The American Journal of Gastroenterology最新文献

{"title":"S140 Metastatic Crohn’s Disease in a Patient in Deep Remission","authors":"Caio Cesar Furtado Freire, Milena Santana Girão, Arthur Alencar Arrais de Souza, Ricardo Alves Martins, Eliseu Sousa do Amaral Júnior, Carla Mendes Abreu, Mariana Tomaz. Pinheiro","doi":"10.14309/01.ajg.0000996304.33301.9b","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996304.33301.9b","url":null,"abstract":"Background: Serum assays to measure biologic drugs, especially TNF inhibitors, and their anti-drug antibodies (ADAb) are utilized to manage suboptimal response including that caused by reversible immunogenicity and to proactively titrate doses and dosing intervals. Here, 72,819 in fl iximab (IFX) and 53,131 adalimumab (ADL) recent patient results were analyzed. Methods: Drug and ADAb levels are measured by drug-speci fi c lab-developed chemiluminescent immunoassays. Lower limits of quantitation are 0.4 and 0.6 ug/mL for IFX and ADL, and 22 and 25 ng/mL for respective ADAb assays. Drug assays measure free (ADAb-unbound) biologic drug (validated for originator as well as biosimilars) while ADAb assays detect total antibodies (including IgM & IgG subtypes) and are drug-tolerant to the presence of up to . 50 m g/mL drug. All ADAb positive samples undergo a con fi rmatory step to con fi rm the drug speci fi city of antibodies. Results: Of a total of 72,819 IFX and 53,131","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"69 2","pages":"S37 - S37"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S26 Clinical Practice Experience With Subcutaneous Vedolizumab for the Treatment of Patients With Ulcerative Colitis and Crohn’s Disease","authors":"Kirk Russ, Abigail Wojtowicz, Lisa Young, Anita Afzali","doi":"10.14309/01.ajg.0000995840.58130.4f","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995840.58130.4f","url":null,"abstract":"Background","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"235 ","pages":"S8 - S8"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S38 Efficacy and Safety of Nonmedical Switching From Infliximab Originator to Infliximab Biosimilar CT-P13 in Patients With Inflammatory Bowel Disease, A Single-Center Prospective Study in Japan","authors":"T. Takeda, Atsushi Takahashi, Hiroyuki Mikumo, Ken Kinjo, Shigeyoshi Yasukawa, Akihiro Koga, N. Takatsu, T. Hisabe, Hisatomi Arima, So Imakiire, Eri Yamauchi, Kenshi Yao, Fumihito Hirai","doi":"10.14309/01.ajg.0000995888.93815.3f","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995888.93815.3f","url":null,"abstract":"and adalimumab (0.003), and ustekinumab/vedolizumab (0.002). We also looked at outcomes of the patients who had HF as an adverse event due to biologics, including hospitalizations and it showed it was highest with adalimumab,followed by In fl iximab and vedolizumab. The other outcome we looked at was mortality for patients who had HF with biologics, it was highest in patients who had used adalimumab, followed by In fl iximab and ustekinumab. Conclusions: Our study adds further to the literature regarding biologics adverse events, speci fi cally heart failure. Tofacitinib had the highest ratio of heart failure among all adverse e ff ects, followed by the already-established In fl iximab. All other newer biologics had a relatively lower ratio. Despite tofacitinibhavingthehighestratioforheartfailure,wecannotattributesigni fi cancetothisduetothis drug having only one reported case compared to other drugs. Furthermore, we can conclude that newer biologics have a relatively very small ratio for the risk of heart failure compared to In fl iximab. Further data is needed for the newer biologics.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"48 1","pages":"S11 - S11"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S34 Intestinal Ultrasound to Assess Clinical Response After Induction With Upadacitinib in Acute Severe Ulcerative Colitis","authors":"Lindsey Shipley, Kirk Russ, Mohd Zahid, Mohamed Ismail","doi":"10.14309/01.ajg.0000995872.32570.7e","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995872.32570.7e","url":null,"abstract":"his weight had increased from 127 to 149 pounds, he was experiencing a clinical remission and down to 15mg prednisone daily. At 3 month follow up he was in steroid free clinical remission. Conclusions: UPA is e ff ective in achieving rapid clinical response assessed by improvement in the bowel wall thickness and vascularity on IUS in a patient with ASUC. This case report is the fi rst to show treatment response after induction with UPA in a patient with ASUC with IUS as an objective tool, o ff ering an additional non-invasive, cost-e ff ective method for monitoring disease activity as well as an alternative salvage treatment in those with ASUC who fail anti-TNF medications. Further prospective studies are needed to assess e ff ectiveness of UPA in ASUC as well as IUS monitoring in this population.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"33 7","pages":"S10 - S10"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S149 Role of the Nurse in a Center of Excellence in Inflammatory Bowel Disease in Colombia","authors":"V. Parra-izquierdo, J. Frías-Ordoñez, Ginary Orduz-Diaz, Juliep Sarmiento-Navarro, Silvia Hoyos-Rondon, Luis-enrique Bohorquez, Diego-Fernando Cano, Ó. Pinto-Saavedra, Alexis Duarte, C. Cuadros, John Garces, Juan Javier Acevedo, Andres Barco, C. Flórez-Sarmiento","doi":"10.14309/01.ajg.0000996340.19201.a4","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996340.19201.a4","url":null,"abstract":"Questionnaire","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"155 ","pages":"S40 - S40"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S103 Proximal Small Bowel Crohn’s Disease is Associated With More Severe Injury and Need for Treatment With Biologics","authors":"Joao Carlos Goncalves, C. Arieira, S. Xavier, J. Magalhães, M. Moreira, B. Rosa, J. Cotter","doi":"10.14309/01.ajg.0000996156.61174.a0","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996156.61174.a0","url":null,"abstract":"Background: Pediatric in fl ammatory bowel disease (IBD), de fi ned as diagnosis before the age of 19, has garnered increasing attention due to its potential implications for disease outcomes. Evidence suggests that the age of disease manifestation might in fl uence disease progression. There are very few reports of pediatric-onset IBD in Hispanics. This study aims to characterize pediatric onset of Crohn ’ s disease (CD) in a cohort of Hispanics and compare it to adult-onset CD subjects. Methods: The UPR Registry of IBD is an ongoing database actively recruiting participants since 1995. A cohort of 322 patients with con fi rmed CD recruited between 2002 and 2022 was analyzed. Subjects were categorized into pediatric ( # 18 years) and adult diagnosis ( . 19 years) cohorts. Univariate analysis was employed for population description. Categorical variables were compared via Chi2 test, while continuous variables were compared using Wilcoxon rank-sum test. Statistical signi fi cance was set at p , 0.05. The study is approved by the MSC-IRB. Results: 322 CD patients, 126 with pediatric diagnosis and 196 with adult diagnosis were included. Gender distribution, phenotype, location, hospitalizations, and surgery exhibited no signi fi cant differences (p 5 0.164,p 5 0.365, p 5 0.780, p 5 0.490, p 5 0.741, respectively). Family historyof IBD showed a trend towards signi fi cance (p 5 0.074). Pediatric patients experienced a shorter delay in diagnosis (1.2 years) compared to adults (3.7 years). The presence of extraintestinal manifestations (EIMs) showed a signi fi cant association with age at diagnosis (p 5 0.012), with pediatric subjects exhibiting a higher prevalence of EIMs (22.2%) compared to adults (11.7%). Perianal disease was signi fi cantly higher (p 5 0.039), in pediatric subjects (38.8%) than in adults (26.5%). Conclusions: This study of a Hispanic cohort of patients with IBD reveals some signi fi cant associations in disease characteristics linked to a diagnosis of CD in childhood. The higher prevalence of EIMs and perianal disease, and a shorter diagnostic delay in the pediatric group represent important di ff erences from adults. More studiesare needed to explore therole of childhoodonset in thisdisease and to guide management of this vulnerable population.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"111 ","pages":"S28 - S28"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S116 Validation of an Automated Data Collection Method of Inflammatory Bowel Disease Medications in the National Veterans Affairs Healthcare System","authors":"Saffia Bajwa, P. Sinh, Katherine Sherman, Julie Lorscheter, Paraj Patel, Colleen Veenendaal, Mary Whooley, Katherine Hoggatt, Salim Virani, Shirley Cohen-Mekelburg, Eman Mansoor, Raymond Cross, Jeffrey Whittle, Jason Hou","doi":"10.14309/01.ajg.0000996208.00566.51","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996208.00566.51","url":null,"abstract":") after sustained clinical remission. Our aim was to directly compare the outcomes between LDA monotherapy and NST in this setting. Methods: Our investigation has retrospectively included patients with small bowel CD (Montreal classi fi cation L1 6 L4) in corticosteroid-free remission, who were previously medicated with azathi-oprine in monotherapy, and posteriorly LDA or NST. A minimal follow-up period of 24 months was required.Patientswithpreviousbiologicorsurgicaltherapieswereexcluded.Themeasuredoutcomes were the probability of maintaining clinical (need for therapeutic step-up) and biochemical (C-reactive protein and fecal calprotectin) remission, as well as the occurrence of infections during the follow-up period. Results: Fifty patients were included, from which 17 (34%) were females, with a mean age of 43 6 11 years.Fromthese,29(58%)wereunderNSTforCD,while21(42%)wereunderLDA.Nostatistically signi fi cant di ff erences were found regarding the need for therapeutic step-up (6.9% NST vs 9.5% LDA;p 5 0.564),aswellasbiochemicalremission(C-reactiveproteinat1yearp","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"122 ","pages":"S31 - S31"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139018150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S30 Disparities in Clinical Outcomes Between Younger and Older IBD Patients With Respect to Insurance Status: An Analysis of the National Inpatient Sample 2016-2020","authors":"C. Chhoun, Fanchen Zhou, Marisa Pope, David J. Truscello, N. Dasu, Yaser Khalid, Jianle Gao","doi":"10.14309/01.ajg.0000995856.55191.a5","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995856.55191.a5","url":null,"abstract":",","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"122 1","pages":"S9 - S9"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S7 Efficacy of Upadacitinib in Patients With One or More Prior Surgical Procedures for Crohn’s Disease: A Post Hoc Analysis of U-EXCEL, U-EXCEED, and U-ENDURE Phase 3 Trials","authors":"Edward V. Loftus, Miguel Regueiro, B. Sands, Fernando Magro, Peter Lakatos, Ana Lacerda, Brooke Kim, John Liu, Samuel I. Anyanwu, K. Kligys, Andrew Garrison, Tim Raine, Gary R. Lichtenstein","doi":"10.14309/01.ajg.0000995764.89379.2a","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995764.89379.2a","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"91 2","pages":"S3 - S3"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S31 Anti-TNF Therapy in Elderly Patients With Inflammatory Bowel Disease in a Tuberculosis-Endemic Country","authors":"L. Barros, Matheus Freitas Cardoso de Azevedo, Alexandre de Souza Carlos, Paula De Azevedo Lopes, Andre Okuhara Fujita, Daniela Sanches Brito, Daniela Midori Kamada, Rita de Cássia Parente Prado, Julia Carvalho De Andrade, J. Oba, Aderson Omar Mourão Cintra Damião","doi":"10.14309/01.ajg.0000995860.28083.ae","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995860.28083.ae","url":null,"abstract":",","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"72 ","pages":"S9 - S9"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}