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In vivo CAR T cells move into clinical trials 体内 CAR T 细胞进入临床试验阶段
Nature Reviews Drug Discovery Pub Date : 2024-09-16 DOI: 10.1038/d41573-024-00150-z
{"title":"In vivo CAR T cells move into clinical trials","authors":"","doi":"10.1038/d41573-024-00150-z","DOIUrl":"https://doi.org/10.1038/d41573-024-00150-z","url":null,"abstract":"Drug developers want to reprogramme immune cells directly in the body, opening up new gene therapy frontiers in cancer and autoimmunity.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating an AI-first drug discovery engine 创建人工智能药物发现引擎
Nature Reviews Drug Discovery Pub Date : 2024-09-13 DOI: 10.1038/d41573-024-00149-6
{"title":"Creating an AI-first drug discovery engine","authors":"","doi":"10.1038/d41573-024-00149-6","DOIUrl":"https://doi.org/10.1038/d41573-024-00149-6","url":null,"abstract":"Najat Khan — Chief R&D Officer and Chief Commercial Officer at Recursion — discusses the proposed merger of Recursion and Exscientia.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Antimalarial drug discovery: progress and approaches. 作者更正：抗疟药物的发现：进展与方法。
Nature Reviews Drug Discovery Pub Date : 2024-09-13 DOI: 10.1038/s41573-024-01045-9
Jair L Siqueira-Neto,Kathryn J Wicht,Kelly Chibale,Jeremy N Burrows,David A Fidock,Elizabeth A Winzeler
{"title":"Author Correction: Antimalarial drug discovery: progress and approaches.","authors":"Jair L Siqueira-Neto,Kathryn J Wicht,Kelly Chibale,Jeremy N Burrows,David A Fidock,Elizabeth A Winzeler","doi":"10.1038/s41573-024-01045-9","DOIUrl":"https://doi.org/10.1038/s41573-024-01045-9","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting cytokine networks in neuroinflammatory diseases 针对神经炎性疾病中的细胞因子网络
Nature Reviews Drug Discovery Pub Date : 2024-09-11 DOI: 10.1038/s41573-024-01026-y
Burkhard Becher, Tobias Derfuss, Roland Liblau
{"title":"Targeting cytokine networks in neuroinflammatory diseases","authors":"Burkhard Becher, Tobias Derfuss, Roland Liblau","doi":"10.1038/s41573-024-01026-y","DOIUrl":"https://doi.org/10.1038/s41573-024-01026-y","url":null,"abstract":"<p>In neuroinflammatory diseases, systemic (blood-borne) leukocytes invade the central nervous system (CNS) and lead to tissue damage. A causal relationship between neuroinflammatory diseases and dysregulated cytokine networks is well established across several preclinical models. Cytokine dysregulation is also observed as an inadvertent effect of cancer immunotherapy, where it often leads to neuroinflammation. Neuroinflammatory diseases can be separated into those in which a pathogen is at the centre of the immune response and those of largely unknown aetiology. Here, we discuss the pathophysiology, cytokine networks and therapeutic landscape of ‘sterile’ neuroinflammatory diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), neurosarcoidosis and immune effector cell-associated neurotoxicity syndrome (ICANS) triggered by cancer immunotherapy. Despite successes in targeting cytokine networks in preclinical models of neuroinflammation, the clinical translation of targeting cytokines and their receptors has shown mixed and often paradoxical responses.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142166599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upcoming market catalysts in Q4 2024 2024 年第四季度即将出现的市场催化剂
Nature Reviews Drug Discovery Pub Date : 2024-09-10 DOI: 10.1038/d41573-024-00148-7
{"title":"Upcoming market catalysts in Q4 2024","authors":"","doi":"10.1038/d41573-024-00148-7","DOIUrl":"https://doi.org/10.1038/d41573-024-00148-7","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurons give metastatic cells a push 神经元为转移细胞提供动力
Nature Reviews Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00144-x
{"title":"Neurons give metastatic cells a push","authors":"","doi":"10.1038/d41573-024-00144-x","DOIUrl":"https://doi.org/10.1038/d41573-024-00144-x","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splice-switching ASO curtails brain calcification 剪接转换 ASO 可抑制大脑钙化
Nature Reviews Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00147-8
{"title":"Splice-switching ASO curtails brain calcification","authors":"","doi":"10.1038/d41573-024-00147-8","DOIUrl":"https://doi.org/10.1038/d41573-024-00147-8","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PPAR agonists provide new treatment options for inflammatory liver disease PPAR 激动剂为炎症性肝病提供了新的治疗方案
Nature Reviews Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00145-w
{"title":"PPAR agonists provide new treatment options for inflammatory liver disease","authors":"","doi":"10.1038/d41573-024-00145-w","DOIUrl":"https://doi.org/10.1038/d41573-024-00145-w","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RIPTACs expand anticancer target space RIPTACs 拓展了抗癌靶点空间
Nature Reviews Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00146-9
{"title":"RIPTACs expand anticancer target space","authors":"","doi":"10.1038/d41573-024-00146-9","DOIUrl":"https://doi.org/10.1038/d41573-024-00146-9","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organoids identify a role for IL-7 in coeliac disease 器官组织确定了 IL-7 在乳糜泻中的作用
Nature Reviews Drug Discovery Pub Date : 2024-09-09 DOI: 10.1038/d41573-024-00143-y
{"title":"Organoids identify a role for IL-7 in coeliac disease","authors":"","doi":"10.1038/d41573-024-00143-y","DOIUrl":"https://doi.org/10.1038/d41573-024-00143-y","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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