2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)最新文献

Development of low-resistivity silicon drift detector arrays for soft X-rays 软x射线低阻硅漂移探测器阵列的研制

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-30 DOI: 10.1109/NSSMIC.2012.6551243

W. Chen, G. de Geronimo, J. Gaskin, S. Li, Z. Li, B. Ramsey, G. Smith

引用次数: 4

Charge pump detector: Optimization with process and device simulation 电荷泵检测器:优化过程和设备模拟

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-18 DOI: 10.1109/NSSMIC.2012.6551158

J. Segal, C. Kenney

引用次数: 2

High-Z radiation shields for x-ray free electron laser detectors x射线自由电子激光探测器的高z辐射屏蔽

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-06 DOI: 10.1109/NSSMIC.2012.6551159

A. Tomada, S. Boutet, B. Duda, P. Hart, C. Kenney, L. Manger, M. Messerschmidt, J. Tice, G. Williams

引用次数: 5

Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution 基于mppc的亚毫米级三维分辨率DOI-PET模块的开发

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551714

A. Kishimoto, J. Kataoka, T. Kato, T. Miura, T. Nakamori, K. Kamada, S. Nakamura, Kenichi Sato, Y. Ishikawa, K. Yamamura, S. Yamamoto

{"title":"Development of a MPPC-based DOI-PET module with submillimeter 3-D resolution","authors":"A. Kishimoto, J. Kataoka, T. Kato, T. Miura, T. Nakamori, K. Kamada, S. Nakamura, Kenichi Sato, Y. Ishikawa, K. Yamamura, S. Yamamoto","doi":"10.1109/NSSMIC.2012.6551714","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551714","url":null,"abstract":"We are proposing a novel design for a module with depth of interaction (DOI) capability for gamma rays by measuring the pulse-height ratio of double-sided Multi-Pixel Photon Counters (MPPCs) coupled at both ends of a scintillation crystal block. Thanks to newly developed monolithic MPPC arrays consisting of 4 × 4 channels with a three-side buttable package, the module is very thin and compact, thereby enabling less dead space between each module when arranged into a fully designed gantry. To demonstrate our concept of a DOI measuring technique, we first made a 1-D crystal array consisting of five Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) cubic crystals measuring 3 × 3 × 3 mm3 in size, separated by a layer of air. When the light signals output from both ends are read with the MPPCs, the position of each crystal is clearly distinguished with a spatial uncertainty of 0.48 ± 0.03 mm. For 3-D measurements, we then fabricated three different type arrays: [A] 4 × 4 × 4 matrix of 3 × 3 × 3 mm3 pixels, [B] 5 × 5 × 5 matrix of 2 × 2 × 2 mm3 pixels, and [C] 10 × 10 × 10 matrix of 1 × 1 × 1 mm3 pixels, with each pixel divided by a BaSO4 reflector in the 2-D direction and by a layer of air in the DOI direction. We demonstrated that the 3-D position of each Ce:GAGG pixel was clearly distinguished when illuminated by 662 keV gamma rays uniformly. Average energy resolutions of 9.8 ± 0.8 %,9.8 ± 0.9 %, and 13.2 ± 1.7 % were obtained for types A, B and C, respectively. These results suggest that our proposed method is simple and offers promise in achieving 1 mm 3-D spatial resolution for future medical imaging, partic","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133736087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The effect of non-rigid misregistration in sequential quantitative SPECT for targeted radionuclide therapy— a simulation study 非刚性错配对靶向放射性核素治疗的序列定量SPECT的影响-模拟研究

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551671

G. Mok, Edwin C. I. Ao, N. Song, E. Frey

{"title":"The effect of non-rigid misregistration in sequential quantitative SPECT for targeted radionuclide therapy— a simulation study","authors":"G. Mok, Edwin C. I. Ao, N. Song, E. Frey","doi":"10.1109/NSSMIC.2012.6551671","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551671","url":null,"abstract":"Non-rigid organ misregistration is an important problem for patients undergoing sequential quantitative SPECT for 3D dosimetry for targeted radionuclide therapy (TRT) treatment planning. This study aims to evaluate effects of these misregistrations on the accuracy of 3D dosimetry. We used 3 anatomical variations and 3 respective In-Ill Zevalin distributions of the digital 4D Extended Cardiac Torso (XCAT) phantom to model the deformation in different organs such as liver, kidneys, spleen and stomach. We simulated SPECT scans acquired at 5 time points, i.e., 1, 12, 24, 72 and 144 hrs postinjection of 111In Zevalin. Organs with uniform activity concentrations were randomly translated and rotated within 5 pixels/degrees, while the change of the total volume of each organ was within 5% except for the stomach. The 24-hr scan served as a reference. An analytical projector modeling attenuation, scatter and the geometric collimator-detector-response of a medium energy collimator was used to generate noisy projections representing a realistic count level for 128 views over 360°. Reconstructed images were obtained using OS-EM with attenuation, scatter and geometric collimator-detector-response compensation. Voxel-by-voxel integration over different time points followed by convolution with a 90Y dose kernel was used to generate 3D dose distribution images. For each phantom, we compared the organ dose and its dose volume histogram (DVH) for (i) no organ deformation and (ii) organs with deformation. The mean difference of organ doses between two sets of images were 3.88%, -6.73%, -7.32% and -14.42% for lung, liver, kidneys and spleen respectively. However, even for the organs with dose errors <;5%, the associated normalized absolute errors in DVH were >10%. We conclude that organ misregistration a","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130188333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging performance of DOI measurable PET systems for breast imaging: Monte Carlo simulation studies 乳腺成像DOI可测量PET系统的成像性能:蒙特卡罗模拟研究

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551516

Jing Wu, Xishan Sun, K. Lou, Yan Xia, Tianyu Ma, Y. Shao

{"title":"Imaging performance of DOI measurable PET systems for breast imaging: Monte Carlo simulation studies","authors":"Jing Wu, Xishan Sun, K. Lou, Yan Xia, Tianyu Ma, Y. Shao","doi":"10.1109/NSSMIC.2012.6551516","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551516","url":null,"abstract":"GATE based simulation studies were conducted to guide breast PET system designs with different system geometries. A breast phantom (modeled as a half prolate spheroid with 7 cm equatorial radii and 11 cm polar radius) was generated for the study with warm background and hot lesions of different diameters (2, 3, 4 and 6 mm) and lesion/background activity ratios (3:1, 5:1 and 8:1, F-18 isotope). Each detector consists of an 8 × 8 array of 2 mm × 2 mm × 30 mm LSO scintillators with depth-of-interaction (DOI) measurement capability. Four systems were simulated: two stationary systems both with four detector panels arranged in a box-shaped geometry but different panel-to-panel separations of 17.2 cm and 20.4 cm, a system with two rotating detector panels separated at 17.2 cm panel-to-panel distance, and a whole-body (WB) PET with ~90 cm detector ring diameter. Axial FOVs are 12.8 cm for all three breast systems and 16 cm for WB PET. A list-mode OSEM algorithm with 40 subsets and one-pass iteration was used for image reconstruction. The reconstructed images and measured contrast-noise-ratio (CNR) with different system configurations, DOI resolutions, lesion size, and activity ratios were used to compare the imaging performance of different systems. The results validate that DOI is critical to providing uniform spatial resolution across the FOV for a breast PET system with compact geometry, and show that the full-tomographic configuration with detectors encompassing the FOV provides superior imaging performance than that from the rotating detector PET or WB PET, with very high sensitivity (> 60% at the center of FOV), much better lesion visual identification, and significantly improved CNR. Based on these quantitative evaluations, this simulation study has demonstrated that even coarse DOI resolution (~5 mm) can provide substantially improved imaging performance for a small bore system and design flexbility with different system geometries.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125983328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Properties of a very large volume LaBr3:Ce detector 超大体积LaBr3:Ce探测器的性能

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551119

A. Giaz, L. Pellegri, S. Riboldi, F. Camera, N. Blasi, C. Boiano, S. Brambilla, S. Ceruti, F. Crespi, M. Csatlós, J. Gulyás, A. Krasznahorkay, S. Lodetti, B. Million, L. Stuhl, O. Wieland

引用次数: 0

Large area sensing arrays for detection of thermal neutrons 用于探测热中子的大面积传感阵列

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551083

G. Kunnen, Daniel Pressler, Edward H. Lee, D. Allee, John W. Murphy, I. Mejia, M. Quevedo, B. Gnade

引用次数: 5

TIMPIC-II: The second version time-based-readout ASIC for SSPM based PET applications TIMPIC-II:第二版基于时间的读出ASIC，用于基于SSPM的PET应用

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551356

Xuezhou Zhu, Zhi Deng, Kejian A. Lan, Xishan Sun, Yi Liu, Yiping Shao

{"title":"TIMPIC-II: The second version time-based-readout ASIC for SSPM based PET applications","authors":"Xuezhou Zhu, Zhi Deng, Kejian A. Lan, Xishan Sun, Yi Liu, Yiping Shao","doi":"10.1109/NSSMIC.2012.6551356","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551356","url":null,"abstract":"A second version ASIC for front-end detector readout, TIMPIC-II, has been developed for Solid-State Photomultiplier (SSPM) based PET applications. It uses the previously developed and evaluated time-based-readout (TBR) architecture. However, several major changes have been made to make TIMPIC-II more flexible and suited for PET applications, including adding a common energy trigger to select the true events and using a constant width integrator to improve linearity. A special logic unit is added to combine the energy and the timing pulses into one output signal that reduces half of the output pins. A 16channel chip has been designed and fabricated with 0.3S,.m 2P4M CMOS technology. The die area is 3mm × 3mm, and the chip is provided in a compact 14mm × 14mm BGA package. TIMPIC-II initial evaluated result shows that the trigger and TBR with control logic function works as designed. And the ASIC specifications including linearity, intrinsic noise and timing jitter, etc. are well achieved as the linear regression R > 0.999 in full dynamic range, intrinsic energy resolution is better than 0.1 % FWHM of SOOpC and the timing jitter standard deviation is 100-300ps for different input signal range. This ASIC is also tested and used for a PET front-end detector module with FPGAbased TDC and acquisition.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123196379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Simulation studies with SiPM arrays and LYSO crystal matrix analyzing a new readout scheme 用SiPM阵列和LYSO晶体矩阵进行了仿真研究，分析了一种新的读出方案

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) Pub Date : 2012-12-01 DOI: 10.1109/NSSMIC.2012.6551608

A. Krizsan, S. Kis, J. Gál, G. Hegyesi, L. Balkay

{"title":"Simulation studies with SiPM arrays and LYSO crystal matrix analyzing a new readout scheme","authors":"A. Krizsan, S. Kis, J. Gál, G. Hegyesi, L. Balkay","doi":"10.1109/NSSMIC.2012.6551608","DOIUrl":"https://doi.org/10.1109/NSSMIC.2012.6551608","url":null,"abstract":"The concept of implementing Positron Emission Tomography and Magnetic Resonance Imaging in a dual modality imaging system gained high scientific importance recently. SiPM photo detectors became a solution for operation in high magnetic fields instead of the conventional photomultipliers. The method of Anger logics in the SiPM readout of pixelated scintillator crystals would produce significant noise in the readout signals, while single channel readout for each crystal pixel would not be cost effective. Another solution could be defined if we sum the SiPM signals for each row and column and an appropriate algorithm may select the X and Y coordinates of the original position of the scintillation source. It is expected that the highest signal related row and column would indicate correct position. The scope of this work was to calculate the optimal light distribution for different SiPM and scintillator matrix geometries, that would result in the greatest signal difference between the primary and adjacent readout channels and therefore would perform the best reliable selection of the relevant row and column indices.","PeriodicalId":187728,"journal":{"name":"2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115284986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2