利用光致发光测量方法检测二硫化钼上的DNA杂交

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED) Pub Date : 2015-11-01 DOI:10.1109/NANOMED.2015.7492514

Chang-Hsiao Chen

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引用次数: 2

摘要

我们制造了一种二维材料异质结构(石墨烯/MoS2)，用于DNA杂交的无标记选择性检测。石墨烯保护二硫化钼不受环境湿度和氧气的影响，并作为DNA分子的生物相容性宿主。二硫化钼层的光致发光强度随着靶DNA浓度的增加而增加。互补和单碱基错配DNA与二维材料异质结构的分化可以在低至1原子摩尔(10-18 M)的浓度下进行。

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Label-free detection of DNA hybridization on MoS2 using photoluminescence measurements

We have fabricated a 2d-materials heterostructure (graphene/MoS2) for label-free selective detection of DNA hybridization. The graphene protected the MoS2 from ambient moisture and oxygen and acted as a biocompatible host for the DNA molecules. The photoluminescence intensity from the MoS2 layer increased with increased concentration of target DNA. The differentiation of complementary and one-base mismatched DNA with the 2d-materials heterostructure could be performed at a concentration as low as 1 attomole (10-18 M).

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来源期刊

2015 9th IEEE International Conference on Nano/Molecular Medicine & Engineering (NANOMED)

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