Naheed Fatima, Leon Azefack Tapondjou, David Lontsi, B L Sondengam, Atta-Ur-Rahman, M Iqbal Choudhary
{"title":"Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.","authors":"Naheed Fatima, Leon Azefack Tapondjou, David Lontsi, B L Sondengam, Atta-Ur-Rahman, M Iqbal Choudhary","doi":"10.1080/10575630290033169","DOIUrl":null,"url":null,"abstract":"<p><p>Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ([structure: see text]) and its glycoside derivatives [structure: see text] and [structure: see text]. The other constituents isolated include alpha-amyrin, 3beta-acetyl ursolic acid and a mixture of oleanolic and ursolic acid and beta-sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds [structure: see text] and [structure: see text] were, respectively, identified as quinovic acid 3-O-[beta-D-glucopyranoside] (quinovin glycoside C) and quinovic acid 3-O-[beta-D-quinovopyranoside]-27-O-[beta-D-glucopyranosyl] ester. Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I.</p>","PeriodicalId":18873,"journal":{"name":"Natural Product Letters","volume":"16 6","pages":"389-93"},"PeriodicalIF":0.0000,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10575630290033169","citationCount":"30","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10575630290033169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 30
Abstract
Phytochemical investigations on the non-alkaloidal extracts of Mitragyna stipulosa bark has led to the isolation of a series of triterpenoids mainly consisting of quinovic acid ([structure: see text]) and its glycoside derivatives [structure: see text] and [structure: see text]. The other constituents isolated include alpha-amyrin, 3beta-acetyl ursolic acid and a mixture of oleanolic and ursolic acid and beta-sitosterol glucopyranoside. Their structures were identified by spectral and chemical studies and compounds [structure: see text] and [structure: see text] were, respectively, identified as quinovic acid 3-O-[beta-D-glucopyranoside] (quinovin glycoside C) and quinovic acid 3-O-[beta-D-quinovopyranoside]-27-O-[beta-D-glucopyranosyl] ester. Compounds [structure: see text] and [structure: see text] showed significant inhibitory activity against snake venom phosphodiesterase I.
通过对密天牛树皮非生物碱提取物的植物化学研究,分离出一系列主要由奎诺维奇酸([结构:见文])及其苷类衍生物[结构:见文]和[结构:见文]组成的三萜。分离的其他成分包括α -amyrin, 3 -乙酰熊果酸和齐墩果酸、熊果酸和-谷甾醇-葡萄糖苷的混合物。通过光谱和化学研究鉴定了它们的结构,化合物[结构:见文]和[结构:见文]分别鉴定为喹诺维奇酸3-O-[β - d -喹诺维奇葡萄糖苷](喹诺维奇糖苷C)和喹诺维奇酸3-O-[β - d -喹诺维奇葡萄糖苷]-27- o -[β - d - glucopyranoyl]酯。化合物[结构:见文]和[结构:见文]对蛇毒磷酸二酯酶I表现出显著的抑制活性。