2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)最新文献

Electromechanical properties of one dimensinal carbon chains 一维碳链的机电性能

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492501

Z. Salman, A. Nair, S. Tung

{"title":"Electromechanical properties of one dimensinal carbon chains","authors":"Z. Salman, A. Nair, S. Tung","doi":"10.1109/NANOMED.2015.7492501","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492501","url":null,"abstract":"Carbon based nanostructures such as graphene and carbon nanotubes have received widespread attention due to their unique mechanical and electronic properties. This paper describes a quantum mechanics based study of the electronic band structures and transport properties of one-dimensional (1D) carbon chains, the thinnest nanowires available in nature. The study is based on the application of density functional theory and non-equilibrium Green's function where maximally localized Wannier functions and Landauer formalism are combined to compute the electronic band structures and quantum conductance of the 1D carbon chains. The simulation result indicates that the peak quantum conductance of 1D carbon chains is about five times smaller than that of carbon nanotubes. However, the quantum conductance is also a function of the length and chemical bonds of the carbon chains. When the carbon chains are mechanically strained at 3%, the quantum conductance is reduced by about 50%. This result suggests 1D carbon chains can provide ultra high-resolution electromechanical measurements of important biomolecules such as DNA.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121452571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microchannel fabrication by local melting of hydrogel toward in vitro 3D cell structures 水凝胶局部熔融制备微通道制备体外三维细胞结构

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492499

Masaru Takeuchi, Tomoyuki Oya, A. Ichikawa, K. Ohara, M. Nakajima, T. Fukuda, Y. Hasegawa

{"title":"Microchannel fabrication by local melting of hydrogel toward in vitro 3D cell structures","authors":"Masaru Takeuchi, Tomoyuki Oya, A. Ichikawa, K. Ohara, M. Nakajima, T. Fukuda, Y. Hasegawa","doi":"10.1109/NANOMED.2015.7492499","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492499","url":null,"abstract":"In this paper, we propose a new method to fabricate microchannels inside cell embedded hydrogel blocks using local heating from electrodes on a substrate for tissue engineering applications. The cell embedded hydrogel blocks are locally melted and the melted area can be used as microchannels as like vascular networks. The size and fabrication timing of the microchannels can be controlled by the proposed method. The different hydrogels were tested to validate the cell growth and melting point to achieve the proposed method. Temperature distribution inside hydrogel during the heating was simulated using 1D unsteady heat conduction equation. The simulation results showed that the microchannel width and height can be controlled in several hundred microns by the time and amplitude of applied voltage to the microheater. Chrome/gold electrodes were fabricated as microheaters using lift-off process of photolithography technology. The gelatin-agar mixed hydrogel was melted by the fabricated electrodes and microchannel fabrication was experimentally validated. The results indicate that the proposed method can be used to making vascular-like networks inside cell structures to construct in vitro 3D cell systems.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Force curve classification using independent component analysis and support vector machine 基于独立分量分析和支持向量机的力曲线分类

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492512

F. Zhou, Wenxue Wang, Mi Li, Lianqing Liu

{"title":"Force curve classification using independent component analysis and support vector machine","authors":"F. Zhou, Wenxue Wang, Mi Li, Lianqing Liu","doi":"10.1109/NANOMED.2015.7492512","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492512","url":null,"abstract":"The development of single-molecule force spectroscopy (SMFS) technique, especially the atomic force microscope (AFM) based SMFS technique, has been widely applied to the studies of receptor-ligand at single-cell and single-molecule level and has greatly enhanced the understanding of biological activity like the drug action on the cells. The studies have shown that three types of acting forces between proteins and ligands, specific binding, non-specific binding, and non-interaction, can be distinguished manually according to the characteristics of force curves for further analysis. However the efficiency of manual classification of such force curves is low and results in difficulty in analyzing large set of experimental data. In this study, we demonstrate a machine learning based approach to automatic classification of the three types of force curves and a low pass filter for noise removal, independent component analysis for dimensionality reduction and support vector machine for data classification are involved in this process. It is validated by the experiments that the three types of force curves recorded using AFM can be effectively and efficiently classified with the proposed approach.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127015156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Electrochemical biosensor based on MoS2/Graphene for highly sensitive detection of human parathyroid hormone 基于二硫化钼/石墨烯的电化学生物传感器高灵敏度检测人甲状旁腺激素

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492506

H. Kim, Kook-Nyung Lee, Min-Ho Lee, Hyeong-U. Kim, Chisung Ahn, Taesung Kim

引用次数: 1

Pressure transmitter for local pressure sensing in a microchannel 用于微通道局部压力传感的压力变送器

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492498

C. Tsai, M. Kaneko

引用次数: 0

Imaging and mapping individual target proteins on clinical lymphoma cells by AFM 利用原子力显微镜对临床淋巴瘤细胞的单个靶蛋白进行成像和定位

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492507

Mi Li, Lianqing Liu, N. Xi, Yuechao Wang, Wenxue Wang

引用次数: 1

Exploring molecular distributed detection 探索分子分布式检测

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492511

U. Rogers, Min-Sung Koh

{"title":"Exploring molecular distributed detection","authors":"U. Rogers, Min-Sung Koh","doi":"10.1109/NANOMED.2015.7492511","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492511","url":null,"abstract":"Chemical-exchange provides a fundamental mechanism by which microorganisms and biological cells communicate. Using this concept and the idea of biological sized nanomachines, this paper explores the detection of a undesired biological agent in a distributed setting. Distributed in the sense that the system information is dispersed across the nanomachines, each possessing limited communication capabilities. To study this problem, the molecular distributed detection system is divided into four major components. The first is the biological agent itself. The second is a collection of autonomous nano-sized sensors, capable of observing the environment, and releasing a certain type of communication molecule directly related to that observation. The third is an aqueous molecular transmission channel under drift, modeled using Brownian motion. The fourth is a fusion stage that collects the communication molecules and fuses this information to determine if a biological agent is present or not. Using this framework, we explore biological agent detection performance using optimal and suboptimal fusion rules in a parallel topology for diverse potential applications.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127310763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and characterization of gold encapsulated and tamoxifen loaded PLGA nanoparticles for breast cancer theranostics 金包封和负载他莫昔芬的乳腺癌治疗用PLGA纳米颗粒的合成和表征

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492510

D. Chauhan, R. Srivastava

引用次数: 2

Single-transfer method for fabrication of linear array of graphene-based nanodevices 石墨烯基纳米器件线性阵列的单转移制备方法

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492509

Hengkai Zhang, Xin Tang, Guangfu Wu, K. Lai

引用次数: 0

Label-free detection of DNA hybridization on MoS2 using photoluminescence measurements 利用光致发光测量方法检测二硫化钼上的DNA杂交

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492514

Chang-Hsiao Chen

引用次数: 2