Molecular plant pathology最新文献

{"title":"The Basic Helix-Loop-Helix Transcription Factors UvBhlh1 and UvBhlh6 Coordinate Virulence in the Rice False Smut Fungus Ustilaginoidea virens.","authors":"Huijuan Cao, Hao Gong, Xiaohong Huang, Jialin Lei, Mina Yu, Xiayan Pan, Tianqiao Song, Junjie Yu, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yongfeng Liu","doi":"10.1111/mpp.70267","DOIUrl":"10.1111/mpp.70267","url":null,"abstract":"<p><p>Ustilaginoidea virens is the causal agent of rice false smut, a devastating and globally widespread fungal disease. Transcription factors are crucial regulators of fungal development and pathogenicity. In this study, we demonstrated that the bHLH transcription factor UvBhlh6 in U. virens plays a critical role during plant infection. Using yeast two-hybrid (Y2H) and bimolecular fluorescence complementation (BiFC) assays, we showed that UvBhlh6 physically interacts with UvBhlh1, UvBhlh4 and UvBhlh7, and also forms homodimers. Among these, UvBhlh1 was also essential for full virulence. Notably, UvBhlh1 and UvBhlh6 form a heterodimer, and UvBhlh1 mediates the nuclear localisation of UvBhlh6, enabling their cooperative regulation of downstream target genes. Phenotypic analysis revealed that ΔUvbhlh1 and ΔUvbhlh6 mutants displayed reduced tolerance to H₂O₂-induced oxidative stress. Moreover, ΔUvbhlh6 showed severely impaired growth under osmotic stress, with inhibition rates exceeding 90% on media containing sorbitol or NaCl. Affinity capture followed by mass spectrometry identified several UvBhlh6-interacting proteins, including the carbohydrate metabolic enzymes UDP galactose 4-epimerase (UvGal10) and isocitrate dehydrogenase (NAD) subunit 1 precursor (UvIdh1), as well as Pot1 (3-ketoacyl-CoA thiolase), a key enzyme in the fatty acid β-oxidation pathway. These findings suggest that bHLH transcription factors play conserved roles in modulating carbohydrate and lipid metabolism in fungi. Taken together, our results demonstrate that UvBhlh1 and UvBhlh6 are key regulators of early infection and virulence in U. virens.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70267"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Candidatus Liberibacter asiaticus' Effector SDE4250 Targets Citrus Proteasome Protein RPN10 to Inhibit Salicylic Acid-Mediated Citrus Immunity.","authors":"Yalin Mei, Xinyi Deng, Zaiyu Yang, Qiying Wang, Changyong Zhou, Xuefeng Wang, Yingzhe Yuan, Shimin Fu","doi":"10.1111/mpp.70264","DOIUrl":"10.1111/mpp.70264","url":null,"abstract":"<p><p>Ubiquitin-proteasome is a conserved mechanism that regulates cellular responses and disease resistance in plants. However, the regulatory role of ubiquitin-proteasome in the pathogenicity of \"Candidatus Liberibacter asiaticus\" (CLas), the causal agent of citrus huanglongbing (HLB), one of the most serious citrus diseases, remains poorly defined. In this study, we demonstrated that CLIBASIA_04250 (SDE4250) suppresses 26S proteasome activity in citrus, leading to a reduction in salicylic acid (SA) levels and downregulation of SA-responsive genes. Further investigation revealed that SDE4250 specifically targets the citrus 26S proteasome non-ATPase regulatory subunit 4 homologue (CsRPN10) and enhances its degradation via the 26S proteasome pathway. Moreover, overexpression of CsRPN10 inhibited CLas proliferation in citrus hairy roots, which was accompanied by a significant accumulation of SA content and upregulation of related defence genes. Collectively, our findings indicate that SDE4250 targets the citrus 26S proteasome to disrupt SA-mediated citrus immunity.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70264"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ustilago maydis Phosphatidic Acid and Phosphatidylserine-Targeting Secreted Lipase Lip3 Is Involved in Pathogenesis.","authors":"Anisha Roy, Rituparna Mondal, Anupama Ghosh","doi":"10.1111/mpp.70235","DOIUrl":"10.1111/mpp.70235","url":null,"abstract":"<p><p>Lipases constitute important virulence factors. By targeting specific lipids involved in various cellular processes, lipases regulate growth, development, and pathogenic mechanisms in many organisms. The Ustilago maydis genome codes for a set of secreted lipases that exhibit differential expression during infection. In this study, the biological function of one of the secreted lipases, Lip3, during pathogenesis of U. maydis was investigated. Pathogenicity assays with a deletion mutant of the gene showed slow progress of infection with much reduced sporulation. Through the analysis of the total lipids isolated from plants infected with either SG200 or SG200Δlip3, the substrate preference of Lip3 towards different phospholipids, including phosphatidic acid (PA) and phosphatidylserine (PS), was shown. The interaction of Lip3 with PA and PS was further confirmed through in vitro lipid binding assays. Recombinant Lip3 showed lipolytic activity against purified PA and PS from sunflower and Glycine max, respectively. Using a PS targeting lactadherin C2 domain-based biosensor, the differential distribution of PS within the biotrophic interfacial membrane of SG200 and SG200Δlip3 infected Zea mays plants was demonstrated. We also detected apoplast alkalinisation in the case of SG200 infection that was absent in the case of SG200Δlip3 infection. It is possible that Lip3 contributes to the pathogenesis of U. maydis by regulating apoplastic pH. However, the precise mechanism of pH regulation requires further investigation.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70235"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering the 3'-UTR of Tobacco Vein Mottling Virus to Confer Cross-Protection Against Potyviruses.","authors":"Haijuan Wang, Zhenqi Sun, Baolong Zhang, Zhaoran Wu, Jiaxin Xu, Mingmin Zhao","doi":"10.1111/mpp.70268","DOIUrl":"https://doi.org/10.1111/mpp.70268","url":null,"abstract":"<p><p>Tobacco vein mosaic virus (TVMV) is a member of the family Potyviridae. We explored if engineering the 3' noncoding RNA would alter viral infection symptoms and viral infectivity of TVMVwt, which could be used for cross-protection. We engineered an infectious clone of TVMV mutant virus pLX-TVMV58 (TVMV58), which contains a 58-nt 'AT' fragment in the 3'-untranslated region (UTR) of the full-length cDNA infectious clone pLX-TVMVwt (TVMVwt), using a one-step assembly method. We explored whether the mechanism of the attenuated symptoms in Nicotiana benthamiana caused by TVMV58 compared with that by TVMVwt is linked to the stem structure of TVMV58 3'-UTR. The viral infectivity of the mutant virus TVMV58mutA (with three loops in the structure of TVMV58 3'-UTR) was slightly higher than TVMV58, whereas the viral infectivity of the mutant virus TVMV58mutB (with two loops in the structure of TVMV58 3'-UTR) decreased significantly. However, we observed that the mutant virus TVMV58mutC (with no loop in the structure of TVMV58 3'-UTR) or TVMVmutTG lost infectivity. The infectivity of TVMV58 and its mutants was independent of the RNA silencing mechanism, which was supported by a similar infection pattern in NbDCL-silenced plants. Moreover, TVMV58 showed high cross-protection against PVY-Ros1 (potato virus Y isolate carrying the Rosea1 gene) and TuMV-GFP (turnip mosaic virus expressing GFP) in N. benthamiana, but showed no cross-protection effect against tobacco mosaic virus (TMV) infection.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70268"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147817643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Differentiation in the SdhC Subunit Confers Intrinsic Resistance to SDHI Fungicides in Fusarium asiaticum.","authors":"Jichang Song, Jiakai Wang, Xudong Liu, Yinkai Liu, Lianyu Bi, Meixia Li, Yiqiang Cai, Mingguo Zhou, Yabing Duan","doi":"10.1111/mpp.70269","DOIUrl":"10.1111/mpp.70269","url":null,"abstract":"<p><p>Fusarium head blight (FHB), caused by Fusarium asiaticum, is a significant wheat disease in China, reducing yields and contaminating grain with deoxynivalenol (DON). Due to the absence of highly resistant wheat varieties, chemical control remains the primary method for managing FHB. This study identified two homologous SDHC genes in F. asiaticum, namely FaSDHC1 and FaSDHC2. Deletion of FaSDHC2 impaired fungal sporulation, virulence and DON production, whereas the loss of FaSDHC1 increased DON production. Both genes were found to regulate sensitivity to SDHI fungicides-ΔFaSDHC1 showed decreased sensitivity, while ΔFaSDHC2 exhibited increased sensitivity. To explore the regulatory role of the SdhC subunit in SDHI fungicides sensitivity in F. asiaticum, this study obtained 11 boscalid-resistant mutants from ΔFaSDHC2 through chemical taming. Genetic analysis identified six mutation genotypes, including two previously reported in Fusarium species (FaSdhB-H248Y and FaSdhD-E166K) and four novel mutations in the Fusarium genus (FaSdhC1-H144Y, FaSdhC1-H144N, FaSdhD-H122Y and FaSdhD-D133N). The site-directed mutation verification and sensitivity assays revealed that mutants harbouring FaSdhC1-H144Y/N, FaSdhD-H122Y, FaSdhD-D133N or FaSdhD-E166K exhibited resistance to multiple SDHI fungicides (boscalid, fluopyram, pydiflumetofen, isopyrazam and benzovindiflupyr). In contrast, FaSdhB-H248Y mutants remained sensitive to fluopyram while showing resistance to other SDHI fungicides. This study elucidates the important regulatory role of SdhC genetic differentiation to SDHI fungicide sensitivity in F. asiaticum. Furthermore, it confirms that specific variations within distinct subunits of the SDH complex endow F. asiaticum with resistance to SDHI fungicides. The findings advance understanding of SDHI fungicides resistance mechanisms and provide a basis for developing FaSdhC-specific inhibitors and resistance management strategies.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70269"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rice Stripe Virus p2 Interacts With Lsm1 and Disrupts the Lsm1-Lsm4 Complex to Facilitate the Viral infection.","authors":"Anqi Hu, Zizhou Zhao, Minjie Shen, Yi Chen, Ying Chen, Miaomiao Li, Lin Lin, Hongying Zheng, Jiejun Peng, Yan Liang, Jianping Chen, Fei Yan, Yuwen Lu","doi":"10.1111/mpp.70271","DOIUrl":"10.1111/mpp.70271","url":null,"abstract":"<p><p>Processing bodies (P-bodies) play central roles in RNA metabolism and in the regulation of viral infection. However, whether they function during infection by negative-strand RNA viruses, and how such viruses manipulate P-body activities, remain largely unclear. Here, we showed that the p2 protein encoded by rice stripe virus (RSV), a segmented negative-strand RNA virus, interacted with Lsm1, a core subunit of the Lsm1-7 complex responsible for decapping-dependent 5'-3' mRNA decay in P-bodies. Genetic analyses in rice and Nicotiana benthamiana demonstrated that Lsm1 negatively regulates RSV infection. Mechanistically, p2 binds a 17-amino-acid motif at the N terminus of OsLsm1 and competitively disrupts its association with OsLsm4, thereby impairing Lsm1-7 complex assembly. Consequently, RSV infection impairs P-body-mediated mRNA decay activity, as evidenced by the delayed turnover of marker transcripts (EXPL1 and SEN1). Our work suggests that P-bodies constitute a post-transcriptional barrier that restricts RSV infection. RSV overcomes this barrier by deploying p2 to associate with Lsm1 and weaken Lsm1-Lsm4 complex assembly. This counterdefence strategy allows RSV to modulate host RNA decay pathways to its advantage.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70271"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dual Role of Methyl Caffeate: Growth Inhibition of Pseudomonas syringae and Induction of Resistance to Bacterial Speck Disease in Tomato.","authors":"Yarui Yang, Jikai Yu, Jinxi Yang, Yulin Wang, Wenrui Hou, Dongfang Zhang, Jianquan Wang, Wenfeng Nie, Yan Zhang, Xiaoyun Wang, Xiuming Li, Qinghua Shi","doi":"10.1111/mpp.70265","DOIUrl":"10.1111/mpp.70265","url":null,"abstract":"<p><p>Bacterial speck of tomato, caused by Pseudomonas syringae pv. tomato (Pst), is a globally significant disease leading to substantial yield losses. This study demonstrated that methyl caffeate (MC), a plant-derived phenolic acid, exhibited dual functionality against Pst strain DC3000 through direct antibacterial action and indirect host resistance priming. In vitro assays revealed MC's potent inhibitory activity against bacterial growth, characterised by disruption of membrane integrity, leading to intracellular content leakage and reactive oxygen species (ROS) accumulation. Transcriptomic analysis identified 434 upregulated and 326 downregulated genes, with differentially expressed genes primarily enriched in pathways related to flagellar assembly, motility, quorum sensing, chemotaxis and the type III secretion system (T3SS), thereby impairing bacterial motility and virulence. Concurrently, MC enhances plant defence responses by inducing the transcriptional expression of defence hormone signalling pathway-related genes and increasing the activities of defence enzymes such as phenylalanine ammonia-lyase (PAL) and polyphenol oxidase (PPO). This modulation helps maintain ROS homeostasis and alleviates oxidative damage caused by Pst infection, thereby attenuating disease progression. These findings established MC as a multifunctional agent combining direct bactericidal effects with plant immunity induction, providing a sustainable strategy for bacterial speck management.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 5","pages":"e70265"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Methyltransferase CcKmt3 Regulates Cell Wall Degradation Enzymes Activity to Enhance the Infection Process in Cytospora chrysosperma.","authors":"Wenjun Song, Yicheng Li, Wenwen Li, Yonglin Wang","doi":"10.1111/mpp.70246","DOIUrl":"10.1111/mpp.70246","url":null,"abstract":"<p><p>Woody canker diseases cause devastating timber losses worldwide. Canker fungi exploit cell wall-degrading enzymes (CWDEs) to promote plant infection, yet the underlying mechanism of the transcriptional regulation of CWDEs remains largely unknown. Using RNA-seq analysis and biochemical assays, we show that the poplar pathogen Cytospora chrysosperma upregulates CWDEs during canker progression, especially increased secretion of laccases. The histone lysine methyltransferase Kmt3 (CcKmt3) is induced by C. chrysosperma infection. Loss of CcKmt3 leads to a genome-wide reduction in H3K36me3 methylation. The ΔCckmt3 strain presented hyphal growth defects, reduced production of hydrolytic enzymes, and impaired virulence. By combining ChIP-seq with RNA-seq, we demonstrated that CcKmt3 controls two hydrolases, CcLac11 and CcPme5, for plant cell degradation and virulence in C. chrysosperma. Furthermore, we showed that CcKmt3 affects hyphal growth by regulating the fungal cell wall integrity pathway. Taken together, this study demonstrates that CcKmt3 regulates the transcriptional expression of genes related to CWDEs by modulating H3K36me3 levels. This regulation influences enzyme activity, ultimately impacting the degradation of the plant cell wall and the pathogenicity processes of the poplar canker fungus.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 4","pages":"e70246"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"TaELP2 Interacts With TaDCL1 and Negatively Regulates Wheat Resistance Against Stripe Rust\".","authors":"","doi":"10.1111/mpp.70262","DOIUrl":"10.1111/mpp.70262","url":null,"abstract":"","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 4","pages":"e70262"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungus Derived Indole-3-Acetic Acid Controls Developmental Conidial Death in Magnaporthe oryzae.","authors":"Yuming Ma, Qiao Liu, Qing Shen, Ruhui Long, Xiaofang Xie, Lihong Dong, Zhibin Liang, Yi Zhen Deng","doi":"10.1111/mpp.70252","DOIUrl":"10.1111/mpp.70252","url":null,"abstract":"<p><p>Ferroptotic death of the developing conidia is important for pathogenicity of the blast fungus Magnaporthe oryzae, yet its regulatory mechanism is not fully elucidated in fungal cell. In this study, we found that elevated indole-3-acetic acid (IAA) promoted iron and lipid peroxide accumulation, leading to a higher degree of ferroptotic death of conidia. By characterising the IAA biosynthesis mutant, tam1Δ, we found that conidial death was positively correlated with levels of endogenous IAA. Furthermore, we found an IAA-dependent lipid metabolism gene mutant ppoaΔ displayed deficiencies in conidial death and the consequent delay in appressorium formation, and reduced pathogenicity. Exogenous addition of two types of phosphatidylethanolamines (PEs), DOPE and SLPE, could at least partially restore such defects in both tam1Δ and ppoaΔ, indicating that IAA promotes ferroptosis by affecting lipid metabolism and/or peroxidation. Additionally, we found TAM1 affected autophagy by modulating transcription of the ATG8 gene. Overall, our study reveals that M. oryzae produces and uses IAA to promote pathogenicity through triggering ferroptotic conidial death during pathogenic development. Our results provide a theoretical basis for blast disease control using IAA synthesis inhibitors.</p>","PeriodicalId":18763,"journal":{"name":"Molecular plant pathology","volume":"27 4","pages":"e70252"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}