Naunyn-Schmiedeberg's archives of pharmacology最新文献

{"title":"Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis.","authors":"Hugo Giordano Tavares, Patrícia Ribeiro Orlando, Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz E Magalhães, Gabriela Silva, Alice Dos Santos Nunes Ferreira, Bruna Caroline Chaves Garcia, Karen Rodrigues Lima, Etel Rocha Vieira, Leonardo Barros Dobbss, Marco Fabrício Dias-Peixoto, Alan Rodrigues Teixeira Machado, Luciano José Pereira, Eric Francelino Andrade","doi":"10.1007/s00210-024-03747-8","DOIUrl":"https://doi.org/10.1007/s00210-024-03747-8","url":null,"abstract":"<p><p>The progression of periodontal disease (PD) involves the action of oxidative stress mediators. Antioxidant agents may potentially attenuate the development of this condition. Thus, we aimed to evaluate the effects of different doses of humic acid (HA), extracted from biomass vermicomposting, on redox status and parameters related to PD progression in rats. Fifty-four adult male Wistar rats were distributed into six experimental groups (control; PD; PD + 40 mg/kg of HA; PD + 80 mg/kg of HA; PD + 160 mg/kg of HA; PD + 320 mg/kg of HA). HA was administered by gavage for 28 days, and PD was induced by ligature on the mandibular first molars on the 14th day of treatment. After euthanasia, alveolar bone loss, oxidative stress in the gum and erythrocytes, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine were analyzed. Animals treated with HA showed less bone loss at the dose of 80 mg/kg compared to the untreated PD group (p < 0.05). Animals treated with HA at doses higher than 80 mg/kg showed improvements in local and systemic redox status parameters (total antioxidant activity, thiobarbituric reactive substances, carbonyl derivatives, and superoxide dismutase) compared to the PD group (p < 0.05). Treatment with HA reduced serum levels of creatinine (at doses of 80 and 160 mg/kg) and AST (at doses of 40 and 80 mg/kg) compared to the PD group (p < 0.05). HA treatment attenuated alveolar bone loss and improved local and systemic oxidative stress parameters in ligature-induced PD rats.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling.","authors":"Chunmei Qian, Xing Zhang, Yu-Shi Tian, Lin Yuan, Qiao Wei, Yifu Yang, Midie Xu, Xiaoyu Wang, Menghong Sun","doi":"10.1007/s00210-024-03765-6","DOIUrl":"https://doi.org/10.1007/s00210-024-03765-6","url":null,"abstract":"<p><p>Esophageal carcinoma is a highly prevalent malignancy worldwide. The present study aimed to investigate the mechanism by which the natural compound coptisine affects pyroptosis in esophageal squamous cell carcinoma (ESCC). The expression of c-Met in ESCC patients was assessed by immunohistochemical analysis of tissue microarrays. Natural drugs that bind to c-Met were identified by screening and molecular docking. The effect of coptisine on the proliferation of ESCC cells was detected by CCK-8 and colony formation assays. Cell cycle progression and cell apoptosis were detected by flow cytometry. The levels of mRNAs related to pyroptosis and miR-21 after coptisine treatment were assessed via real-time quantitative PCR. The effect of pyroptosis was evaluated by reactive oxygen species level detection and transmission electron microscopy (TEM) analysis. The expression of proteins related to pyroptosis and the HGF/c-Met pathway was detected by western blotting. A xenograft tumor model was established, and the inhibitory effect of coptisine was evaluated by observing tumor growth. The results showed that the highly expressed protein c-Met in esophageal cancer could bind with coptisine. Coptisine inhibited c-Met phosphorylation and proliferation in ESCC cells. Furthermore, coptisine inhibited the expression of downstream proteins of the HGF/c-Met signaling pathway and induced ROS generation. Tumor xenograft experiments demonstrated that coptisine effectively inhibited tumor growth by reducing the levels of pyroptosis-associated proteins. In conclusion, these findings indicate that inhibition of the HGF/c-Met signaling pathway suppresses pyroptosis to enhance the antitumor effect of coptisine in ESCC and support the potential use of coptisine for EC treatment.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol mitigates heat stress-induced testicular injury in rats: enhancing male fertility via antioxidant, antiapoptotic, pro-proliferative, and anti-inflammatory mechanisms.","authors":"Mona Hafez Hafez, Sara El-Sayed El-Kazaz, Mahmoud S El-Neweshy, Mustafa Shukry, Heba I Ghamry, Hossam G Tohamy","doi":"10.1007/s00210-024-03759-4","DOIUrl":"https://doi.org/10.1007/s00210-024-03759-4","url":null,"abstract":"<p><p>This study investigates the protective effects of resveratrol (RSV) against heat stress (HS)-induced testicular injury in rats. Climate change has exacerbated heat stress, particularly affecting male fertility by impairing testicular function and sexual behavior. A total of 32 rats were allocated into four experimental groups: control, RSV control, HS control, and RSV + HS. The HS groups were subjected to a 43 °C water bath for 20 min to induce testicular hyperthermia, while the RSV + HS group received 20 mg/kg of RSV starting just before HS and continuing for eight weeks. Our findings reveal that HS significantly impairs male sexual behavior, evidenced by reduced mount and intromission numbers, and increased latencies. It also negatively affects the reproductive system, decreasing the weights of testes (Cohen's d = 1.8), epididymis, and accessory sex glands, and deteriorating sperm profile parameters such as motility (Cohen's d = 2.1), viability, and morphology. Furthermore, HS notably decreases reproductive performance in female rats, reducing litter size, live births, and conception rates. Biochemically, HS decreases activities of key antioxidant enzymes in the testes-glutathione peroxidase, superoxide dismutase, and catalase-while increasing lipid peroxidation, nitrite levels, and proinflammatory cytokines (IL-1β and TNF-α). It also reduces serum levels of reproductive hormones like testosterone (Cohen's d = 2.0) and 17β-estradiol. These results were affirmed with the histopathological evaluation and the immunohistochemistry staining (Ki-67, PCNA, Bax 5, and caspase-3 protein expression). Remarkably, RSV treatment mitigated these adverse effects, restoring both physiological and biochemical parameters toward normal levels (e.g., testicular weight Cohen's d = 1.6, sperm motility Cohen's d = 1.9, and testosterone levels Cohen's d = 1.7). This suggests that RSV's antioxidative, anti-inflammatory, antiapoptotic, and androgenic properties could effectively counteract the degenerative impacts of testicular hyperthermia. This highlights the potential of RSV as a therapeutic agent against climate change-induced fertility issues in males.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis.","authors":"Miao Luo, Luorui Shang, Jiao Xie, Tao Zhou, Chengyi He, David Fisher, Khrystyna Pronyuk, Erkin Musabaev, Nguyen Thi Thu Hien, Huan Wang, Lei Zhao","doi":"10.1007/s00210-024-03758-5","DOIUrl":"https://doi.org/10.1007/s00210-024-03758-5","url":null,"abstract":"<p><p>Emodin, as a natural active ingredient, has shown great application potential in the fields of medicine, food and cosmetics due to its unique pharmacological effects, such as anti-inflammatory, antioxidant, anti-cancer, etc. In recent years, with the development of science and technology and the increase of people's demand for natural medicine, emodin research has been paid more and more attention by the global scientific research community. The bibliometric analysis of emodin and the construction of knowledge map are still blank. We searched the publications of emodin related studies in the Web of Science Core Collection (WoSCC) database from 2004 to 2024 and conducted a bibliometric analysis. Data processing was done using the R packages Bibliometrix, VOSviewer and CiteSpace. The consensus identified 4,125 emodin related articles from multiple countries, with China being the main contributor. The number of publications in this field is increasing year by year. China Medical University, the Chinese Academy of Sciences, and Nanjing University of Traditional Chinese Medicine are all prominent research institutions in this field. The Journal of ethnopharmacology published the most articles on the subject. The total number of authors of these articles has reached 14,991, among which Yi Wang is the author with the most output and Xiaoxv Dong is the author with the most cited times. \"emodin\", \"apoptosis\", and \"liver injury\" were the main research focuses. Topics such as \"pharmacology\", \"photodynamic therapy\", \"advancing drug discovery\" and \"gallbladder cancer cell\" may represent emerging areas of research in medicine. The results of this study help to identify the latest research frontiers and hot topics, and provide a valuable reference for the study of emodin family.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.","authors":"Yue Li, Hailan Li, Minhui Sun, Hong Chen, Yao Xiao, Jieman Wang, Yuanyuan Zhang, Shuhua Fang, Junping Kou","doi":"10.1007/s00210-024-03760-x","DOIUrl":"https://doi.org/10.1007/s00210-024-03760-x","url":null,"abstract":"<p><p>Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silibinin meglumine (SM) is a water-soluble derivative of silibinin that has shown significant potential in liver fibrosis. However, the potential effects and underlying mechanisms of SM on acute liver failure (ALF) are still not fully understood. This study aims to find the likely mechanism. An ALF mouse model and a cell model were established with GalN/LPS. SM was administered to mice via the tail vein or to a hepatocyte line (alpha mouse liver 12, AML12). The results showed that SM particularly lowered the mortality and improved liver pathological lesions in ALF mice. Meanwhile, SM improved the levels of GSH, SOD, TNF-α, IL-6, IL-1β, and IL-10 in the liver tissues and serum. Additionally, SM enhanced cell viability and reduced oxidative stress in vitro. In the AKT/GSK3β/Nrf2/GPX4 pathway, the subpathway of AKT/GSK3β was inhibited, and the subpathway of Nrf2/GPX4 was activated by SM both in vivo and in vitro. In addition, ferrostatin-1, a ferroptosis inhibitor, and the silencing of AKT using siRNA weakened the protective effect of SM, indicating that this process is mediated in an AKT-dependent manner. All the results suggested that SM inhibits inflammation and oxidative stress by modulating the AKT/GSK3β/Nrf2/GPX4 pathway.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of PI3K/AKT signaling and DFT modeling via selected pharmaceutical compounds attenuates carrageenan-induced inflammation and oxidative stress in rats.","authors":"Ahmed A Abd-Rabou, Marwa Kamal, Hussam Y Alharbi, Majed S Aljohani, Mohamed A El-Atawy, Mohamed S Kishta","doi":"10.1007/s00210-024-03689-1","DOIUrl":"https://doi.org/10.1007/s00210-024-03689-1","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The main goal of the current study is to estimate the in vivo anti-inflammatory/antioxidant ability of four selected pharmaceutical compounds: bisoprolol (Biso), piracetam (Pirc), clopidogrel (Clop), and cinnarizine (Cinna). Indomethacin (Indo) was used as a reference drug to perform a realistic comparison between the four compounds and the Indo in vivo through tracking PI3K/AKT signaling and computational chemistry via density functional theory (DFT) modeling to analyze the electrostatic potential across the molecule and provide insight into the regions for receptor binding of the studied compounds. To achieve the safe dose of these compounds, cytotoxicity was performed against isolated adipose tissue-derived mesenchymal stem cells (ADMSCs) using MTT assay. In vivo determination of anti-inflammatory/antioxidant biochemical and genetic parameters of the tested compounds against rats' paw carrageenan (Carg)-induced inflammation was assessed. The data showed that there was no significant different in cell viability of ADMSCs until dose 10 µg/ml, so we used this concentration for in vivo experiments. Carg high significantly increased the volume of the paw edema at 120 min and 180 min compared to the control group (p &lt; 0.01). Cinna (10 mg/kg), relatively similar to Indo, was the most anti-inflammatory compound among others, followed by Clop and Pirc, where they decreased the volume of the paw edema significantly (p &lt; 0.01) at 120 min and 180 min compared to the Carg-group. Microscopic examination confirmed the above results indicating that paw tissue of Carg-group shows edema formation and massive inflammation compared with control. In comparison to the control group, Carg high significantly increased the malondialdehyde (MDA) levels (p &lt; 0.01), whereas, at the concentration 10 mg/kg of the tested compounds, the MDA concentrations significantly reduced, especially the Clop, Cinna, and Indo-treated groups. On the contrary, total antioxidant capacity (TAC) and 5-lipoxygenase (5-LOP) concentrations were significantly decreased in Carg-group (p &lt; 0.01) compared with control. Cyclooxygenase-2 (COX-2), phosphoinositide 3-kinase (PI3k), and protein kinase B (AKT) gene expressions were high and significantly upregulated in Carg-group compared to control, while the tested compounds downregulated their expressions compared to the Carg-group. Moreover, COX-2, interleukins (IL-10/IL-6/IL-4), PI3k, and AKT protein concentrations were high and significantly increased in Carg-group compared to control, however the tested compounds were high and significantly decreased their concentrations compared to the Carg-group. DFT modeling aligned with the biochemical data and indicated that Cinna emerges as the most reactive drug with high polarizability (302.741 a.u.), a relative small FMOs energy gap (ΔE 5.002 eV), relative low molecular hardness (2.501 eV), relative high softness (0.400 eV&lt;sup&gt;-1&lt;/sup&gt;), and distinct nucleophilic/electrophilic interaction sites, ind","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer's disease in rats: relevance to its anti-inflammatory and antioxidant effects.","authors":"Seyede Nazanin Zarneshan, Elham Arkan, Amir Kiani, Seyede Zahra Hosseini, Fatemeh Abbaszadeh, Sajad Fakhri","doi":"10.1007/s00210-024-03696-2","DOIUrl":"https://doi.org/10.1007/s00210-024-03696-2","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most frequent cause of dementia. Since there are complex pathophysiological mechanisms behind AD, and there is no effective treatment strategy, it is necessary to introduce novel multi-targeting agents with fewer side effects and higher efficacy. Polydatin (PD) is a naturally occurring resveratrol glucoside employing multiple mechanisms toward neuroprotection. In the current study, the anti-AD mechanisms of a novel amphiphilic chitosan nanocarrier formulation (ACN) of PD (NPD) were studied. After preparing the amphiphilic chitosan nanoformulation (i.e., NPD), physicochemical properties were assessed, including particle size, zeta potential, drug loading, drug release, MTT, Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). For in vivo analysis, aluminum chloride (AlCl3) was injected intraperitoneally for 14 days to induce AD in male Albino Wistar rats. To examine the anti-AD mechanisms of NPD, a total of 36 rats were divided into six groups of six. Behavioral tests, including open field, Y-maze, elevated plus maze, and shuttle box were done on days 7, 8, 14, and 15. Additionally, zymography, biochemical analysis, and histological studies were done. NPD, as a newly synthesized formulation for PD, potentially improved memory and cognitive behavioral parameters and reduced the activity of inflammatory matrix metalloproteinase 9 (MMP9) and serum nitrite levels, while increasing anti-inflammatory MMP2, antioxidant catalase, and glutathione. NPD also prevented morphological changes and increased neuronal survival in the CA2, CA4, and DG regions of the rat hippocampus. In conclusion, NPD is a novel formulation against AD through anti-inflammatory, antioxidant, and neuroprotective mechanisms.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senkyunolide I prevent chondrocytes from oxidative stress through Nrf2/HO-1 signaling pathway.","authors":"Pengbin Li, Wenjuan Tang, Haiyan Wen, Siqi Zhou, Hui Cao","doi":"10.1007/s00210-024-03776-3","DOIUrl":"https://doi.org/10.1007/s00210-024-03776-3","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a degenerative musculoskeletal disease, featured by the destruction of articular cartilage. Oxidative stress, one of the drivers of the extracellular matrix degradation in cartilage, plays a vital role in OA pathogenesis. Senkyunolide I (SEI) is a natural compound with a prominent anti-oxidative stress property against multiple diseases. However, the protective effect of SEI on OA has not been explored. Here, we aimed to elucidate the effect of SEI on OA in vitro. Our results showed that SEI suppressed the expression of senescence-related markers such as P16 and P21 in IL-1β-induced chondrocytes. Besides, SEI alleviated IL-1β-induced the degradation of extracellular matrix (ECM) by suppressing the matrix proteinase like MMP13 and ATAMDS5 while promoting matrix synthesis regulated biomarkers like COL2A1 and ACAN in chondrocytes. Mechanically, the mitochondrial dysfunction and overproduction of intracellular reactive oxygen species (ROS) in chondrocytes induced by IL-1β were reversed by SEI. Additionally, the ROS inhibitor N-acetylcysteine (NAC) synergistically enhanced the biological effect of SEI in IL-1β-induced chondrocytes. Moreover, it was also found that the expression of Nrf2 and HO-1 was increased by the treatment of SEI in IL-1β-stimulated chondrocytes, while the Nrf2 inhibitor ML385 reversed the protective effect of SEI on OA chondrocytes. In conclusion, SEI could inhibit senescence, the degradation of ECM, and the production of ROS through activating Nrf2/ HO-1 signaling pathway, which provide a novel candidate for OA treatment.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anticancer efficacy of survivin si-RNA functionalized combined drug-loaded mesoporous silica nanoparticles in a lung cancer mouse model.","authors":"Fahima Dilnawaz, Sarita Jena, Sunita Nayak","doi":"10.1007/s00210-024-03751-y","DOIUrl":"https://doi.org/10.1007/s00210-024-03751-y","url":null,"abstract":"<p><p>Lung cancer continues to be the leading cause of mortality globally. Nanotechnology-mediated targeted drug delivery approach is one of the promising strategies for the treatment of lung cancer. Due to their multifactorial role, mesoporous silica nanoparticles (MSNs), have attracted a lot of attention for drug delivery. The emerging dual-drug co-delivery approach has drawn much attention due to circumventing various drug-resistant mechanisms in tumor cells. Further, functionalization of si-RNA (survivin) to the dual drugs (etoposide plus carfilzomib) or (docetaxel plus carfilzomib) loaded MSNs can be a potential tool to inhibit gene expression specifically. In the present study, we investigated the comparative therapeutic efficacy of co-delivered anticancer drugs functionalized with survivin siRNA in MSNs for lung cancer. According to our findings, this kind of combination therapy has inhibited the function of the survivin protein while promoting increased therapeutic efficacy due to synergistic pharmacological activity, and found si-RNA- (etoposide plus carfilzomib) to be a better candidate for lung cancer treatment in the future.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development.","authors":"Sajjad Eslamkhah, Elif Sibel Aslan, Cuneyd Yavas, Nermin Akcalı, Lutfiye Karcıoglu Batur, Asmaa Abuaisha, Erva Esma Yildirim, Mustafa Solak, Kenneth N White","doi":"10.1007/s00210-024-03649-9","DOIUrl":"https://doi.org/10.1007/s00210-024-03649-9","url":null,"abstract":"<p><p>Mpox, formerly known as monkeypox, is a zoonotic disease caused by the Mpox virus (MPXV), which has recently attracted global attention due to its potential for widespread outbreaks. Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particularly rodents. Historically confined to Africa, the virus has expanded beyond endemic regions, with notable outbreaks in Europe and North America in 2022, especially among men who have sex with men (MSM). The World Health Organization (WHO) has declared the current Mpox outbreak a Public Health Emergency of International Concern. This review explores the epidemiology, pathophysiology, and clinical manifestations of MPXV, along with current treatment strategies and the role of mRNA vaccines. It emphasizes the importance of understanding the changing dynamics of Mpox transmission, which are influenced by factors such as waning immunity from smallpox vaccinations and increased global interconnectedness. The potential for developing multi-epitope vaccines that can stimulate robust immune responses is highlighted, showcasing how bioinformatics can facilitate the identification of immunogenic antigens. Continued research and investment in vaccine development are crucial to address the urgent need for effective candidates that can protect at-risk populations. In summary, this review underscores the necessity for proactive public health measures and collaborative efforts among healthcare authorities, researchers, and communities to mitigate the impact of Mpox and enhance global preparedness for future outbreaks.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}