Natural Polysaccharides in Drug Delivery and Biomedical Applications最新文献

{"title":"Dextran: Sources, Structures, and Properties","authors":"E. Díaz-Montes","doi":"10.3390/POLYSACCHARIDES2030033","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2030033","url":null,"abstract":"Dextran is an exopolysaccharide (EPS) synthesized by lactic acid bacteria (LAB) or their enzymes in the presence of sucrose. Dextran is composed of a linear chain of d-glucoses linked by α-(1→6) bonds, with possible branches of d-glucoses linked by α-(1→4), α-(1→3), or α-(1→2) bonds, which can be low (<40 kDa) or high molecular weight (>40 kDa). The characteristics of dextran in terms of molecular weight and branches depend on the producing strain, so there is a great variety in its properties. Dextran has commercial interest because its solubility, viscosity, and thermal and rheological properties allow it to be used in food, pharmaceutical, and research areas. The aim of this review article is to compile the latest research (in the past decade) using LAB to synthesize high or low molecular weight dextran. In addition, studies using modified enzymes to produce dextran with specific structural characteristics (molecular weights and branches) are addressed. On the other hand, special attention is paid to LAB extracted from unconventional sources to expose their capacities as dextran producers and their possible application to compete with the only commercial strain (Leuconostoc mesenteroides NRRL B512).","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89351118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheological and Microstructural Features of Plant Culture Media Doped with Biopolymers: Influence on the Growth and Physiological Responses of In Vitro-Grown Shoots of Thymus lotocephalus","authors":"N. Coelho, Alexandra Filipe, B. Medronho, Solange Magalhães, C. Vitorino, L. F. Alves, S. Gonçalves, A. Romano","doi":"10.3390/POLYSACCHARIDES2020032","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2020032","url":null,"abstract":"In vitro culture is an important biotechnological tool in plant research and an appropriate culture media is a key for a successful plant development under in vitro conditions. The use of natural compounds to improve culture media has been growing and biopolymers are interesting alternatives to synthetic compounds due to their low toxicity, biodegradability, renewability, and availability. In the present study, different culture media containing one biopolymer (chitosan, gum arabic) or a biopolymer derivative [hydroxyethyl cellulose (HEC), carboxymethyl cellulose (CMC)], at 100 or 1000 mg L−1, were tested regarding their influence on the growth and physiological responses of Thymus lotocephalus in vitro culture. Cellulose-based biopolymers (HEC and CMC) and gum arabic were used for the first time in plant culture media. The results showed that CMC at 100 mg L−1 significantly improved shoot elongation while chitosan, at the highest concentration, was detrimental to T. lotocephalus. Concerning only the evaluated physiological parameters, all tested biopolymers and biopolymer derivatives are safe to plants as there was no evidence of stress-induced changes on T. lotocephalus. The rheological and microstructural features of the culture media were assessed to understand how the biopolymers and biopolymer derivatives added to the culture medium could influence shoot growth. As expected, all media presented a gel-like behaviour with minor differences in the complex viscosity at the beginning of the culture period. Most media showed increased viscosity overtime. The surface area increased with the addition of biopolymers and biopolymer derivatives to the culture media and the average pore size was considerably lower for CMC at 100 mg L−1. The smaller pores of this medium might be related to a more efficient nutrients and water uptake by T. lotocephalus shoots, leading to a significant improvement in shoot elongation. In short, this study demonstrated that the different types of biopolymers and biopolymer derivatives added to culture medium can modify their microstructure and at the right concentrations, are harmless to T. lotocephalus shoots growing in vitro, and that CMC improves shoot length.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80891820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of Lead, Cadmium, and Aluminum Sulfate from Simulated and Real Water with Native and Oxidized Starches","authors":"Konstantin B. L. Borchert, Rahma Boughanmi, Berthold Reis, Philipp Zimmermann, Christine Steinbach, Peter Graichen, Anastasiya Svirepa, J. Schwarz, R. Boldt, S. Schwarz, M. Mertig, Dana Schwarz","doi":"10.3390/POLYSACCHARIDES2020027","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2020027","url":null,"abstract":"The separation of toxic pollutants such as Pb2+, Cd2+, and Al3+ from water is a constant challenge as contamination of natural water bodies is increasing. Al3+ and especially Pb2+ and Cd2+ are ecotoxic and highly toxic for humans, even in ppb concentrations, and therefore removal below a dangerous level is demanding. Herein, the potential adsorber material starch, being ecofriendly, cheap, and abundantly available, was investigated. Thus, four different native starch samples (potato, corn, waxy corn, and wheat starch) and two oxidized starches (oxidized potato and corn starch) were comprehensively analyzed with streaming potential and charge density measurements, SEM-EDX, ATR-FTIR, 1H-NMR, and TGA. Subsequently, the starch samples were tested for the adsorption of Pb2+, Cd2+, and Al3+ from the respective sulfate salt solution. The adsorption process was analyzed by ICP-OES and SEM-EDX, and the adsorption isotherms were fitted comparing Langmuir, Sips, and Dubinin-Radushkevich models. Oxidized starch, for which chemical modification is one of the simplest, and also native potato starch were excellent natural adsorber materials for Al3+, Cd2+, and especially Pb2+ in the low concentration range, exhibiting maximum adsorption capacities of 84, 71, and 104 µmol/g for oxidized potato starch, respectively.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81352616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharide-Based Packaging Functionalized with Inorganic Nanoparticles for Food Preservation","authors":"L. M. Anaya-Esparza, Zuamí Villagrán-de la Mora, Noé Rodríguez-Barajas, J. M. Ruvalcaba-Gómez, Laura Elena Iñiguez-Muñoz, C. I. Maytorena-Verdugo, E. Montalvo-González, A. Pérez-Larios","doi":"10.3390/POLYSACCHARIDES2020026","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2020026","url":null,"abstract":"Functionalization of polysaccharide-based packaging incorporating inorganic nanoparticles for food preservation is an active research area. This review summarizes the use of polysaccharide-based materials functionalized with inorganic nanoparticles (TiO2, ZnO, Ag, SiO2, Al2O3, Fe2O3, Zr, MgO, halloysite, and montmorillonite) to develop hybrid packaging for fruit, vegetables, meat (lamb, minced, pork, and poultry), mushrooms, cheese, eggs, and Ginkgo biloba seeds preservation. Their effects on quality parameters and shelf life are also discussed. In general, treated fruit, vegetables, mushrooms, and G. biloba seeds markedly increased their shelf life without significant changes in their sensory attributes, associated with a slowdown effect in the ripening process (respiration rate) due to the excellent gas exchange and barrier properties that effectively prevented dehydration, weight loss, enzymatic browning, microbial infections by spoilage and foodborne pathogenic bacteria, and mildew apparition in comparison with uncoated or polysaccharide-coated samples. Similarly, hybrid packaging showed protective effects to preserve meat products, cheese, and eggs by preventing microbial infections and lipid peroxidation, extending the food product’s shelf life without changes in their sensory attributes. According to the evidence, polysaccharide-hybrid packaging can preserve the quality parameters of different food products. However, further studies are needed to guarantee the safe implementation of these organic–inorganic packaging materials in the food industry.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"39 1","pages":"400-428"},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86659580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of Surface Properties of Hyaluronan/Chitosan Multilayered Coatings for Tumor Cell Capture","authors":"Giulia Grassa Lima, J. R. Rocha Neto, H. F. Carvalho, M. Beppu","doi":"10.3390/POLYSACCHARIDES2020025","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2020025","url":null,"abstract":"Prostate cancer (PCa) is a slow-growing neoplasm that has, when diagnosed in its early stages, great chances of cure. During initial tumor development, current diagnostic methods fail to have the desired accuracy, thus, it is necessary to develop or improve current detection methods and prognostic markers for PCa. In this scenario, films composed of hyaluronic acid (HA) and chitosan (CHI) have demonstrated significant capture potential of prostate tumor cells (PC3 line), exploring HA as a CD44 receptor ligand and direct mediator in cell-film adhesion. Here, we present a strategy to control structural and cell adhesion properties of HA/CHI films based on film assembly conditions. Films were built via Layer-by-layer (LbL) deposition, where the pH conditions (3.0 and 5.0) and number of bilayers (3.5, 10.5, and 20.5) were controlled. The characterization of these films was carried out using profilometry, ultraviolet-visible (UV-VIS), atomic force microscopy (AFM) and contact angle measurements. Multilayer HA/CHI films produced at pH 3.0 gave optimum surface wettability and availability of free carboxyl groups. In turn, at pH 5.0, the coverings were thinner and presented a smoother surface. Films prepared with 3.5 bilayers showed greater tumor cell capture regardless of the pH condition, while films containing 10.5 and 20.5 bilayers presented a significant swelling process, which compromised their cell adhesion potential. This study shows that surface chemistry and morphology are critical factors for the development of biomaterials designed for several cell adhesion applications, such as rapid diagnostic, cell signaling, and biosensing mechanisms.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"26 1","pages":"387-399"},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87934212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible Films and Coatings Formulated with Arrowroot Starch as a Non-Conventional Starch Source for Plums Packaging","authors":"Gislaine Ferreira Nogueira, Bianca de Oliveira Leme, G. Santos, J. A. D. Silva, P. Nascimento, C. Soares, F. Fakhouri, R. D. de Oliveira","doi":"10.3390/POLYSACCHARIDES2020024","DOIUrl":"https://doi.org/10.3390/POLYSACCHARIDES2020024","url":null,"abstract":"Increasing environmental awareness has promoted an interest in alternative strategies to common plastics obtained from fossil sources, stimulating research on the use of biodegradable and edible films/coatings obtained from renewable sources such as arrowroot starch. This research work aimed to evaluate the use of arrowroot starch on the formation of edible films and coatings. Increasing the concentration of arrowroot starch (from 1% to 5%, mass/mass) in the film produced by casting resulted in increased water vapor permeability (from 2.20 to 3.68 g mm/m2 day kPa), moisture content (3.22% to 7.95%), increased thickness (from 0.029 to 0.101 mm), and decreased solubility in water (from 22.45% to 13.89%). The films were homogeneous, transparent and manageable, with the exception of the film with 1% starch. Film-forming solutions at concentrations of 0%, 2%, and 4% (mass/mass) of arrowroot starch were prepared and applied to plums to evaluate post-harvest behavior when stored at 25 and 5 °C for 35 days. The 2% coating adhered well to the plums’ surfaces, was bright and was effective in reducing mass loss and respiratory rate, associated with storage temperature of 5 °C. The 4% coating presented an opaque and flocculated appearance.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"68 1","pages":"373-386"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88483063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Polysaccharides: Properties and Applications","authors":"O. Michael, C. Adetunji, A. Ayeni, M. Akram, Inamuddin, J. B. Adetunji, M. Olaniyan, M. Muhibi","doi":"10.1002/9781119711414.CH20","DOIUrl":"https://doi.org/10.1002/9781119711414.CH20","url":null,"abstract":"","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72756137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alginates: Properties and Applications","authors":"S. Raghav, P. Jain, Dinesh Kumar","doi":"10.1002/9781119711414.CH19","DOIUrl":"https://doi.org/10.1002/9781119711414.CH19","url":null,"abstract":"","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82746917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Polysaccharides: Properties and Applications","authors":"Tonmoy Ghosh, Rabinder Singh, A. A. Nesamma, P. P. Jutur","doi":"10.1002/9781119711414.CH3","DOIUrl":"https://doi.org/10.1002/9781119711414.CH3","url":null,"abstract":"","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74078935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Wall Polysaccharides","authors":"A. Ullah, Lutufur Rahman, Muhammad Bilal Yazdani, Muhammad Irfan, Waheed S. Khan, A. Rehman","doi":"10.1002/9781119711414.CH2","DOIUrl":"https://doi.org/10.1002/9781119711414.CH2","url":null,"abstract":"","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":"714 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86610557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}