Naunyn-Schmiedeberg's archives of pharmacology最新文献

{"title":"Trilobatin is associated with reduced lipid accumulation in multiple biological models: insights from transcriptomics, molecular docking, and molecular dynamics simulations.","authors":"Mingyue Xu, Litao Wang, Qi Gu, Wanmei Zhou, Guosheng Liu, Chenlu Wang, Jie Yang, Jiandong Wang, Xinlin Zhang, Haiting Tian, Yujie Fu","doi":"10.1007/s00210-026-05339-0","DOIUrl":"https://doi.org/10.1007/s00210-026-05339-0","url":null,"abstract":"<p><p>Trilobatin (TLB), a natural dihydrochalcone abundant in Lithocarpus litseifolius (Hance) Chun, was the focus of this study, which sought to explore its regulatory role in lipid accumulation and the associated potential molecular mechanisms, aiming to provide preliminary theoretical support for its subsequent development and application. In free fatty acid (FFA)-induced HepG2 cells, TLB was found to reduce intracellular TC and TG levels and mitigate lipid accumulation. In high-glucose-induced C. elegans, TLB lowered glucose, TC, and TG levels, prolonged the lifespan of C. elegans, and alleviated glucotoxicity-induced oxidative stress to some extent. In high-fat diet (HFD)-induced mice, 100 mg/kg TLB decreased body weight by 10.32%, reduced the liver index to 3.2%, ameliorated hepatic pathological damage, lowered serum TC, TG and LDL-C levels, and elevated HDL-C levels. Transcriptomic enrichment analysis suggested a potential association between the AMPK signaling pathway and the lipid-lowering effects of TLB. Molecular docking and 100-ns molecular dynamics simulations indicated that TLB has compatible binding with AMPK, ACC1, SREBP1, and FASN, suggesting potential protein-ligand interactions. RT-qPCR and Western blot analyses showed that TLB treatment was correlated with increased phosphorylation levels of AMPK and ACC1, as well as downregulated protein expression of lipogenic factors SREBP1 and FASN. Collectively, these findings imply that TLB may exert a certain regulatory effect on lipid accumulation by modulating the AMPK-ACC1 signaling pathway and the SREBP1-FASN axis, and thus has potential value as a nutritional health supplement and food-medicine dual-use product for the prevention of hyperlipidemia.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The design and synthesis of cysteine protease inhibitors containing isoxazole bearing warheads against Leishmania donovani.","authors":"Gowsia Akhter, Mirza A Beg, Sayeed Ur Rehman, Angamuthu Selvapandiyan, Kalicharan Sharma, Bharti Dhawan, Md Sarfaraz, Mohammad Sarwar Alam, Mushtaq A Tantray, Hinna Hamid","doi":"10.1007/s00210-026-05323-8","DOIUrl":"https://doi.org/10.1007/s00210-026-05323-8","url":null,"abstract":"<p><p>Cysteine proteases are critical drug targets for Trypanosomatids, crucial for the host cell invasion, survival and establishing infection. The current therapeutic regimen for leishmaniasis is inadequate, necessitating the search for safer anti-leishmanial agents. A fourteen-member library of new isoxazole derivatives was synthesised using a 1, 3-dipolar cycloaddition approach and then evaluated for antileishmanial activity. Ligands PB, PM and PE were found most effective against intramacrophage amastigotes of Leishmania donovani with EC₅₀ values of 2.42μM, 2.93 μM and 5.19μM, respectively, compared to Amphotericin-B (IC₅₀ 2.15 μM). They also inhibited the promastigote stage of the parasite with an EC₅₀ of 9.44 µM, 11.99µM and 14.81 µM, respectively. Mechanistic in silico studies against cysteine protease, followed by in vitro corroboration using Bz-Arg-AMC hydrochloride fluorogenic peptide substrate ascertained the promising potential of PM (IC₅₀ 10.34 μM) as a cysteine protease inhibitor. Compounds fared well in the toxicity screen against THP-1 human monocytic cells. Compounds PB, PM and PE emerged as potent hits, and PM with high activity and low toxicity can be further developed into a potent lead molecule (s) to fight Leishmania donovani. The design of isoxazole-based small molecule libraries presents a promising strategy for the development of safer and potent antileishmanial agents targeting cysteine proteases.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of Lupeol isolated from Ochrosia elliptica Labill. leaves in polycystic ovarian syndrome.","authors":"Essam Abdel-Sattar, Marwa A Ibrahim, Fady Sayed Youssef, Marwa S Khattab, Riham A El-Shiekh, Rehab A Ghandour, Shimaa R Emam, Heba Hozyen, Marwa Zakaria, Samar M Mouneir","doi":"10.1007/s00210-026-05390-x","DOIUrl":"https://doi.org/10.1007/s00210-026-05390-x","url":null,"abstract":"<p><p>This study evaluated the therapeutic potential of lupeol (LUP), a naturally occurring pentacyclic triterpenoid isolated from Ochrosia elliptica (Labill)., in a rat model of letrozole-induced polycystic ovary syndrome (PCOS). Thirty-five adults female Wistar rats were randomly allocated into five groups: normal control, PCOS model, clomiphene citrate-treated (1 mg/kg), and two LUP-treated groups (10 and 20 mg/kg). Following PCOS induction, treatments were administered orally for 28 consecutive days. PCOS rats exhibited significantly elevated MDA levels and reduced SOD and CAT activities, indicating severe oxidative stress. Lupeol treatment significantly attenuated lipid peroxidation and enhanced SOD activity. However, the increase in CAT activity did not reach statistical significance compared with the PCOS group. Hormonal analysis showed that both lupeol and clomiphene citrate significantly reduced the high LH and testosterone levels in the PCOS group. Lupeol demonstrated a dose-dependent response, lowering testosterone by 22% at 15 mg/kg and 27.9% at 30 mg/kg At the molecular level, quantitative real-time PCR analysis showed that PCOS was associated with upregulation of steroiFdogenic genes (Cyp17a1 and Hsp3β) and downregulation of the antioxidant regulator Nrf2 and aromatase gene Cyp19a1. These dysregulated gene expression patterns were markedly ameliorated by LUP treatment. Histopathological evaluation revealed multiple enlarged cystic follicles with diminished corpora lutea in PCOS ovaries, whereas LUP administration substantially improved folliculogenesis and luteal development. Immunohistochemical analysis further demonstrated elevated caspase-3 expression in granulosa cells of PCOS ovaries, which was significantly suppressed by LUP in a dose-dependent manner. Collectively, these findings indicate that lupeol exerts potent antioxidant, anti-apoptotic, and hormone-modulatory effects, highlighting its promise as a novel phytotherapeutic candidate for the management of polycystic ovary syndrome.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of syringic acid on the indomethacin-induced gastric ulcer model in rats: in vivo and in silico study.","authors":"Aslıhan Atasever, Fikret Çelebi, Serkan Yildirim, İsmail Bolat, Burak Çinar","doi":"10.1007/s00210-026-05351-4","DOIUrl":"https://doi.org/10.1007/s00210-026-05351-4","url":null,"abstract":"<p><p>In this study, the potential protective effects of syringic acid (SA) on gastric tissue were investigated in an indomethacin (INDO)-induced gastric ulcer model. A total of 84 male Sprague-Dawley rats were randomly divided into seven groups. In the in vivo experiments, rats were administered SA at doses of 5, 50, and 100 mg/kg and omeprazole (OMP) at a dose of 5 mg/kg intragastrically (i.g.) for 14 days, and indomethacin (100 mg/kg, i.g.) was administered on the final day. Following INDO administration, the rats were sacrificed under anesthesia, and gastric tissues were carefully excised for further analyses. The collected gastric tissues were subjected to biochemical, histopathological, and immunofluorescence analyses. In addition, in silico analyses were performed to support the INDO-induced gastric ulcer model. Using the licensed Schrödinger Maestro 2025/1 software, the binding properties of INDO to the COX-1 receptor were evaluated through molecular docking, MM-GBSA, and pharmacophore matching analyses. INDO administration was associated with oxidative stress, inflammation, apoptosis, and histopathological damage in gastric tissue. SA treatment appeared to alleviate INDO-induced gastric injury through its antioxidant, anti-inflammatory, and anti-apoptotic properties. SA treatment ameliorated histopathological alterations in ulcerated areas, particularly at doses of 50 and 100 mg/kg, whereas the 5 mg/kg dose did not show a significant protective effect. In addition, in silico analyses suggested that INDO may contribute to ulcer formation by inhibiting COX-1, thereby reducing prostaglandin production in the gastric mucosa. Overall, the findings of this study suggest that SA may reduce oxidative stress, suppress inflammatory responses, and inhibit apoptosis, thereby contributing to the protection of gastric tissue against INDO-induced injury. These results indicate that SA may have therapeutic potential for the prevention of NSAID-induced gastric injury; however, further experimental and clinical studies are needed to confirm these effects and clarify the underlying mechanisms.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethylene glycol-liposomal doxorubicin triggers ferroptosis in breast cancer through the KEAP1/NRF2 signaling pathway.","authors":"Yuanyuan Shen, Qingling Hua, Jinnan Wang, Menghao Dong, Wencheng Li","doi":"10.1007/s00210-026-05408-4","DOIUrl":"https://doi.org/10.1007/s00210-026-05408-4","url":null,"abstract":"<p><p>Ferroptosis, a regulated form of cell death characterized by iron accumulation and lipid peroxidation, has gained increasing attention as a therapeutic target in cancer. Polyethylene glycol-liposomal doxorubicin (PLD), a nanocarrier formulation with improved pharmacological properties, shows promise in breast cancer therapy, yet the molecular mechanisms underlying its effects on ferroptosis remain unclear. Breast cancer cell lines (MDA-MB-231 and MCF-7) were treated with PLD to evaluate its anti-tumor effects. Cell viability, colony formation, and migration assays were performed, while lipid ROS accumulation was assessed using BODIPY-C11, and oxidative stress markers (MDA, Fe, GSH, and SOD) were quantified. Western blotting and immunofluorescence were used to examine NRF2/xCT/GPX4 signaling, and molecular docking predicted the interactions of PLD with KEAP1 and NRF2. Functional roles were further validated through NRF2 overexpression and KEAP1-R483S mutation. PLD exerts potent anti-breast cancer effects by suppressing cell viability, colony formation, and migration in MDA-MB-231 and MCF-7 cells. Mechanistically, PLD induces ferroptosis, evidenced by increased lipid ROS, elevated MDA and Fe levels, decreased GSH content and SOD activity, and downregulation of xCT and GPX4. NRF2 overexpression attenuates these effects by restoring antioxidant defenses, reducing lipid peroxidation and iron accumulation, and partially rescuing cell proliferation and migration. Molecular docking further revealed stable interactions of PLD with KEAP1 and NRF2, with Arg483 identified as a key residue mediating KEAP1-NRF2 and PLD-KEAP1 binding, suggesting that KEAP1 modulates NRF2 stability and cellular susceptibility to ferroptosis. Collectively, these results indicate that PLD partially inhibits breast cancer growth through KEAP1/NRF2-mediated ferroptosis, highlighting a novel mechanism underlying its anti-tumor activity.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exposure to lisdexamfetamine dimesylate on hepatic parameters of pubertal rats.","authors":"João Vinícius Honório da Silva, Letícia Cavalcante Santos, Rafaela Pires Erthal, Dayane Priscila Dos Santos, Camila Rodrigues Ferraz, Camila Franciele de Souza, Luís Eduardo Duarte Gonçalves, Waldiceu Aparecido Verri, Niels Olsen Saraiva Câmara, Ernane Torres Uchôa, Glaura Scantamburlo Alves Fernandes, Fábio Goulart de Andrade","doi":"10.1007/s00210-026-05370-1","DOIUrl":"https://doi.org/10.1007/s00210-026-05370-1","url":null,"abstract":"<p><p>Lisdexamfetamine dimesylate (LDX) is a psychostimulant, that has been widely recommended in recent years for the treatment of Attention-Deficit/Hyperactivity Disorder. The present study aims to evaluate the effects of LDX administration on the hepatic morphophysiology of pubertal Wistar rats, since the liver plays a central role in systemic metabolism. Male Wistar rats were randomly distributed into two experimental groups: LDX group (LDX) - received 11.3 mg/kg/day of LDX diluted in tap water; and the Control group (C) - received tap water only. Animals were treated by gavage during puberty, from postnatal day (PND) 25 to PND 65. The results showed that administration of LDX decreased white adipose tissue weight without altering overall body weight gain. Plasma biochemical analysis demonstrated an increase in plasma total cholesterol and in the concentration of hepatic transaminases in LDX rats. In addition, LDX animals exhibited an increase in N-acetyl-β-D-glucosaminidase activity, indirectly indicating macrophage recruitment to the liver. This study shows that daily exposure to LDX during puberty causes early liver inflammation and damage due, in part, to increased hepatic transaminases and associated with indirect signs of macrophage recruitment. This finding highlights the importance of monitoring the indiscriminate use of amphetamines and alerting patients to possible liver disorders.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring peripheral immune mechanisms and potential therapeutic drugs for Alzheimer's disease.","authors":"Wenwen Zhu, Daqian Zhou, Guochun Zhang, Wenbin Dai","doi":"10.1007/s00210-026-05397-4","DOIUrl":"https://doi.org/10.1007/s00210-026-05397-4","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder characterised by cognitive decline. Peripheral immune dysregulation often precedes central immune abnormalities and may therefore provide valuable clues for the early diagnosis and stratification of AD. Current research on peripheral immunity in AD remains limited. This study provides new insights into the pathogenesis and therapeutic strategies for AD. Bioinformatics and single-cell RNA sequencing were used to analyse peripheral immune-related gene expression in AD. Key genes and immune cell populations linked to AD were identified. Quercetin (Que) was selected as a potential therapeutic agent using drug prediction methods. Molecular docking, Western blotting (WB), and qRT-PCR were further performed to preliminarily assess the regulation of these hub genes by quercetin in an H₂O₂-induced HT22 neuronal oxidative stress model. Several immune-related genes, including ACTB, TP53, HIF1A, and BCL-2, were differentially expressed in AD. Gene function analysis revealed their involvement in processes like apoptosis and viral response. Pathway enrichment analysis highlighted the significance of the p53, apoptosis, and HIF-1 signaling pathways in AD. Single-cell sequencing identified key immune cell populations, such as CD4 + memory cells and NK cells. Drug prediction and experimental results indicated that quercetin may modulate these genes in a neuronal stress context, providing preliminary experimental support for its regulatory effects on AD-related hub genes. This study identified peripheral immune-related molecular features of AD and highlighted several hub genes that may represent shared molecular nodes linking peripheral immune alterations and central neuronal stress responses. The in vitro findings provide preliminary support for the regulatory effects of quercetin on these AD-related hub genes, although further validation in peripheral immune cell and in vivo models is still required.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A novel mechanism of chlorogenic acid against type 2 diabetes‑induced diabetic retinopathy: suppressing ferroptosis via NRF2/xCT/GPX4 and STAT3 signaling.","authors":"Jie Zheng, Xilong Wang, Yiyuan Guo, Lixia Feng","doi":"10.1007/s00210-026-05252-6","DOIUrl":"https://doi.org/10.1007/s00210-026-05252-6","url":null,"abstract":"","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying therapeutic target genes for rheumatoid arthritis-associated interstitial lung disease by systematic druggable genome-wide Mendelian randomization analysis.","authors":"Lianzhi Chen, Mingxi Gu, Ziyu Chen, Gengmin Zhou, Ren Chen, Jintao Chen, Qingwen Wang","doi":"10.1007/s00210-026-05310-z","DOIUrl":"https://doi.org/10.1007/s00210-026-05310-z","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) is a progressive fibrotic condition that markedly reduces survival and increases mortality rates in patients with rheumatoid arthritis (RA). Currently, the treatment of RA-ILD remains highly challenging. This study aims to identify potential therapeutic targets for RA-ILD through a systematic druggable genome-wide Mendelian randomization (MR) analysis. We performed a genome-wide MR analysis by integrating expression quantitative trait loci (eQLT) of 6888 druggable genes and genetic summary statistics from a genome-wide association study of RA-ILD. A colocalization analysis was performed to prioritize genes strongly associated with RA-ILD. Enrichment analysis, protein-protein interaction network construction, drug prediction, and molecular docking were further conducted to provide valuable guidance for the development of targeted therapies. A total of 33 druggable genes showed significant association with RA-ILD, one of which, CISD1, was robustly validated through colocalization analysis. Notably, three key target genes-CST7, ATN1, and FCER2-were identified as potential mediators of the treatment effect of cyclophosphamide, a current clinical treatment for RA-ILD. This study employed MR and colocalization analysis to identify 33 potential drug-target genes for RA-ILD, including three genes associated with the mechanism of action of cyclophosphamide. These findings offer a promising roadmap for developing targeted therapies, potentially shifting treatment strategies from broad immunosuppression to precise molecular interventions.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: The effects of curcumin and sertraline on stress-induced changes in the stomach tissues of rats.","authors":"Marzieh Owrang, Ali Noorafshan, Ali Rafati, Saied Karbalay-Doust","doi":"10.1007/s00210-026-05420-8","DOIUrl":"https://doi.org/10.1007/s00210-026-05420-8","url":null,"abstract":"","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}