Naunyn-Schmiedeberg's archives of pharmacology最新文献

Association of stroke and mortality among patients receiving heart transplantation-a nationwide study.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-19 DOI: 10.1007/s00210-025-04026-w

Wei-Syun Hu, Cheng-Li Lin

引用次数: 0

Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-19 DOI: 10.1007/s00210-025-04000-6

Vijay Kumar, G S Sri Bharathi, Mohit Bhatia, Sankha Shubhra Chakrabarti, Upinder Kaur, Jai Krishn Mishra

{"title":"Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India.","authors":"Vijay Kumar, G S Sri Bharathi, Mohit Bhatia, Sankha Shubhra Chakrabarti, Upinder Kaur, Jai Krishn Mishra","doi":"10.1007/s00210-025-04000-6","DOIUrl":"https://doi.org/10.1007/s00210-025-04000-6","url":null,"abstract":"The study aimed to analyze therapeutic outcomes with bedaquiline-based all-oral regimens for drug-resistant tuberculosis. A prospective observational study was conducted from August 2022 to March 2024 and patients of drug-resistant tuberculosis on all-oral regimens were enrolled. Among 100 patients enrolled (83 on longer-oral and 17 on shorter-oral), 73 patients from longer-oral regimens and 15 from the shorter-oral regimen were followed up at 6 months. Sixty-two (83.8%) patients of longer-oral, and 11 (64.7%) patients of the shorter oral regimen achieved microbiologic improvement in one sample. Clinical improvement occurred in the majority. Forty-five (60.8%) patients in the longer oral and six (35.3%) patients in the shorter-oral regimen required treatment modification, and the major reason was intolerability due to peripheral neuropathy. Skin pigmentation (43.2%), anemia (35.1%), and thrombocytopenia (25.7%) were other common adverse events in longer-oral regimen recipients. Optic neuritis occurred in two patients in the longer-oral regimen. Hepatitis and thrombocytopenia were common with regimens combining bedaquiline and delamanid. Linezolid dose was reduced in 44.6% and was replaced in 17.8% of the patients. Fluoroquinolone resistance emerged in 17.6% and 11.8% of patients in the longer-oral and shorter-oral regimens respectively. Interim microbiological outcomes with all-oral regimens of drug-resistant tuberculosis were favorable. Extended monitoring is needed to assess sustained treatment effect. Adverse events such as peripheral neuropathy are a major challenge and emphasize the need for a reduced dose of linezolid or newer regimens with better safety profiles.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note to: Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-19 DOI: 10.1007/s00210-025-04049-3

Yasaman Hamidavi Mohammadpour, Mohammad Javad Khodayar, Layasadat Khorsandi, Hadi Kalantar

引用次数: 0

MED12 dysregulation: insights into cancer and therapeutic resistance.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-19 DOI: 10.1007/s00210-025-04006-0

Ritesh Bhole, Jagruti Shinkar, Sonali Labhade, Pawan Karwa, Harshad Kapare

{"title":"MED12 dysregulation: insights into cancer and therapeutic resistance.","authors":"Ritesh Bhole, Jagruti Shinkar, Sonali Labhade, Pawan Karwa, Harshad Kapare","doi":"10.1007/s00210-025-04006-0","DOIUrl":"https://doi.org/10.1007/s00210-025-04006-0","url":null,"abstract":"MED12, a critical subunit of the mediator (MED) complex, plays a central role in transcriptional regulation by bridging signal-dependent transcription factors and RNA polymerase II. Dysregulation of MED12, often through mutation, has emerged as a significant driver in various cancers, including uterine leiomyomas, breast cancer (B.C.), and prostate cancer (P.C.). These mutations disrupt normal transcriptional processes by impairing the mediator complex's ability to properly regulate gene expression, which activates oncogenic pathways such as Wnt/β-catenin and TGF-β signaling, promoting tumorigenesis and drug resistance. Specifically, mutations in the MED12 gene lead to altered interactions with the transcriptional machinery, fostering aberrant activation of oncogenic networks. MED12 alterations have also been implicated in chemoresistance, particularly to therapies targeting EGFR, ALK, and BRAF, highlighting its role as a barrier to effective treatment. This review explores the mechanisms underlying MED12 dysregulation, its impact on cancer progression, and its association with therapeutic resistance. By examining its potential as a predictive biomarker and a therapeutic target, the article underscores the importance of MED12 in advancing precision oncology. Understanding MED12-mediated mechanisms offers insights into overcoming therapeutic resistance and paves the way for innovative, personalized cancer treatments.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-19 DOI: 10.1007/s00210-025-04046-6

Shorouk A Alafifi, Sara A Wahdan, Alzahraa A Elhemiely, Doaa A Elsherbiny, Samar S Azab

引用次数: 0

A comprehensive review on diabetic cardiomyopathy (DCM): histological spectrum, diagnosis, pathogenesis, and management with conventional treatments and natural compounds. 糖尿病心肌病（DCM）综合综述：组织学谱系、诊断、发病机制以及传统疗法和天然化合物的管理。

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-18 DOI: 10.1007/s00210-025-03980-9

Ahmed R Abdullah, Mahmoud A Seliem, Emad Gamil Khidr, Ayah M Sobhy, Riham A El-Shiekh, Mohamed S Abd El Hafeez, Ahmed A El-Husseiny

{"title":"A comprehensive review on diabetic cardiomyopathy (DCM): histological spectrum, diagnosis, pathogenesis, and management with conventional treatments and natural compounds.","authors":"Ahmed R Abdullah, Mahmoud A Seliem, Emad Gamil Khidr, Ayah M Sobhy, Riham A El-Shiekh, Mohamed S Abd El Hafeez, Ahmed A El-Husseiny","doi":"10.1007/s00210-025-03980-9","DOIUrl":"https://doi.org/10.1007/s00210-025-03980-9","url":null,"abstract":"Diabetic complications are among the most pressing health issues currently. Cardiovascular problems, particularly diabetic cardiomyopathy (DCM), are responsible for almost 80% of diabetic deaths. Because of the increasing prevalence of diabetes and the increased threat of death from its consequences, researchers are searching for new pharmaceutical targets to delay or cure it. Currently, there are a few medicines available for the treatment of DCM, some of which have serious side effects. To address this issue, researchers are focusing on natural products. Thus, in this review, we discuss the prevalence, incidence, risk factors, histological spectrum, diagnosis, pathogenic pathways of DCM, genetic and epigenetic mechanisms involved in DCM, the current treatments, and the beneficial effects of natural product-based therapeutics. Natural treatments range from single doses to continuous regimens lasting weeks or months. Flavonoids are the largest class of natural compounds reported for the treatment of DCM. Natural regimens may cover the way for new treatment strategies for DCM for being multi-target agents in the treatment of DCM, with the ability to play a variety of functions via distinct signaling pathways.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating cyclophosphamide-induced hepatorenal toxicity: Linalool's role in modulating oxidative stress, inflammation, and apoptosis.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-18 DOI: 10.1007/s00210-025-04042-w

Gharam Saad Alserhani, Maged E Mohamed, Nancy Safwat Younis

{"title":"Mitigating cyclophosphamide-induced hepatorenal toxicity: Linalool's role in modulating oxidative stress, inflammation, and apoptosis.","authors":"Gharam Saad Alserhani, Maged E Mohamed, Nancy Safwat Younis","doi":"10.1007/s00210-025-04042-w","DOIUrl":"https://doi.org/10.1007/s00210-025-04042-w","url":null,"abstract":"Cyclophosphamide (CP) is associated with detrimental side effect including hepatic and renal toxicities. Linalool (LIN), acyclic monoterpene alcohol, is acquired from several plants' essential oils. Rats were disseminated into four groups. Group 1: Normal and Cyclophosphamide (CP) groups in which rats were given normal saline or CP intraperitoneally (200 mg/kg, ip on 12nd). Group 3 and 4 (LIN 50 + CP and LIN 100 + CP) groups in which rats were administered LIN (50 or 100 mg/kg) orally for 14 days and CP (200 mg/kg, ip on 12nd). Assessment of hepatic and renal function tests and histopathological examination were performed. Oxidative stress indicators, inflammatory mediators, and apoptosis markers in hepatic and renal homogenates were assessed. JAK2/STAT3/NFκB gene expression was measured. The network pharmacology study suggests JAK2 as one the targets so molecular docking of LIN against JAK2 was accomplished. LIN administration with CP resulted in a significant reduction in liver function test including ALT, AST, LDL, bilirubin, and γGTT1 and in renal function markers including BUN, creatinine, uric acid, Kim-1, NGAL, and CysC. Also, LIN increases in antioxidant ability via enhancing GST, GSH-Px, GSH-R, SOD, and catalase as well as a declining NO, MDA levels. Furthermore, LIN significantly diminished JAK2/STAT3/NFκB gene expressions with subsequent reduction in the inflammatory markers including TNF-α, MPO, ICAM-1, IL-6, and IL-1β levels and the apoptotic markers Bax and cleavage caspase-3 and 9. LIN protected the hepatic and renal tissues from ROS damage and mitigated JAK2/STAT3/NFκB with subsequent anti-inflammatory and anti-apoptotic properties.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Friedelin: A natural compound exhibited potent antibacterial, anti-inflammatory, and wound healing properties against MRSA-infected wounds.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-18 DOI: 10.1007/s00210-025-03965-8

Riham A El-Shiekh, Mai Hussin Radi, Rana Elshimy, Essam Abdel-Sattar, Ali M El-Halawany, Marwa A Ibrahim, Merhan E Ali, Eman I Hassanen

{"title":"Friedelin: A natural compound exhibited potent antibacterial, anti-inflammatory, and wound healing properties against MRSA-infected wounds.","authors":"Riham A El-Shiekh, Mai Hussin Radi, Rana Elshimy, Essam Abdel-Sattar, Ali M El-Halawany, Marwa A Ibrahim, Merhan E Ali, Eman I Hassanen","doi":"10.1007/s00210-025-03965-8","DOIUrl":"https://doi.org/10.1007/s00210-025-03965-8","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) is primarily recognized as a pathogen responsible for skin, soft tissue, and multiple organs infection. The colonization of the skin and mucous membranes by hypervirulent resistant bacteria like MRSA during hospitalization significantly contributes to life-threatening conditions. Friedelin (FRN) is a pentacyclic triterpene (C30H50O) isolated from Euphorbia grantii Oliv. The current work aims to determine the efficacy of FRN against MRSA-infected wounds in mice besides the in vitro study to evaluate its bactericidal activity. The in vitro study revealed that FRN was strongly active against MRSA which had a wide zone of MRSA growth inhibition and promising minimum inhibitory concentration (MIC). Moreover, FRN downregulated the major virulence genes seb and icaD, responsible for the production of staphylococcal enterotoxin SED and biofilm formation, respectively in contrast to the untreated group. The dressing of MRSA-infected wound with 40 ppm FRN significantly reduced the wound size and bacterial count and accelerated the process of wound healing which had a higher immune expression of both VEGF (vascular endothelial growth factor) and α-SMA (alpha smooth muscle actin) compared with other treated groups. Additionally, FRN could reduce the inflammatory response of MRSA in a dose-dependent manner by downregulating the TNF-α (tumor necrosis factor-α) and PGS-2 (prostaglandin synthase-2) gene expression levels. FRN is effective against MRSA-infected wounds via its potent bactericidal and anti-inflammatory activities that accelerate angiogenesis and wound maturation.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotechnology: traditional re-interpreting personalized medicine through targeted therapies and regenerative solutions.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-18 DOI: 10.1007/s00210-025-04038-6

Sayantani Chattopadhyay, Arunava Goswami, Moumita Sil

{"title":"Nanobiotechnology: traditional re-interpreting personalized medicine through targeted therapies and regenerative solutions.","authors":"Sayantani Chattopadhyay, Arunava Goswami, Moumita Sil","doi":"10.1007/s00210-025-04038-6","DOIUrl":"https://doi.org/10.1007/s00210-025-04038-6","url":null,"abstract":"Nanobiotechnology is transforming personalized medicine by leveraging the unique properties of nanomaterials to address key challenges in targeted drug delivery, regenerative medicine, and diagnostics. The development of nanocarriers, such as liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, has enabled precise drug delivery with enhanced bioavailability and reduced systemic toxicity. Concurrently, nanostructured scaffolds have advanced regenerative medicine by supporting stem cell differentiation, modulating cellular microenvironments, and enhancing tissue repair. These nanoscale innovations have also led to highly sensitive biosensors and imaging agents, significantly improving early disease detection and biomarker monitoring. Despite these advancements, challenges persist, including nanoparticle-induced cytotoxicity, immunogenicity, scalability issues, and regulatory hurdles requiring extensive evaluation of long-term biocompatibility and pharmacokinetics. Addressing these limitations, recent breakthroughs in AI-assisted nanotechnology and CRISPR-Cas9-mediated gene editing are driving next-generation precision medicine, integrating nanoscale therapeutics with computational approaches to enhance efficacy. Future directions focus on nanorobotics, bioengineered nanovaccines, and theranostic platforms capable of simultaneous diagnosis and treatment, paving the way for real-time, patient-specific interventions. The successful translation of nanomedicine into clinical practice will require interdisciplinary collaboration across nanoscience, bioengineering, and translational medicine to refine nanoparticle functionalization, optimize safety profiles, and ensure equitable access to nanotherapeutics. This review provides a comprehensive overview of these advancements, challenges, and emerging opportunities in nanobiotechnology-driven precision medicine.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin augments anti-tumor activity and alleviates nephrotoxicity of gemcitabine in a pancreatic cancer xenograft model targeting P62/Keap1 pathway.

IF 3.1 4区医学

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-03-18 DOI: 10.1007/s00210-025-03938-x

Samar Ibrahim, Eman H Yousef, Ahmed M El-Dessouki, Nahed A Raslan, Amany A Alzokaky

{"title":"Melatonin augments anti-tumor activity and alleviates nephrotoxicity of gemcitabine in a pancreatic cancer xenograft model targeting P62/Keap1 pathway.","authors":"Samar Ibrahim, Eman H Yousef, Ahmed M El-Dessouki, Nahed A Raslan, Amany A Alzokaky","doi":"10.1007/s00210-025-03938-x","DOIUrl":"https://doi.org/10.1007/s00210-025-03938-x","url":null,"abstract":"Although gemcitabine is a primary chemotherapy for pancreatic cancer, its effectiveness is limited by chemoresistance and nephrotoxicity, posing significant clinical challenges. Therefore, the development of novel therapeutic approaches to prevent pancreatic malignancy remains crucial. This study aimed to investigate the potential of melatonin in enhancing gemcitabine's anticancer efficacy while mitigating its nephrotoxic effects through modulation of the Keap1/p62 pathway. A pancreatic cancer xenograft model was established in rats, which received either gemcitabine (50 mg/kg, I.P.), melatonin (50 mg/kg, I.P.), or their combination three times per week for 2 weeks. Our findings demonstrate that melatonin potentiates gemcitabine's cancer-suppressing effects via modulation of the Kelch-like-ECH associated protein-1 (Keap1)/p62 pathway, resulting in reduced fibrosis, oxidative stress, and inflammatory markers. Additionally, melatonin significantly mitigated gemcitabine-induced nephrotoxicity. These results suggest that melatonin may serve as an adjuvant therapy in pancreatic cancer treatment, enhancing chemotherapy efficacy while reducing its adverse effects.","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0