Biology, Medicine, & Natural Product Chemistry最新文献_第4页

Immunoprotective Effect of Cocos nucifera Oil on Sheep Red Blood Cell-Induced Immunocompromised Rats 椰子油对绵羊红细胞免疫功能低下大鼠的免疫保护作用

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-24 DOI: 10.14421/biomedich.2023.121.159-169

M. Idu, Igori Debby, B. Gabriel

{"title":"Immunoprotective Effect of Cocos nucifera Oil on Sheep Red Blood Cell-Induced Immunocompromised Rats","authors":"M. Idu, Igori Debby, B. Gabriel","doi":"10.14421/biomedich.2023.121.159-169","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.159-169","url":null,"abstract":"The aim of this study is to investigate the immunoprotective effects of cold-pressed coconut oil in immunocompromised rat. Standard procedure was used to perform this research work with a modified method. The effect of immunomodulatory properties of coconut oil was evaluated after challenging the animals with 0.3 ml sheep red blood cells (SRBCs) intraperitoneally and further treated with graded doses (0.25, 0.5 and 1.0 ml/kg i.p) of the oil extract for 21 days. The hematological, CD4, CD8 biochemical and histopathological analysis were evaluated. Result obtained from this study showed a significant increase in hematological indexes (WBC: 11.70; LYM: 9.9 GRAN: 8.0 and HGB: 15.57) across the treated groups, but majorly at lowest dose (0.25 ml/kg). More so a significant increase in CD4 and CD8 Count specifically at 0.25 ml/kg (7.763 and 7.830). Anti-oxidant property of the oil extract at 0.25 ml/kg had a significant reduction in malondialdehyde with an increased in antioxidant enzymes (SOD, CAT and GPx) when compared with untreated control. The body weight of the animals in the treated groups showed a significant increase at 0.25 ml/kg of the oil extract when compared with the untreated control. Liver function test (ALT, AST and ALP) showed no significant increase in the treatment groups when compared with the controls. The histopathological result reveals a normal physiological structure of the heart, lungs, spleen, liver and kidney in lowest dose of the oil extract. In conclusion, this study validated the ethnomedicinal property of the plant.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128436087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lupenone Isolated from Diospyros melanoxylon Bark Non-competitively Inhibits alpha-amylase Activity 从黑梭子树皮中分离的Lupenone非竞争性抑制α -淀粉酶活性

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-24 DOI: 10.14421/biomedich.2023.121.171-176

Mohan Krishna Durgam, P. Vemuri, V. Bodiga, Sreedhar Bodiga

引用次数: 0

A New ent-kaurene Diterpenoid Isolated from Leaves of Espeletia semiglobulata Cuatrec. and its Potential Antimicrobial Activity 从半小叶柏叶中分离得到一个新的对karen二萜。及其潜在的抗菌活性

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-24 DOI: 10.14421/biomedich.2023.121.151-157

Andrés Eduardo Márquez, A. Pérez, L. Rojas, Rosa Aparicio, Freddy A Ramos, Ysbelia M Obregón, A. Usubillaga

{"title":"A New ent-kaurene Diterpenoid Isolated from Leaves of Espeletia semiglobulata Cuatrec. and its Potential Antimicrobial Activity","authors":"Andrés Eduardo Márquez, A. Pérez, L. Rojas, Rosa Aparicio, Freddy A Ramos, Ysbelia M Obregón, A. Usubillaga","doi":"10.14421/biomedich.2023.121.151-157","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.151-157","url":null,"abstract":"The fraction of the neutral extraction of the leaves of Espeletia semiglobulata Cuatrec. was subjected to chromatographic separation, it yielded four ent-kaurene type diterpenoids: three known [ent-kaur-16-en-19-al (I), ent-kaur-18-nor-16-en-4-ol (III), ent-kaur-16-en-19-ol (IV)] and a new one elucidated as ent-kaur-3-acetoxy-15-ene (II), based on the physicochemical and spectroscopic data of FTIR, GC-MS, and 1D and 2D NMR. These compounds were subjected to antimicrobial bioassay studies. This new ent-kaurene showed a significant inhibition potential against the growth of gram negative bacterial strains [Escherichia coli (ATCC 25922): 8 mm, Klebsiella pneumoniae (ATCC 23357): 10 mm, Pseudomonas aeruginosa (ATCC 27853): 8 mm], it also showed inhibition against the growth of fungal strain (Candida krusei: 8 mm), at a 2 mg/mL concentration. The compounds (I), (III) and (IV) failed to show any significant results in the antimicrobial screening against five bacterial strains [Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Klebsiella pneumoniae (ATCC 23357), Escherichia coli (ATCC 25922) y Pseudomonas aeruginosa (ATCC 27853)] and one fungal strain [Candida krusei (ATCC 6558)]. These results reveal a remarkable natural structure-activity relationship of the ent-kaurene core regarding the C-3 position (A ring of perhydrophenanthrene unit), whose oxygenation or addition of a hydrogen bond acceptor or donor group, improves the antimicrobial activity.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123717799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnobotanical Survey of Aromatic and Medicinal Plants Used in Traditional Medicine and Agri-Food in The Fez-Meknes Region 非斯-梅克内斯地区用于传统医药和农业食品的芳香和药用植物的民族植物学调查

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-14 DOI: 10.14421/biomedich.2023.121.133-141

Hamza El Finou, Nadia Salhi, Asma Halmoune, Lhoussaine El Rhaffari

{"title":"Ethnobotanical Survey of Aromatic and Medicinal Plants Used in Traditional Medicine and Agri-Food in The Fez-Meknes Region","authors":"Hamza El Finou, Nadia Salhi, Asma Halmoune, Lhoussaine El Rhaffari","doi":"10.14421/biomedich.2023.121.133-141","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.133-141","url":null,"abstract":"In order to identify the medicinal plants used in agri-food and traditional medicine by the population of Fez-Meknes region (Morocco), a floristic and ethnobotanical study was carried out in 4 provinces of this region (Fez, Meknes, Azrou, Taza). Questionnaire forms were used to survey the usual users of the plants and herbalists and to collect as much information as possible on the therapeutic and dietary use of aromatic and medicinal plants in the region. For plants used for food, our survey identified 29 species divided into 26 genera and 16 families, including herbaceous plants (70%), trees (16.60%), shrubs (10%) and bushes (3.30%). The study of the medicinal flora used in traditional medicine also allowed the inventory 81 species belonging to 47 families. Leaves are the most commonly used part and the majority of remedies were prepared in the form of infusion (47%) and decoction (26%). Among all the diseases treated, digestive diseases are the most cited (25%), followed by dermatological diseases (21%). The present study allowed us to evaluate some traditional practices used by the Fez-Meknes region population. In this context, it is essential to carry out similar investigations in other regions of the kingdom, in order to safeguard this precious natural heritage by means of a monograph that is as complete as possible and to validate the remedies and preparations identified using rigorous scientific protocols.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124255843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model 大叶乳香根乙醇提取物的植物化学、抗氧化筛选、抗伤及抗炎活性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-14 DOI: 10.14421/biomedich.2023.121.143-150

M. Idu, Anthonia Omoregbee, B. Gabriel

{"title":"Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model","authors":"M. Idu, Anthonia Omoregbee, B. Gabriel","doi":"10.14421/biomedich.2023.121.143-150","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.143-150","url":null,"abstract":"This study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in baker’s yeast-induced pyrexia in mice, analgesic property (hotplate and acetic acid-induced in mice), acute anti–inflammation (carrageenan-induce in rats) and chronic arthritis (formalin–induced in rats) on Boswellia dalzielii root ethanol extract. The phytochemical results revealed the presence of phenol, ascorbic acid, flavonoids, alkaloids, cardiac glycoside, tannin, saponin. The extract had a significant reduction in the body temperature in graded doses and 100 mg/kg paracetamol at 60 minutes when compared with the control, but 400 mg/kg was more effective (p<0.01). Morphine and plant extract showed a slight significant analgesic property at 0 and 30 minute compared to the control. The extract at 100 mg/kg elicited a significant increase at 60 and 90 minutes compared with the control, and it is comparable to 5 mg/kg morphine. The plant extract (100, 200, and 400 mg/kg) and aspirin (100mg/kg) shows significant analgesic properties compared to control (p<0.01) but 200 mg/kg of extract revealed highest percentage inhibition. The extract produced no significant reduction on carrageenan induced inflammatory at all dose level compared to control (p>0.05). The plant extract (100, 200, 400 mg/kg) and Indomethacin (1 mg/kg) reduced paw volume across the doses from day 4 compared to the control (p<0.01). The Boswellia dalzielii root extract is a promising anti–inflammatory agent, it also possesses antipyretics, and analgesics effect validating the folklore claim.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130206023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Vivo Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Solanum anomalum Leaf Extract and Fractions 龙葵叶片提取物及其组分体内α -淀粉酶和α -葡萄糖苷酶抑制活性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-13 DOI: 10.14421/biomedich.2023.121.127-132

J. Okokon, I. C. Etuk, J. Udobang, Nwakaego Omonigho Ebong

{"title":"In-Vivo Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Solanum anomalum Leaf Extract and Fractions","authors":"J. Okokon, I. C. Etuk, J. Udobang, Nwakaego Omonigho Ebong","doi":"10.14421/biomedich.2023.121.127-132","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.127-132","url":null,"abstract":"Solanum anomalum Thonn. ex Schumach. (family Solanaceae), an edible shrub whose fruits and leaves are used medicinally to treat diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (70-210 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate, methanol, 140 mg/kg) of S. anomalum were evaluated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf extract especially middle dose (140 mg/kg) and fractions (ethyl acetate and hexane) caused significant (p<0.05) reduction in blood glucose levels of treated with the various substrates used. Ethyl acetate fraction exerted the highest inhibitory effect when starch and maltose were used as substrates followed by n-hexane and methanol. n-Hexane was the most active fraction followed by ethyl acetate when sucrose was used as substrate. The results suggest that the leaf extract and fractions of S. anomalum have the potentials to inhibit alpha amylase and glucosidase in rats.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"530 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116200056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC 石竹的植物化学、抗菌和细胞毒活性

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-12 DOI: 10.14421/biomedich.2023.121.119-126

Julius Leke Abiola, O. O. Aiyelaagbe

{"title":"Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC","authors":"Julius Leke Abiola, O. O. Aiyelaagbe","doi":"10.14421/biomedich.2023.121.119-126","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.119-126","url":null,"abstract":"Strophanthus sarmentosus DC is used traditionally in the management of snake-bite, arthritis, eye infection, rheumatism, emetic and venereal diseases. Freshly collected mature Strophanthus sarmentosus plant parts were air-dried at room temperature. Each of the plant parts (leaf, stem and roots) was successively extracted by cold extraction method using hexane, ethyl acetate and methanol respectively. The crude extracts were subjected to phytochemical, antimicrobial and cytotoxicity analysis by employing chemical tests, agar diffusion and brine shrimps methods.The phytochemical screening showed the presence of tannins, saponins, glycosides, flavonoids, phenols, steroids, terpenoids and carbohydrates in all the extracts. The extracts demonstrated broad spectrum activities against both gram- positive and gram-negative bacteria and the fungi tested. The MIC and MMC of ethyl acetate and methanol extracts of the S. sarmentosus (stem) is between 0.3 and 5.0 mg/mL. The cytotoxic activity (LC50) of the S. sarmentosus extracts (leaf, stem and root) ranged between 117 µg/mL and 270 µg/mL, showing that the extracts are within the medium toxic level according to Clarkson’s toxicity index. ","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124813764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Antibacterial Activity of Pomegranate Extract (Punica granatum L.) in Lip Balm Formulation 石榴提取物在润唇膏配方中的抗氧化和抗菌活性

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-11 DOI: 10.14421/biomedich.2023.121.109-117

Maria Grasela Kase, Aniek Prasetyaningsih, Dwi Aditiyarini

引用次数: 0

Potential Inhibition of ACE2 Membrane Protein by Flavone Glycosides for Blocking Entrance of SARS- CoV-2 into the Cells; a Computational Study 黄酮类苷对ACE2膜蛋白阻断SARS- CoV-2进入细胞的潜在抑制作用a计算研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-01-10 DOI: 10.14421/biomedich.2023.121.97-108

Ahsan Ibrahim, Ehtisham Ul Haq

{"title":"Potential Inhibition of ACE2 Membrane Protein by Flavone Glycosides for Blocking Entrance of SARS- CoV-2 into the Cells; a Computational Study","authors":"Ahsan Ibrahim, Ehtisham Ul Haq","doi":"10.14421/biomedich.2023.121.97-108","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.97-108","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), since its emergence in Wuhan city of China in late 2019, had been a dilemma for the global healthcare system. Humongous efforts have been put in ascertaining the effective treatments for attenuation of the spread of corona virus disease (COVID-19) pandemic. The aim of this research study is to probe the potential inhibition of angiotensin converting enzyme 2 (ACE2) membrane protein by well-known flavone glycosides, hence preventing the binding of spike proteins with ACE2 and subsequent prevention of entry of SARS- CoV-2 inside the cells. The molecular docking analysis, for total ten flavone glycosides was carried out, that laid out propitious results in terms of binding energies towards the active residues of ACE2 protein with a range of -9.3 to -7.1 kcal/mol. The molecular dynamics simulation also yielded promising outcomes. The in-silico toxicity analysis of all the potential drug candidates was carried out that revealed that all the compounds were non-toxic and safe. Studies may be required for optimum formulation development using these compounds as a part of drug discovery and development phenomenon. This study may play a vital part in exploration of natural compounds in pharmacotherapy of COVID-19.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121804781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiotoxicity Effects of Herbal Medicine, A Review Article 中草药的心脏毒性作用，综述文章

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-12-13 DOI: 10.14421/biomedich.2023.121.89-96

S. Gavanji

{"title":"Cardiotoxicity Effects of Herbal Medicine, A Review Article","authors":"S. Gavanji","doi":"10.14421/biomedich.2023.121.89-96","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.89-96","url":null,"abstract":"With the development of human's modern society more and more people tend to use complementary and alternative medicine (CAM). Toxicological studies indicated that many herbal medicines have direct toxic effects on the circulatory system or cardiovascular system and cause harmful effects on the body. Cardiotoxicity or heart damage is a serious issue defined as heart electrophysiology dysfunction, affecting the cardiac structure, and muscle damage that arises from the drug or chemical poisoning agents, that may lead to heart failure. The aim of this review article is to provide various information about the potential adverse effects of herbal medicine on the cardiovascular system and introduce herbs that induced cardiac toxicity. To provide this review, all reported cases of cardiac toxicity induced by herbal medicines and natural products were collected through research articles and documents, and the most relevant articles, and books in various authentic search engines including Scopus, PubMed, SID (scientific information database), Science Direct and Google Scholar, from 1984 to April 2022 were searched, and selected herbs with therapeutic properties which induce toxic effects on the cardiovascular system are introduced. In this review, scientific data regarding cardiotoxicity showed that 16 herbs from 11 families may increase cardiac toxicity. Therefore, it's important to use herbal medicines and natural products under the guidance of medical professionals.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132185644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biology, Medicine, &amp; Natural Product Chemistry最新文献

Biology, Medicine, & Natural Product Chemistry最新文献