Mycoses最新文献

{"title":"Investigating Asthma After Coccidioidomycosis Among Patients With Commercial Health Insurance, United States, 2017-2022.","authors":"Kaitlin Benedict, Dallas J Smith, Angela Haczku, Amir A Zeki, Joy Hsu, Mitsuru Toda, Nicholas J Kenyon, George R Thompson","doi":"10.1111/myc.70033","DOIUrl":"10.1111/myc.70033","url":null,"abstract":"<p><strong>Background: </strong>The relationship between asthma and coccidioidomycosis has not been fully described. We have hypothesised that Coccidioides could trigger inflammatory airway responses, similar to other fungi.</p><p><strong>Objectives: </strong>To estimate the frequency of new-onset asthma-related symptoms after coccidioidomycosis and identify potentially associated factors.</p><p><strong>Patients/methods: </strong>We used a large health insurance claims database to identify patients with coccidiomycosis with and without an asthma diagnosis code or a short-acting β₂ agonist prescription in the year after diagnosis.</p><p><strong>Results: </strong>Thirteen per cent of 1657 patients with an asthma diagnosis code or a short-acting β₂ agonist prescription (median 2.5 months later).</p><p><strong>Conclusions: </strong>Increased healthcare provider awareness of asthma as a potential coccidioidomycosis complication could benefit patients, especially female patients and patients with severe pulmonary infection.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 2","pages":"e70033"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Epidemiology and Antifungal Susceptibility Profile of Candidozyma Isolates From Argentina.","authors":"Constanza Giselle Taverna, Susana Córdoba, Maria Sol Haim, Micaela Lombardo, Matías Ezequiel Vivot, Bárbara Abigail Arias, Walter Vivot, Wanda Szusz, Darren Abbey, Tomas Javier Poklépovich, Cristina Elena Canteros","doi":"10.1111/myc.70025","DOIUrl":"10.1111/myc.70025","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological surveillance of Candidozyma sp. has become important because many species of this new genus have been reported to be responsible for nosocomial outbreaks and to exhibit elevated minimal inhibitory concentrations (MIC) to one or more classes of antifungal drugs.</p><p><strong>Objectives: </strong>To describe the genetic relationships among Argentinian clinical isolates belonging to the Candidozyma genus and to study the molecular mechanisms associated with antifungal resistance.</p><p><strong>Methods: </strong>We performed whole-genome sequencing of 41 isolates. Identification was based on ribosomal DNA sequencing and susceptibility testing was determined according to the EUCAST document. Phylogenetic analysis, non-synonymous mutations in genes associated with antifungal resistance and the presence of copy number variations (CNVs) were investigated.</p><p><strong>Results: </strong>We identified 12 Candidozyma haemuli, 11 Candidozyma haemuli var. vulneris, 5 Cz. haemuli/ Cz. haemuli var. vulneris ITS hybrids, 8 Candidozyma duobushaemuli and 5 Candidozyma cf. pseudohaemuli. Phylogenetic analysis, together with clinical data, demonstrated nosocomial transmission events. In addition, Cz. haemuli and Cz. haemuli var. vulneris were not separated in the phylogenetic tree; the Cz. cf. pseudohaemuli isolates clustered distantly from the Cz. pseudohaemuli type strain. Most isolates were resistant to amphotericin B, and two Cz. haemuli isolates showed fluconazole resistance and Y132F mutation in ERG11. We did not find CNV in genes associated with antifungal resistance.</p><p><strong>Conclusions: </strong>These findings highlight the need for epidemiological surveillance of these species and the study of molecular mechanisms associated with antifungal resistance. Furthermore, we propose a taxonomic revision for Cz. haemuli var. vulneris and Cz. pseudohaemuli based on genomic data.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70025"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terbinafine Resistance in Trichophyton Species From Patients With Recalcitrant Infections Detected by the EUCAST Broth Microdilution Method and DermaGenius Resistance Multiplex PCR Kit.","authors":"Liv Duus, Pernille Kræmer Schachsen, Jan Berg Gertsen, Karen Marie Thyssen Astvad, Lise Kristensen","doi":"10.1111/myc.70011","DOIUrl":"https://doi.org/10.1111/myc.70011","url":null,"abstract":"<p><strong>Background: </strong>Emerging terbinafine resistance in Trichophyton species has been reported globally. The prevalence in clinical samples from patients with treatment failure is unknown in Denmark.</p><p><strong>Objectives: </strong>Prospective study of terbinafine resistance in Trichophyton isolates from patients with recalcitrant skin or nail infections.</p><p><strong>Patients/methods: </strong>Clinical samples (nails or skin scrapings) from patients with recalcitrant infections were included. Isolates were tested with the EUCAST broth microdilution method, E.Def 11.0 and DermaGenius Resistance Multiplex PCR kit (PathoNostics, The Netherlands).</p><p><strong>Results: </strong>Thirty-three isolates were included in the study, 27 (81.8%) T. rubrum, 2 (6.1%) T. interdigitale, 1 (3.0%) T. mentagrophytes and 3 (9.1%) T. indotineae. Sixteen of 31 isolates (52%) were terbinafine resistant with the EUCAST broth microdilution method, 13 T. rubrum and 3 T. indotineae. Two isolates did not grow in the broth culture medium. The DermaGenius Resistance Multiplex PCR kit showed mutations associated with terbinafine resistance in 11 isolates. All of the 11 isolates with detected mutations by PCR also displayed terbinafine resistance by the EUCAST method.</p><p><strong>Conclusions: </strong>Terbinafine resistance was detected in 52% of Trichophyton isolates from recalcitrant infections by the EUCAST broth microdilution. T. rubrum was the most common species among the resistant isolates (81.3%). The DermaGenius Resistance Multiplex PCR kit was a reliable tool for the detection of mutations associated with terbinafine resistance and is suitable as an initial screening for terbinafine resistance before results from EUCAST broth microdilution testing is available. Susceptibility testing of Trichophyton spp. from skin and nail samples is highly relevant from patients with terbinafine treatment failure.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70011"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Prognostic Effects of Aspergillosis as a Complication of Nontuberculous Mycobacterial Pulmonary Disease: A Nested Case-Control Study.","authors":"Takahiro Takazono, Shotaro Ide, Motohiko Adomi, Yoshimasa Ogata, Yoshiyuki Saito, Masataka Yoshida, Kazuaki Takeda, Naoki Iwanaga, Naoki Hosogaya, Noriho Sakamoto, Izumi Sato, Akitsugu Furumoto, Koichi Izumikawa, Hiroshi Mukae","doi":"10.1111/myc.70022","DOIUrl":"https://doi.org/10.1111/myc.70022","url":null,"abstract":"<p><strong>Objective: </strong>The global prevalence of nontuberculous mycobacterial pulmonary disease (NTM-PD) has been steadily increasing. A few small retrospective studies have reported a poor prognosis associated with chronic pulmonary aspergillosis (CPA) as a complication of NTM-PD. Furthermore, the prognostic impact of CPA may have been inadequately assessed due to differences in background factors. This study aimed to identify the risk factors for CPA in NTM-PD and compare the risk of in-hospital mortality between patients with and without aspergillosis.</p><p><strong>Methods: </strong>Data were obtained from a large-scale claims database. Patients with NTM-PD who met the inclusion criteria and those who developed CPA after the NTM diagnosis were identified. The incidence of CPA was evaluated, and risk factors were identified using multiple logistic analyses. Mortality rates were evaluated and compared between patients with and without aspergillosis after adjusting for background CPA risk factors.</p><p><strong>Results: </strong>The incidence of CPA was 2.29% (265/11,587). The identified risk factors included male sex, chronic respiratory failure, asthma, interstitial pneumonia, pulmonary tuberculosis sequelae and systemic corticosteroid use. A total of 219 patients with CPA were matched with control cases using propensity scores based on age and identified risk factors for CPA. The adjusted hazard ratio for in-hospital mortality was 2.6 (95% CI: 1.8-3.9).</p><p><strong>Conclusions: </strong>CPA as a complication of NTM-PD is associated with significantly higher mortality rates. Clinicians should consider the necessity of promptly diagnosing CPA in patients with NTM-PD and the associated risk factors.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70022"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of SYBR Green Real-Time PCR for Rapid and Specific Identification of Trichophyton indotineae.","authors":"Faezeh Rouhi, Shima Aboutalebian, Ali Rezaei-Matehkolaei, Zahra Jahanshiri, Mohammad-Reza Shidfar, Amir-Shayan Chadeganipour, Shahla Shadzi, Mahboobeh Kharazi, Mahzad Erami, Hossein Mirhendi","doi":"10.1111/myc.70015","DOIUrl":"https://doi.org/10.1111/myc.70015","url":null,"abstract":"<p><strong>Background: </strong>Since 2017, dermatophytosis caused by the newly introduced species Trichophyton indotineae has gained new interest worldwide due to the rise in terbinafine resistance and difficulty in the treatment of recalcitrant infections. Distinguishing T. indotineae from other Trichophyton species based on morphological features is impossible and DNA sequencing is necessary for accurate identification. Though early identification of the species is not solely sufficient for the treatment of infected cases, it is important for clinicians to take the next appropriate modalities such as antifungal susceptibility testing especially when the patients have extensive skin lesions recalcitrant to therapy by terbinafine. Here, we developed a rapid diagnostic scheme using SYBR Green real-time PCR for the specific detection/identification of T. indotineae.</p><p><strong>Methods: </strong>DNA was extracted from 397 dermatophyte isolates and two SYBR Green real-time PCR assays targeting the C120-287 and E054-58 intergenic loci were developed. Using a collection of 132 T. indotineae and 128 non-T. indotineae strains, all had already been identified by ITS-PCR-sequencing and 137 unknown dermatophyte isolates, the assays were evaluated.</p><p><strong>Results: </strong>In both real-time PCR assays, 130 out of 132 T. indotineae strains were positive while all non-T. indotineae species were negative. Among 137 unknown tested isolates, 72 were identified as T. indotineae based on two real-time PCR assays, while 65 showed no peak and were considered non-T. indotineae. Based on PCR-sequencing as the reference standard, the SYBR Green real-time PCR assays demonstrated a sensitivity of 98.48% and a specificity of 100%.</p><p><strong>Conclusion: </strong>The developed diagnostic assays using SYBR Green real-time PCR provided a rapid and accurate method for the distinction of cultured T. indotineae isolates and can be considered to evaluate for the detection of T. indotineae directly from clinical samples.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70015"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Mycobiota-Microbiota During Pulmonary Exacerbation of Cystic Fibrosis Patients: A Culture and Targeted Sequencing Study.","authors":"Cécile Angebault, Louise-Eva Vandenborght, Laurence Bassinet, Nathalie Wizla, Agnès Ferroni, Rodrigue Dessein, Natacha Remus, Caroline Thumerelle, Nathalie Fauchet, Ralph Epaud, Laurence Delhaes, Françoise Botterel","doi":"10.1111/myc.70024","DOIUrl":"10.1111/myc.70024","url":null,"abstract":"<p><strong>Background: </strong>The airways of patients with cystic fibrosis (pwCF) harbour complex fungal and bacterial microbiota involved in pulmonary exacerbations (PEx) and requiring antimicrobial treatment. Descriptive studies analysing bacterial and fungal microbiota concomitantly are scarce, especially using both culture and high-throughput-sequencing (HTS).</p><p><strong>Objectives: </strong>We analysed bacterial-fungal microbiota and inter-kingdom correlations in two French CF centres according to clinical parameters and antimicrobial choices.</p><p><strong>Methods: </strong>Forty-eight pwCF with PEx from Creteil (n = 24) and Lille (n = 24) CF centres were included over 2 years. Sputa were collected for culture and targeted-HTS (ITS2 and V3-V4 targets). Sequencing and culture data, along with clinical, radiological and treatment data, were analysed. Two-level stratified analysis was performed to study potential confounding factors (age, CF mutation, FEV1 and antibiotics) on the centre factor. Inter-kingdom correlations were analysed.</p><p><strong>Results: </strong>Significant differences in the bacterial microbiota profile were found between centres (p-value = 0.03). For mycobiota, the taxonomic distribution and diversity were comparable. HTS provided concordant but more detailed information than culture and increased detection of main CF fungi (> 25% more positive samples for Aspergillus or Scedosporium). FEV1 and systemic antibiotic before PEx influenced bacterial microbiota, but no clinical association was found with the mycobiota. No inter-kingdom correlation between Pseudomonas and fungi was found.</p><p><strong>Conclusions: </strong>Describing concomitant bacterial and fungal communities of pwCF at the beginning of PEx using culture and HTS shows greater diversity in HTS and better detection in case of low microbial load. Interesting inter-kingdom correlations were observed, requiring further research on larger cohorts to understand the potential microbial interactions.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70024"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posaconazole for Prevention of COVID-19-Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients: A European Multicentre Case-Control Study (POSACOVID).","authors":"Juergen Prattes, Daniele R Giacobbe, Cristina Marelli, Alessio Signori, Silvia Dettori, Greta Cattardico, Stefan Hatzl, Alexander C Reisinger, Philipp Eller, Robert Krause, Florian Reizine, Matteo Bassetti, Jean-Pierre Gangneux, Martin Hoenigl","doi":"10.1111/myc.70023","DOIUrl":"10.1111/myc.70023","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the impact of posaconazole (POSA) prophylaxis in COVID-19 patients with acute respiratory failure receiving systemic corticosteroids on the risk for the development of COVID-19-associated pulmonary aspergillosis (CAPA).</p><p><strong>Methods: </strong>The primary aim of this prospective, multicentre, case-control study was to assess whether application of POSA prophylaxis in mechanically ventilated COVID-19 patients reduces the risk for CAPA development. All consecutive patients from centre 1 (cases) who received POSA prophylaxis as standard-of-care were matched to one subject from centre 2 and centre 3 who did not receive any antifungal prophylaxis, using propensity score matching for the following variables: (i) age, (ii) sex, (iii) treatment with tocilizumab and (iv) time at risk.</p><p><strong>Results: </strong>Eighty-three consecutive patients receiving POSA prophylaxis were identified at centre 1 and matched to 166 controls. In the matched cohort, incidence rates of CAPA were 1.69 (centre 1), 0.84 (centre 2) and 7.18 (centre 3) events per 1000 ICU days. In multivariable logistic regression analysis, the presence of an EORTC/MSGERC risk factor at ICU admission (OR 4.35) and centre 3 versus centre 1 (OR 6.07; 95% CI 1.76-20.91; p = 0.004) were associated with an increased risk of CAPA. No increased risk of CAPA was registered for centre 2 versus centre 1.</p><p><strong>Conclusions: </strong>The impact of POSA prophylaxis depends on the baseline CAPA incidence rate, which varies widely between centres. Future trials should therefore investigate targeted antifungal prophylaxis (e.g., stratified for high-prevalence centres or high-risk patients) in COVID-19 patients.</p><p><strong>Trial registration: </strong>NCT05065658.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70023"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Clinical Detection of Rapid Molecular Diagnostic System for Pathogenic Dermatophytes of Tinea Capitis of Multiple Centres in China.","authors":"Peiqiu Zhu, Jin Shao, Ruojun Wang, Yuanyuan Xiao, Yabin Zhou, Qian Li, Yinggai Song, Zhe Wan, Ruoyu Li, Jin Yu","doi":"10.1111/myc.70008","DOIUrl":"10.1111/myc.70008","url":null,"abstract":"<p><strong>Objectives: </strong>Tinea capitis remains a common fungal infection in children worldwide. Species identification is critical for determining the source of infection and reducing transmission. In conventional methods, macro- and microscopic analysis is time-consuming and results in slow fungal growth or low specificity. We propose a rapid real-time diagnostic PCR method that allows species-specific identification of dermatophytes, including the Microsporum canis complex, Trichophyton mentagrophytes complex, Trichophyton rubrum complex and Trichophyton tonsurans, in patients with tinea capitis.</p><p><strong>Methods: </strong>Hair and scrapings samples were collected from 231 patients with tinea capitis who were positive for fungal elements via direct microscopy with potassium hydroxide. Each sample was subjected to a two-step real-time PCR (RT-PCR) assay, which was designed on the basis of differences in the DNA fragments of the internal transcribed spacer (ITS) and β-tubulin covering the Microsporum canis complex, T. mentagrophyte complex, T. rubrum complex, T. tonsurans, T. verrucosum, T. schoenleinii and N. gypseum.</p><p><strong>Results: </strong>In total, 186/231 samples (80.52%) were positive for fungal culture. The two-step RT-PCR was positive in 215/231 samples (93.07%), among which 179 were culture positive. The combined efficacy was 96.81%, which was significantly different when the RT-PCR assays were performed in parallel with fungal culture. A total of 126 samples (54.55%) were identified as Microsporum canis by fungal culture, among which the positive rate of M. canis complex RT-PCR was 97.62% (123/126). A total of 45 samples were negative for fungal culture, of which 80.0% (36/45) were positive by RT-PCR, and the percentage of M. canis complex-positive samples was 53.33% (24/45). The RT-PCR assays were negative for 16/231 samples, among which 7 were culture positive, including M. canis (n = 3), T. violaceum (n = 3) and N. gypseum (n = 1).</p><p><strong>Conclusion: </strong>We developed a new diagnostic assay system using a rapid real-time TaqMan PCR assay with specific primers that can be applied in routine laboratory practice for hair and skin samples of tinea capitis to detect dermatophytes and increase diagnostic efficiency.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70008"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult With Tinea Capitis: A Five-Year (2015-2019) Trend Study Among Patients Attending the Aristide Le Dantec University Hospital in Dakar, Senegal.","authors":"Khadim Diongue, Mamadou Alpha Diallo, Abdoulaye Diop, Mame Cheikh Seck, Mouhamadou Ndiaye, Aïda Sadikh Badiane, Daouda Ndiaye","doi":"10.1111/myc.70030","DOIUrl":"10.1111/myc.70030","url":null,"abstract":"<p><strong>Background: </strong>Although tinea capitis (TC) is most commonly diagnosed in children, several studies have also shown that it is far from unusual in adults.</p><p><strong>Objectives: </strong>To determine the frequency and risk factors of TC in adults in Dakar, Senegal.</p><p><strong>Patients and methods: </strong>A cross-sectional study including all patients who visited the Parasitology and Mycology Lab at Aristide Le Dantec University Hospital for suspicion of TC was conducted from 1 January 2015 to 31 December 2019. The diagnosis was performed using conventional techniques.</p><p><strong>Results: </strong>In sum, 458 adults were included. The majority (89%) were female. The patients' mean age was 35 ± 12 years (ranges: 18-84). Of the 458, 92 (20%) were confirmed with TC. The frequency trend, by year, showed a significant decrease ranging from 26.3% in 2015 to 19.2% in 2019. By sex, females (20.5%) were more affected than males (17.6%). According to age, the elderly present the highest infestation rate (36.4%). TC was diagnosed alone in 91.3%. T. soudanense (57.6%) was the most common species, followed by M. audouinii (34.8%).</p><p><strong>Conclusion: </strong>TC is frequent among adults in Senegal, particularly in women, and the main causal agent is T. soudanense. Its duration seems to indicate a chronic form previously acquired between 1 and 10 years ago. Thus, early management will be essential to avoid epidemic proportions.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70030"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial Fungal Infections and Artificial Intelligence: A Review on Current Advances and Opportunities: REVISION.","authors":"Bahareh Hasan Pour","doi":"10.1111/myc.70007","DOIUrl":"10.1111/myc.70007","url":null,"abstract":"<p><strong>Background: </strong>Superficial fungal infections are among the most common infections in world, they mainly affect skin, nails and scalp without further invasion. Superficial fungal diseases are conventionally diagnosed with direct microscopy, fungal culture or histopathology, treated with topical or systemic antifungal agents and prevented in immunocompetent patients by improving personal hygiene. However, conventional diagnostic tests can be time-consuming, also treatment can be insufficient or ineffective and prevention can prove to be demanding. Artificial Intelligence (AI) refers to a digital system having an intelligence akin to a human being. The concept of AI has existed since 1956, but hasn't been practicalised until recently. AI has revolutionised medical research in the recent years, promising to influence almost all specialties of medicine.</p><p><strong>Objective: </strong>An increasing number of articles have been published about the usage of AI in cutaneous mycoses.</p><p><strong>Methods: </strong>In this review, the key findings of articles about utilisation of AI in diagnosis, treatment and prevention of superficial fungal infections are summarised. Moreover, the need for more research and development is highlighted.</p><p><strong>Results: </strong>Fifty-four studies were reviewed. Onychomycosis was the most researched superficial fungal infection. AI can be used diagnosing fungi in macroscopic and microscopic images and classify them to some extent. AI can be a tool and be used as a part of something bigger to diagnose superficial mycoses.</p><p><strong>Conclusion: </strong>AI can be used in all three steps of diagnosing, treating and preventing. AI can be a tool complementary to the clinician's skills and laboratory results.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"68 1","pages":"e70007"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}