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Base editing reduces prion protein 碱基编辑减少了朊病毒蛋白
Nature Reviews Drug Discovery Pub Date : 2025-01-22 DOI: 10.1038/d41573-025-00016-y
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引用次数: 0
J&J buys Intra-Cellular Therapies for US$14.6 billion, expanding its neuroscience portfolio 强生以146亿美元收购细胞内疗法，扩大其神经科学产品组合
Nature Reviews Drug Discovery Pub Date : 2025-01-22 DOI: 10.1038/d41573-025-00015-z
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引用次数: 0
2024 FDA approvals exceed average number but have lower sales projections 2024年FDA批准的数量超过平均水平，但销售预期较低
Nature Reviews Drug Discovery Pub Date : 2025-01-17 DOI: 10.1038/d41573-025-00014-0
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引用次数: 0
Outlook for medicines development and use in 2025 2025年药物开发和使用展望
Nature Reviews Drug Discovery Pub Date : 2025-01-15 DOI: 10.1038/d41573-025-00012-2
Sarah Rickwood, Helena Bayley, Stefan Lutzmayer, Meike Madelung, Markus Gores
{"title":"Outlook for medicines development and use in 2025","authors":"Sarah Rickwood, Helena Bayley, Stefan Lutzmayer, Meike Madelung, Markus Gores","doi":"10.1038/d41573-025-00012-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00012-2","url":null,"abstract":"Oncology innovations, obesity medicines, an uptick for mergers and acquisitions, regulation for artificial intelligence applications and growing consumerization are expected to be key topics.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopharma dealmaking in 2024 2024年的生物制药交易
Nature Reviews Drug Discovery Pub Date : 2025-01-15 DOI: 10.1038/d41573-025-00013-1
{"title":"Biopharma dealmaking in 2024","authors":"","doi":"10.1038/d41573-025-00013-1","DOIUrl":"https://doi.org/10.1038/d41573-025-00013-1","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting mitophagy in neurodegenerative diseases 靶向线粒体自噬在神经退行性疾病中的应用
Nature Reviews Drug Discovery Pub Date : 2025-01-14 DOI: 10.1038/s41573-024-01105-0
Odetta Antico, Paul W. Thompson, Nicholas T. Hertz, Miratul M. K. Muqit, Laura E. Parton
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引用次数: 0
FDA approves next-generation triple therapy for cystic fibrosis FDA批准下一代三重治疗囊肿性纤维化
Nature Reviews Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00008-y
{"title":"FDA approves next-generation triple therapy for cystic fibrosis","authors":"","doi":"10.1038/d41573-025-00008-y","DOIUrl":"https://doi.org/10.1038/d41573-025-00008-y","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting inherited mutations to prevent metastasis 靶向遗传突变以防止转移
Nature Reviews Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00009-x
{"title":"Targeting inherited mutations to prevent metastasis","authors":"","doi":"10.1038/d41573-025-00009-x","DOIUrl":"https://doi.org/10.1038/d41573-025-00009-x","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DLL3 draws two antibody–drug conjugate deals DLL3获得了两笔抗体-药物结合物交易
Nature Reviews Drug Discovery Pub Date : 2025-01-13 DOI: 10.1038/d41573-025-00011-3
{"title":"DLL3 draws two antibody–drug conjugate deals","authors":"","doi":"10.1038/d41573-025-00011-3","DOIUrl":"https://doi.org/10.1038/d41573-025-00011-3","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-PKcs inhibitor causes genomic alterations DNA-PKcs抑制剂引起基因组改变
Nature Reviews Drug Discovery Pub Date : 2025-01-10 DOI: 10.1038/d41573-025-00004-2
{"title":"DNA-PKcs inhibitor causes genomic alterations","authors":"","doi":"10.1038/d41573-025-00004-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00004-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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