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Nature Reviews Drug Discovery最新文献

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The landscape for radioligand therapies in oncology 肿瘤学放射配体治疗的前景
Nature Reviews Drug Discovery Pub Date : 2025-06-03 DOI: 10.1038/d41573-025-00096-w
{"title":"The landscape for radioligand therapies in oncology","authors":"","doi":"10.1038/d41573-025-00096-w","DOIUrl":"https://doi.org/10.1038/d41573-025-00096-w","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lowering pathological α-synuclein 降低病理性α-突触核蛋白
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00093-z
{"title":"Lowering pathological α-synuclein","authors":"","doi":"10.1038/d41573-025-00093-z","DOIUrl":"https://doi.org/10.1038/d41573-025-00093-z","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development 肠道微生物组作为癌症免疫治疗的靶点：药物开发的机遇和挑战
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/s41573-025-01211-7
Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, Bastien Castagner, Bertrand Routy
{"title":"The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development","authors":"Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, Bastien Castagner, Bertrand Routy","doi":"10.1038/s41573-025-01211-7","DOIUrl":"https://doi.org/10.1038/s41573-025-01211-7","url":null,"abstract":"<p>The gut microbiome has a critical role in shaping the patient’s immune response and influencing the efficacy of anticancer immunotherapy. Emerging evidence suggests that modulating the gut microbiome through interventions such as faecal microbiota transplantation, probiotics, prebiotics and lifestyle modifications may enhance therapeutic outcomes. Consequently, drug development efforts in immuno-oncology have expanded to explore microbiome-based therapeutic strategies. In this Review, we examine the rationale for targeting the microbiome in cancer treatment, highlighting key advances in clinical microbiome characterization and their implications for immunotherapy. We discuss findings from recent clinical trials evaluating microbiome-based interventions and address the challenges associated with translating these approaches into clinical practice. Finally, we outline future directions for the development and integration of microbiome-targeted therapies in oncology, with a focus on optimizing efficacy, safety and patient stratification strategies.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a universal snake antivenom 走向一种通用的抗蛇毒血清
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00092-0
{"title":"Towards a universal snake antivenom","authors":"","doi":"10.1038/d41573-025-00092-0","DOIUrl":"https://doi.org/10.1038/d41573-025-00092-0","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonging the antidepressant effects of ketamine 延长氯胺酮的抗抑郁作用
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00094-y
{"title":"Prolonging the antidepressant effects of ketamine","authors":"","doi":"10.1038/d41573-025-00094-y","DOIUrl":"https://doi.org/10.1038/d41573-025-00094-y","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blocking a cell surface protein beats AML 阻断细胞表面蛋白可以治疗AML
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00095-x
{"title":"Blocking a cell surface protein beats AML","authors":"","doi":"10.1038/d41573-025-00095-x","DOIUrl":"https://doi.org/10.1038/d41573-025-00095-x","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new drug target for NRAS(Q61) mutant-expressing cancers 表达NRAS（Q61）突变的癌症的新药物靶点
Nature Reviews Drug Discovery Pub Date : 2025-05-29 DOI: 10.1038/d41573-025-00091-1
{"title":"A new drug target for NRAS(Q61) mutant-expressing cancers","authors":"","doi":"10.1038/d41573-025-00091-1","DOIUrl":"https://doi.org/10.1038/d41573-025-00091-1","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: GLP-1-based therapies for diabetes, obesity and beyond 作者更正：glp -1为基础的治疗糖尿病，肥胖和其他疾病
Nature Reviews Drug Discovery Pub Date : 2025-05-28 DOI: 10.1038/s41573-025-01231-3
Daniel J. Drucker
{"title":"Author Correction: GLP-1-based therapies for diabetes, obesity and beyond","authors":"Daniel J. Drucker","doi":"10.1038/s41573-025-01231-3","DOIUrl":"https://doi.org/10.1038/s41573-025-01231-3","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Drug Discovery</i> https://doi.org/10.1038/s41573-025-01183-8, published online 25 April 2025.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triggering ferroptosis in drug-tolerant cancer cells 引发耐药癌细胞铁下垂
Nature Reviews Drug Discovery Pub Date : 2025-05-27 DOI: 10.1038/d41573-025-00090-2
{"title":"Triggering ferroptosis in drug-tolerant cancer cells","authors":"","doi":"10.1038/d41573-025-00090-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00090-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Medicines Initiative public–private partnerships to enhance translational safety 创新药物倡议公私伙伴关系，加强转化安全
Nature Reviews Drug Discovery Pub Date : 2025-05-22 DOI: 10.1038/d41573-025-00080-4
Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs, Shashi K. Ramaiah, Jacques Richard, Gunnar Schütz, Nathalie Seigneuret, Thomas Steger-Hartmann, Elisabetta Vaudano
{"title":"Innovative Medicines Initiative public–private partnerships to enhance translational safety","authors":"Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs, Shashi K. Ramaiah, Jacques Richard, Gunnar Schütz, Nathalie Seigneuret, Thomas Steger-Hartmann, Elisabetta Vaudano","doi":"10.1038/d41573-025-00080-4","DOIUrl":"https://doi.org/10.1038/d41573-025-00080-4","url":null,"abstract":"Innovative Medicines Initiative projects focused on translational safety have developed a range of tools to improve preclinical assessments of potential drug toxicities, and demonstrated the value of integrating data from multiple companies.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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