Natural Polysaccharides in Drug Delivery and Biomedical Applications最新文献_第8页

Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications 环糊精:结构、化学和物理性质及应用

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-12-28 DOI: 10.3390/polysaccharides3010001

B. G. Poulson, Q. Alsulami, Abeer A. Sharfalddin, E. E. El Agammy, Fouzi Mouffouk, A. Emwas, L. Jaremko, Mariusz Jaremko

{"title":"Cyclodextrins: Structural, Chemical, and Physical Properties, and Applications","authors":"B. G. Poulson, Q. Alsulami, Abeer A. Sharfalddin, E. E. El Agammy, Fouzi Mouffouk, A. Emwas, L. Jaremko, Mariusz Jaremko","doi":"10.3390/polysaccharides3010001","DOIUrl":"https://doi.org/10.3390/polysaccharides3010001","url":null,"abstract":"Due to their unique structural, physical and chemical properties, cyclodextrins and their derivatives have been of great interest to scientists and researchers in both academia and industry for over a century. Many of the industrial applications of cyclodextrins have arisen from their ability to encapsulate, either partially or fully, other molecules, especially organic compounds. Cyclodextrins are non-toxic oligopolymers of glucose that help to increase the solubility of organic compounds with poor aqueous solubility, can mask odors from foul-smelling compounds, and have been widely studied in the area of drug delivery. In this review, we explore the structural and chemical properties of cyclodextrins that give rise to this encapsulation (i.e., the formation of inclusion complexes) ability. This review is unique from others written on this subject because it provides powerful insights into factors that affect cyclodextrin encapsulation. It also examines these insights in great detail. Later, we provide an overview of some industrial applications of cyclodextrins, while emphasizing the role of encapsulation in these applications. We strongly believe that cyclodextrins will continue to garner interest from scientists for many years to come, and that novel applications of cyclodextrins have yet to be discovered.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85543589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Analysis of the Heterogeneities of First and Second Order of Cellulose Derivatives: A Complex Challenge 纤维素一、二级衍生物的异质性分析:一个复杂的挑战

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-11-03 DOI: 10.3390/polysaccharides2040051

P. Mischnick, Kristin Voiges, Julia Cuers-Dammann, Inga Unterieser, Patrick Sudwischer, Anika Wubben, P. Hashemi

{"title":"Analysis of the Heterogeneities of First and Second Order of Cellulose Derivatives: A Complex Challenge","authors":"P. Mischnick, Kristin Voiges, Julia Cuers-Dammann, Inga Unterieser, Patrick Sudwischer, Anika Wubben, P. Hashemi","doi":"10.3390/polysaccharides2040051","DOIUrl":"https://doi.org/10.3390/polysaccharides2040051","url":null,"abstract":"The complexity of the substituent distribution in polysaccharide derivatives is discussed and defined. The challenges regarding analytical characterization that results from various interrelated categories of distributions, including molecular weight, chemical composition, and microstructure, are outlined. Due to these convoluted levels of complexity, results should always be interpreted with carefulness. Various analytical approaches which have been applied to starch and cellulose derivatives are recapped, including enzymatic, mass spectrometric, and chromatographic methods. The relation of heterogeneities of first and second order among and along the polysaccharide chains is addressed. Finally, examples of own analytical work on cellulose ethers are presented, including the MS analysis of methyl cellulose (MC) blends and fractionation studies of fully esterified MC, especially its 4-methoxybenzoates by gradient HPLC on normal phase. Preparative fractionation according to the degree of substitution (DS) allows follow-up analysis in order to get more detailed information on the substituent distribution in such sub-fractions.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75838612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Characterization of Cassava Starch and Its Structural Changes Resulting of Thermal Stress by Functionally-Enhanced Derivative Spectroscopy (FEDS) 功能增强导数光谱(fed)表征木薯淀粉及其热应力引起的结构变化

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-11-03 DOI: 10.3390/polysaccharides2040052

Viviana Garcés, Angélica García-Quintero, Tulio A. Lerma, Manuel Palencia, E. Combatt, A. Arrieta

{"title":"Characterization of Cassava Starch and Its Structural Changes Resulting of Thermal Stress by Functionally-Enhanced Derivative Spectroscopy (FEDS)","authors":"Viviana Garcés, Angélica García-Quintero, Tulio A. Lerma, Manuel Palencia, E. Combatt, A. Arrieta","doi":"10.3390/polysaccharides2040052","DOIUrl":"https://doi.org/10.3390/polysaccharides2040052","url":null,"abstract":"Starch is one of the biopolymers that has been recognized as promising for its application as an eco-friendly substitute for conventional polymers due to its biodegradable nature, low cost, and considerable abundance from renewable vegetal-type resources. In particular, the use of cassava starch as raw material in the manufacture of packaging materials has increased in recent years. Consequently, the analytical study of the quality and features of starch and its derivatives throughout their entire life cycle have gained importance, with non-destructive sample methods being of particular interest. Among these, spectroscopic methods stand out. The aim of this study was evaluated using spectroscopic techniques (i.e., mid-infrared spectroscopy (MIRS) and functional-enhanced derivative spectroscopy (FEDS)) for the monitoring of the effect of the thermal stress of starch in conjunction with computational tools such as density-functional theory (DFT). It is concluded that the FEDS technique in conjunction with DFT calculations can be a useful tool for the high-precision spectral analysis of polymers subjected to small thermal perturbations. In addition, it is demonstrated that small changes produced by thermal stress can be monitored by infrared spectroscopy in conjunction with FEDS at wavenumber range between 3800 and 3000 cm−1, which would allow for the implementation of spectral techniques instead of thermal techniques for out-lab evaluations and for the study of the thermal stress of biomaterials.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89325966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Native Cyclodextrins and Their Derivatives as Potential Additives for Food Packaging: A Review 天然环糊精及其衍生物作为食品包装添加剂的研究进展

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-11-02 DOI: 10.3390/polysaccharides2040050

T. R. Arruda, C. Marques, N. Soares

引用次数: 9

Ruminal Lipid A Analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry 基质辅助激光解吸/电离飞行时间质谱法分析瘤胃脂质A

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-11-01 DOI: 10.3390/polysaccharides2040049

E. Sarmikasoglou, J. Vinyard, Mohamed S. Khan, Treenate Jiranantasak, A. Ravelo, R. Lobo, P. Fan, K. Jeong, A. Tuanyok, A. Faciola

{"title":"Ruminal Lipid A Analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry","authors":"E. Sarmikasoglou, J. Vinyard, Mohamed S. Khan, Treenate Jiranantasak, A. Ravelo, R. Lobo, P. Fan, K. Jeong, A. Tuanyok, A. Faciola","doi":"10.3390/polysaccharides2040049","DOIUrl":"https://doi.org/10.3390/polysaccharides2040049","url":null,"abstract":"Lipopolysaccharides (LPS) are cell wall components from Gram-negative bacteria and are composed of three covalently linked regions: the O-antigen, the core oligosaccharide, and the lipid A moiety, which carries most of their endotoxic activity. The objective of this study was to isolate and compare the lipid A structures from ruminal LPS derived from total mixed ration (TMR)- and pasture-fed cows, by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Ruminal bacteria were collected from two rumen-cannulated Holstein cows; one fed a TMR (60:40, forage–concentrate) and the other pasture fed. The representativeness of each sample was validated by comparing the rumen microbiome from the cows in our study to the core rumen microbiome from the previous literature. Lipopolysaccharides from each respective sample were extracted with a phenol–water extraction procedure and purified via ultracentrifugation. To isolate lipid A from the core and O-antigen, pure ruminal LPS samples were hydrolyzed with acetic acid. Lipid A derived from the TMR-fed cow potentially exhibited a tetra-acylated structure, whereas lipid A derived from the pasture-fed cow potentially exhibited a penta-acylated lipid A structure. Both samples were quantified using limulus amebocyte lysate (LAL) assay and exhibited low endotoxic activity, consistent with the MALDI-TOF MS observations. Results indicate that the lipid A acylation pattern differs between diets, and that ruminal bacteria express solely under-acylated lipid A structures contrary to hexa-acylated lipid A, typically expressed by bacteria such as E. coli.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88608858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Using Chitosan or Chitosan Derivatives in Cancer Therapy 壳聚糖及其衍生物在癌症治疗中的应用

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-10-13 DOI: 10.3390/polysaccharides2040048

Md. Salman Shakil, Kazi Mustafa Mahmud, M. Sayem, Mahruba Sultana Niloy, S. Halder, Md. Sakib Hossen, Md. Forhad Uddin, Md. Ashraful Hasan

引用次数: 23

Chitin as a Sorbent Superior to Other Biopolymers: Features and Applications in Environmental Research, Energy Conversion, and Understanding Evolution of Animals 几丁质作为一种优于其他生物聚合物的吸附剂:特征及其在环境研究、能量转换和理解动物进化中的应用

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-10-09 DOI: 10.3390/polysaccharides2040047

Felix Blind, S. Fränzle

{"title":"Chitin as a Sorbent Superior to Other Biopolymers: Features and Applications in Environmental Research, Energy Conversion, and Understanding Evolution of Animals","authors":"Felix Blind, S. Fränzle","doi":"10.3390/polysaccharides2040047","DOIUrl":"https://doi.org/10.3390/polysaccharides2040047","url":null,"abstract":"Chitin is an effective sorbent which can be used in environmental monitoring, beyond obvious applications in withholding metal-containing pollutants from wastewater- or nuclear fuel reprocessing flows, since background levels in (purified) chitin are very low except for a few metals (Fe, Cu, Al, Ti, and Zn). Since retention of Mx+ and their complexes on chitin depend on an oxidation state, and to a lesser extent the presence of possible ligands or co-ligands, partition between chitin samples exposed to sediment and those exposed to water can be changed by environmental factors such as local biota producing or absorbing/metabolizing effective ligands such as citrate or oxalate and by changes of redox potential. Thermodynamics are studied via log P, using calibration functions log P vs. 1/r or log P vs. Σσ (sum of Hammett parameters of ligand donor groups) for di- and trivalent elements not involved in biochemical activity (not even indirectly) and thus measuring “deviations” from expected values. These “deviations” can be due to input as a pollutant, biochemical use of certain elements, precipitation or (bio-induced reduction of SO42− or CO2) dissolution of solids in sediment. Biochemical processes which occur deep in sediment can be detected due to this effect. Data from grafted chitin (saturation within ≤ 10 min) and from outer surfaces of arthropods caught at the same site do agree well. Log P is more telling than total amounts retrieved. Future applications of these features of chitin are outlined.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81092181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Development of Chitosan Films from Edible Crickets and Their Performance as a Bio-Based Food Packaging Material 食用蟋蟀壳聚糖薄膜的研制及其作为生物基食品包装材料的性能

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-10-01 DOI: 10.3390/polysaccharides2040045

Morgan Malm, A. Liceaga, Fernanda San Martin-Gonzalez, O. Jones, Jose M. Garcia-Bravo, I. Kaplan

{"title":"Development of Chitosan Films from Edible Crickets and Their Performance as a Bio-Based Food Packaging Material","authors":"Morgan Malm, A. Liceaga, Fernanda San Martin-Gonzalez, O. Jones, Jose M. Garcia-Bravo, I. Kaplan","doi":"10.3390/polysaccharides2040045","DOIUrl":"https://doi.org/10.3390/polysaccharides2040045","url":null,"abstract":"Edible insects have gained attention due to their impressive nutritional composition, as well as their efficient use of natural resources. However, a research gap remains on the applications of insect chitosan, especially as it relates to their potential use as food packaging material. Chitosan from two reared cricket species (Acheta domesticus and Gryllodes sigillatus) was evaluated for use as food packaging material. Cricket chitosan films (CCF) were structurally similar to commercial shrimp chitosan films (SCF) at controlled glycerol levels, as seen by shared spectral peaks in FT-IR analyses. Mechanical properties of CCF showed they had equal or greater tensile strength when compared to commercial SCF, although flexibility was lower. Scanning electron microscopy showed increased roughness of microstructure, likely increasing the tortuosity. As a result, CCF had improved water vapor permeability compared to commercial SCF. Melanin complexes present in cricket chitin and chitosan increased hydrophobicity and decreased light transmittance. This study also revealed that intrinsic species differences, which occur during insect and crustacean exoskeleton development, could have effects on the functionality of chitosan packaging materials. Overall, CCF were found to be as effective as commercial SCF, while providing additional advantages. CCF derived from reared crickets have good mechanical and barrier properties, and improved water resistance and light barrier characteristics. Edible cricket chitosan has the potential to be used as bio-based packaging material for food and pharmaceutical applications.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90437074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Microalgae Polysaccharides: An Overview of Production, Characterization, and Potential Applications 微藻多糖:生产、表征和潜在应用综述

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-10-01 DOI: 10.3390/polysaccharides2040046

J. Costa, B. F. Lucas, Ana Gabrielle Pires Alvarenga, Juliana Botelho Moreira, M. G. de Morais

{"title":"Microalgae Polysaccharides: An Overview of Production, Characterization, and Potential Applications","authors":"J. Costa, B. F. Lucas, Ana Gabrielle Pires Alvarenga, Juliana Botelho Moreira, M. G. de Morais","doi":"10.3390/polysaccharides2040046","DOIUrl":"https://doi.org/10.3390/polysaccharides2040046","url":null,"abstract":"Microalgae and cyanobacteria are photosynthetic microorganisms capable of synthesizing several biocompounds, including polysaccharides with antioxidant, antibacterial, and antiviral properties. At the same time that the accumulation of biomolecules occurs, microalgae can use wastewater and gaseous effluents for their growth, mitigating these pollutants. The increase in the production of polysaccharides by microalgae can be achieved mainly through nutritional limitations, stressful conditions, and/or adverse conditions. These compounds are of commercial interest due to their biological and rheological properties, which allow their application in various sectors, such as pharmaceuticals and foods. Thus, to increase the productivity and competitiveness of microalgal polysaccharides with commercial hydrocolloids, the cultivation parameters and extraction/purification processes have been optimized. In this context, this review addresses an overview of the production, characterization, and potential applications of polysaccharides obtained by microalgae and cyanobacteria. Moreover, the main opportunities and challenges in relation to obtaining these compounds are highlighted.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87164362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Agave By-Products: An Overview of Their Nutraceutical Value, Current Applications, and Processing Methods 龙舌兰副产物:其营养价值、当前应用和加工方法综述

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-09-21 DOI: 10.3390/polysaccharides2030044

Jimena Álvarez-Chávez, M. Villamiel, Liliana Santos-Zea, A. K. Ramírez-Jiménez

{"title":"Agave By-Products: An Overview of Their Nutraceutical Value, Current Applications, and Processing Methods","authors":"Jimena Álvarez-Chávez, M. Villamiel, Liliana Santos-Zea, A. K. Ramírez-Jiménez","doi":"10.3390/polysaccharides2030044","DOIUrl":"https://doi.org/10.3390/polysaccharides2030044","url":null,"abstract":"Agave, commonly known as “maguey” is an important part of the Mexican tradition and economy, and is mainly used for the production of alcoholic beverages, such as tequila. Industrial exploitation generates by-products, including leaves, bagasse, and fibers, that can be re-valorized. Agave is composed of cellulose, hemicellulose, lignin, fructans, and pectin, as well as simple carbohydrates. Regarding functional properties, fructans content makes agave a potential source of prebiotics with the capability to lower blood glucose and enhance lipid homeostasis when it is incorporated as a prebiotic ingredient in cookies and granola bars. Agave also has phytochemicals, such as saponins and flavonoids, conferring anti-inflammatory, antioxidant, antimicrobial, and anticancer properties, among other benefits. Agave fibers are used for polymer-based composite reinforcement and elaboration, due to their thermo-mechanical properties. Agave bagasse is considered a promising biofuel feedstock, attributed to its high-water efficiency and biomass productivity, as well as its high carbohydrate content. The optimization of physical and chemical pretreatments, enzymatic saccharification and fermentation are key for biofuel production. Emerging technologies, such as ultrasound, can provide an alternative to current pretreatment processes. In conclusion, agaves are a rich source of by-products with a wide range of potential industrial applications, therefore novel processing methods are being explored for a sustainable re-valorization of these residues.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89892165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9