Natural Polysaccharides in Drug Delivery and Biomedical Applications最新文献

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Nanocellulose in Heterogeneous Water-Based Polymerization for Wood Adhesives 纳米纤维素在木材胶粘剂非均相水基聚合中的应用
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-02-15 DOI: 10.3390/polysaccharides3010012
Consuelo Fritz, J. Olivera
{"title":"Nanocellulose in Heterogeneous Water-Based Polymerization for Wood Adhesives","authors":"Consuelo Fritz, J. Olivera","doi":"10.3390/polysaccharides3010012","DOIUrl":"https://doi.org/10.3390/polysaccharides3010012","url":null,"abstract":"The interest in the development of biobased adhesives has increased due to environmental concerns. Moreover, as the production of engineered wood products (EWPs) is expected to grow, the wood adhesives market needs to transit toward formaldehyde-free products. Cellulose nanoparticles (CNPs) are a material with unique properties and advantages for producing hybrid materials as biobased wood adhesives. Besides their traditional use as reinforcing additives, CNPs can be incorporated at the beginning of the polymerization reaction to form in situ polymerized hybrid adhesives with better mechanical and physicochemical properties than the neat adhesive. Despite their outstanding characteristics, CNPs are still an emerging nanomaterial in the wood adhesive field, and the studies are incipient. This review explores the utilization of CNPs in heterogeneous polymerization for the production of polyvinyl acetate, polymeric isocyanates, waterborne polyurethane systems, and other waterborne polymer latexes. The main challenges are discussed, and some recommendations are set down for the manufacture of these novel hybrid nanocomposites.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78435940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Acknowledgment to Reviewers of Polysaccharides in 2021 向2021年《多糖》审稿人致谢
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-02-08 DOI: 10.3390/polysaccharides3010011
{"title":"Acknowledgment to Reviewers of Polysaccharides in 2021","authors":"","doi":"10.3390/polysaccharides3010011","DOIUrl":"https://doi.org/10.3390/polysaccharides3010011","url":null,"abstract":"Rigorous peer-reviews are the basis of high-quality academic publishing [...]","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85151669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Stabilization behind Cardamom Pickering Emulsion Using Nanocellulose 纳米纤维素对豆蔻酸洗乳化学稳定性的影响
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-02-01 DOI: 10.3390/polysaccharides3010010
Alana Gabrieli Souza, Rafaela Reis Ferreira, Éder Ramin de Oliveira, M. Kato, S. Mitra, D. Rosa
{"title":"Chemical Stabilization behind Cardamom Pickering Emulsion Using Nanocellulose","authors":"Alana Gabrieli Souza, Rafaela Reis Ferreira, Éder Ramin de Oliveira, M. Kato, S. Mitra, D. Rosa","doi":"10.3390/polysaccharides3010010","DOIUrl":"https://doi.org/10.3390/polysaccharides3010010","url":null,"abstract":"Cardamom essential oil (EO) is a rare oil of high scientific and economic interest due to its biofunctionality. This work aims to stabilize the EO by Pickering emulsions with nanocellulose, in the form of nanocrystals (CNC) or nanofibers (CNF), and to investigate the stability and chemical and physical interactions involved in the process. The emulsions were characterized by droplet size, morphology, stability, surface charges, Fourier transform infrared spectroscopy, FT-Raman, nuclear magnetic resonance, and scanning electron microscopy. Stable emulsions were prepared with cellulose morphologies and CNCs resulted in a 34% creaming index, while CNFs do not show instability. Emulsions indicate a possible interaction between nanocellulose, α-terpinyl acetate, and 1,8-cineole active essential oil compounds, where α-terpinyl acetate would be inside the drop and 1,8-cineole is more available to interact with cellulose. The interaction intensity depended on the morphology, which might be due to the nanocellulose’s self-assembly around oil droplets and influence on oil availability and future application. This work provides a systematic picture of cardamomum derived essential oil Pickering emulsion containing nanocellulose stabilizers’ formation and stability, which can further be extended to other value-added oils and can be an alternative for the delivery of cardamom essential oil for biomedical, food, cosmetics, and other industries.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89830706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Structure and Conformation Study of the O-Antigen from the Lipopolysaccharide of Cupriavidus Metallidurans CH34 金属铜藻CH34脂多糖o抗原的结构与构象研究
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-01-20 DOI: 10.3390/polysaccharides3010009
A. Notaro, Adele Vanacore, A. Molinaro, Immacolata Speciale, C. de Castro
{"title":"Structure and Conformation Study of the O-Antigen from the Lipopolysaccharide of Cupriavidus Metallidurans CH34","authors":"A. Notaro, Adele Vanacore, A. Molinaro, Immacolata Speciale, C. de Castro","doi":"10.3390/polysaccharides3010009","DOIUrl":"https://doi.org/10.3390/polysaccharides3010009","url":null,"abstract":"Cupriavidus metallidurans is a Gram-negative bacterium that has attracted the attention of the scientific community since its discovery back in 1976. It was initially studied as a model organism for bioremediation processes due to its ability to survive in heavy metal-rich environments. However, in recent years, there is evidence that this bacterium can be a potential pathogen for humans. How C. metallidurans can survive in such different environments is unknown and prompted the following work. Its great adaptability could be explained by the structural and conformational studies of the O-antigen portion of the lipopolysaccharide, the main constituent of the outer membrane of Gram-negative bacteria, which is the one in direct contact with the external environment. Therefore, a combination of chemical and spectroscopic analyses was used to define the O-antigen structure, disclosing that it is a polysaccharide constituted of a linear tetrasaccharide repeating unit that does not resemble other structures already reported for bacteria: [4)-α-d-GalNAc-(1→3)-α-d-Qui2NAc4NHBA-(1→3)-α-l-Rha-(1→3)-α-l-Rha-(1→]. Interestingly, the molecular dynamics studies revealed that the three-dimensional structure of the O-antigen is highly flexible: it might adopt three different right-handed helix conformations described by a two, three, or four-fold symmetry. This conformational behavior could represent the reason behind the survival of C. metallidurans in different environments.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73165293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface Property Modification of Collagen, Hyaluronic Acid, and Chitosan Films with the Neodymium Laser 用钕激光修饰胶原蛋白、透明质酸和壳聚糖薄膜的表面性能
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-01-19 DOI: 10.3390/polysaccharides3010008
Sylwia Grabska-Zielińska, A. Sionkowska
{"title":"Surface Property Modification of Collagen, Hyaluronic Acid, and Chitosan Films with the Neodymium Laser","authors":"Sylwia Grabska-Zielińska, A. Sionkowska","doi":"10.3390/polysaccharides3010008","DOIUrl":"https://doi.org/10.3390/polysaccharides3010008","url":null,"abstract":"In this paper, surfaces of thin films prepared from blends of collagen, hyaluronic acid, and chitosan and modified by neodymium laser radiation were researched. To evaluate the laser beam effect on the surface structure, scanning electron microscopy (SEM) imaging and infrared spectroscopy (FTIR-ATR) were employed. The results demonstrated that during laser treatment the specimens lost water due to the evaporation process. SEM images revealed some changes in the biopolymer films structure. After laser treatment, the micro-foam formation was observed on the biopolymeric films. The micro-foaming in films based on ternary blends was more extensive than in those made of a single biopolymer. The results of this study indicate that collagen, hyaluronic acid, and chitosan materials can be modified with laser treatment. Such treatment can be used for material modification for potential biomedical purposes.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cassava-Starch-Based Films Incorporated with Buriti (Mauritia flexuosa L.) Oil: A New Active and Bioactive Material for Food Packaging Applications 与Buriti公司合并的木薯淀粉基电影(毛里求斯flexuosa L.)油:一种用于食品包装的新型活性和生物活性材料
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-01-12 DOI: 10.3390/polysaccharides3010006
Danusa Silva da Costa, K. Takeuchi, R. M. D. Silva, J. O. Oliveira Filho, M. Bertolo, C. M. Belisário, M. Egea, G. R. Plácido
{"title":"Cassava-Starch-Based Films Incorporated with Buriti (Mauritia flexuosa L.) Oil: A New Active and Bioactive Material for Food Packaging Applications","authors":"Danusa Silva da Costa, K. Takeuchi, R. M. D. Silva, J. O. Oliveira Filho, M. Bertolo, C. M. Belisário, M. Egea, G. R. Plácido","doi":"10.3390/polysaccharides3010006","DOIUrl":"https://doi.org/10.3390/polysaccharides3010006","url":null,"abstract":"The objective of this study was to develop and characterize cassava-starch-based films incorporated with buriti (Mauritia flexuosa L.) oil and emulsifier (Tween 20). An experimental factorial design 22 with three central points was used to develop the films, by varying the concentrations of buriti oil (0.15 to 0.45% w/v) and emulsifier (0.02 to 0.04% w/v). Film thickness and weight increased with increasing buriti oil concentration. The water vapor permeability of the films ranged from 0.22 to 0.366 g mm h−1 m−2 kPa−1. The tensile strength values varied from 4.21 to 6.95 MPa, the elasticity modulus varied from 538.53 to 722.78 MPa, and elongation to rupture varied from 1.13 to 1.66%. The film color was characterized as yellowish, dark, and intense (higher oil content); and clear and a low-intensity color (lower oil content). The films presented a total carotenoid content ranging from 3.63 to 29.73 μg β-carotene/g, which may have resulted in their antioxidant potential against DPPH• (1,1-diphenyl-2-picryl-hydrazyl) radical (from 74.28 to 87.74%). The central formulation of the experimental design (buriti oil 0.30% and emulsifier 0.03%) presented a good performance and can be applied as packaging for foods with a lower water content and that demand protection against oxidation.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87981773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Polysaccharides in Agro-Industrial Biomass Residues 农业-工业生物质残基中的多糖
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-01-09 DOI: 10.3390/polysaccharides3010005
M. A. D. Souza, Isis Tavares Vilas-Boas, Jôse Maria Leite-da-Silva, Pérsia do Nascimento Abrahão, B. E. TEIXEIRA-COSTA, V. Veiga-Junior
{"title":"Polysaccharides in Agro-Industrial Biomass Residues","authors":"M. A. D. Souza, Isis Tavares Vilas-Boas, Jôse Maria Leite-da-Silva, Pérsia do Nascimento Abrahão, B. E. TEIXEIRA-COSTA, V. Veiga-Junior","doi":"10.3390/polysaccharides3010005","DOIUrl":"https://doi.org/10.3390/polysaccharides3010005","url":null,"abstract":"The large-scale industrial use of polysaccharides to obtain energy is one of the most discussed subjects in science. However, modern concepts of biorefinery have promoted the diversification of the use of these polymers in several bioproducts incorporating concepts of sustainability and the circular economy. This work summarizes the major sources of agro-industrial residues, physico-chemical properties, and recent application trends of cellulose, chitin, hyaluronic acid, inulin, and pectin. These macromolecules were selected due to their industrial importance and valuable functional and biological applications that have aroused market interests, such as for the production of medicines, cosmetics, and sustainable packaging. Estimations of global industrial residue production based on major crop data from the United States Department of Agriculture were performed for cellulose content from maize, rice, and wheat, showing that these residues may contain up to 18%, 44%, and 35% of cellulose and 45%, 22%, and 22% of hemicellulose, respectively. The United States (~32%), China (~20%), and the European Union (~18%) are the main countries producing cellulose and hemicellulose-rich residues from maize, rice, and wheat crops, respectively. Pectin and inulin are commonly obtained from fruit (~30%) and vegetable (~28%) residues, while chitin and hyaluronic acid are primarily found in animal waste, e.g., seafood (~3%) and poultry (~4%).","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78227046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Polysaccharide Stalks in Didymosphenia geminata Diatom: Real World Applications and Strategies to Combat Its Spread 双硅藻中的多糖茎:现实世界的应用和对抗其传播的策略
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-01-06 DOI: 10.3390/polysaccharides3010004
Esther Somanader, Roshini Sreenivas, Golnoosh Siavash, Nicole Rodriguez, T. Gao, H. Ehrlich, M. Rahman
{"title":"Polysaccharide Stalks in Didymosphenia geminata Diatom: Real World Applications and Strategies to Combat Its Spread","authors":"Esther Somanader, Roshini Sreenivas, Golnoosh Siavash, Nicole Rodriguez, T. Gao, H. Ehrlich, M. Rahman","doi":"10.3390/polysaccharides3010004","DOIUrl":"https://doi.org/10.3390/polysaccharides3010004","url":null,"abstract":"Didymosphenia geminata is a species of freshwater diatom that is known as invasive and is propagating quickly around the world. While invasive species are generally considered a nuisance, this paper attempts to find useful applications for D. geminata in the biomedical field and wastewater remediation. Here, we highlight the polysaccharide-based stalks of D. geminata that enable versatile potential applications and uses as a biopolymer, in drug delivery and wound healing, and as biocompatible scaffolding in cell adhesion and proliferation. Furthermore, this review focuses on how the polysaccharide nature of stalks and their metal-adsorption capacity allows them to have excellent wastewater remediation potential. This work also aims to assess the economic impact of D. geminata, as an invasive species, on its immediate environment. Potential government measures and legislation are recommended to prevent the spread of D. geminata, emphasizing the importance of education and collaboration between stakeholders.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88791192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Delving into the Role of Dietary Fiber in Gluten-Free Bread Formulations: Integrating Fundamental Rheological, Technological, Sensory, and Nutritional Aspects 深入研究膳食纤维在无麸质面包配方中的作用:整合基本流变学,技术,感官和营养方面
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-12-30 DOI: 10.3390/polysaccharides3010003
Marijana Djordjević, Miljana Djordjević, D. Šoronja-Simović, I. Nikolić, Z. Šereš
{"title":"Delving into the Role of Dietary Fiber in Gluten-Free Bread Formulations: Integrating Fundamental Rheological, Technological, Sensory, and Nutritional Aspects","authors":"Marijana Djordjević, Miljana Djordjević, D. Šoronja-Simović, I. Nikolić, Z. Šereš","doi":"10.3390/polysaccharides3010003","DOIUrl":"https://doi.org/10.3390/polysaccharides3010003","url":null,"abstract":"The evidenced relevance of dietary fibers (DF) as functional ingredients shifted the research focus towards their incorporation into gluten-free (GF) bread, aiming to attain the DF contents required for the manifestation of health benefits. Numerous studies addressing the inclusion of DF from diverse sources rendered useful information regarding the role of DF in GF batter’s rheological properties, as well as the end product’s technological and nutritional qualities. The presented comprehensive review aspires to provide insight into the changes in fiber-enriched GF batter’s fundamental rheological properties, and technological, sensory, and nutritional GF bread quality from the insoluble and soluble DF (IDF and SDF) perspective. Different mechanisms for understanding IDF and SDF action on GF batter and bread were discussed. In general, IDF and SDF can enhance, but also diminish, the properties of GF batter and bread, depending on their addition level and the presence of available water in the GF system. However, it was seen that SDF addition provides a more homogenous GF batter structure, leading to bread with higher volumes and softer crumb, compared to IDF. The sensory properties of fiber-enriched GF breads were acceptable in most cases when the inclusion level was up to 7 g/100 g, regardless of the fiber type, enabling the labeling of the bread as a source of fiber.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82225237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Natural Polymers Used in Edible Food Packaging—History, Function and Application Trends as a Sustainable Alternative to Synthetic Plastic 用于食用食品包装的天然聚合物——作为合成塑料的可持续替代品的历史、功能和应用趋势
Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2021-12-29 DOI: 10.3390/polysaccharides3010002
B. E. TEIXEIRA-COSTA, C. T. Andrade
{"title":"Natural Polymers Used in Edible Food Packaging—History, Function and Application Trends as a Sustainable Alternative to Synthetic Plastic","authors":"B. E. TEIXEIRA-COSTA, C. T. Andrade","doi":"10.3390/polysaccharides3010002","DOIUrl":"https://doi.org/10.3390/polysaccharides3010002","url":null,"abstract":"In this review, a historical perspective, functional and application trends of natural polymers used to the development of edible food packaging were presented and discussed. Polysaccharides and proteins, i.e., alginate; carrageenan; chitosan; starch; pea protein, were considered. These natural polymers are important materials obtained from renewable plant, algae and animal sources, as well as from agroindustrial residues. Historically, some of them have been widely used by ancient populations for food packaging until these were replaced by petroleum-based plastic materials after World War II. Nowadays, biobased materials for food packaging have attracted attention. Their use was boosted especially because of the environmental pollution caused by inappropriate disposal of plastic packaging. Biobased materials are welcome to the design of food packaging because they possess many advantages, such as biodegradability, biocompatibility and low toxicity. Depending on the formulation, certain biopolymer-based packaging may present good barrier properties, antimicrobial and antioxidant activities Thus, polysaccharides and proteins can be combined to form diverse composite films with improved mechanical and biological behaviors, making them suitable for packaging of different food products.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82785538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
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