Biology, Medicine, & Natural Product Chemistry最新文献_第3页

Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax 金合槐、黄芩和蜂蜡局部乳膏的化学成分及抗酪氨酸酶和抗氧化作用的评价

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-03-13 DOI: 10.14421/biomedich.2023.121.251-258

A. N. Tamfu, Alain Yaya Koudoro, Selcuk Kucukaydin, Théophile Olayé, Pascal Dossa Cokou Agbangnan, D. C. Sohounhloué, F. Avlessi

{"title":"Chemical Composition and Evaluation of Anti-tyrosinase and Anti-Oxidative Effects of Topical Cream Formulation from Acacia sieberiana, Vitellaria paradoxa and Beeswax","authors":"A. N. Tamfu, Alain Yaya Koudoro, Selcuk Kucukaydin, Théophile Olayé, Pascal Dossa Cokou Agbangnan, D. C. Sohounhloué, F. Avlessi","doi":"10.14421/biomedich.2023.121.251-258","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.251-258","url":null,"abstract":"Skin diseases can get natural therapies from medicinal plant-based products. In this study, a topical cream was formulated from ethanol extract of Acacia sieberiana, beeswax and Vitellaria paradoxa (shea) butter. GC-MS characterization with co-injection of the topical cream revealed Stearic acid (31.43%), Palmitic acid (23.15%), Oleic acid (21.44%) and Linoleic acid (16.20%) as the major components. Seven phenolic conpounds were identified and quantified by HPLC- DAD and Ferulic acid (12.81±0.26 mg/g) was the most abundant. The cream showed good antioxidant properties evaluated through ?-Carotene-linoleic acid assay, DPPH• radical scavenging, ABTS•+ assay, CUPRAC assay, and metal chelating assay. The cream had higher activity in the DPPH• assay (IC50 = 32.10±0.84 µg/mL), ABTS•+ assay (IC50 = 22.49±0.62 µg/mL) and CUPRAC assay (IC50 = 49.27±0.79 µg/mL) than ?-Tocopherol. The antioxidant effects are an indication that the cream can reduce oxidative stress on the skin including aging, carcinogenesis and inflammation. At 100 µg/mL, the topical cream showed tyrosinase inhibition of 48.23±0.87% regarded as relatively good compared to the standard tyrosinase inhibitor kojic acid, which showed 79.50±0.32% inhibition at the same concentration. The cosmetic cream was able to inhibit the melanin production rate-limiting enzyme, tyrosinase, indicating that it can control hyperpigmentation and skin spots.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121519578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties 肉桂载抗糖尿病牛血清白蛋白微颗粒的合成与表征

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-03-03 DOI: 10.14421/biomedich.2023.121.241-250

Binuki Wanniarachchi, H.M.W.K. Sathsarani, B. Jayawardena, H. Dewangani

{"title":"Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties","authors":"Binuki Wanniarachchi, H.M.W.K. Sathsarani, B. Jayawardena, H. Dewangani","doi":"10.14421/biomedich.2023.121.241-250","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.241-250","url":null,"abstract":"Conventional medicine that is being used to treat diabetes exert adverse side effects and therefore scientists have focused on natural hypoglycemic agents. “Sri Wijaya” (CCSW) is an accession of Cinnamomum zeylanicum, which shows higher hypoglycemic activity. Pressured water extract of its dried quills can be used as an antidiabetic nutraceutical. Higher stability, ease of storage and transportation, make powder form nutraceuticals more preferred. The objective of this study was to develop cinnamon encapsulated microparticles as a powder form nutraceutical with higher hypoglycemic activity. Four different products were synthesized. Two of them were synthesized using bovine serum albumin (BSA) (8.8 % (w/v), pH=5) in the presence of citric acid and ascorbic acid as cross-linking agents separately. The other products were synthesized using BSA (20 mg/ mL, pH=9) in the presence of same cross-linking agents. Antidiabetic activity of the products was determined using alpha-amylase and alpha glucosidase inhibition assays and compared with that of crude cinnamon extract and positive control acarbose. Since the product synthesized using BSA (20 mg/ mL, pH=9) and citric acid showed the highest alpha amylase inhibition activity, solubility, cinnamon loading percentage and cinnamon entrapment efficiency those conditions were concluded as the optimum conditions required to synthesize microparticles with higher hypoglycemic activity. Particle size, polydispersity index, and zeta potential of that product were 1.281 ± (0.004) µm, 0.460 ± (0.018) and -1.09 ± (0.03) mV respectively. According to the SEM image, microparticles have a spherical morphology. The UV-visible spectrum and the FT-IR spectrum confirm the entrapment of cinnamon compounds.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121866552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Frequent Therapeutic Administration of Artesunate-amodiaquine and Artemether-lumefantrine on Haematological Markers in BALB/c Mice 频繁给予青蒿琥酯-阿莫地喹和蒿甲醚-氨苯曲明治疗对BALB/c小鼠血液学标志物的影响

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-03-02 DOI: 10.14421/biomedich.2023.121.233-240

D. Audu, O. Idowu, V. Patel, M. F. Mshelbwala, A. B. Idowu

{"title":"The Effects of Frequent Therapeutic Administration of Artesunate-amodiaquine and Artemether-lumefantrine on Haematological Markers in BALB/c Mice","authors":"D. Audu, O. Idowu, V. Patel, M. F. Mshelbwala, A. B. Idowu","doi":"10.14421/biomedich.2023.121.233-240","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.233-240","url":null,"abstract":"Artemisinin Combination Therapy (ACT) is readily available in malaria-endemic nations, leading to repeated drug usage by undiagnosed persons. Repeated use of ACT therapy by non-infected individuals may affect blood cells. This study explored how repeated artesunate-amodiaquine (A/A) and artemether-lumefantrine (A/L) treatment in non-infected mice affected haematological markers. 100 male BALB/c mice were randomly divided into 5 groups: non-infected and Plasmodium berghei NK65 infected treated with A/L and A/A 1X, 2X, 3X, 4X, 5X, and 6X, and the control group. Packed cell volume (PCV), Haemoglobin (Hb), and red blood cell (RBC) were reduced (p>0.05) non-significantly in the non-infected group treated with A/L or A/A six times compared to the control and infected groups. WBC rose in infected and non-infected mice treated with A/L or A/A 1X, 2X, 3X, and 6X, with a substantial rise in non-infected mice treated with A/L (p < 0.01) and A/A (p < 0.001) three times. WBC mainly rose due to lymphocytes, although neutrophils decreased. Repeated therapeutic use of A/L and A/A without infection may cause a haematological change. Continuous efforts are needed to educate the public about screening for malaria parasites before using drugs.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133852745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Profile and in-silico Docking Studies on Bioactives from Essential Oil of Cymbopogan pendulus Targeting Penicillin Binding Proteins (PBPs) in Bacteria 针对细菌中青霉素结合蛋白(PBPs)的Cymbopogan pendulus挥发油生物活性的化学特征及计算机对接研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-17 DOI: 10.14421/biomedich.2023.121.225-232

Amit Kumar Sharma, I. Kaur

{"title":"Chemical Profile and in-silico Docking Studies on Bioactives from Essential Oil of Cymbopogan pendulus Targeting Penicillin Binding Proteins (PBPs) in Bacteria","authors":"Amit Kumar Sharma, I. Kaur","doi":"10.14421/biomedich.2023.121.225-232","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.225-232","url":null,"abstract":"Antibiotic resistance in bacteria is the major concern worldwide. PBP (Penicillin binding proteins) have been cited as an appropriate target for therapeutic drug design. In the present study molecular docking followed by wet lab validation was designed to estimate the effect of potent bioactive molecules from Cymbopogan pendulus essential oil against PBP5 protein. GC-FID (gas chromatography with flame-ionization detection) based composition profile, and in-silico docking study was conducted by using CB-dock 2 analysis followed by 2D and 3D interactions. GC-FID revealed Limonene, Neral, Geranial, Linalool, Myrcene as major and minor compounds in Cymbopogan pendulus essential oil. The docking score indicated effective binding of ligands to PBP5. Interactions results indicated that, PBP5/ligand complexes form hydrogen and hydrophobic interactions. Wet lab study validated the anti-bacterial potential of oil against gram-positive and gram-negative bacteria. Therefore, essential oil from Cymbopogan pendulus essential oil may represent potential herbal treatment to mitigate bacterial infections.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123996853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Ouabain in Ehrlich Tumor Development in vitro and in vivo 瓦巴因在体外和体内对埃利希瘤发展的影响

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-16 DOI: 10.14421/biomedich.2023.121.215-224

Amanda Costa Ayres Salmeron, Maria Beatriz Calado, Mateus Da Silva Matias Antunes, G. R. Silva, D. Carvalho, Beatriz Fernandes de Souza, M. Piuvezam, S. Rodrigues-Mascarenhas

{"title":"Effects of Ouabain in Ehrlich Tumor Development in vitro and in vivo","authors":"Amanda Costa Ayres Salmeron, Maria Beatriz Calado, Mateus Da Silva Matias Antunes, G. R. Silva, D. Carvalho, Beatriz Fernandes de Souza, M. Piuvezam, S. Rodrigues-Mascarenhas","doi":"10.14421/biomedich.2023.121.215-224","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.215-224","url":null,"abstract":"Ouabain (OUA) is a cardiotonic steroid with an immunomodulatory and anti-inflammatory role in different experimental models. Currently, the potential antineoplastic effect of OUA has been studied, however, research is needed to better understand OUA role during tumor development. Therefore, our aim was to investigate the OUA effects on Ehrlich tumor (ET) development in vitro and in vivo. To evaluate the cytotoxic effects of OUA on ET in vitro the cells were incubated with different concentrations of OUA during 24h and 48h and our results showed that only the [1000 ?M] decreased the number and viability of ET cells in the two analyzed times. To study the OUA effects on ET in vivo, Swiss mice were pretreated with 0.56 mg/kg of OUA intraperitoneally (i.p.) for three consecutive days. To develop ET in the solid form, one hour after the last day of pretreatment, ET cells were inoculated subcutaneously into the footpad and the animals were monitored for 13 days. To develop the ascitic form, ET cells were inoculated (i.p.) and the animals were monitored for 3 days. OUA was able to reduce the thickness and weight of the tumor paw, in addition to reduce the weight of the popliteal lymph node. In the ascitic tumor, OUA reduced the number of neutrophils and macrophages and increased the lymphocytes in the peritoneum. Thus, we demonstrated that OUA affects ET development both in vitro and in vivo. Our results suggest a new perspective in the anti-inflammatory, immunomodulatory and a possible anti-cancer role of ouabain and brings new concepts about the pathophysiological role of this substance.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115522699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Compound in Solanum torvum and Its Potential as Functional Food and Drink: A Review torvum的生物活性成分及其作为功能性食品和饮料的潜力

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-15 DOI: 10.14421/biomedich.2023.121.205-213

Nina Nurazizah Purnomo Putri, Rista Anggriani, S. Sukardi

引用次数: 0

Comparative Cough Suppression of Chitosan Crab Extract of Uca tangeri and Dihydrocodeine 壳聚糖蟹提取物与二氢可待因抑咳作用的比较

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-14 DOI: 10.14421/biomedich.2023.121.197-203

Joshua Charles Isirima, P. O. Uahomo

{"title":"Comparative Cough Suppression of Chitosan Crab Extract of Uca tangeri and Dihydrocodeine","authors":"Joshua Charles Isirima, P. O. Uahomo","doi":"10.14421/biomedich.2023.121.197-203","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.197-203","url":null,"abstract":"Cough is an inmate primitive reflex and acts as a part of the body's immune system to protect against foreign materials from the respiratory tract. This study was done to investigate the cough suppression potential of Uca tangeri. A day before the test, guinea pigs were placed individually in a transparent chamber (60 × 36 × 60 cm) for 5 minutes before cough was induced by exposure to 15% citric acid, delivered using an Omron compressor nebulizer (rate of 0.4 ml/minutes and particle size 5?m) for 10 minutes. The animals were then monitored visually within this exposure time for cough; the latency and counts, of which, were taken as the basal values. The animals exhibiting 10 - 20 bouts of cough were selected for the study and fasted overnight but with access to water. The selected animals were randomly allotted to 5 groups (n=5 per group). The animals were treated orally thus: Group 1 was the control group and received 2 ml/kg of normal saline; group 2 received 25 mg/kg dihydrocodeine; Group 3 received 150 mg/kg extract; group 4 received 300 mg/kg extract and group 5 received 600 mg/kg of the extract. An hour after administration, they were re-exposed to citric acid aerosol (as earlier described) and the latency of cough and cough count were recorded. The procedure was repeated at hours 2 and 3 after treatment. Antitussive activity was then evaluated in each guinea-pig as the percentage reduction in the number of coughs also known as percentage suppression of cough and percentage increase in latency of cough. The results revealed that Uca tangeri exhibited a dose dependent percentage increase in cough latency period as well as percentage increase in suppression of cough which was inferior to dihydrocodeine, but significantly greater than normal saline and basal levels.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"97 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131879345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-1 as a Predictor Cytokine SARS-CoV: Article Review 白细胞介素-1作为预测SARS-CoV的细胞因子:文献综述

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-11 DOI: 10.14421/biomedich.2023.121.187-190

Lisa Savitri, E. R. Kasimo, Rochmad Krissanjaya, Syntia Tanu Juwita, Ester Lianawati Antoro, Ida Septika Wulansari

引用次数: 0

Antihypertensive Drugs Therapy in Hypertension and Covid-19 Comorbidity 降压药治疗高血压和Covid-19合并症

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-02-11 DOI: 10.14421/biomedich.2023.121.191-196

E. G. Moke, E. E. Ahama, P. Y. Toloyai, M. Enaohwo, Ekuerhare Basil, E. K. Umukoro, A. Eduviere, Ikuesirioghene Udumebraye, Choice Udufowe

引用次数: 0

Comparative Assessment of the Proximate Composition, Functional Properties and Amino Acid Profile of Dioscorea bulbifera, Dioscorea alata and Dioscorea rotundata Found in Minna, Niger State 尼日尔州明纳地区黄薯蓣、褐薯蓣和圆形薯蓣的近似组成、功能特性和氨基酸谱的比较研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-24 DOI: 10.14421/biomedich.2023.121.177-185

Eneogwe Okechukwu Godfrey, Obuye Faith, Ibrahim Izihyi Esther

{"title":"Comparative Assessment of the Proximate Composition, Functional Properties and Amino Acid Profile of Dioscorea bulbifera, Dioscorea alata and Dioscorea rotundata Found in Minna, Niger State","authors":"Eneogwe Okechukwu Godfrey, Obuye Faith, Ibrahim Izihyi Esther","doi":"10.14421/biomedich.2023.121.177-185","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.177-185","url":null,"abstract":"The proximate composition, functional properties and amino acid profile of samples of Dioscorea alata, Dioscorea rotundata and Dioscorea bulbifera were investigated using standard analytical methods. The results showed that Dioscorea alata had the highest ash (5.59±0.06 %) and crude fiber content (12.12±0.20 %), indicating that it has more mineral stuffing and is best to reduce the risk of obesity. Dioscorea rotundata had the highest fat content (11.63±0.04 %) as well as the lowest moisture content (7.04±0.06 %), indicating that it is a better source of calories and has a longer shelf-life than other yam species analysed. Dioscorea bulbifera also had the highest crude protein (8.64±0.03 %) and carbohydrates (77.51±0.08 %) than other yam species analysed, indicating high bodybuilding capacity and a better source of energy than other yam samples analysed. Dioscorea alata showed the highest bulk density (0.87±0.02 g/cm3) and swelling capacity (15.25±0.03 g/g). It is indicating its usefulness in the reduction of paste thickness and water-holding capacity of starch granules respectively while Dioscorea rotundata, showed the highest water absorption capacity (164.02±0.02 %), oil absorption capacity (149.76±0.02 %) and dispersibility (72.17±0.01 %). This indicates its importance in the consistency and bulking of products, flavour retaining in food and reconstitution of flour samples in water to give a fine consistent paste during mixing. The yam species were also rich in amino acids which are building blocks of protein. However, Dioscorea rotundata was the richest in amino acid content, as it had 36.32±0.16 g/100g and 36.49±0.16 g/100g, for essential and non-essential amino acids respectively.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129584315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biology, Medicine, &amp; Natural Product Chemistry最新文献

Biology, Medicine, & Natural Product Chemistry最新文献