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Novel drug targets in 2024 2024年新的药物靶点
Nature Reviews Drug Discovery Pub Date : 2025-04-04 DOI: 10.1038/d41573-025-00069-z
{"title":"Novel drug targets in 2024","authors":"","doi":"10.1038/d41573-025-00069-z","DOIUrl":"https://doi.org/10.1038/d41573-025-00069-z","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker-guided decision making in clinical drug development for neurodegenerative disorders 神经退行性疾病临床药物开发中的生物标志物引导决策
Nature Reviews Drug Discovery Pub Date : 2025-04-04 DOI: 10.1038/s41573-025-01165-w
Jeffrey L. Cummings, Charlotte E. Teunissen, Brian K. Fiske, Isabelle Le Ber, Kristin R. Wildsmith, Michael Schöll, Billy Dunn, Philip Scheltens
{"title":"Biomarker-guided decision making in clinical drug development for neurodegenerative disorders","authors":"Jeffrey L. Cummings, Charlotte E. Teunissen, Brian K. Fiske, Isabelle Le Ber, Kristin R. Wildsmith, Michael Schöll, Billy Dunn, Philip Scheltens","doi":"10.1038/s41573-025-01165-w","DOIUrl":"https://doi.org/10.1038/s41573-025-01165-w","url":null,"abstract":"<p>Neurodegenerative disorders are characterized by complex neurobiological changes that are reflected in biomarker alterations detectable in blood, cerebrospinal fluid (CSF) and with brain imaging. As accessible proxies for processes that are difficult to measure, biomarkers are tools that hold increasingly important roles in drug development and clinical trial decision making. In the past few years, biomarkers have been the basis for accelerated approval of new therapies for Alzheimer disease and amyotrophic lateral sclerosis as surrogate end points reasonably likely to predict clinical benefit.Blood-based biomarkers are emerging for Alzheimer disease and other neurodegenerative disorders (for example, Parkinson disease, frontotemporal dementia), and some biomarkers may be informative across multiple disease states. Collection of CSF provides access to biomarkers not available in plasma, including markers of synaptic dysfunction and neuroinflammation. Molecular imaging is identifying an increasing array of targets, including amyloid plaques, neurofibrillary tangles, inflammation, mitochondrial dysfunction and synaptic density. In this Review, we consider how biomarkers can be implemented in clinical trials depending on their context of use, including providing information on disease risk and/or susceptibility, diagnosis, prognosis, pharmacodynamic outcomes, monitoring, prediction of response to therapy and safety. Informed choice of increasingly available biomarkers and rational deployment in clinical trials support drug development decision making and de-risk the drug development process for neurodegenerative disorders.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in the drug target landscape for autoimmune diseases 自身免疫性疾病药物靶点的发展趋势
Nature Reviews Drug Discovery Pub Date : 2025-04-03 DOI: 10.1038/d41573-025-00061-7
{"title":"Trends in the drug target landscape for autoimmune diseases","authors":"","doi":"10.1038/d41573-025-00061-7","DOIUrl":"https://doi.org/10.1038/d41573-025-00061-7","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA approves siRNA drug for haemophilia prophylaxis FDA批准用于血友病预防的siRNA药物
Nature Reviews Drug Discovery Pub Date : 2025-04-02 DOI: 10.1038/d41573-025-00066-2
{"title":"FDA approves siRNA drug for haemophilia prophylaxis","authors":"","doi":"10.1038/d41573-025-00066-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00066-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral IL-23-blocking peptide racks up phase III wins in inflammatory disease 口服il -23阻断肽在炎症性疾病中取得III期胜利
Nature Reviews Drug Discovery Pub Date : 2025-04-01 DOI: 10.1038/d41573-025-00063-5
{"title":"Oral IL-23-blocking peptide racks up phase III wins in inflammatory disease","authors":"","doi":"10.1038/d41573-025-00063-5","DOIUrl":"https://doi.org/10.1038/d41573-025-00063-5","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New antibiotic for urinary tract infections nabs FDA approval 治疗尿路感染的新抗生素获FDA批准
Nature Reviews Drug Discovery Pub Date : 2025-03-31 DOI: 10.1038/d41573-025-00064-4
{"title":"New antibiotic for urinary tract infections nabs FDA approval","authors":"","doi":"10.1038/d41573-025-00064-4","DOIUrl":"https://doi.org/10.1038/d41573-025-00064-4","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs 出版商更正：纤维化：跨器官生物学和创新药物开发途径
Nature Reviews Drug Discovery Pub Date : 2025-03-31 DOI: 10.1038/s41573-025-01190-9
Florian Rieder, Laura E. Nagy, Toby M. Maher, Jörg H. W. Distler, Rafael Kramann, Boris Hinz, Marco Prunotto
{"title":"Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs","authors":"Florian Rieder, Laura E. Nagy, Toby M. Maher, Jörg H. W. Distler, Rafael Kramann, Boris Hinz, Marco Prunotto","doi":"10.1038/s41573-025-01190-9","DOIUrl":"https://doi.org/10.1038/s41573-025-01190-9","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Drug Discovery</i> https://doi.org/10.1038/s41573-025-01158-9, published online 18 March 2025.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-incretin peptide curbs appetite 非肠促胰岛素肽抑制食欲
Nature Reviews Drug Discovery Pub Date : 2025-03-28 DOI: 10.1038/d41573-025-00062-6
{"title":"Non-incretin peptide curbs appetite","authors":"","doi":"10.1038/d41573-025-00062-6","DOIUrl":"https://doi.org/10.1038/d41573-025-00062-6","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two routes to tamp down microglia in traumatic brain injury 两种途径抑制创伤性脑损伤中的小胶质细胞
Nature Reviews Drug Discovery Pub Date : 2025-03-26 DOI: 10.1038/d41573-025-00060-8
{"title":"Two routes to tamp down microglia in traumatic brain injury","authors":"","doi":"10.1038/d41573-025-00060-8","DOIUrl":"https://doi.org/10.1038/d41573-025-00060-8","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards an oral norovirus vaccine 研制口服诺如病毒疫苗
Nature Reviews Drug Discovery Pub Date : 2025-03-25 DOI: 10.1038/d41573-025-00058-2
{"title":"Towards an oral norovirus vaccine","authors":"","doi":"10.1038/d41573-025-00058-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00058-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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