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S1 Risankizumab Versus Ustekinumab in Patients With Moderate to Severe Crohn’s Disease: Results From the Phase 3B SEQUENCE Trial S1 Risankizumab 对比 Ustekinumab 治疗中重度克罗恩病患者：3B期SEQUENCE试验结果
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995740.88073.c5
L. Peyrin-Biroulet, Casey Chapman, J. Colombel, F. Caprioli, G. D’Haens, M. Ferrante, S. Schreiber, R. Atreya, S. Danese, James O. Lindsay, P. Bossuyt, B. Siegmund, Peter M. Irving, R. Panaccione, E. Neimark, Kori L Wallace, Toni Anschutz, K. Kligys, W. Duan, V. Pivorunas, Xiu Huang, S. Berg, Lei Shu, Marla C. Dubinsky
{"title":"S1 Risankizumab Versus Ustekinumab in Patients With Moderate to Severe Crohn’s Disease: Results From the Phase 3B SEQUENCE Trial","authors":"L. Peyrin-Biroulet, Casey Chapman, J. Colombel, F. Caprioli, G. D’Haens, M. Ferrante, S. Schreiber, R. Atreya, S. Danese, James O. Lindsay, P. Bossuyt, B. Siegmund, Peter M. Irving, R. Panaccione, E. Neimark, Kori L Wallace, Toni Anschutz, K. Kligys, W. Duan, V. Pivorunas, Xiu Huang, S. Berg, Lei Shu, Marla C. Dubinsky","doi":"10.14309/01.ajg.0000995740.88073.c5","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995740.88073.c5","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"193 ","pages":"S1 - S1"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S4 Risankizumab Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Efficacy and Safety in the Randomized Phase 3 INSPIRE Study S4 利桑珠单抗对中度至重度活动性溃疡性结肠炎患者的诱导治疗：随机 3 期 INSPIRE 研究的疗效和安全性
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995752.19097.c8
É. Louis, R. Panaccione, Gareth Parkes, Laurent Pevrin-Biroulet, M. Ferrante, Ken Takeuchi, B. Siegmund, Phillip Levine, J. Kalabic, E. Neimark, Kori L Wallace, Su Chen, W. Duan, Alessandro Armuzzi, L. Biedermann, Edward V. Loftus, G. Melmed, S. Schreiber
{"title":"S4 Risankizumab Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis: Efficacy and Safety in the Randomized Phase 3 INSPIRE Study","authors":"É. Louis, R. Panaccione, Gareth Parkes, Laurent Pevrin-Biroulet, M. Ferrante, Ken Takeuchi, B. Siegmund, Phillip Levine, J. Kalabic, E. Neimark, Kori L Wallace, Su Chen, W. Duan, Alessandro Armuzzi, L. Biedermann, Edward V. Loftus, G. Melmed, S. Schreiber","doi":"10.14309/01.ajg.0000995752.19097.c8","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995752.19097.c8","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"50 11","pages":"S2 - S2"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S131 Respiratory Manifestations in Patients With Inflammatory Bowel Disease in a Reference Center in Salvador, Bahia, Brazil S131 巴西巴伊亚州萨尔瓦多市一家参考中心的炎症性肠病患者的呼吸系统表现
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996268.57085.92
F. Fortes, N. Almeida, Erick Nery, Lara Arenas, Gabriela Sousa, Ana Maria Santos, Julia Gonçalves, Clara Freitas, Andrea Pimentel, Jaciane Fontes, V. Surlo, Eduardo Netto, G. Santana
{"title":"S131 Respiratory Manifestations in Patients With Inflammatory Bowel Disease in a Reference Center in Salvador, Bahia, Brazil","authors":"F. Fortes, N. Almeida, Erick Nery, Lara Arenas, Gabriela Sousa, Ana Maria Santos, Julia Gonçalves, Clara Freitas, Andrea Pimentel, Jaciane Fontes, V. Surlo, Eduardo Netto, G. Santana","doi":"10.14309/01.ajg.0000996268.57085.92","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996268.57085.92","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"312 ","pages":"S35 - S35"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S43 Development of a Protocol to Induce Quiescence in In Vitro Culture of CCD-18 Colonic Fibroblasts S43 在 CCD-18 结肠成纤维细胞体外培养中诱导衰老的方案开发
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995912.96332.4b
Zahra Mohammadalizadeh, Ana Maria Porras
{"title":"S43 Development of a Protocol to Induce Quiescence in In Vitro Culture of CCD-18 Colonic Fibroblasts","authors":"Zahra Mohammadalizadeh, Ana Maria Porras","doi":"10.14309/01.ajg.0000995912.96332.4b","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995912.96332.4b","url":null,"abstract":", immunohistochemical staining for IgG4 was performed on the patient ’ s colon biopsies, which revealed a high percentage of the IgG cells in the lamina propria with . 50% positivity for IgG4. This con fi rmed the patient ’ s IgG4 mediated colitis, and he has now started rituximab therapy. Conclusions: We demonstrate a case of IgG4-RD misclassi fi ed as CD and GPA and emphasize the importance of consideration of this rare disorder in appropriate patients. Clinical follow-up and response to rituximab will be described at the time of this case presentation.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"489 ","pages":"S12 - S12"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S70 Real-World Experience and Perspectives on the Treatment of Crohn’s Disease: Results From a Health Care Provider Survey S70 克罗恩病治疗的实际经验和观点：医疗服务提供者调查结果
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996024.15400.5e
C. Chhoun, Jianle Gao, Fanchen Zhou, Marisa Pope, David J. Truscello, N. Dasu, Yaser Khalid
{"title":"S70 Real-World Experience and Perspectives on the Treatment of Crohn’s Disease: Results From a Health Care Provider Survey","authors":"C. Chhoun, Jianle Gao, Fanchen Zhou, Marisa Pope, David J. Truscello, N. Dasu, Yaser Khalid","doi":"10.14309/01.ajg.0000996024.15400.5e","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996024.15400.5e","url":null,"abstract":"wounddehiscenceand smallbowelobstruction when compared to patients without IBD. When comparing di ff erent types of RT, one study con-fi","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"31 3","pages":"S19 - S20"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138987068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S25 Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Impact of Moderate to Severe Crohn’s Disease Symptoms on Health Care Professional Treatment Decisions in the United States and Europe S25 沟通 IBD 体验的需求和特征 (CONFIDE) 调查：美国和欧洲中重度克罗恩病症状对医护人员治疗决定的影响
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995836.97423.bc
Marla C. Dubinsky, T. Gibble, Simon Travis, R. Panaccione, T. Hibi, A. Bleakman, Tommaso Panni, C. Kayhan, Angelo D. Favia, C. Atkinson, S. Schreiber, David T. Rubi
{"title":"S25 Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Impact of Moderate to Severe Crohn’s Disease Symptoms on Health Care Professional Treatment Decisions in the United States and Europe","authors":"Marla C. Dubinsky, T. Gibble, Simon Travis, R. Panaccione, T. Hibi, A. Bleakman, Tommaso Panni, C. Kayhan, Angelo D. Favia, C. Atkinson, S. Schreiber, David T. Rubi","doi":"10.14309/01.ajg.0000995836.97423.bc","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995836.97423.bc","url":null,"abstract":"Background","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"20 ","pages":"S7 - S8"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S86 Findings in Magnetic Resonance Enterography and Experience With Maria Score Assessment in a Colombian Inflammatory Bowel Disease Referral Center: Observational Study S86 哥伦比亚炎症性肠病转诊中心的磁共振肠造影结果和玛利亚评分评估经验：观察性研究
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996092.66504.a2
V. Parra-izquierdo, J. Frías-Ordoñez, Alexis Duarte, Ginary Orduz-Diaz, Silvia Hoyos-Rondon, Luis-enrique Bohorquez, Diego-Fernando Cano, Ó. Pinto-Saavedra, C. Flórez-Sarmiento, C. Cuadros, Juan Javier Acevedo, Andres Barco
{"title":"S86 Findings in Magnetic Resonance Enterography and Experience With Maria Score Assessment in a Colombian Inflammatory Bowel Disease Referral Center: Observational Study","authors":"V. Parra-izquierdo, J. Frías-Ordoñez, Alexis Duarte, Ginary Orduz-Diaz, Silvia Hoyos-Rondon, Luis-enrique Bohorquez, Diego-Fernando Cano, Ó. Pinto-Saavedra, C. Flórez-Sarmiento, C. Cuadros, Juan Javier Acevedo, Andres Barco","doi":"10.14309/01.ajg.0000996092.66504.a2","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996092.66504.a2","url":null,"abstract":"speci","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"675 ","pages":"S24 - S24"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S77 Safety and Efficacy of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) in Older Patients With Recurrent Clostridioides difficile Infection: Findings From an Integrated Analysis of Phase 3 Trials S77 粪便微生物群孢子活菌-brpk（原 SER-109）对复发性艰难梭菌感染老年患者的安全性和有效性：3期试验的综合分析结果
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996052.73742.a6
Bret Lashner, Lisa von Moltke, A. de, Darrell Pardi
{"title":"S77 Safety and Efficacy of Fecal Microbiota Spores, Live-brpk (Formerly SER-109) in Older Patients With Recurrent Clostridioides difficile Infection: Findings From an Integrated Analysis of Phase 3 Trials","authors":"Bret Lashner, Lisa von Moltke, A. de, Darrell Pardi","doi":"10.14309/01.ajg.0000996052.73742.a6","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996052.73742.a6","url":null,"abstract":"of drug-induced","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"652 ","pages":"S21 - S21"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S139 Exploring Novel Immunologic or Microbiologic Mechanisms Leading to Iron Deficiency in Quiescent Pediatric Crohn’s Disease S139 探索导致静止期小儿克罗恩病缺铁的新型免疫学或微生物学机制
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996300.14758.d9
Elliott Gordon, Jennifer Lentine, Charlene Thomas, Linda M Gerber, R. Sockolow, Gregory F. Sonnenberg
{"title":"S139 Exploring Novel Immunologic or Microbiologic Mechanisms Leading to Iron Deficiency in Quiescent Pediatric Crohn’s Disease","authors":"Elliott Gordon, Jennifer Lentine, Charlene Thomas, Linda M Gerber, R. Sockolow, Gregory F. Sonnenberg","doi":"10.14309/01.ajg.0000996300.14758.d9","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996300.14758.d9","url":null,"abstract":"Background: Serum assays to measure biologic drugs, especially TNF inhibitors, and their anti-drug antibodies (ADAb) are utilized to manage suboptimal response including that caused by reversible immunogenicity and to proactively titrate doses and dosing intervals. Here, 72,819 in fl iximab (IFX) and 53,131 adalimumab (ADL) recent patient results were analyzed. Methods: Drug and ADAb levels are measured by drug-speci fi c lab-developed chemiluminescent immunoassays. Lower limits of quantitation are 0.4 and 0.6 ug/mL for IFX and ADL, and 22 and 25 ng/mL for respective ADAb assays. Drug assays measure free (ADAb-unbound) biologic drug (validated for originator as well as biosimilars) while ADAb assays detect total antibodies (including IgM & IgG subtypes) and are drug-tolerant to the presence of up to . 50 m g/mL drug. All ADAb positive samples undergo a con fi rmatory step to con fi rm the drug speci fi city of antibodies. Results: Of a total of 72,819 IFX and 53,131","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"134 ","pages":"S37 - S37"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S130 Use of Anti-TNF Agent in Refractory Ulcerative and CMV Colitis: A Case Report S130 抗肿瘤坏死因子制剂在难治性溃疡性结肠炎和 CMV 结肠炎中的应用：病例报告
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996264.69934.09
Jered S. Schenk, Erin Forster, Yadis Arroyo
{"title":"S130 Use of Anti-TNF Agent in Refractory Ulcerative and CMV Colitis: A Case Report","authors":"Jered S. Schenk, Erin Forster, Yadis Arroyo","doi":"10.14309/01.ajg.0000996264.69934.09","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996264.69934.09","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"110 ","pages":"S35 - S35"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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