Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.

Naheed Fatima, Leon Azefack Tapondjou, David Lontsi, B L Sondengam, Atta-Ur-Rahman, M Iqbal Choudhary
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引用次数: 30

Abstract

Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ([structure: see text]) and its glycoside derivatives [structure: see text] and [structure: see text]. The other constituents isolated include alpha-amyrin, 3beta-acetyl ursolic acid and a mixture of oleanolic and ursolic acid and beta-sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds [structure: see text] and [structure: see text] were, respectively, identified as quinovic acid 3-O-[beta-D-glucopyranoside] (quinovin glycoside C) and quinovic acid 3-O-[beta-D-quinovopyranoside]-27-O-[beta-D-glucopyranosyl] ester. Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I.

来自密天牛的奎诺维奇酸苷——蛇毒磷酸二酯酶I天然抑制剂的第一个例子。
通过对密天牛树皮非生物碱提取物的植物化学研究,分离出一系列主要由奎诺维奇酸([结构:见文])及其苷类衍生物[结构:见文]和[结构:见文]组成的三萜。分离的其他成分包括α -amyrin, 3 -乙酰熊果酸和齐墩果酸、熊果酸和-谷甾醇-葡萄糖苷的混合物。通过光谱和化学研究鉴定了它们的结构,化合物[结构:见文]和[结构:见文]分别鉴定为喹诺维奇酸3-O-[β - d -喹诺维奇葡萄糖苷](喹诺维奇糖苷C)和喹诺维奇酸3-O-[β - d -喹诺维奇葡萄糖苷]-27- o -[β - d - glucopyranoyl]酯。化合物[结构:见文]和[结构:见文]对蛇毒磷酸二酯酶I表现出显著的抑制活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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