Mycoses最新文献

{"title":"New Insights on Transmission of Sporothrix brasiliensis.","authors":"Regielly C R Cognialli, Flávio Queiroz-Telles, Alyson M Cavanaugh, Bruno C Rediguieri, Giovanna C D Santos, Felipe Moreira Matias, Luciano Moreira Filho, Elias N Monteiro Neto, Mônica Surek, Vânia A Vicente, Izabella C R Santos-Weiss","doi":"10.1111/myc.70047","DOIUrl":"https://doi.org/10.1111/myc.70047","url":null,"abstract":"<p><strong>Background: </strong>Sporotrichosis is the most prevalent saprozoonotic implantation mycosis worldwide.</p><p><strong>Objectives: </strong>A prospective experimental study was performed to evaluate persistence on surfaces such as stainless steel medium-density fiberboard (MDF) wood, tile, and polyester fabric.</p><p><strong>Methods: </strong>The different surfaces were homogeneously contaminated using the yeast phase of Sporothrix brasiliensis. Fungal culture was carried out in triplicate on Mycosel agar, at time 0 and then every 24 h, until 792 h (33 days).</p><p><strong>Results: </strong>Sporothrix brasiliensis persists on MDF wood for up to 240 h (10 days), tile for 288 h (12 days), polyester fabric for 384 h (16 days), and stainless steel for up to 600 h (25 days).</p><p><strong>Conclusions: </strong>Based on these findings, in concordance with published clinical reports suggesting fomite transmission, we propose an updated schematic of S. brasiliensis transmission. This is the first in vitro study about the persistence of S. brasiliensis on different surfaces, which is essential to understand transmission routes for a One Health Approach.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70047"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrections to \"Epidemiology of Vulvovaginal Candidiasis in Greece: A 2-Year Single-Centre Study\".","authors":"","doi":"10.1111/myc.70036","DOIUrl":"https://doi.org/10.1111/myc.70036","url":null,"abstract":"","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70036"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Paediatric European Confederation of Medical Mycology (ECMM) Quality (Paed-EQUAL) Candida Score for the Management of Candidaemia in Children and Neonates.","authors":"Abhijit M Bal, Zoi Dorothea Pana, Fabianne Carlesse, Aleksandra Marek, Danila Seidel, Katrin Mehler, Sarina Butzer, Rosanne Sprute, Jannik Stemler, Daniel Ludwig-Bettin, Andreas H Groll, Oliver A Cornely, Sibylle C Mellinghoff","doi":"10.1111/myc.70041","DOIUrl":"https://doi.org/10.1111/myc.70041","url":null,"abstract":"<p><p>Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug-resistant species such as Candida auris, which is associated with outbreaks. Guidelines on the management of candidaemia emphasise identification of species and determination of antifungal susceptibility to guide appropriate treatment, performing relevant investigations to rule out deep-seated infection, and removal of central venous catheters. However, it is difficult to apply guidelines in routine practice. The European Confederation of Medical Mycology candidaemia scoring tool (the EQUAL score) has facilitated adherence to guidelines by using a point-based system. We have designed a point-based paediatric EQUAL (paed-EQUAL) score tool for the management of candidaemia in neonates and children. The paed-EQUAL scoring tool can be applied to improve guideline adherence and facilitate antifungal stewardship.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70041"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest Computed Tomography Findings of Disseminated Histoplasmosis in Advanced HIV Disease.","authors":"Alessandro C Pasqualotto, Lisandra S Damasceno, Terezinha M J S Leitao, Renata B A Soares, Cassia S M Godoy, Marineide Melo, Felipe Schutz, Bruno Hochhegger","doi":"10.1111/myc.70046","DOIUrl":"https://doi.org/10.1111/myc.70046","url":null,"abstract":"<p><strong>Background: </strong>Disseminated histoplasmosis is a severe and often fatal opportunistic infection, particularly among individuals with advanced HIV disease (AHD). Despite its significance, diagnosis is often delayed due to nonspecific clinical and imaging findings, as well as the limitations of classical diagnostic methods.</p><p><strong>Objectives: </strong>This study aimed to evaluate the chest computed tomography (CT) findings in patients with disseminated histoplasmosis and AHD to provide insights into the radiological patterns associated with this condition.</p><p><strong>Patients/methods: </strong>A total of 38 patients from a phase II clinical trial on liposomal amphotericin B were included based on the availability of high-resolution chest CT scans. Images were analysed by two radiologists, focusing on lung abnormalities such as nodules, ground-glass attenuation and lymphadenopathy. Clinical presentations, co-infections and other systemic findings were also documented.</p><p><strong>Results: </strong>The patients were predominantly male (78.9%) with a median age of 37.8 years. Severe immunosuppression was noted, with a median CD4 count of 22 cells/mm³. Pulmonary symptoms were present in 65.8% of patients, while 73.7% reported significant weight loss. All patients had abnormal chest CT findings, with small miliary nodules (89.5%) and ground-glass attenuation (86.8%) being the most common. Large nodules were seen in 73.8% and cavitated nodules in 26.3%. Mediastinal lymphadenopathy was observed in 84.2% of cases, and pleural effusions in 23.7%. Co-infections were detected in 36.8% of the patients.</p><p><strong>Conclusions: </strong>Chest CT findings in disseminated histoplasmosis are variable and often nonspecific, complicating diagnosis. The presence of diffuse micronodular patterns should raise suspicion for histoplasmosis in endemic regions, particularly among immunocompromised individuals.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70046"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Phenotypes in Patients With Invasive Mould Infection Support the Use of PD-1 Inhibition as Potential Treatment Option.","authors":"Sibylle C Mellinghoff, Martin Thelen, Michael von Bergwelt-Baildon, Hans A Schlößer, Oliver A Cornely, Rosanne Sprute, Jannik Stemler, Leonie Mayer, Leonie Marie Weskamm, Monika Friedrich, My Linh Ly, Christine Dahlke, Marylyn M Addo","doi":"10.1111/myc.70044","DOIUrl":"10.1111/myc.70044","url":null,"abstract":"<p><strong>Background: </strong>Invasive mould infections (IMI) cause substantial morbidity and mortality in populations at risk. Novel treatment approaches are urgently needed. Targeting immune checkpoints may reverse hyporesponsiveness of the innate and adaptive immune systems.</p><p><strong>Methods: </strong>In this prospective, observational study, we investigated immune checkpoint expression levels on immune cells in patients with invasive aspergillosis (IA; n = 25) and mucormycosis (MU; n = 7). Healthy controls (HC; n = 5) and patients with matched haematological diseases but without IMI served as control populations (CP; n = 10). Multicolour flow cytometry analysis was used to compare immune cell subsets and the expression of immune-regulatory molecules in peripheral blood mononuclear cells (PBMCs).</p><p><strong>Results: </strong>Lymphocyte subsets and immune phenotypes in PBMCs were similar between patients with IMI and haematological CP, except for regulatory T cells, which were increased in PBMCs of patients with IA and MU compared to HCs. In IA and MU, PBMCs showed increased expression of immune checkpoint molecules compared to healthy controls and matched haematological CP, with this effect being more pronounced in IA than in MU. We found heterogeneous, disease-, molecule-, and patient-specific expression patterns of immune checkpoint molecules. For example, PD-1 expression was highest in MU PBMCs, followed by IA PBMCs, while HC PBMCs showed lower expression levels. Overall mortality in our patient population was 44.0% (IPA) and 80.0% (MU).</p><p><strong>Conclusions: </strong>We report an immune phenotype consistent with T-cell exhaustion in IMI, indicating potential contributions from haematological treatment, underlying disease, and infection. However, the primary underlying cause remains unclear and requires further investigation. A marker that was notably higher in IMI patients was PD-1, and treatment approaches specifically targeting this molecule may be promising.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70044"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Niosomal Gel for Topical Delivery of Miltefosine Against Trichophyton indotineae Dermatophytosis in Animal Model.","authors":"Iman Haghani, Fatemeh Khosravi Ebrahimi, Mahdi Abastabar, Robab Ebrahimi Barough, Fereshteh Talebpour Amiri, Mohammad Taghi Hedayati, Narges Vaseghi, Javad Javidnia, Mohsen Nosratabadi, Zahra Yahyazadeh, Lotfollah Davoodi, Tahereh Shokohi, Maryam Moazeni, Akbar Hoseinnejad, Pedram Ebrahimnejad, Gholamreza Houshmand, Hamid Badali, Seyyed Mobin Rahimnia","doi":"10.1111/myc.70045","DOIUrl":"https://doi.org/10.1111/myc.70045","url":null,"abstract":"<p><strong>Introduction: </strong>Dermatophytosis, a cutaneous fungal infection worldwide, is generally localised to the skin's superficial layers and keratinised structures. Although most agents are susceptible to current antifungal drugs available in clinical settings, frequent relapses and failures, especially in cases due to Trichophyton indotineae, have been frequently reported. Therefore, alternative targets and therapeutic approaches are highly required. In the present study, we compared the efficacies of terbinafine with conventional and niosomal forms of miltefosine (MFS) against dermatophytosis in the guinea pig model.</p><p><strong>Material and methods: </strong>Initially, 30 guinea pigs were divided into five groups (e.g., untreated control, treated groups by MFS niosomal gel 1%, MFS gel 1%, terbinafine 1% and niosome) and were infected with terbinafine-resistant Trichophyton indotineae and subsequently scored both clinically and mycologically until day 35 of inoculation. MFS was encapsulated into niosomes, elastic vesicles made of non-ionic surfactants that enhance drug delivery through the skin.</p><p><strong>Results: </strong>Results showed that the MFS niosomal gel 1% significantly reduced lesion scores, mycological evidence of infection and inflammation compared to the untreated control and terbinafine-treated groups (p < 0.05). Moreover, the lesion score in the niosomal gel and terbinafine groups did not differ from the untreated control (p > 0.05). Histopathological analysis confirmed reduced epidermal thickening and fungal burden in treated models with the MFS niosomal gel 1%.</p><p><strong>Conclusion: </strong>The findings highlighted MFS niosomal gel 1% as a potentially effective, targeted therapy for drug-resistant T. indotineae, offering a safer and more effective alternative to topical and oral antifungal treatments. However, further studies are warranted to continue correlating these findings with more clinical outcomes.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 3","pages":"e70045"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Bronchopulmonary Aspergillosis in Patients With Prior Pulmonary Tuberculosis: A Study on the Burden, Clinic-Radiological Features, Treatment Outcomes and Comparison With Chronic Pulmonary Aspergillosis and Post-Tubercular Lung Disease Patients.","authors":"Anuj Ajayababu, Ved Prakash Meena, Prayas Sethi, Amandeep Singh, Ranveer Singh Jadon, Gagandeep Singh, Immaculata Xess, Stanzin Spalkit, Neeraj Nischal, Surabhi Vyas, Sanjeev Sinha, Naveet Wig, Animesh Ray","doi":"10.1111/myc.70034","DOIUrl":"https://doi.org/10.1111/myc.70034","url":null,"abstract":"<p><strong>Background: </strong>Post-tuberculosis lung disease (PTLD) is a precursor to Aspergillus-related lung diseases. While Chronic Pulmonary Aspergillosis (CPA) has been extensively studied in the background of tuberculosis, Allergic Bronchopulmonary Aspergillosis (ABPA) has been reported sporadically with limited information on its prevalence, clinical-radiological features, and treatment outcomes.</p><p><strong>Objective: </strong>This study, conducted in a high TB burden setting, aimed to address this knowledge gap by systematically evaluating ABPA in PTLD patients.</p><p><strong>Methods: </strong>This retrospective cohort study screened PTLD patients presenting with respiratory or constitutional symptoms persisting for more than 3 months. The objective was to report the prevalence, clinical-radiological-laboratory data, and outcomes of ABPA-PTLD compared to a cohort of CPA (CPA-PTLD) and patients with PTLD (PTLD only).</p><p><strong>Results: </strong>Out of a total of 1012 PTLD patients, ABPA was seen in 2.27%, CPA in 20.75% and Aspergillus sensitization in 0.7%. ABPA patients primarily presented with breathlessness (91.3%) and cough (82.6%) while haemoptysis (43.5%), weight loss (13%), and anorexia (21.7%) were also observed, albeit less commonly than in CPA-PTLD. Bronchiectasis (100%) and nodules (87%) were more frequent in ABPA-PTLD patients, whereas consolidation (21.7%), cavities (30.4%), pleural thickening (8.7%), and 'fungal ball' (9.1%) were also seen, although less commonly than in CPA-PTLD. Most patients received azoles (78%) as first-line therapy, with symptomatic improvement (partial/complete) observed in ~78%.</p><p><strong>Conclusion: </strong>ABPA may occur in PTLD patients, with specific clinical (e.g., haemoptysis) and radiological (e.g., cavity and fungal ball) features uncommon in other types of ABPA, but resembling other PTLD conditions. Future studies should focus on identifying differences in the natural course and appropriate treatment paradigms of ABPA-PTLD patients compared to ABPA occurring in asthma and cystic fibrosis patients.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 2","pages":"e70034"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Skin Disease Incidence, Prevalence and Disability-Adjusted Life Years in Four Asian Countries (1990-2019).","authors":"Yuan Xihua, Qin Xiaofeng, Tang Lulu, Kong Zhiyu, Deng Min, Wu Yi","doi":"10.1111/myc.70004","DOIUrl":"https://doi.org/10.1111/myc.70004","url":null,"abstract":"<p><strong>Background: </strong>Fungal skin diseases are a significant burden in Asia, with varying trends from 1990 to 2019, highlighting the need for targeted interventions.</p><p><strong>Objective: </strong>To investigate long-term trends in the incidence, prevalence and disability-adjusted life-year rates for fungal skin diseases in China, India, Japan and Singapore from 1990 to 2019.</p><p><strong>Patients/methods: </strong>Data were obtained from the 2019 Global Burden of Disease Study. Independent age, period and cohort effects were calculated using age-period-cohort analysis.</p><p><strong>Results: </strong>Age-standardised incidence, prevalence and disability-adjusted life-year rates of fungal skin diseases in China, India, Japan and Singapore decreased from 1990 to 2019. India has the highest standardised incidence, prevalence and disability-adjusted life-year rates. The crude incidence, prevalence and disability-adjusted life-year rates showed an increasing trend in China, Japan and Singapore, and a decreasing trend in India. The age-period-cohort analysis found that the age effect increased in China, Japan and Singapore at ages 45-94 years, and India showed higher risk coefficients at ages 5-20 and 45-94 years. The period effect increased in the four countries, with more pronounced increases in Japan and Singapore. The cohort effect showed a monotonic decline with birth cohort in the four countries, with a slightly slower decline in India.</p><p><strong>Conclusion: </strong>Fungal skin diseases pose a serious burden in Asian countries. We recommend raising awareness and providing specialised interventions for fungal skin diseases, especially for high-risk groups, such as middle-aged and older adults aged ≤ 45 years and young Indians aged ≤ 20 years.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 2","pages":"e70004"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virulence of Candida spp. Isolates From Patients With Recurrent Vulvovaginal Candidosis Is Associated With the Number of Episodes.","authors":"Jeiser Marcelo Consuegra-Asprilla, Felipe Taborda, Verónica Pérez, Brajhan Torres, Carolina Rodríguez-Echeverri, Julián E Muñoz, Ángel González","doi":"10.1111/myc.70031","DOIUrl":"https://doi.org/10.1111/myc.70031","url":null,"abstract":"<p><strong>Background: </strong>Recurrent vulvovaginal candidosis (RVVC) has been associated with increased antifungal resistance. Recently, we reported that Candida isolates from Colombian patients with RVVC did not show an increase in antifungal resistance.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the virulence of Candida isolates from patients with RVVC.</p><p><strong>Methods: </strong>A total of 40 Candida isolates were evaluated (37 C. albicans and 3 C. lusitaniae ). C. albicans isolates were divided into two groups based on the number of VVC episodes in patients per year: Group 1 (four to seven episodes; n = 26) and Group 2 (≥ eight episodes; n = 11). The XTT assay was used to assess biofilm formation. Galleria mellonella larvae were used for survival analysis and fungal load assessment, and the qPCR technique to determine the expression of the PRA1 gene.</p><p><strong>Results: </strong>It was observed that C. lusitaniae and C. albicans isolates from patients with ≥ eight VVC episodes per year exhibited a greater capacity to form biofilms compared to those from patients with four to seven VVC episodes. Moreover, in the G. mellonella model, larvae inoculated with isolates from RVVC patients exhibited approximately 80% mortality. Similarly, larvae infected with C. albicans from patients who experienced ≥ eight VVC episodes showed a significantly higher fungal load compared to the other evaluated groups; likewise, the expression of the PRA1 gene was significantly higher in isolates from patients with ≥ eight VVC episodes.</p><p><strong>Conclusion: </strong>These results indicate that Candida isolates from patients with RVVC exhibit a high degree of virulence and suggest that virulence may be one of the mechanisms explaining recurrence rather than antifungal resistance itself.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 2","pages":"e70031"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Onchomycosis in Psoriasis Patients: A Systematic Review and Meta-Analysis.","authors":"Mengying Liu, Yuying Kang, Ruijun Zhang","doi":"10.1111/myc.70035","DOIUrl":"https://doi.org/10.1111/myc.70035","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis, a common nail disease characterised by thickened, discoloured and brittle nails, has been observed to have varying prevalence rates in psoriasis patients compared to the general population. Psoriasis is a chronic autoimmune condition affecting approximately 2%-3% of the global population, with nail involvement impacting up to 79% of these patients. The clinical features of onychomycosis and nail psoriasis often overlap, complicating accurate diagnosis. This systematic review and meta-analysis aims to evaluate whether the prevalence of onychomycosis differs between psoriasis patients and non-psoriasis individuals, thereby providing evidence-based insights for clinical practice.</p><p><strong>Methods: </strong>The research question and keywords were developed following the Population, Intervention, Comparator, and Outcome (PICO) framework. As of October 26, 2024, records in English or Chinese were obtained from PubMed, Embase, Cochrane Library, CNKI, CBM and Web of Science, using the keywords \"onychomycosis,\" \"psoriasis,\" etc. Furthermore, the meta-analysis was carried out with STATA.</p><p><strong>Results: </strong>A total of 967 records were identified, with 13 studies comprising 2751 psoriasis patients and 10,967 non-psoriasis individuals included in the final analysis. The meta-analysis revealed that psoriasis patients had a significantly higher prevalence of onychomycosis, 1.68 times greater than those without psoriasis (95% CI: 1.21-2.33). Subgroup analysis showed that among clinically unsuspected patients, the risk of onychomycosis in those with psoriasis was 1.78 times higher (95% CI: 1.33-2.38) than in non-psoriasis individuals. The majority of the studies included were of moderate to low bias.</p><p><strong>Conclusion: </strong>The prevalence of onychomycosis is significantly higher in psoriasis patients compared to those without. However, limitations in research methods, variability in study populations, and small sample sizes in some studies suggest that further investigation is necessary. Future research should employ standardised methodologies, larger sample sizes, and long-term follow-up to enhance the accuracy and reliability of findings. Based on the results of this review and meta-analysis, it is crucial to rule out onychomycosis-related nail lesions before diagnosing psoriasis, especially prior to initiating immunosuppressive treatments such as steroids, methotrexate, or biologics, as these may exacerbate fungal infections.</p><p><strong>Protocol registration: </strong>PROSPERO-CRD42023399195.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 2","pages":"e70035"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}