The clinical impact of chronopharmacology on current medicine.

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY

Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2025-01-10 DOI:10.1007/s00210-025-03788-7

Mert Kaşkal, Mustafa Sevim, Gökay Ülker, Caner Keleş, Berna Terzioğlu Bebitoğlu

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Abstract

One of the goals of clinical pharmacology is to optimize patient treatment by adopting new treatment strategies which will increase the efficacy of the treatment and decrease the adverse effects of the drugs. In the literature, it has shown that the effectiveness and toxicity of medications can vary significantly based on when they are administered, making timing a crucial factor in treatment plans. Chronopharmacology a relatively new branch of clinical pharmacology focuses on adjusting drug administration times to enhance patient outcomes. Chronopharmacology is largely influenced by an individual's circadian rhythm which refers to periodic changes in biological processes depending on the time of the day. The chronopharmacology influences clinical practice, and the accumulating knowledge in this field will likely lead healthcare providers to adopt new strategies for drug treatment regimens. This review aims to summarize the impact of chronopharmacology particularly on current clinical practices and highlight the latest findings related to chronophysiological mechanisms.

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时间药理学对现代医学的临床影响。

临床药理学的目标之一是通过采用新的治疗策略来优化患者的治疗，从而提高治疗效果并减少药物的不良反应。在文献中，它已经表明药物的有效性和毒性可以根据它们的使用时间有很大的不同，这使得时间成为治疗计划中的一个关键因素。时间药理学是临床药理学的一个相对较新的分支，其重点是调整给药时间以提高患者的治疗效果。时间药理学在很大程度上受到个体昼夜节律的影响，昼夜节律指的是生物过程中取决于一天中的时间的周期性变化。时间药理学影响临床实践，在这一领域积累的知识可能会导致医疗保健提供者采用新的药物治疗方案策略。本文旨在总结时间药理学的影响，特别是对当前临床实践的影响，并重点介绍与时间生理机制有关的最新发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Naunyn-Schmiedeberg's archives of pharmacology 医学-药学

CiteScore

6.20

自引率

5.60%

发文量

142

审稿时长

4-8 weeks

期刊介绍： Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.