T. Dai, Xiao Deng, C. Ionita, Qingyang Wei, Tianyu Ma, Yaqiang Liu, D. Bednarek, S. Rudin, R. Yao
{"title":"Development and assessment of statistical iterative image reconstruction for CT on a small animal SPECT/CT dual-modality system","authors":"T. Dai, Xiao Deng, C. Ionita, Qingyang Wei, Tianyu Ma, Yaqiang Liu, D. Bednarek, S. Rudin, R. Yao","doi":"10.1109/NSSMIC.2012.6551776","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551776","url":null,"abstract":"We developed a statistical iterative CT image reconstruction software for a newly constructed high-resolution small animal SPECT/CT dual-modality system, and assessed its performance at different radiation exposure levels. The objective of this work was to preserve or improve reconstructed image quality at either the same or reduced animal x-ray radiation exposure. The SPECT/CT system used a single detector for both the CT and SPECT modalities that consists of a micro-columnar CsI(TI) phosphor, a light image intensifier (LII) and a CCD sensor. The CT reconstruction software was based on the ordered-subset-convex (OSC) algorithm, and the system matrix was calculated through a ray-driven approach. A self-calibration method was implemented to calculate the offset of the axis of rotation (AOR), an important geometry parameter of the system. An endovascular stent was imaged to evaluate the high resolution performance of the statistical reconstructed image. A sacrificed mouse was scanned at different exposure levels to assess the effect of statistical noise on the image. The mouse studies were reconstructed with both the statistical reconstruction software and a filtered back-projection (FBP) program. The images were assessed and compared by contrast to noise ratio (CNR) in the region of interest. The images yielded by the statistical reconstruction software were artifact free and show superior noise performance to those from FBP reconstruction at different radiation exposure levels. The statistical reconstructed images with reduced exposure showed obviously higher image quality than those from FBP reconstruction at full exposure.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115415457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response evolution of the CMS ECAL and R&D studies for electromagnetic calorimetry at the high-luminosity LHC","authors":"F. Nessi-Tedaldi","doi":"10.1109/NSSMIC.2012.6551434","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551434","url":null,"abstract":"While the CMS experiment is currently harvesting LHC collision data at CERN, the performance of its electromagnetic calorimeter (ECAL) is being constantly monitored, and work has started to assess the need for changes to the detector to ensure an adequate performance for High-Luminosity LHC (HL-LHC) running, which is planned for 2022 and beyond. In this paper, results from CMS running, beam tests and laboratory measurements are combined to anticipate the detector performance evolution at the HL-LHC. Further, various R&D studies are illustrated, that will provide a useful choice for electromagnetic calorimetry at the HL-LHC.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116655302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Konik, P. Dasari, J. M. Mukherjee, Karen L. Johnson, E. Helfenbein, Simon C. Chien, S. Babaeizadeh, L. Shao, J. Dey, M. King
{"title":"Respiratory tracking using EDR for list-mode binning in cardiac emission tomography: Comparison with MRI heart motion measurements","authors":"A. Konik, P. Dasari, J. M. Mukherjee, Karen L. Johnson, E. Helfenbein, Simon C. Chien, S. Babaeizadeh, L. Shao, J. Dey, M. King","doi":"10.1109/NSSMIC.2012.6551488","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551488","url":null,"abstract":"In cardiac emission tomography, the respiratory motion of the heart forms an important source of artifact in the reconstructed images, which can mislead diagnosis. Various methods have been developed to measure the respiratory signal externally (e.g., bellow and visual tracking systems) and estimate the motion of the heart. However, most of these methods tend to be time consuming, costly and require additional effort both from patients and technicians. An alternative to these methods is ECG/EMG derived respiration (EDR), which uses ECG leads already placed on the patient without requiring any additional hardware set-up. In this work, we performed a series of volunteer MRI studies to compare the actual heart motion and EDR signals. Simultaneous to these acquisitions, external motion information from a bellow placed on the abdomen and a visual tracking system (VTS) were also obtained. These external measurements were compared with the \"true\" respiratory heart motion information provided by MRI. Our preliminary work indicated that the EDR-in average-had lower correlation values compared to the other two external methods. However, this must be mainly because of the ECG distortion in the MR magnetic field. As the EDR does not require any additional instrument, it could become a practical respiratory tracking method for cardiac emission tomography provided the issues with body motion are addressed.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116763334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Genat, O. Le Dortz, A. Lounis, G. Martin-Chassard, J. Tongbong, D. Thienpont
{"title":"OMEGAPIX2: 3D integrated circuit prototype dedicated to the ATLAS pixel detector for the High Luminosity LHC","authors":"J. Genat, O. Le Dortz, A. Lounis, G. Martin-Chassard, J. Tongbong, D. Thienpont","doi":"10.1109/NSSMIC.2012.6551212","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551212","url":null,"abstract":"The OMEGAPIX2 chip embeds a matrix of channels implemented in two vertically integrated (3D) circuits and designed to read out a matrix of 96×24 plannar pixels. The form factor of each pixel is 35×200 μm. The first 3D devices's layer includes the analogue part of the channel processing, it will be bounded to the sensor by connecting the channel inputs and the sensors pixels by the Through Silicon Vias (TSV); the other layer performs the digital memorization of each events and manages the sorting of good events after the Level 1 (L1) trigger acquisition. In this paper, the 3D technology is briefly described, some design considerations are discussed and some typical simulations are shown. The circuit has been submitted in October 2011 and is waited to be received in December 2012.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116923984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of cardiac abnormalities from MRI sequences by using a deformable mesh model","authors":"Felipe M. Parages, J. Brankov","doi":"10.1109/NSSMIC.2012.6551921","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551921","url":null,"abstract":"In this work, we explore the potential of estimated ventricle motion, using a deformable mesh model (DMM), to detect cardiac pathologies such as hypertension and mitral regurgitation in MRI cardiac gated image sequences. In DMM, left ventricle motion was estimated by deforming a 3D-mesh along pixel-intensity variations of combined tagged and cine MRI sequences. Next, dense motion fields obtained from DMM were used to compute 3D torsion maps for the LV using a B-Spline model. Features extracted from the torsion maps were used for detection of hypertension and mitral regurgitation by performing Fisher Discriminant Analysis. Finally, detection performance of DMM motion was compared to other known motion-tracking approaches, such as Feature Based (FB) analysis and Unwrapped Phase Strain (SUP).","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117112340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High energy gamma-ray imaging using Cherenkov cone detection - A Monte Carlo study with application to a Compton camera system","authors":"Todd E. Peterson, A. Brill, A. Walenta","doi":"10.1109/NSSMIC.2012.6551741","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551741","url":null,"abstract":"With the availability of single-photon detecting Si-APD's and multi-anode PM tubes, the technical basis for the detection of Cherenkov light produced by Compton electrons in a dense absorbing detector from 1 to 10 MeV gamma rays is given. In a Monte Carlo simulation study using detailed electron track and Cherenkov light simulation, we show that in many transparent materials enough visible light photons are created (up to 400) to support detection of high energy gamma rays. Since the opening angle of the light cone is practically saturated, the reconstruction of the 3D position of interaction should be possible. At the same time we found that the angular spread is dominated by multiple scattering, compromising this option. However, a more detailed study of materials shows that optimization may make possible good position resolution and depth measurement for parallax correction.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117124934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Anokhin, M. Lerch, M. Petasecca, A. Rosenfeld, O. Zinets
{"title":"Response of silicon diodes for synchrotron radiation","authors":"I. Anokhin, M. Lerch, M. Petasecca, A. Rosenfeld, O. Zinets","doi":"10.1109/NSSMIC.2012.6551445","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551445","url":null,"abstract":"Because of very high intensity and pulsed nature of synchrotron radiation the nonlinear effects in recombination-generation kinetics must be taken into account in the response of silicon diodes under irradiation. Dependences of the charge carrier lifetime and the ambipolar diffusion coefficient on the excess carrier density generated by the synchrotron radiation have been considered. Response of silicon diodes on photons from synchrotron sources with energy 20-100 keV has been calculated using the Shockley-Reed recombination statistics. Diffusion equation with time-dependent generation functions has been solved numerically for various intensity of the photon beam and parameters of diodes (diodes design and characteristics of impurity centers). Optimal choice of parameters of diodes for the short-cut current and the photovoltaic operation mode are discussed. Dependencies of responses on the generation rate can be converted into the dose rate responses of diodes by calculating the energy deposition in silicon. At very high beam intensity (the excess minority carrier density is much larger than the density of the majority charge carriers), the Shockley-Reed recombination model would be invalid and the Auger recombination becomes dominant. To explain experimental data on the dose rate response it is needed to use a correct function of the excess carrier lifetime versus the carrier density.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117129987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of patient doses at different CT scanners with same acquisition protocol","authors":"L. Balkay, A. Oszhinszki, A. Krizsan","doi":"10.1109/NSSMIC.2012.6551837","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551837","url":null,"abstract":"In the last decade both the number of powerful CT scanners and the number of patient investigations increased with a consequent increase of the patient radiation dose. There are large dose variations (more than 10 fold) among individual CT centers and it remains true if they include the same model of CT scanners. The aim of this study was to compare the patient effective dose (De) during the CT examinations from different manufacturer models presuming the same acquisition protocol and using the imPACT patient organ and effective dose calculator program. The following manufacturers and models were selected in the program: GE (LightSpeed Ultra, LightSpeed 16, LightSpeed Pro 16, LightSpeed VCT), Philips (Brilliance 16, Brilliance 16 Power, Big Bore, Brilliance 64/40) and the Siemens (Emotion 6, Sensation 16, Sensation 16 Straton, Sensation 64, Definition AS). Head and body scans were defined for all cases altering tube voltages, while dose calculations were normalized to 100 mAs X-ray exposure. It was found that in body investigations the calculated De for the GE scans were higher by 20% comparing to Siemens and Philips related values. For the head examinations the differences were larger by almost 55%. We also demonstrated that a power relationship can be found between the De and the tube voltage with the exponent of 3.02±0.14 kV-1 and 2.68±0.14 kV-1 for the body and the head scans respectively. It can be concluded that the patient effective dose could be different in CT examinations using distinct CT scanners but defining the same acquisition protocol. Considering the patient dose, this also means that the scan protocols cannot be transferred between different models without specific investigation.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"55 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120818475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Andreotti, W. Baldini, M. Benettoni, R. Calabrese, V. Carassiti, G. Cibinetto, A. Cotta, F. Daicorso, C. Dedonato, F. Fabbri, E. Luppi, R. Malaguti, A. Montanari, A. Pietropaolo, M. Posocco, M. Rotondo, V. Santoro, R. Stroili, L. Tomassetti, G. Tellarini, N. Tosi
{"title":"The SuperB muon detector, status and perspectives","authors":"M. Andreotti, W. Baldini, M. Benettoni, R. Calabrese, V. Carassiti, G. Cibinetto, A. Cotta, F. Daicorso, C. Dedonato, F. Fabbri, E. Luppi, R. Malaguti, A. Montanari, A. Pietropaolo, M. Posocco, M. Rotondo, V. Santoro, R. Stroili, L. Tomassetti, G. Tellarini, N. Tosi","doi":"10.1109/NSSMIC.2012.6551436","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551436","url":null,"abstract":"The superB project foresees the construction of a high intensity super-flavor factory at the Cabibbo Lab, in Tor Vergata (near Rome). The experiment, based on a high intensity asymmetric electron-positron collider, and on the related detector, is expected to reach a very high luminosity: 2 × 1036 cm-2s-1, that will allow the high statistic study of rare decays and, possibly, will show evidences of new physics. The Muon Detector plays the fundamental role of identifying (mainly) muons tracks, present in many important decays. In order to cope with the very high particle flux, the detector must provide a very fast response and has to be very robust with respect to radiation damage and aging effects. The adopted technique exploits extruded plastic scintillators as active material, WLS fibers for the light collection and Silicon Photon Multipliers (SiPM) as photo-detectors In this manuscript, a complete description of the designed Muon detector and of all the related studies will be presented. In particular, we will focus on the results of a beam tests performed at Fermilab on a large scale prototype and on radiation tests of the most sensitive parts of the detector.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121048877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Xia, A. Maier, F. Dennerlein, H. Hofmann, J. Hornegger
{"title":"Efficient 2D filtering for cone-beam VOI reconstruction","authors":"Yan Xia, A. Maier, F. Dennerlein, H. Hofmann, J. Hornegger","doi":"10.1109/NSSMIC.2012.6551549","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551549","url":null,"abstract":"In some clinical applications, e.g., examination of deployed stents or coils during the intervention, only a small portion of the patient may be of diagnostic interest. For the sake of dose reduction to the patient, it is practicable to deploy a collimator to block radiation dose outside volume of interest (VOl). The resulting truncation, however, particularly in lateral direction, poses a challenge to the conventional reconstruction methods. The Approximated Truncation Robust Algorithm for Computed Tomography (ATRACT) is able to reconstruct images without the use of any explicit extrapolation schemes, even for highly truncated data. It is based on a decomposition of the standard ramp-filter into a local and a non-local filtering step, where the local step coincides with the two-dimensional (2D) Laplace operator and the non-local step is a 2D Radon-based filtering. In a practical implementation, the Radon-based filtering is not computationally efficient. In this paper, we present an improvement of the original ATRACT algorithm. The 2D Radon-based filtering step in the original algorithm is replaced by an analytical 2D convolution, resulting in a significant improvement in computational performance while retaining the image quality benefits of the VOl algorithm.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"05 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127193787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}