Nature ecology & evolution最新文献_第5页

Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex 二十年的结核病驱动选择塑造了猫鼬主要组织相容性复合体的进化

IF 16.8 1区生物学

Nature ecology & evolution Pub Date : 2025-08-25 DOI: 10.1038/s41559-025-02837-x

Nadine Müller-Klein, Alice Risely, Kerstin Wilhelm, Vanessa Riegel, Marta Manser, Tim Clutton-Brock, Luke Silver, Pablo S. C. Santos, Dominik W. Melville, Simone Sommer

{"title":"Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex","authors":"Nadine Müller-Klein, Alice Risely, Kerstin Wilhelm, Vanessa Riegel, Marta Manser, Tim Clutton-Brock, Luke Silver, Pablo S. C. Santos, Dominik W. Melville, Simone Sommer","doi":"10.1038/s41559-025-02837-x","DOIUrl":"https://doi.org/10.1038/s41559-025-02837-x","url":null,"abstract":"Pathogen-mediated balancing selection (PMBS) drives host evolution across the tree of life. Distinguishing between the three main mechanisms underlying PMBS, that is, rare-allele advantage, fluctuating selection and heterozygote advantage, remains difficult, limiting our understanding of frequency-dependent adaptations by hosts and counter-adaptation by pathogens. Here we leverage immune genetic and disease surveillance data from over 1,500 wild meerkats (Suricata suricatta) to track how selection by the tuberculosis (TB)-causing Mycobacterium suricattae shaped the evolution of the meerkats’ major histocompatibility complex (MHC) over two decades. Compared with neutral genetic markers, we detect more rapid differentiation and recycling of alleles at the MHC-DRB loci, suggesting that TB imposes strong PMBS on wild meerkats. In addition, we show that meerkats carrying the MHC allele Susu-DRB*13 were initially more likely to develop clinical signs of TB, with the effect reversing over the course of the study, followed by an increase in the frequency of Susu-DRB*13. Meerkats carrying Susu-DRB*13 also showed slower progression to TB signs and longer survival once signs of TB manifested. Lifetime reproductive success reflected the resilience effect conferred by Susu-DRB*13. Based on several lines of evidence, we propose that rare-allele advantage or fluctuating selection, rather than heterozygote advantage, drive our observation in this longitudinally sampled wild mammal population.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"95 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited plastic responses in safety traits support greater hydraulic risk under drier conditions 在干燥条件下，安全特性的有限塑性响应支持更大的水力风险

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-22 DOI: 10.1038/s41559-025-02830-4

José A. Ramírez-Valiente, Rafael Poyatos, Chris J. Blackman, Antoine Cabon, Eva Castells, Hervé Cochard, Danielle Creek, Sylvain Delzon, Raúl García-Valdés, Jean-Marc Limousin, Rosana López, Nicolas Martin-StPaul, Myriam Moreno, Lucy Rowland, Louis S. Santiago, Bernhard Schuldt, José M. Torres-Ruiz, Aude Valade, Jordi Martínez-Vilalta, Maurizio Mencuccini

{"title":"Limited plastic responses in safety traits support greater hydraulic risk under drier conditions","authors":"José A. Ramírez-Valiente, Rafael Poyatos, Chris J. Blackman, Antoine Cabon, Eva Castells, Hervé Cochard, Danielle Creek, Sylvain Delzon, Raúl García-Valdés, Jean-Marc Limousin, Rosana López, Nicolas Martin-StPaul, Myriam Moreno, Lucy Rowland, Louis S. Santiago, Bernhard Schuldt, José M. Torres-Ruiz, Aude Valade, Jordi Martínez-Vilalta, Maurizio Mencuccini","doi":"10.1038/s41559-025-02830-4","DOIUrl":"10.1038/s41559-025-02830-4","url":null,"abstract":"Understanding how plants adjust their hydraulic system to the environment is essential to predict how these organisms will respond to global change. Here we compiled a dataset and performed meta-analysis on 223 studies on plastic and evolutionary adjustments of hydraulic traits to air temperature, CO2 concentration, irradiance, soil nutrient and water availability. On average, species plastically increased embolism resistance and sapwood area per leaf area under drier conditions, with a decrease in stem-specific hydraulic conductivity and water potential at the turgor loss point, which are consistent with adaptive responses. However, the average increased embolism resistance was not sufficient to compensate the reduction in the minimum water potential, implying a lower safety margin from lethal hydraulic failure under drought. These results point towards a general critical increase in the risk of hydraulic failure in future drier environments. Plastic responses to increased soil nutrient content and irradiance did not always align with those to drought, highlighting the potential for changes in light and nutrient conditions to modify plant hydraulic responses to climate-change-driven droughts. Plants across many ecosystems are increasingly exposed to dryness stress. Using meta-analysis, the authors show that plants can adjust their hydraulic traits in response to drought and other global change factors, but not equally across traits and not enough to prevent lethal hydraulic failure.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"9 10","pages":"1825-1836"},"PeriodicalIF":13.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary drivers of divergent collateral sensitivity responses during antibiotic therapy 抗生素治疗期间不同侧支敏感性反应的进化驱动因素

IF 16.8 1区生物学

Nature ecology & evolution Pub Date : 2025-08-22 DOI: 10.1038/s41559-025-02831-3

Sander K. Casier, Bram Lories, Hans P. Steenackers

{"title":"Evolutionary drivers of divergent collateral sensitivity responses during antibiotic therapy","authors":"Sander K. Casier, Bram Lories, Hans P. Steenackers","doi":"10.1038/s41559-025-02831-3","DOIUrl":"https://doi.org/10.1038/s41559-025-02831-3","url":null,"abstract":"With antibiotic resistance on the rise and the development of new antibiotics stagnating, novel antimicrobial strategies that slow down resistance evolution and extend the lifetime of existing drugs are urgently needed. One possible solution focuses on rationalizing antimicrobial combination and cycling therapies on the basis of the concept of collateral sensitivity, in which resistance mutations acquired against one antibiotic increase the susceptibility towards a second antibiotic. However, the clinical potential of collateral sensitivity is still uncertain as collateral responses for the same combination of antibiotics may vary from collateral sensitivity to cross-resistance, depending on stochasticity, environmental conditions and the genetic background of the pathogen. This Review therefore discusses the drivers behind this variability and proposes that they can influence collateral sensitivity either by selecting different resistance mutations with distinct collateral responses or by modulating how a given resistance mutation affects the cell, thereby altering or even inverting the collateral response. Moreover, we discuss the dynamics of collateral sensitivity in duotherapy and highlight how the selection of multi-drug resistance may contribute to the variability in treatment outcomes. To aid the translation of collateral sensitivity to a clinical setting, we finally present several strategies that could circumvent the variability in collateral sensitivity outcomes.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"65 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fish without borders 没有国界的鱼

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-21 DOI: 10.1038/s41559-025-02852-y

Walter Andriuzzi

引用次数: 0

Global covariation of forest age transitions with the net carbon balance 林龄变迁与净碳平衡的全球共变。

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-19 DOI: 10.1038/s41559-025-02821-5

Simon Besnard, Viola H. A. Heinrich, Nuno Carvalhais, Philippe Ciais, Martin Herold, Ingrid Luijkx, Wouter Peters, Daniela Requena Suarez, Maurizio Santoro, Hui Yang

{"title":"Global covariation of forest age transitions with the net carbon balance","authors":"Simon Besnard, Viola H. A. Heinrich, Nuno Carvalhais, Philippe Ciais, Martin Herold, Ingrid Luijkx, Wouter Peters, Daniela Requena Suarez, Maurizio Santoro, Hui Yang","doi":"10.1038/s41559-025-02821-5","DOIUrl":"10.1038/s41559-025-02821-5","url":null,"abstract":"Forest age transitions are critical in shaping the global carbon balance, yet their influence on carbon stocks and fluxes remains poorly quantified. Here we analyse global forest age dynamics from 2010 to 2020 using the Global Age Mapping Integration v2.0 dataset, alongside satellite-derived aboveground carbon (AGC) and atmospheric inversion-derived net CO2 flux data. We reveal widespread declines in forest age across the Amazon, Congo Basin, Southeast Asia and parts of Siberia, primarily driven by stand-replacing disturbances such as fire and harvest, leading to the replacement of older forests by younger stands. Meanwhile, forests in China, Europe and North America experienced net ageing. Globally, stand replacement resulted in substantial AGC losses, with old forests (>200 years, ~98.0 MgC ha−1) transitioning to younger, carbon-poor stands (<20 years, ~43.5 MgC ha−1), leading to a net AGC loss of ~0.14 PgC per year. Despite this, regions with high rates of young stands replacing old forests exhibited a temporary strengthening of the carbon sink, driven by the rapid regrowth of these young stands. Crucially, these young forests do not compensate for the long-term carbon storage of old forests. Our findings underscore the importance of protecting old forests while optimizing forest management strategies to maximize carbon gains and enhance climate mitigation. A global analysis reveals regional trends of net forest ageing but also that widespread stand-replacing disturbances, such as fire and harvest, are driving declining forest age in many areas, often accompanied by substantial losses in aboveground carbon stocks and shifts in carbon sink dynamics.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"9 10","pages":"1848-1860"},"PeriodicalIF":13.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41559-025-02821-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EdgeHOG: a method for fine-grained ancestral gene order inference at large scale EdgeHOG：一种大规模细粒度祖先基因顺序推断方法。

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-19 DOI: 10.1038/s41559-025-02818-0

Charles Bernard, Yannis Nevers, Naga Bhushana Rao Karampudi, Kimberly J. Gilbert, Clément Train, Alex Warwick Vesztrocy, Natasha Glover, Adrian Altenhoff, Christophe Dessimoz

{"title":"EdgeHOG: a method for fine-grained ancestral gene order inference at large scale","authors":"Charles Bernard, Yannis Nevers, Naga Bhushana Rao Karampudi, Kimberly J. Gilbert, Clément Train, Alex Warwick Vesztrocy, Natasha Glover, Adrian Altenhoff, Christophe Dessimoz","doi":"10.1038/s41559-025-02818-0","DOIUrl":"10.1038/s41559-025-02818-0","url":null,"abstract":"Ancestral genomes are essential for studying the diversification of life from the last universal common ancestor to modern organisms. Methods have been proposed to infer ancestral gene order, but they lack scalability, limiting the depth to which gene neighbourhood evolution can be traced back. Here we introduce edgeHOG, a tool designed for accurate ancestral gene order inference with linear time complexity. We validated edgeHOG on various benchmarks and applied it to the entire OMA orthology database, encompassing 2,845 extant genomes across all domains of life. We reconstructed ancestral gene order for 1,133 ancestral genomes, including ancestral contigs for the last common ancestor of eukaryotes, dating back around 1.8 billion years, and observed significant functional association among neighbouring genes. EdgeHOG also dates gene adjacencies, allowing the detection of both conserved gene clusters and chromosomal rearrangements. A new method to reconstruct ancestral genomes is used to estimate contigs of the last common ancestor of eukaryotes and to infer features such as the age of gene adjacencies and chromosome rearrangements.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"9 10","pages":"1951-1961"},"PeriodicalIF":13.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41559-025-02818-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging threats to Antarctic conservation 南极保护面临的新威胁

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-15 DOI: 10.1038/s41559-025-02814-4

Zachary T. Carter, Michael Bode, Steven L. Chown, Joanna L. Burrows, Justine D. Shaw, Jessica C. Walsh, Mark A. Burgman, Phillip Cassey, Kerrie A. Wilson

{"title":"Emerging threats to Antarctic conservation","authors":"Zachary T. Carter, Michael Bode, Steven L. Chown, Joanna L. Burrows, Justine D. Shaw, Jessica C. Walsh, Mark A. Burgman, Phillip Cassey, Kerrie A. Wilson","doi":"10.1038/s41559-025-02814-4","DOIUrl":"10.1038/s41559-025-02814-4","url":null,"abstract":"Antarctica, long considered an environmental sanctuary, now confronts accelerating, complex and inter-related conservation challenges. The vast size and remote location of the continent introduce substantial uncertainty in understanding and predicting these threats. Here, using strategic foresight techniques, we synthesized insights from a global horizon scan with 131 experts from 42 countries. We identified ten emerging conservation challenges across six thematic categories. Key issues included extreme precipitation, emerging animal pathogens, human pandemics, security threats, reduced cooperation among Antarctic Treaty parties and potential agricultural expansion. Several of these challenges stem from persistent underlying drivers, revealing how longstanding processes are giving rise to new and increasingly acute conservation concerns. Others, driven by global disruptions, have no historical precedent in the region but increasingly constrain decision-making and international coordination. This horizon scan reveals substantial limitations in the ability of the Antarctic Treaty system to address these challenges, underscoring the need to reassess existing governance mechanisms to protect the unique ecosystems of Antarctica and its vital role in the global climate system. A horizon scan of international respondents identifies and discusses ten developing challenges in Antarctic conservation, revealing an increased emphasis on challenges related to governance, geopolitics and economics compared to a similar scan from 2012.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"9 10","pages":"1885-1896"},"PeriodicalIF":13.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increase the regulation of biodiversity effects from private equity markets 加强对私人股本市场对生物多样性影响的监管

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-12 DOI: 10.1038/s41559-025-02828-y

Harrison Carter, Nell Miles, Isobel Hawkins, Toscanie Hulett, Sophus O. S. E. zu Ermgassen

引用次数: 0

Large reductions in tropical bird abundance attributable to heat extreme intensification 极端高温加剧导致热带鸟类丰度大幅减少

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-11 DOI: 10.1038/s41559-025-02811-7

Maximilian Kotz, Tatsuya Amano, James E. M. Watson

{"title":"Large reductions in tropical bird abundance attributable to heat extreme intensification","authors":"Maximilian Kotz, Tatsuya Amano, James E. M. Watson","doi":"10.1038/s41559-025-02811-7","DOIUrl":"10.1038/s41559-025-02811-7","url":null,"abstract":"Although species exhibit widespread sensitivity to environmental conditions, the extent to which human-driven climate change may have already altered their abundance remains unclear. Here we quantify the impact of climate change on bird populations from across the world by combining models of their response to environmental conditions with a climate attribution framework. We identify a dominant role of intensified heat extremes compared to changes in average temperature and precipitation. Increased interannual exposure to hot extremes reduces annual abundance growth rates most strongly in lower-latitude tropical regions, with effects robust when controlling for changing human industrial pressure and other long-term drivers. Compared to a counterfactual without human-driven climate change, the historical intensification of heat extremes has caused a 25–38% reduction in the level of abundance of tropical birds, which has accumulated from 1950 to 2020. Across observed tropical bird populations, impacts of climate change have typically been larger than direct human pressure, the opposite across sub-tropical regions. Overall, these results showcase how human-driven climate change is already reshaping biodiversity globally and may explain reported declines of birds in undisturbed tropical habitats. Climate change poses a growing threat to biodiversity, but disentangling its overall impact from other anthropogenic stressors is challenging. Here the authors use a data-driven climate attribution framework to identify a key role of heat extremes in causing changes in bird populations globally.","PeriodicalId":18835,"journal":{"name":"Nature ecology & evolution","volume":"9 10","pages":"1897-1909"},"PeriodicalIF":13.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying coral reef–ocean interactions is critical for predicting reef futures under climate change 量化珊瑚礁与海洋的相互作用对于预测气候变化下珊瑚礁的未来至关重要

IF 13.9 1区生物学

Nature ecology & evolution Pub Date : 2025-08-11 DOI: 10.1038/s41559-025-02839-9

Laura E. Richardson, Gareth J. Williams, Aislinn Dunne, Tim Jackson-Bué, J. A. Mattias Green, Tiffany H. Morrison, Michael D. Fox

引用次数: 0