2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)最新文献_第2页

Study on objective platform driven by piezoceramics for cell injection 压电陶瓷驱动细胞注射物镜平台的研究

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492508

Bowen Zhong, Zongwei Li, Zhenhua Wang, Ziqi Jin, Lining Sun, Linsen Chen

{"title":"Study on objective platform driven by piezoceramics for cell injection","authors":"Bowen Zhong, Zongwei Li, Zhenhua Wang, Ziqi Jin, Lining Sun, Linsen Chen","doi":"10.1109/NANOMED.2015.7492508","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492508","url":null,"abstract":"In cell injection, biological microscope is essential. It is commonly that intelligent microscope has many striking features, one of which is having a three-dimensional micro objective platform. The platform has the function of high precision positioning and automatic focus. In this paper, a novel single degree of freedom objective platform based on inertial stick-slip has been designed and fabricated, which works in millimeter movement range and nanoscale resolution. The dynamic model has been built to study the process of the inertial stick-slip and be helpful for designing the precision platform. In consideration of the nonlinear features of friction between the friction interfaces, the LuGre friction model has been mentioned in the dynamic model. The LuGre model describes several friction phenomenon, such as Strbeck, Hysteresis and so on. The 1D objective platform has resolution of 4 nm and is stroke of 20mm. The velocity reaches 3mm/s. Generally, the stage is driven by saw-tooth wave, while the self-defined waveform is discussed in this experiment. Finally, the optimized input signal is obtained.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126514595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left-right asymmetry in cell orientation requires high substrate rigidity 细胞方向的左右不对称要求衬底刚性高

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492496

Yuanye Bao, Zhaobin Guo, Ting-Hsuan Chen

引用次数: 1

A colorimetric method for assessing the adsorption strength of oligonucleotides on noble metal nanoparticles 一种评估寡核苷酸在贵金属纳米颗粒上吸附强度的比色法

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492502

Na Li, Lu Yu, Jiaqi Zou

{"title":"A colorimetric method for assessing the adsorption strength of oligonucleotides on noble metal nanoparticles","authors":"Na Li, Lu Yu, Jiaqi Zou","doi":"10.1109/NANOMED.2015.7492502","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492502","url":null,"abstract":"Oligonucleotide-functionalizing noble metal nanoparticles (NMNPs) have resulted in many interesting applications in engineering, as well as in medicine. Typically, NMNPs are functionalized via thiol-metal interaction using thiol-labeled oligonucleotides. Previous studies have revealed that strong interactions exist between oligonucleotide bases and noble metal surface and these interactions are sequence-dependent. This has provided an alternative way to functionalize NMNPs with unlabeled oligonucleotides. In order to fully utilize the spontaneous interactions between oligonucleotides and NMNPs, quantitative assessment of the interaction strength between different oligonucleotides and NMNPs will be necessary. Existing methods that have been used to determine the interaction strength usually rely on direct quantification of the amount of oligonucleotides adsorbed on NMNPs, and tend to be labor- and time-consuming. Herein we develop a salt titration based colorimetric method as a simple and high-throughput alternative to the existing methods. First, this new method was demonstrated by applying to determine the dissociation constant between gold nanoparticles and DNA oligonucleotides. Then the new method was used to study the sequence and length dependence of NMNP-oligonucleotide interactions.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120995756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A new approach to the development of Nano digital circuits and its applications in molecular medicine 纳米数字电路的发展及其在分子医学中的应用

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492513

Amjad F. Almatrood, Harpreet Singh

{"title":"A new approach to the development of Nano digital circuits and its applications in molecular medicine","authors":"Amjad F. Almatrood, Harpreet Singh","doi":"10.1109/NANOMED.2015.7492513","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492513","url":null,"abstract":"The applications of digital circuits are well known in all walks of life. In this paper the procedure for the development of Nano digital circuits is given. The procedure requires the Boolean function realization for the application in mind. The proposed technique works for any Boolean Function. The Boolean functions are written in the form of Exclusive OR, AND and NOT gates. The functions are then written as ONLY majority gates. The Majority gates are implemented using QCA (Quantum Cellular Automata Logic). QCA are one of the established approaches for nanotechnology. An algorithm is established by which a universal procedure can be established for implementing Boolean Functions using Nano logic. These functions are written in Verilog language. The Verilog program can be tested on FPGA's. Cadence software can be used to design a chip. The research in Nano Medicine has attracted the attention of scientists recently. The applications of Nano digital circuits in Molecular medicine are discussed. It is hoped that this procedure will result in a large number of applications of Nano logic and open a way to the development and use of Nano digital circuits in molecular medicine.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121245089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Large field-of-view super-resolution imaging of endo-cellular structures through micro-beads array 微珠阵列对细胞内结构的大视场超分辨成像

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492497

Yi Li, Hok Sum Sam Lai, Shuhuan Hu, Raymond H. W. Lam, W. Li

{"title":"Large field-of-view super-resolution imaging of endo-cellular structures through micro-beads array","authors":"Yi Li, Hok Sum Sam Lai, Shuhuan Hu, Raymond H. W. Lam, W. Li","doi":"10.1109/NANOMED.2015.7492497","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492497","url":null,"abstract":"This work presents a super-resolution cell imaging method that uses an array of polystyrene (PS) micro-beads lenses embedded in an elastomer thin film on top of a glass substrate. The micro-beads lens array collects reflected near-field light waves from an object's surface and amplifies the waves to allow the formation of enlarged virtual images of the object. We have shown that object images could be magnified up to at least 5 times of the original scale while having a field-of-view of 6 μm (for a single lens), i.e., visible light images of 200 nm features could be captured using a microscope objective lens of 100x (with overall magnification factor of 1000×). Furthermore, using the micro-beads lens array, NIH/3T3 cell internal structures have been successfully imaged under bright-field conditions, showing a much higher resolution image of the internal structures. In summary, we have shown that micro-beads lens array could resolve sub-diffraction-limit features with an overall field-of-view of at least 5000 μm2. Hence, micro-beads lens array shows promising applications in the rapid imaging of large quantity of biomolecules and internal cell structures with wide field-of-view capability.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127885105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SWCNTs modified nanoneedle biosensor for rapid detection of DNA 用于快速检测DNA的SWCNTs修饰纳米针生物传感器

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492505

Darius Saadat-Moghaddam, Jong-Hoon Kim

引用次数: 0

Dissociation of brain tissue into viable single neurons in a microfluidic device 在微流控装置中将脑组织分离成有活力的单个神经元

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492500

Linan Jiang, R. Kraft, L. Restifo, Y. Zohar

引用次数: 3

Tumor cellular behaviors regulated by controlled microenvionment 受控微环境对肿瘤细胞行为的调控

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492503

Wenguang Yang, Haibo Yu, Yuechao Wang, Wenxue Wang, Lianqing Liu

{"title":"Tumor cellular behaviors regulated by controlled microenvionment","authors":"Wenguang Yang, Haibo Yu, Yuechao Wang, Wenxue Wang, Lianqing Liu","doi":"10.1109/NANOMED.2015.7492503","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492503","url":null,"abstract":"Recognizing the microenvironmental cues that affect cellular morphology and mechanical properties will contribute to our general understanding of tumor cells, as well as provide approaches to develop effective anti-cancer therapies. Constructing the designated physical microenvironment in which the tumor cells exist is important for cancer cell studies. Although numerous studies have examined how the local interactions between tumor cells and their surrounding microenvironment can regulate cellular behavior, the methods required are very complex and time-consuming. In this manuscript, we describe a light-addressable method to pattern poly-(ethylene) glycol diacrylate (PEGDA) for constructing the surrounding microenvironment of cancer cells, enabling investigation of the effect of the external environment on cancer cell behavior including cell morphology, proliferation, and migration. This is the first method that can be used to simultaneously study all of these behaviors. Using programmable UV exposure, polymerization of the PEGDA solution was induced to create arbitrary shapes with high biocompatibility, and the resistance to cell attachment enabled the PEGDA-coat film to hinder cell adhesion, while the cells grew in the blank area. Moreover, cancer cell morphology, proliferation, and migration were regulated by the controlled microenvironment as determined by our method.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121310433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorimetric detection of botulinum neurotoxin activity using gold nanoparticles 利用金纳米颗粒比色法检测肉毒杆菌神经毒素活性

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492504

Shan Chen, Lok Ting Chu, Ting-Hsuan Chen

引用次数: 0

Characterization of plasma deposited hydrocarbon diffusion barriers for embolic foam devices 栓塞泡沫装置中等离子沉积碳氢化合物扩散屏障的表征

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI: 10.1109/NANOMED.2015.7492495

L. Nash, Kendal P. Ezell, S. M. Hasan, D. Maitland

{"title":"Characterization of plasma deposited hydrocarbon diffusion barriers for embolic foam devices","authors":"L. Nash, Kendal P. Ezell, S. M. Hasan, D. Maitland","doi":"10.1109/NANOMED.2015.7492495","DOIUrl":"https://doi.org/10.1109/NANOMED.2015.7492495","url":null,"abstract":"Shape memory polymer (SMP) containing medical implants that are delivered through catheters require controlled expansion times to prevent the device from binding in the delivery catheter. Delayed expansion can be accomplished using body temperature and moisture plasticization from the aqueous environment of the blood. Although bulk material approaches are effective at delaying the expansion rate, they often compromise the ultimate expansion volume, or necessitate temperatures above body temperature for actuation. These factors motivate material refinement beyond bulk chemistry changes to achieve nonlinear passive actuation profiles. In this work, plasma deposited hydrocarbon diffusion barriers enable a second degree of material expansion control, facilitating extended catheter delivery times for endovascular medical devices. Hydrocarbon plasma films polymerized from mixtures of acetylene, ethylene and propylene were deposited on silicon wafers and characterized using ellipsometry, static water contact angles, and x-ray photoelectron spectroscopy. Selected plasma processes were applied to polyurethane SMP foams and material performance was characterized using differential scanning calorimetry and unconstrained foam expansion in 37 °C water. These plasma films were found to increase surface hydrophobicity and delay the moisture plasticization rate of shape memory polymer embolic foams without altering bulk thermo-mechanical properties.","PeriodicalId":187049,"journal":{"name":"2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115101679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1