Mycoses最新文献

{"title":"Immunohistochemical analysis of chronic and recurrent dermatophytosis.","authors":"Ramesh M Bhat, Monisha Madhumita, Nisha J Marla, Jyothi Jayaraman","doi":"10.1111/myc.13714","DOIUrl":"10.1111/myc.13714","url":null,"abstract":"<p><strong>Background: </strong>Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis.</p><p><strong>Objectives: </strong>We aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis.</p><p><strong>Methods: </strong>We investigated the density of various immune cells-Langerhans cells (CD1a+), macrophages (CD68+), dermal dendrocytes (Factor XIIIa+) in the skin of chronic dermatophytosis patients and those with successfully resolved lesions (controls).</p><p><strong>Results: </strong>Langerhans cells were significantly decreased in the epidermis of patients, both in affected and unaffected areas in comparison with controls. In the dermis, however, no differences in the density of immune cells (macrophages and fibroblasts) were observed.</p><p><strong>Limitations: </strong>The limited sample size and immune cells evaluated could be expanded further in future research.</p><p><strong>Conclusion: </strong>These results indicate that the decreased number of Langerhans cells could be a potential risk factor for the development of chronic and recurrent dermatophytosis.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 3","pages":"e13714"},"PeriodicalIF":4.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terbinafine resistance in Trichophyton mentagrophytes and Trichophyton rubrum in the Czech Republic: A prospective multicentric study","authors":"Daniela Kolarczyková, Pavlína Lysková, Michaela Švarcová, Ivana Kuklová, Radim Dobiáš, Naďa Mallátová, Miroslav Kolařík, Vit Hubka","doi":"10.1111/myc.13708","DOIUrl":"https://doi.org/10.1111/myc.13708","url":null,"abstract":"Terbinafine, an allylamine antifungal, is crucial for treating dermatophytosis by inhibiting squalene epoxidase (SQLE) in the ergosterol biosynthetic pathway. However, resistance is emerging, particularly in India and Southeast Asia, but reports of resistance spread worldwide. Despite this, comprehensive studies on terbinafine resistance in <i>Trichophyton</i> are still limited.","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"60 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characteristics of Epidermophyton floccosum skin infections: A 12-year retrospective study","authors":"Ya-Nin Nokdhes, Charussri Leeyaphan, Pattriya Jirawattanadon, Bawonpak Pongkittilar, Chudapa Sereeaphinan, Sumanas Bunyaratavej","doi":"10.1111/myc.13702","DOIUrl":"https://doi.org/10.1111/myc.13702","url":null,"abstract":"<i>Epidermophyton floccosum</i> (<i>E. floccosum</i>), an anthropophilic dermatophyte, is the primary causative agent of skin conditions such as tinea cruris, tinea pedis and tinea corporis.","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139771187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of 18F-FDG PET-CT for the management of invasive fungal infections: A retrospective cohort from a tertiary university hospital","authors":"Isabel Gutiérrez-Martín, Sonia García-Prieto, Karina Velásquez, Edith Vanessa Gutiérrez-Abreu, Itziar Diego-Yagüe, Jorge Calderón-Parra, Andrea Gutiérrez-Villanueva, Antonio Ramos-Martínez, Elena Múñez-Rubio, Alejandro Callejas-Díaz, Sara De la Fuente Moral, Alberto Díaz de Santiago, Isabel Sánchez Romero, Begoña Rodríguez Alfonso, Ana Fernández-Cruz","doi":"10.1111/myc.13701","DOIUrl":"https://doi.org/10.1111/myc.13701","url":null,"abstract":"¹⁸F-FDG PET-CT is a potentially useful technique to help manage invasive fungal infection (IFI), but information on this topic is scarce.","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"18 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139771090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic values of ten  methods in patients with onychomycosis: A network meta-analysis","authors":"Yan Zhao, Xinwei Wang, Changyu Lu","doi":"10.1111/myc.13696","DOIUrl":"https://doi.org/10.1111/myc.13696","url":null,"abstract":"Onychomycosis, a disease was with a high global prevalence, has been the focal point of this study. The research aims to compare diagnostic efficacy among various methods, including potassium hydroxide (KOH), Dimethyl sulfoxide (DMSO), specific colour staining (Chlorazol, lactophenol cotton blue and Chicago sky blue stain), fluorescent staining (calcofluor white stain, acridine orange fluorescent dye), culture on dermatophyte test medium (DTM), conventional PCR, dermoscopy, histopathological examination using PAS stain (HEP-PAS), real-time PCR and multiple PCR. This comparison was achieved through a network meta-analysis involving patients with onychomycosis.","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"22 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139760815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of primary metabolites in fungal species of Trichophyton mentagrophyte and Trichophyton rubrum by NMR spectroscopy.","authors":"Rashmi Parihar, Upendra Singh, Anupam Das, Bikash Baishya, Vikramjeet Singh, S C Ahirwar, Sana Islahi, Manodeep Sen, Vineeta Mittal","doi":"10.1111/myc.13699","DOIUrl":"10.1111/myc.13699","url":null,"abstract":"<p><strong>Background: </strong>Superficial mycoses are fungal infections limited to the outermost layers of the skin and its appendages. The chief causative agents of these mycoses are dermatophytes and yeasts. The diagnosis of dermatophytosis can be made by direct mycological examination with potassium hydroxide (10%-30%) of biological material obtained from patients with suspected mycosis, providing results more rapid than fungal cultures, which may take days or weeks. This information, together with clinical history and laboratory diagnosis, ensures that the appropriate treatment is initiated promptly. However, false negative results are obtained in 5%-15%, by conventional methods of diagnosis of dermatophytosis.</p><p><strong>Objectives: </strong>To study the metabolic profiles of the commonly occurring dermatophytes by NMR spectroscopy.</p><p><strong>Patients/materials: </strong>We have used 1D and 2D Nuclear Magnetic Resonance (NMR) experiments along with Human Metabolome Database (HMDB) and Chenomx database search for identification of primary metabolites in the methanol extract of two fungal species: Trichophyton mentagrophyte (T. mentagrophyte) and Trichophyton rubrum (T. rubrum). Both standard strains and representative number of clinical isolates of these two species were investigated. Further, metabolic profiles obtained were analysed using multivariate analysis.</p><p><strong>Results: </strong>We have identified 23 metabolites in the T. mentagrophyte and another 23 metabolites in T. rubrum. Many important metabolites like trehalose, proline, mannitol, acetate, GABA and several other amino acids were detected, which provide the necessary components for fungal growth and metabolism. Altered metabolites were defined between Trichophyton mentagrophyte and T. rubrum strains.</p><p><strong>Conclusion: </strong>We have detected many metabolites in the two fungal species T. mentagrophyte and T. rubrum by using NMR spectroscopy. NMR spectroscopy provides a holistic snapshot of the metabolome of an organism. Key metabolic differences were identified between the two fungal strains. We need to perform more studies on metabolite profiling of the samples from these species for their rapid diagnosis and prompt treatment.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 2","pages":"e13699"},"PeriodicalIF":4.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, diagnosis, and treatment of central nervous system sporotrichosis: Systematic review and meta-analysis.","authors":"Vítor Falcão de Oliveira, Júlia Figueiredo Petrucci, Mariane Taborda, Pedro Zanetta Brener, Pedro Guilherme De Barros Brito Kremer, Bruno Azevedo Randi, Adriana Satie Gonçalves Kono Magri, Marcello Mihailenko Chaves Magri, Anna S Levin, Guilherme Diogo Silva","doi":"10.1111/myc.13697","DOIUrl":"10.1111/myc.13697","url":null,"abstract":"<p><strong>Background: </strong>The clinical features of central nervous system (CNS) sporotrichosis are derived from case reports and a limited series of cases. Our objective was to carry out a systematic review and meta-analysis of CNS sporotrichosis.</p><p><strong>Methods: </strong>We searched PubMed/MEDLINE, Embase, Scopus, and LILACS on 9 September 2023. Our inclusion criteria were documentation of Sporothrix and demonstrated CNS involvement. A metaproportion or metamean analysis was performed to estimate a summary proportion with 95% confidence intervals.</p><p><strong>Results: </strong>We included 52 cases of CNS sporotrichosis published from 1966 to 2023. Forty-six patients were male (88%, 95% CI: 77-95), and the mean age was 39 years (95% CI: 36-43). Close contact with cats was reported in 55% of cases (95% CI: 37-72). Thirty-two (61.5%) patients were from Brazil, 18 patients from the United State of America (34.6%). Only two Sporothrix species were reported: S. schenckii (26/41, 63%), and S. brasiliensis (15/41, 37%). The most common neurological symptom was headache. Meningitis was chronic in approximately 80% of cases. A significant majority of the patients were immunocompromised. HIV infection was the primary cause of immunosuppression (85%, 95% CI: 61-95). Overall mortality was 56% (22/39). The comparison of Kaplan-Meier survival curve showed a higher mortality with a statistically significant difference in immunosuppressed patients (p = .019).</p><p><strong>Conclusion: </strong>CNS sporotrichosis represents a notable cause of chronic meningitis, especially in individuals living in the Americas with HIV infection and concurrent skin lesions.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 2","pages":"e13697"},"PeriodicalIF":4.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High attenuation mucus in bronchi with allergic bronchopulmonary mycosis.","authors":"Shigeaki Hattori, Tsuyoshi Oguma, Takashi Ishiguro, Junko Suzuki, Koichi Fukunaga, Terufumi Shimoda, Hirokazu Kimura, Yasushi Obase, Naoki Okada, Jun Tanaka, Asako Kitahara, Katsuyoshi Tomomatsu, Yoshiki Shiraishi, Koichiro Asano","doi":"10.1111/myc.13705","DOIUrl":"10.1111/myc.13705","url":null,"abstract":"<p><strong>Background: </strong>High-attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT).</p><p><strong>Objectives: </strong>To compare the diagnostic accuracy of the two definitions of HAM and to clarify the clinical and radiographic characteristics of HAM-positive and HAM-negative ABPM.</p><p><strong>Methods: </strong>CT images at the diagnosis of ABPM using Asano's criteria were retrospectively analysed. In Study #1, radiographic data obtained using the same CT apparatus in a single institute were analysed to determine the agreement between the two definitions of HAM: a mucus plug that is visually denser than the paraspinal muscles or that with a radiodensity ≥70 Hounsfield units. In Study #2, HAM was diagnosed by comparison with the paraspinal muscles in patients with ABPM reporting to 14 medical institutes in Japan.</p><p><strong>Results: </strong>In Study #1, 93 mucus plugs from 26 patients were analysed. A substantial agreement for HAM diagnosis was observed between the two methods, with a κ coefficient of 0.72. In Study #2, 60 cases of ABPM were analysed; mucus plugs were present in all cases and HAM was diagnosed in 45 (75%) cases. The median A. fumigatus-specific IgE titre was significantly lower in HAM-positive patients than in HAM-negative patients (2.5 vs. 24.3 U_A /mL, p = .004). Nodular shadows were observed more frequently in the airways distal to HAM than in those distal to non-HAM mucus plugs (59% vs. 32%, p < .001).</p><p><strong>Conclusion: </strong>In conclusion, agreement between the two methods to diagnose HAM was substantial. HAM was associated with some immunological and radiographic characteristics, including lower levels of sensitization to A. fumigatus and the presence of distal airway lesions.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 2","pages":"e13705"},"PeriodicalIF":4.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical prevalence of dermatophytic mycoses with an assessment of its clinical manifestations in a tertiary care hospital at Salem, South India.","authors":"Arul Balasubramanian, Nazer Ali Akbar Ali, Atchaya Pugazhenthi, Kannan Gopalan, Silambarasan Tamil Selvan, Kothai Ramalingam","doi":"10.1111/myc.13707","DOIUrl":"10.1111/myc.13707","url":null,"abstract":"<p><strong>Background: </strong>Dermatophytosis is very common among all age groups throughout the world. The incidence of the same is increasing on a steady basis.</p><p><strong>Aim: </strong>Estimating the clinical prevalence of dermatophytes mycoses among the patients visiting the outpatient unit and assessing its distinct manifestations.</p><p><strong>Methodology: </strong>A prospective observational study was conducted with the patients attending the Skin and STD outpatient unit of a tertiary care teaching hospital in Salem. A total of 3068 outpatients attended the department, of which 420 patients were diagnosed with dermatophytic mycoses and were taken for investigating the prevalence.</p><p><strong>Results: </strong>A total of 420 dermatophytosis patients were included giving a percentage prevalence of 13.69%. There were more female patients (n = 213, 50.71%) than males (n = 207, 49.29%). The most common afflicted age group was 31-40 years (n = 99, 50.71%). Most of the patients had an atypical lesion called tinea incognita (n = 265, 63.09%) where there was no typical classic appearance of dermatophytic infections. The most prevalent clinical manifestation was tinea corporis (n = 73, 17.38%) followed by tinea cruris (n = 69, 16.43%). There were more newly diagnosed dermatophytosis cases (n = 326) than the previously diagnosed cases (n = 94).</p><p><strong>Conclusion: </strong>This study concludes that dermatophytic mycoses were more prevalent among females than males and among the age groups of 31-40 years. The most common clinical presentation was tinea incognita followed by tinea corporis.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 2","pages":"e13707"},"PeriodicalIF":4.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and disability-adjusted life years of Scedosporium/Lomentospora infection in patients after near-drowning.","authors":"Firoozeh Kermani, Jamshid Yazdani Charati, Behrad Roohi, Azam Moslemi, Azadeh Bandeghani, Leila Faeli, Tahereh Shokohi, Emmanuel Roilides","doi":"10.1111/myc.13703","DOIUrl":"10.1111/myc.13703","url":null,"abstract":"<p><p>Scedosporium/Lomentospora species exist as saprophytic moulds that can potentially lead to serious infections in patients who have experienced near-drowning incidents. Scedosporium species are distributed across different regions of the world while Lomentospora prolificans has quite a restricted geographic distribution. We aimed to systematically review scedosporiosis cases after near-drowning, their clinical manifestations, underlying diseases, treatments, outcomes and its impact through disability-adjusted life years (DALYs). Five available sources were searched from 1 January 2007, to 20 April 2022. Thirty-eight studies, including 41 patients, were evaluated. Mean age was 33.6 ± 18.6 years (range 1-68), and 28 were male (68.3%). Central nervous system (CNS) dissemination predominated (36/41; 87.8%), presenting mainly as multiple brain abscesses (26/41; 63.4%), followed by lung involvement (22/41; 56.4%). Scedosporium apiospermum species complex was the most causative agent (38/41; 92.7%). Overall mortality was 51.2%. Half of the patients (18/37) were cured after receiving proper treatment, and in most cases, voriconazole alone or in combination with surgery or other antifungals caused survival. The mean survival time was 123 ± 27 days. Mean DALYs in 1980-2022 were 46.110 ± 3.318 (39.607-52.612). Time to diagnosis was estimated to be 120 days, and there was no association between time to diagnosis and outcome. Voriconazole is a potentially effective therapy, and combination of surgery and antifungal treatment may lead to more favourable outcome. Advances in early diagnosis and appropriate antifungal therapy may have contributed to reducing its mortality.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 2","pages":"e13703"},"PeriodicalIF":4.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}