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Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins Calythropsin和Combretastatins相关六氧合查尔酮的合成、二聚化和生物活性
Natural Product Letters Pub Date : 2002-01-01 DOI: 10.1080/10575630290010993
E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin
{"title":"Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins","authors":"E. Seguin, A. Elomri, P. Magiatis, A. Skaltsounis, L. Chao, F. Tillequin","doi":"10.1080/10575630290010993","DOIUrl":"https://doi.org/10.1080/10575630290010993","url":null,"abstract":"Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87990060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Total Synthesis of (±) Tanikolide (±)谷酸酯的全合成
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041309
J. Krauss
{"title":"Total Synthesis of (±) Tanikolide","authors":"J. Krauss","doi":"10.1080/10575630108041309","DOIUrl":"https://doi.org/10.1080/10575630108041309","url":null,"abstract":"Abstract The natural polyketide (±)-tanikolide (1) was prepared in eight steps starting from hex-5-enol, Key steps in this synthesis are a Sharpless dihydroxylation and a Grignard reaction between an alkyl halogenide and a ketone. The lactonization occurred spontaneously during the oxidation of the primary alcohol function to the carboxy group.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84459178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Minor Diterpenoids from Halimium viscosum 粘盐中微量二萜
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041308
J. G. Urones, M. Sexmero, F. A. Hernandez, A.B. Pedrero P. Basabe, D. Díez, I. Marcos
{"title":"Minor Diterpenoids from Halimium viscosum","authors":"J. G. Urones, M. Sexmero, F. A. Hernandez, A.B. Pedrero P. Basabe, D. Díez, I. Marcos","doi":"10.1080/10575630108041308","DOIUrl":"https://doi.org/10.1080/10575630108041308","url":null,"abstract":"Abstract Two new diterpenic acids with an ent-halimane skeleton have been isolated from the aerial parts of Halimium viscosum (Villarino de los Aires chemotype) and separated as methyl esters. These diterpenes were 13-oxo-14, 15-dinor-1(10), 11E-ent-halimadien-18-oic acid and 15-hydroxy-1 (10), 13Z-ent-halimadien-18-oic acid.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85327813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Chemistry of Plants from Crete: Stachyspinoside, a New Flavonoid Glycoside And iridoids from Stachys spinosa 克里特岛植物化学研究:一种新的类黄酮苷和环烯醚萜化合物
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041307
Maria Kotsos, N. Aligiannis, S. Mitaku, A. Skaltsounis, C. Charvala
{"title":"Chemistry of Plants from Crete: Stachyspinoside, a New Flavonoid Glycoside And iridoids from Stachys spinosa","authors":"Maria Kotsos, N. Aligiannis, S. Mitaku, A. Skaltsounis, C. Charvala","doi":"10.1080/10575630108041307","DOIUrl":"https://doi.org/10.1080/10575630108041307","url":null,"abstract":"Abstract The new flavonoid glycoside stachyspinoside (1), and the three iridoids, 7-O-acetyl-8-epi-loganic acid (2), ajugol (3) and harpagide (4) were isolated from Stachys spinosa. The structures of these compounds were established on the basis of mass spectrometry (ESMS and tandem MS), one-and two-dimensional nuclear magnetic resonance experiments (COSY, COSY LR, HMQC, TOCSY and HMBC) as well as simple chemical derivatization.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74589135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Isolation and Structure Determination of a New Sesquiterpene Lactone from Nauplius aquaticus 一种新型倍半萜内酯的分离及结构分析
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041312
Atef Chaari, H. Jannet, Z. Mighri, C. Robinot, N. Kunesch
{"title":"Isolation and Structure Determination of a New Sesquiterpene Lactone from Nauplius aquaticus","authors":"Atef Chaari, H. Jannet, Z. Mighri, C. Robinot, N. Kunesch","doi":"10.1080/10575630108041312","DOIUrl":"https://doi.org/10.1080/10575630108041312","url":null,"abstract":"Abstract The aerial part of Nauplius aquaticus afforded a new sesquiterpene lactone with a humulanolide skeleton, 6,7,9,10-tetrahydroasteriscunolide (1), in addition to the known asteriscunolides A (2) and D (3). Their structures were established principally by two-dimensional NMR spectroscopy.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74695861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
One Step Conversion of Toxic β-asarone from Acorus calamus into 1-(2,4,5-Trimethoxyphenyl)-1,2-dihydroxypropane and Asaronaldehyde Occurring in Piper clusii* 菖蒲中毒性β-细辛酮一步转化为1-(2,4,5-三甲氧基苯基)-1,2-二羟基丙烷和细辛醛的研究*
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041315
A. K. Sinha, B. P. Joshi, R. Dogra
{"title":"One Step Conversion of Toxic β-asarone from Acorus calamus into 1-(2,4,5-Trimethoxyphenyl)-1,2-dihydroxypropane and Asaronaldehyde Occurring in Piper clusii*","authors":"A. K. Sinha, B. P. Joshi, R. Dogra","doi":"10.1080/10575630108041315","DOIUrl":"https://doi.org/10.1080/10575630108041315","url":null,"abstract":"Abstract 1-(2,4,5-Trimethoxyphenyl)-1,2-dihydroxypropane (2), a natural phenylpropanoid occurring in Piper clusii, has been synthesized for the first time from toxic β-asarone (1) of Acorus calamus with osmium tetroxide, while 1 with osmium tetroxide (catalytic amount) in presence of sodium metaperiodate furnished the asaronaldehyde (3) in high yield.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77104316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
BI- and Tricyclic Diterpenoids from Halimium viscosum 粘盐中的二萜和三环二萜
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041310
J. Rodilla, D. Mendonça, M. I. Ismael, J. A. Figueiredo, Maria Lücia A. Silva, E. Lopes
{"title":"BI- and Tricyclic Diterpenoids from Halimium viscosum","authors":"J. Rodilla, D. Mendonça, M. I. Ismael, J. A. Figueiredo, Maria Lücia A. Silva, E. Lopes","doi":"10.1080/10575630108041310","DOIUrl":"https://doi.org/10.1080/10575630108041310","url":null,"abstract":"Abstract The study of the acid and neutral parts of the n-hexane extract of Halimium viscosum (S. João da Pesqueira, Portugal) has led to the isolation of various known diterpenoids with the ent-halimane skeleton. Five new compounds have now been isolated, one with the ent-halimane skeleton, and four with the valparane skeleton, two of them with the valparane skeleton degraded. The structures of these compounds, determined by spectroscopic methods using 2D experiments (1H-13C, HMQC and HMBC), were dimethyl 1(10)-halimen-15,18-dioate, dimethyl 3,19-dinor-15-valparen-2,4-dioate, methyl 16-nor-2,3-secovalpara-3,15-dioxo-2-oate, 1,3,5,15-valparatetraene and 3R-4α-methoxy-15-valparen-2-one.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82047608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Two New Labdane Diterpene Glycosides from Flowers of Baccharis medullosa dc 两种新的双萜苷类化合物
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041313
D. Cifuente, C. Tonn, O. Giordano
{"title":"Two New Labdane Diterpene Glycosides from Flowers of Baccharis medullosa dc","authors":"D. Cifuente, C. Tonn, O. Giordano","doi":"10.1080/10575630108041313","DOIUrl":"https://doi.org/10.1080/10575630108041313","url":null,"abstract":"Abstract From the flowers of Baccharis medullosa DC (Asteraceae) two new ent-labdane-type diterpene glycosides were isolated. Structures were established by application of various spectroscopic techniques. The sugar residues were identified after acid hydrolysis of the isolated products.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83514585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a New Family of Glycosidase Inhibitors of gem-diamine 1-n-iminosugars 宝石二胺1-n-亚氨基糖糖苷酶抑制剂新家族n-烷基-3-脱羧-3-羟甲基西司他汀B
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041306
Kentaro Kondo, H. Adachi, Y. Nishimura, T. Takeuchi
{"title":"N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a New Family of Glycosidase Inhibitors of gem-diamine 1-n-iminosugars","authors":"Kentaro Kondo, H. Adachi, Y. Nishimura, T. Takeuchi","doi":"10.1080/10575630108041306","DOIUrl":"https://doi.org/10.1080/10575630108041306","url":null,"abstract":"Abstract N-Alkyl-3-decarboxy-3-hydroxymethylsiastatin B, N-alkyl analogues of gem-diamine 1-N-iminosugars, is a new family of glycosidase inhibitors that have been synthesized from siastatin B isolated from Streptomyces culture. These compounds were evaluated as glycosidase inhibitors.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85875795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page for “Natural Product Letters”, Volume 15, Number 6 “天然产品通讯”编辑委员会页面，第15卷，第6期
Natural Product Letters Pub Date : 2001-12-01 DOI: 10.1080/10575630108041305
{"title":"Editorial board page for “Natural Product Letters”, Volume 15, Number 6","authors":"","doi":"10.1080/10575630108041305","DOIUrl":"https://doi.org/10.1080/10575630108041305","url":null,"abstract":"Abstract This is a scanned image of the original Editorial Board page(s) for this issue.","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72555323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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