNA expression was higher in TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> than TIGIT<sup>+</sup>CD38<sup>+</sup>T<sub>M</sub>, elevated in CD biopsies compared to controls, and correlated with severity of intestinal inflammation. Overall, we argue that in a subgroup of pediatric CD, increased IL-12 signaling drives reprogramming of Th17 to inflammatory Th1-like TIGIT<sup>neg</sup>CD38<sup>+</sup>T<sub>M</sub> and causes more severe disease.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 299-311"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease IL-33与病毒性下呼吸道疾病患者肺泡功能障碍相关
IF 7.9 2区 医学
Mucosal Immunology Pub Date : 2025-04-01 DOI: 10.1016/j.mucimm.2024.12.001
Ian C. Scott , Natalie van Zuydam , Jennifer A. Cann , Victor Augusti Negri , Kalliopi Tsafou , Helen Killick , Zhi Liu , Christopher McCrae , D. Gareth Rees , Elizabeth England , Molly A. Guscott , Kirsty Houslay , Dominique McCormick , Anna Freeman , Darren Schofield , Adrian Freeman , E. Suzanne Cohen , Ryan Thwaites , Zach Brohawn , Adam Platt , Tom Wilkinson
{"title":"IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease","authors":"Ian C. Scott ,&nbsp;Natalie van Zuydam ,&nbsp;Jennifer A. Cann ,&nbsp;Victor Augusti Negri ,&nbsp;Kalliopi Tsafou ,&nbsp;Helen Killick ,&nbsp;Zhi Liu ,&nbsp;Christopher McCrae ,&nbsp;D. Gareth Rees ,&nbsp;Elizabeth England ,&nbsp;Molly A. Guscott ,&nbsp;Kirsty Houslay ,&nbsp;Dominique McCormick ,&nbsp;Anna Freeman ,&nbsp;Darren Schofield ,&nbsp;Adrian Freeman ,&nbsp;E. Suzanne Cohen ,&nbsp;Ryan Thwaites ,&nbsp;Zach Brohawn ,&nbsp;Adam Platt ,&nbsp;Tom Wilkinson","doi":"10.1016/j.mucimm.2024.12.001","DOIUrl":"10.1016/j.mucimm.2024.12.001","url":null,"abstract":"<div><div>Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33<sup>red</sup>)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33<sup>ox</sup>)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical outcomes and pathological mechanisms during viral lower respiratory tract disease (LRTD). Ultra-sensitive immunoassays were developed to measure IL-33<sup>red</sup>, IL-33<sup>ox</sup> and IL-33/sST2 complexes in samples from patients hospitalised with COVID-19. Immunohistochemistry and multiomics were used to characterise lung samples. Elevated IL-33 in the airway and IL-33/sST2 complex in the circulation correlated with poor clinical outcomes (death, need for intensive care or mechanical ventilation). IL-33 was localised to airway epithelial and endothelial barriers, whereas <em>IL1RL1</em> was expressed on aerocytes, alveolar endothelial cells specialised for gaseous exchange. IL-33 increased expression of mediators of neutrophilic inflammation, immune cell infiltration, interferon signalling and coagulation in endothelial cell cultures. Endothelial IL-33 signatures were strongly related with signatures associated with viral LRTD. Increased IL-33 release following respiratory viral infections is associated with poor clinical outcomes and might contribute to alveolar dysfunction. Although this does not show a causal relationship with disease, these results provide a rationale to evaluate pathological roles for IL-33 in viral LRTD.</div></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"18 2","pages":"Pages 312-325"},"PeriodicalIF":7.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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