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Covalent BAX inhibitor confers cytoprotection 共价BAX抑制剂具有细胞保护作用
Nature Reviews Drug Discovery Pub Date : 2026-09-22 DOI: 10.1038/d41573-026-00156-9
Sarah Crunkhorn
{"title":"Covalent BAX inhibitor confers cytoprotection","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00156-9","DOIUrl":"https://doi.org/10.1038/d41573-026-00156-9","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149021809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppressor tRNA rescues cystic fibrosis 抑制tRNA拯救囊性纤维化
Nature Reviews Drug Discovery Pub Date : 2026-09-22 DOI: 10.1038/d41573-026-00153-y
Sarah Crunkhorn
{"title":"Suppressor tRNA rescues cystic fibrosis","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00153-y","DOIUrl":"https://doi.org/10.1038/d41573-026-00153-y","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149021807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting norovirus RNA structures 靶向诺如病毒RNA结构
Nature Reviews Drug Discovery Pub Date : 2026-09-22 DOI: 10.1038/d41573-026-00154-x
Sarah Crunkhorn
{"title":"Targeting norovirus RNA structures","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-026-00154-x","DOIUrl":"https://doi.org/10.1038/d41573-026-00154-x","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149021808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective oestrogen receptor degrader class grows with new cancer approval 选择性雌激素受体降解类新癌症批准生长
Nature Reviews Drug Discovery Pub Date : 2026-09-11 DOI: 10.1038/d41573-026-00151-0
Asher Mullard
{"title":"Selective oestrogen receptor degrader class grows with new cancer approval","authors":"Asher Mullard","doi":"10.1038/d41573-026-00151-0","DOIUrl":"https://doi.org/10.1038/d41573-026-00151-0","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to peak sales: how long is the climb? 销售高峰到来的时间：会持续多久？
Nature Reviews Drug Discovery Pub Date : 2026-06-25 DOI: 10.1038/d41573-026-00104-7
Daniel Alvarez,Alexis Saucy,Daniel Saacks
{"title":"Time to peak sales: how long is the climb?","authors":"Daniel Alvarez,Alexis Saucy,Daniel Saacks","doi":"10.1038/d41573-026-00104-7","DOIUrl":"https://doi.org/10.1038/d41573-026-00104-7","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148322681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking biological barriers: nonclinical safety considerations for RNA-based complex biologics. 解锁生物屏障：基于rna的复杂生物制剂的非临床安全性考虑。
Nature Reviews Drug Discovery Pub Date : 2026-04-10 DOI: 10.1038/d41573-026-00056-y
Sheroy Minocherhomji,Katie Sokolowski,Kelle Franklin,Laura Leung,Eileen Blasi,Tae-Won Kim
{"title":"Unlocking biological barriers: nonclinical safety considerations for RNA-based complex biologics.","authors":"Sheroy Minocherhomji,Katie Sokolowski,Kelle Franklin,Laura Leung,Eileen Blasi,Tae-Won Kim","doi":"10.1038/d41573-026-00056-y","DOIUrl":"https://doi.org/10.1038/d41573-026-00056-y","url":null,"abstract":"","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147649097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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