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Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I. 来自密天牛的奎诺维奇酸苷——蛇毒磷酸二酯酶I天然抑制剂的第一个例子。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033169
Naheed Fatima, Leon Azefack Tapondjou, David Lontsi, B L Sondengam, Atta-Ur-Rahman, M Iqbal Choudhary
{"title":"Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.","authors":"Naheed Fatima,&nbsp;Leon Azefack Tapondjou,&nbsp;David Lontsi,&nbsp;B L Sondengam,&nbsp;Atta-Ur-Rahman,&nbsp;M Iqbal Choudhary","doi":"10.1080/10575630290033169","DOIUrl":"https://doi.org/10.1080/10575630290033169","url":null,"abstract":"<p><p>Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ([structure: see text]) and its glycoside derivatives [structure: see text] and [structure: see text]. The other constituents isolated include alpha-amyrin, 3beta-acetyl ursolic acid and a mixture of oleanolic and ursolic acid and beta-sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds [structure: see text] and [structure: see text] were, respectively, identified as quinovic acid 3-O-[beta-D-glucopyranoside] (quinovin glycoside C) and quinovic acid 3-O-[beta-D-quinovopyranoside]-27-O-[beta-D-glucopyranosyl] ester. Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"389-93"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Determination of colchicine content in Colchicum hierosolymitanum and Colchicum tunicatum under cultivation. 栽培秋水仙和秋水仙中秋水仙碱含量的测定。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033178
M Al-Fayyad, F Alali, Ahmad Alkofahi, Abdelmajeed Tell
{"title":"Determination of colchicine content in Colchicum hierosolymitanum and Colchicum tunicatum under cultivation.","authors":"M Al-Fayyad,&nbsp;F Alali,&nbsp;Ahmad Alkofahi,&nbsp;Abdelmajeed Tell","doi":"10.1080/10575630290033178","DOIUrl":"https://doi.org/10.1080/10575630290033178","url":null,"abstract":"<p><p>Corms of Colchicum hierosolymitanum and Colchicum tunicatum were collected, identified and planted under field condition. We report here and for the first time the presence of colchicine in an appreciable amount in both species. The effect of different NPK fertilizer levels on colchicine content of the two Colchicum species at different growth stages were evaluated by HPLC. Results indicated that increasing NPK fertilizer levels significantly improve colchicine content in different plant parts and stages. The highest colchicine content observed in corms was at maturity stage 0.766 mg/g and 0.688 mg/g dry weight with C. hierosolimitanum and C. tunicatum, respectively.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"395-400"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola. 蚜虫头孢菌对(+)-androsta- 1,4 -二烯-3,17-二酮的微生物转化
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033132
M Iqbal Choudhary, S Ghulam Musharraf, Farzana Shaheen, Atta-Ur-Rahman
{"title":"Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola.","authors":"M Iqbal Choudhary,&nbsp;S Ghulam Musharraf,&nbsp;Farzana Shaheen,&nbsp;Atta-Ur-Rahman","doi":"10.1080/10575630290033132","DOIUrl":"https://doi.org/10.1080/10575630290033132","url":null,"abstract":"<p><p>Fermentation of (+)-androsta-1,4-diene-3,17-dione ([structure: see text]) with Cephalosporium aphidicola for 8 days yielded oxidative and reductive metabolites, androst-4-ene-3,17-dione ([structure: see text]), 17beta-hydroxyandrosta-1,4-diene-3-one ([structure: see text]), 11alpha-hydroxyandrosta-1,4-diene-3,17-dione ([structure: see text]), 11alpha-hydroxyandrost-4-ene-3,17-dione ([structure: see text]), 11alpha,17beta-dihydroxyandrost-4-ene-3-one ([structure: see text]) and 11alpha,17beta-dihydroxyandrosta-1,4-diene-3-one ([structure: see text]). The fermentation of [structure: see text] with Fusarium lini also yielded metabolites [structure: see text]. The structures of these metabolites were elucidated on the basis of spectroscopic techniques.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"377-82"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Highly oxygenated triterpenes from the roots of Atropa acuminata. 高氧的三萜从阿托普根。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033097
Arshad Mehmood, Abdul Malik, Itrat Anis, Pir Mohammad Khan, Muhammad Riaz, Talat Makhmoor, M Iqbal Choudhary
{"title":"Highly oxygenated triterpenes from the roots of Atropa acuminata.","authors":"Arshad Mehmood,&nbsp;Abdul Malik,&nbsp;Itrat Anis,&nbsp;Pir Mohammad Khan,&nbsp;Muhammad Riaz,&nbsp;Talat Makhmoor,&nbsp;M Iqbal Choudhary","doi":"10.1080/10575630290033097","DOIUrl":"https://doi.org/10.1080/10575630290033097","url":null,"abstract":"<p><p>Two new oleanane triterpenes; 2alpha,3alpha,24-trihydroxyolean-12-ene-28,30-dioic acid ([structure: see text]) and 2alpha,3alpha,24,28-tetrahydroxyolean-12-ene ([structure: see text]) have been isolated from the roots of Atropa acuminata. Anti-oxidant p-hydroxyphenethyl trans-ferulate ([structure: see text]), beta-sitosterol-3-O-beta-D-glucopyranoside ([structure: see text]) and oleanolic acid ([structure: see text]) have also been reported for the first time from this species. The structures were determined by spectroscopic studies including 2D-NMR.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"371-6"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Alysinol--a new triterpene from Alysicarpus monolifer. Alysinol--来自 Alysicarpus monolifer 的一种新三萜。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290034258
Naheed Riaz, Itrat Anis, Pir Muhammad Khan, Raza Shah, Abdul Malik
{"title":"Alysinol--a new triterpene from Alysicarpus monolifer.","authors":"Naheed Riaz, Itrat Anis, Pir Muhammad Khan, Raza Shah, Abdul Malik","doi":"10.1080/10575630290034258","DOIUrl":"10.1080/10575630290034258","url":null,"abstract":"<p><p>A new triterpene named as alysinol 3alpha, 22beta-dihydroxyolean-12-ene [structure: see text] along with known compounds usnic acid, methyl 2,4-dihydroxy-3,6-dimethyl benzoate, 3-hydroxy benzoic acid, stigmasterol, poriferasterol and ursolic acid have been isolated from Alysicarpus monolifer. The structure of [structure: see text] has been established through spectroscopic techniques.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"415-8"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290034258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Triterpenes and saponins from Ilex psammophila. 沙冬青中的三萜和皂苷。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033187
V S Pires, G Gosmann, D Guillaume, E P Schenkel
{"title":"Triterpenes and saponins from Ilex psammophila.","authors":"V S Pires, G Gosmann, D Guillaume, E P Schenkel","doi":"10.1080/10575630290033187","DOIUrl":"10.1080/10575630290033187","url":null,"abstract":"<p><p>Two new saponins were isolated from the leaves of Ilex psammophila. Their structure was established by chemical and spectroscopic methods as 28-O-beta-D-glucopyranosylester of 20(S)-ilexgenin A ([structure: see text]) and 28-O-beta-D-glucopyranosylester of 20(S)-3beta,19alpha,24-trihydroxyurs-12-ene-23, 28-dioic acid ([structure: see text]).</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"401-6"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Antimycobacterial activity of lipodepsipeptides produced by Pseudomonas syringae pv syringae B359. 丁香假单胞菌pv丁香B359脂沉肽的抑菌活性。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290034294
E Buber, A Stindl, N L Acan, T Kocagoz, R Zocher
{"title":"Antimycobacterial activity of lipodepsipeptides produced by Pseudomonas syringae pv syringae B359.","authors":"E Buber,&nbsp;A Stindl,&nbsp;N L Acan,&nbsp;T Kocagoz,&nbsp;R Zocher","doi":"10.1080/10575630290034294","DOIUrl":"https://doi.org/10.1080/10575630290034294","url":null,"abstract":"<p><p>Some lipodepsipeptides produced by Pseudomonas syringae pv. syringae showed strong antimycobacterial activity towards Mycobacterium smegmatis. MIC values found were between 1.5-3.2 microg/ml, which is comparable to some primary drugs for tuberculosis. Among the lipodepsipeptides, Syringomycin E (SRE) appears to be the most potent antimycobacterial agent.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"419-23"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290034294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Separation and identification of Taxifolin 3-O-glucoside isomers from Chamaecyparis obtusa (Cupressaceae). 柏科柏树中杉素3- o -糖苷异构体的分离与鉴定。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290033141
Akiyo Sakushima, Kosei Ohno, Makusut Coskun, Koh-Ichi Seki, Kazue Ohkura
{"title":"Separation and identification of Taxifolin 3-O-glucoside isomers from Chamaecyparis obtusa (Cupressaceae).","authors":"Akiyo Sakushima,&nbsp;Kosei Ohno,&nbsp;Makusut Coskun,&nbsp;Koh-Ichi Seki,&nbsp;Kazue Ohkura","doi":"10.1080/10575630290033141","DOIUrl":"https://doi.org/10.1080/10575630290033141","url":null,"abstract":"<p><p>Taxifolin 3-O-glucoside isomers, [(2R, 3R)-, (2R, 3S)-, (2S, 3R)- and (2S, 3S)-] were isolated from leaves of Chamaecyparis obtuse (Cupressaceae). Their structures were elucidated on the basis of UV, MS, CD, 1H- and 13C-NMR spectral data, including 2D shift correlation. It was found that the compounds could be distinguished by the use of 1H- and 13C-NMR spectral data.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"383-7"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Steroid and antibacterial steroidal glycosides from marine green alga Codium iyengarii Borgesen. 海洋绿藻中甾体和抗菌甾体苷。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290034249
Muhammad Shaiq Ali, Muhammad Saleem, Raghav Yamdagni, Muhammad Ashfaq Ali
{"title":"Steroid and antibacterial steroidal glycosides from marine green alga Codium iyengarii Borgesen.","authors":"Muhammad Shaiq Ali,&nbsp;Muhammad Saleem,&nbsp;Raghav Yamdagni,&nbsp;Muhammad Ashfaq Ali","doi":"10.1080/10575630290034249","DOIUrl":"https://doi.org/10.1080/10575630290034249","url":null,"abstract":"<p><p>The ethyl acetate soluble part of methanolic extract of marine green alga Codium iyengarii collected from Karachi coast of Arabian Sea afforded a new steroid ([structure: see text], iyengadione) and two new steroidal glycosides [iyengaroside-A ([structure: see text]) and B ([structure: see text])] along with clerosterol galactoside ([structure: see text]). Their structures were elucidated with the aid of 1D-NMR spectroscopy and reconfirmed through HMBC experiments. The bactericidal activity of [structure: see text] was also explored and found positive response from iyengaroside-A ([structure: see text]) and clerosterol galactoside ([structure: see text]).</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"407-13"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290034249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
A new lignan glycoside and other constituents from Cephalaria ambrosioides. 一种新的木脂素苷类化合物及其它成分。
Natural Product Letters Pub Date : 2002-12-01 DOI: 10.1080/10575630290030720
Sofia Pasi, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Ioanna B Chinou
{"title":"A new lignan glycoside and other constituents from Cephalaria ambrosioides.","authors":"Sofia Pasi,&nbsp;Nektarios Aligiannis,&nbsp;Alexios-Leandros Skaltsounis,&nbsp;Ioanna B Chinou","doi":"10.1080/10575630290030720","DOIUrl":"https://doi.org/10.1080/10575630290030720","url":null,"abstract":"<p><p>A new lignan glycoside, 1,5-dihydroxy-2-(4\"-beta-D-glucopyranosyloxy-3\"-methoxyphenyl)-6-(4'-hydroxy-3'-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, named ambrosidine ([structure: see text]), along with seven known compounds (four iridoids and three hydroxycinnamic esters) were isolated from the roots of Cephalaria ambrosioides. The structures of these compounds were determined by use of NMR and MS techniques and by chemical transformations. The cytotoxic activity of the novel compound [structure: see text] was evaluated against five human solid tumour cell lines.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"365-70"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290030720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22139078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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