Monatshefte Fur Chemie最新文献_第8页

Novel naphthylpyridines from cobalt-catalyzed cyclotrimerization of a chiral diyne. 由钴催化手性二炔环三聚反应合成的新型萘基吡啶。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-28 DOI: 10.1007/s00706-017-2083-9

Volkmar Trommer, Fabian Fischer, Marko Hapke

引用次数: 6

Palladium complexes containing imino phenoxide ligands: synthesis, luminescence, and their use as catalysts for the ring-opening polymerization of rac-lactide. 含有亚氨基苯氧配体的钯配合物：合成、发光及其用作 rac-内酰胺开环聚合的催化剂。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-12-12 DOI: 10.1007/s00706-017-2119-1

Mrinmay Mandal, Manuela List, Ian Teasdale, Günther Redhammer, Debashis Chakraborty, Uwe Monkowius

引用次数: 0

Synthesis and evaluation of new amidrazone-derived hydrazides as a potential anti-inflammatory agents. 合成和评估作为潜在抗炎剂的新型脒基肼。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-06-27 DOI: 10.1007/s00706-018-2197-8

Renata Paprocka, Małgorzata Wiese-Szadkowska, Anna Helmin-Basa, Liliana Mazur, Jolanta Kutkowska, Jacek Michałkiewicz, Bożena Modzelewska-Banachiewicz, Leszek Pazderski

{"title":"Synthesis and evaluation of new amidrazone-derived hydrazides as a potential anti-inflammatory agents.","authors":"Renata Paprocka, Małgorzata Wiese-Szadkowska, Anna Helmin-Basa, Liliana Mazur, Jolanta Kutkowska, Jacek Michałkiewicz, Bożena Modzelewska-Banachiewicz, Leszek Pazderski","doi":"10.1007/s00706-018-2197-8","DOIUrl":"10.1007/s00706-018-2197-8","url":null,"abstract":"Abstract: The series of new hydrazide derivatives were synthesized in reactions of N3-substituted amidrazones with cyclic anhydrides as potential anti-inflammatory and antibacterial agents. The compounds were characterized by 1H-13C two-dimensional NMR techniques, which revealed the presence of two tautomeric forms in DMSO-d6 solutions, while the molecular structure of one species was confirmed by single-crystal X-ray diffraction. The anti-inflammatory effects of hydrazides on peripheral blood mononuclear cells were experimentally evaluated. Three compounds showed antiproliferative activity comparable to ibuprofen. One derivative demonstrated strong reduction of lymphocyte proliferation stimulated by anti-CD3 antibody (by 90%) and PHA, as well as low cell toxicity. The obtained compounds exhibited relatively weak antibacterial activity; they were more effective against Gram-positive bacterial strains.Graphical abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"149 8","pages":"1493-1500"},"PeriodicalIF":1.8,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36389687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 2-alkylthio-N-(quinazolin-2-yl)benzenesulfonamide derivatives: anticancer activity, QSAR studies, and metabolic stability. 2-烷基硫代- n-(喹唑啉-2-基)苯磺酰胺衍生物的合成:抗癌活性、QSAR研究和代谢稳定性。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-07-13 DOI: 10.1007/s00706-018-2251-6

Aneta Pogorzelska, Beata Żołnowska, Jarosław Sławiński, Anna Kawiak, Krzysztof Szafrański, Mariusz Belka, Tomasz Bączek

{"title":"Synthesis of 2-alkylthio-N-(quinazolin-2-yl)benzenesulfonamide derivatives: anticancer activity, QSAR studies, and metabolic stability.","authors":"Aneta Pogorzelska, Beata Żołnowska, Jarosław Sławiński, Anna Kawiak, Krzysztof Szafrański, Mariusz Belka, Tomasz Bączek","doi":"10.1007/s00706-018-2251-6","DOIUrl":"https://doi.org/10.1007/s00706-018-2251-6","url":null,"abstract":"Abstract: A new series of 2-alkylthio-N-(quinazolin-2-yl)benzenesulfonamide derivatives have been synthesized and evaluated in vitro for their antiproliferative activity by MTT assay against cancer cell lines HCT-116, MCF-7, and HeLa as well as the NCI-60 human tumor cell lines screen. In NCI screen, three compounds inhibited approximately 50% growth of RPMI-8226 and A549/ATCC cell lines. The mean of IC50 calculated in MTT assays for three tested cell lines was about 45 μM for four compounds. The QSAR allowed finding statistically significant OPLS models for HeLa cell line. Metabolic stability in vitro studies indicated favorable and unfavorable structural elements. The good metabolic stability, with t1/2 higher than 40 min, was observed for three derivatives, which together with their antiproliferative activity and good ADMET profile, makes them good leading structures for further research.Graphical abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"149 10","pages":"1885-1898"},"PeriodicalIF":1.8,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-018-2251-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36510811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Benzil/triethylamine: a photo-reducing system for Cu². 苄基/三乙胺:光还原Cu2体系。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-02-03 DOI: 10.1007/s00706-017-2085-7

Max Schmallegger, Georg Gescheidt

引用次数: 2

Synthesis and characterization of meso-substituted A₂B corroles with extended π-electronic structure. 具有扩展π电子结构的介取代A2B分子的合成与表征。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-29 DOI: 10.1007/s00706-017-2114-6

Michael Haas, Sabrina Gonglach, Stefan Müllegger, Wolfgang Schöfberger

引用次数: 0

Adsorption of adenine on mercury electrode in acetate buffer at pH 5 and pH 6 and its effect on electroreduction of zinc ions. 在 pH 值为 5 和 6 的醋酸盐缓冲液中，腺嘌呤在汞电极上的吸附及其对锌离子电还原的影响。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-06-28 DOI: 10.1007/s00706-018-2183-1

Dorota Gugała-Fekner

引用次数: 0

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine. 新型单核和双核过渡金属配合物与源自香豆素衍生物和草酰二肼的腙席夫碱的合成、表征和生物活性。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-27 DOI: 10.1007/s00706-017-2075-9

Esther Theresa Knittl, Azza A Abou-Hussein, Wolfgang Linert

{"title":"Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine.","authors":"Esther Theresa Knittl, Azza A Abou-Hussein, Wolfgang Linert","doi":"10.1007/s00706-017-2075-9","DOIUrl":"10.1007/s00706-017-2075-9","url":null,"abstract":"Abstract: A hydrazone Schiff base ligand was synthesized by the condensation of 3-formyl-4-hydroxycoumarin and oxalyldihydrazide in the molar ratio 2:1. The Schiff base ligand acts as a mono-, bi-, tri- or even tetradentate ligand with metal cations in the molar ratios 1:1 or 2:1 (M:L) to yield either mono- or binuclear complexes as keto or enol isomers, where M = Co(II), Ni(II), Cu(II), VO(IV), and Fe(III). The ligand and its metal complexes were characterized by elemental analyses, IR, 1H NMR, mass, and UV-Vis spectroscopy. Furthermore, the magnetic moments were calculated from the measured electric conductivities of the complexes. According to the received data, the dihydrazone ligand contains one or two units of ONO domains and can bind to the metal ions via the azomethine nitrogen, the carbonyl oxygen atoms, and/or the phenolic oxygen atoms. Electronic spectra and the magnetic moments of all complexes show that the complexes' geometries are either octahedral, tetrahedral, square planar, or square pyramidal. Cyclic voltammograms of the mononuclear Co(II) and Ni(II) complexes show quasi-reversible peaks. Tests against two pathogenic bacteria as Gram-positive and Gram-negative bacteria for both, the Schiff base ligand and its metal complexes were carried out. In addition, also one kind of fungi was tested. The synthesized complexes demonstrate mild antibacterial and antifungal activities against these organisms.Graphical abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"149 2","pages":"431-443"},"PeriodicalIF":1.8,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35876774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of physical division of tablets on the variability of release kinetics of gliclazide. 片剂物理划分对格列齐特释放动力学变异性的影响。

IF 1.8 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2018-03-03 DOI: 10.1007/s00706-018-2176-0

Dorota Wójcik-Pastuszka, Anna M Biedrawa, Dorota Haznar-Garbacz, Witold S Musiał

{"title":"The influence of physical division of tablets on the variability of release kinetics of gliclazide.","authors":"Dorota Wójcik-Pastuszka, Anna M Biedrawa, Dorota Haznar-Garbacz, Witold S Musiał","doi":"10.1007/s00706-018-2176-0","DOIUrl":"https://doi.org/10.1007/s00706-018-2176-0","url":null,"abstract":"Abstract: Tablets are often used in splitting process when the appropriated, registered dose is not available on the market or patients exhibit swallowing difficulties caused by the size of the tablet. The aim of the work was to assess the impact of physical division of tablets on the kinetics of in vitro gliclazide release from the intact and divided tablets. Gliclazide was released from prolonged release tablets containing 30 or 60 mg of the drug into a phosphate buffer, pH 7.4 and the amount of the drug in acceptor fluid was determined by UV-Vis spectrophotometry. The dissolution profiles were fit to zero- and first-order kinetics as well as to the Korsmeyer-Peppas equation. The largest discrepancy in the values of rate constants was obtained in the case of the release of gliclazide from intact and from splitting tablets using zero- and first-order kinetics. The values of the rate constants k0 obtained from the release of the drug from the intact tablets and from fragments with a dose of the drug of 30 mg were (4.2 ± 0.1) × 10-5 g min-1 and (5.8 ± 0.1) × 10-5 g min-1, respectively, and k1 were (2.3 ± 0.1) × 10-3 min-1 and (4.7 ± 0.6) × 10-3 min-1, respectively. These discrepancies were confirmed by the value of f2 coefficient that was 45.9. The results suggest that physical division of tablets accelerate the release of gliclazide from its prolonged form.Graphical abstract: ","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"149 5","pages":"953-959"},"PeriodicalIF":1.8,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-018-2176-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36064558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regioselective synthesis of pyridines by redox alkylation of pyridine N-oxides with malonates. 通过吡啶 N-氧化物与丙二酸盐的氧化还原烷基化作用，实现吡啶的区域选择性合成。

IF 1.7 4区化学

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-28 DOI: 10.1007/s00706-017-2081-y

Miran Lemmerer, Christopher J Teskey, Daniel Kaiser, Nuno Maulide

引用次数: 0