N-alkyl-3-decarboxy-3-hydroxymethylsiastatin B, a New Family of Glycosidase Inhibitors of gem-diamine 1-n-iminosugars

Abstract

Abstract N-Alkyl-3-decarboxy-3-hydroxymethylsiastatin B, N-alkyl analogues of gem-diamine 1-N-iminosugars, is a new family of glycosidase inhibitors that have been synthesized from siastatin B isolated from Streptomyces culture. These compounds were evaluated as glycosidase inhibitors.