Microbial drug resistance最新文献

{"title":"Performance of Carbapenemase Nordmann-Poirel, Modified Carbapenem Inactivation, and EDTA Carbapenem Inactivation Methods for Detecting Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates.","authors":"Kamalakar Sarva, Rameshkumar Marimuthu Ragavan, Lakshmi Jyothi Tadi, Sundaramurthy Raja, Arunagirinathan Narasingam","doi":"10.1089/mdr.2023.0040","DOIUrl":"10.1089/mdr.2023.0040","url":null,"abstract":"<p><p>Infections caused by carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) are a major threat to public health. Timely detection of CRKP will help treat patients with appropriate antibiotics. This study aimed to evaluate the performance of the carbapenemase Nordmann-Poirel (CarbaNP), modified carbapenem inactivation (mCIM), and EDTA carbapenem inactivation (eCIM) methods for the detection of CRKP. We compared the results of the three assays with that of real-time PCR. In total, 195 <i>K. pneumoniae</i> isolates, including 150 carbapenem-resistant and 45 carbapenem-susceptible isolates, were investigated. Carbapenem-resistance genes, such as <i>bla</i>_KPC, <i>bla</i>_NDM, <i>bla</i>_VIM, <i>bla</i>_IMP, and <i>bla</i>_OXA-48-like, were identified using real-time PCR. Among the 150 CRKP isolates, 94 (62.7%) were positive for <i>bla</i>_NDM, 29 (19.3%) were positive for <i>bla</i>_OXA-48-like, and 27 (18%) were positive for both <i>bla</i>_NDM and <i>bla</i>_OXA-48-like. For detecting CRKP isolates, CarbaNP, mCIM, and eCIM showed 96.0%, 95.4%, and 96.7% sensitivity, respectively, and all three methods showed 100% specificity. All three phenotypic confirmatory tests are reliable for identifying CRKP, easy to perform, cost-effective, and can be incorporated with routine antibiotic susceptibility testing.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"504-509"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41134629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colistin Resistance in Multidrug-Resistant <i>Escherichia coli</i> Isolated from Retail Broiler Meat in Bangladesh.","authors":"Chandan Nath, Tridip Das, Md Sirazul Islam, F M Yasir Hasib, Shuvo Singha, Avijit Dutta, Himel Barua, Md Zohorul Islam","doi":"10.1089/mdr.2023.0026","DOIUrl":"10.1089/mdr.2023.0026","url":null,"abstract":"<p><p>The emergence of colistin resistance in <i>Escherichia coli</i> is a global public health concern. Contaminated food can accelerate the spread of colistin-resistant <i>E. coli</i> to humans. This study aimed to detect and characterize colistin-resistant <i>E. coli</i> from broiler meat in Bangladesh. We analyzed 136 pooled broiler meat samples from 240 carcasses collected from 40 live bird markets in urban and rural areas and 8 metropolitan supermarkets. The mean count of <i>E. coli</i> in broiler meat samples collected from rural retail shops, metropolitan supermarkets, and urban retail shops was 5.3 ± 1.1, 4.1 ± 1.4, and 3.9 ± 0.8 log₁₀ colony-forming unit per gram, respectively. Colistin-resistant <i>E. coli</i> (minimum inhibitory concentration >2 mg/L) was found in 78% (95% confidence interval 70.2-84.1%) of the samples. All colistin-resistant isolates harbored the <i>mcr</i>-<i>1</i> gene, while the rest of the <i>mcr</i> genes (<i>mcr</i>-<i>2</i> to <i>mcr</i>-<i>9</i>) were not detected. Most colistin-resistant <i>E. coli</i> isolates (98%) showed coresistance to tetracycline, sulfamethoxazole/trimethoprim followed by ciprofloxacin (95%). Alarmingly, all of the colistin-resistant isolates were found to be multidrug resistant. Phylogenetic analysis showed close similarities of the <i>mcr</i>-<i>1</i> gene sequences of this study with many strains of Enterobacterales isolated from humans, animals, and the environment. This study detected colistin-resistant <i>E. coli</i> contamination in broiler meat, which can pose a serious public health threat.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"523-532"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex Hybrid Capture Improves the Deep Detection of Antimicrobial Resistance Genes from Wastewater Treatment Plant Effluents to Assess Environmental Issues.","authors":"Tsuyoshi Sekizuka, Nobuyasu Yamaguchi, Hajime Kanamori, Makoto Kuroda","doi":"10.1089/mdr.2023.0016","DOIUrl":"10.1089/mdr.2023.0016","url":null,"abstract":"<p><p>Metagenomic sequencing (mDNA-seq) is one of the best approaches to address antimicrobial resistance (AMR) issues and characterize AMR genes (ARGs) and their host bacteria (ARB); however, the sensitivity provided is insufficient for the overall detection in wastewater treatment plant (WWTP) effluents because the effluent is well treated. This study investigated the multiplex hybrid capture (xHYB) method (QIAseq × HYB AMR Panel) and its potential to increase AMR assessment sensitivity. The mDNA-Seq analysis suggested that the WWTP effluents had an average of 104 reads per kilobase of gene per million (RPKM) for the detection of all targeted ARGs, whereas xHYB significantly improved detection at 601,576 RPKM, indicating an average 5,805-fold increase in sensitivity. For instance, <i>sul1</i> was detected at 15 and 114,229 RPKM using mDNA-seq and xHYB, respectively. The <i>bla</i>_CTX-M, <i>bla</i>_KPC, and <i>mcr</i> gene variants were not detected by mDNA-Seq but were detected by xHYB at 67, 20, and 1,010 RPKM, respectively. This study demonstrates that the multiplex xHYB method could be a suitable evaluation standard with high sensitivity and specificity for deep-dive detection, highlighting a broader illustration of ongoing dissemination in the entire community.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"510-515"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9773124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Report of Antibiotic Resistance Markers <i>cfi</i>A and <i>nim</i> Among <i>Bacteroides fragilis</i> Group Strains in Ecuadorian Patients.","authors":"Gabriela Sevillano, Ariane Paz Y Miño, María Belén Solís, Juan Pablo Vaca, Camilo Zurita-Salinas, Jeannete Zurita","doi":"10.1089/mdr.2023.0125","DOIUrl":"10.1089/mdr.2023.0125","url":null,"abstract":"<p><p>In recent years, increasing resistance of <i>Bacteroides fragilis</i> to several antibiotics has been reported in different countries. The aim of this study was to evaluate the antibiotic resistance profiles of <i>Bacteroides</i> spp. isolated from clinical samples by phenotypic and molecular methods. A total of 40 nonrepetitive isolates of the <i>B. fragilis</i> group were studied from 2018 to 2019. The species was identified by API 20A system. The minimum inhibitory concentrations (MICs) were determined by Sensititre anaerobe MIC plate. The presence of the <i>nim</i> and <i>cfiA</i> genes was checked by conventional PCR. The association between genes and insertion sequence (IS) was performed by whole genome sequencing. Eleven isolates were categorized as metronidazole-resistant and only 2 isolates harbored the <i>nim</i> gene. Five isolates were imipenem-resistant, but <i>cfiA</i> gene was detected in two isolates. <i>cfi</i>A gene was closely related to the <i>cfi</i>A-4 allele and associated with IS614B. The <i>nim</i> gene was not related to any <i>nim</i> gene type and was considered a new variant named <i>nim</i>L. IS612 was found upstream of <i>nim</i>L gene. In view of the scarcity of data on <i>B. fragilis</i>, there is a need to surveil antibiotic resistance levels and molecular mechanisms to implement better antimicrobial therapies against this important group of bacteria.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"533-539"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Frequency of Methicillin-Resistant and Multidrug-Resistant Strains of <i>Staphylococcus aureus</i> Colonizing Students in Okada, Edo State, Nigeria.","authors":"Maureen Uchechukwu Okwu, Augustine Obhioze Akpoka, Olley Mitsan, Osazee Ekundayo Izevbuwa, Anita Osamede, Jan Tkadlec","doi":"10.1089/mdr.2023.0001","DOIUrl":"10.1089/mdr.2023.0001","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> is one of the most common bacterial pathogens, often asymptomatically colonizing healthy people, but capable of causing fatal disease. The ability to treat <i>S. aureus</i> infections is limited by the rapid spread of multidrug-resistant strains. This study aimed to determine the prevalence of <i>S. aureus</i> carriage among students from Okada, Edo State, Nigeria, to analyze the antibiotic resistance patterns and molecular characteristics of <i>S. aureus</i> isolates. One hundred healthy students from Okada, Nigeria, were tested for nasal colonization by <i>S. aureus.</i> Isolates were identified using standard microbiological methods. The susceptibilities of the isolates to a panel of 22 antimicrobials were tested. <i>spa</i> and staphylococcal cassette chromosome <i>mec</i> typing were performed. The prevalence of <i>S. aureus</i> and methicillin-resistant <i>S. aureus</i> (MRSA) among the students was 23% and 6%, respectively. Of the six (26.1%; 6/23) MRSA isolates detected, CC88-MRSA-IVa (<i>n</i> = 2) and CC7-MRSA-V (<i>n</i> = 2) were the most frequent clones. The CC7-MRSA-V isolates were resistant to multiple antimicrobials. Overall, resistance to beta-lactams, tetracyclines, fluoroquinolones, and aminoglycosides was detected among the <i>S. aureus</i> and MRSA isolates. The high prevalence of MRSA and methicillin-susceptible isolates with resistance to multiple antimicrobial classes observed among the students is an alarming finding. This study indicated the circulation of resistant clones of <i>S. aureus</i> in Nigerian educational institutions and the community.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"516-522"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10609436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Antimicrobial Resistance and Biofilm Production Among <i>Staphylococcus pseudintermedius</i> from Canine Skin Lesions.","authors":"Sahar Nouri Gharajalar,&nbsp;Sadegh Tanhaee,&nbsp;Mahdieh Omidzadeh,&nbsp;Masoud Onsori","doi":"10.1089/mdr.2022.0257","DOIUrl":"https://doi.org/10.1089/mdr.2022.0257","url":null,"abstract":"<p><p><b><i>Aims:</i></b> <i>Staphylococcus pseudintermedius</i> is an opportunistic pathogen also indicated as one of the major causes of skin infections in dogs. This study aimed to identify <i>S. pseudintermedius</i> isolated from canine skin lesions, evaluate their antibiotic resistance profile and biofilm production ability. <b><i>Methodology:</i></b> Lesions from 50 rural dogs with different skin lesions were sampled after pyoderma diagnosis by private practices. Bacterial species determination was investigated and susceptibility to nine antimicrobials were determined by means of Kirby-Bauer assay. Then seven antibiotic resistance genes, including <i>mecA, blaZ, tetK, tetM, bla_SHV, bla_OXA-</i>₁, and <i>bla_TEM</i> were screened by PCR. Moreover, biofilm formation ability of the strains was determined using the microtiter plate assay along with the presence of <i>icaADBC</i> genes. <b><i>Results:</i></b> A total of 37 (74%) isolates were identified as <i>S. pseudintermedius.</i> All <i>S. pseudintermedius</i> isolates were resistant to multiple drugs. Resistance to penicillin, amoxicillin-clavulanic acid, and cefazolin were higher than other antimicrobials. All the beta-lactam-resistant isolates carried <i>blaZ</i>, whereas <i>mecA</i> was found in 6 (16.21%) of them. Among tetracycline-resistant strains, the frequency of <i>tetK</i> and <i>tetM</i> determinants were 19 (90.47%) and 21 (100%), respectively. Finally, most cefazolin-resistant strains 31 (91.89%) were positive for <i>blaTEM</i> gene. The rate of biofilm production ability among <i>S. pseudintermedius</i> isolates was 35 (94.59%). Furthermore, the presence of <i>icaA/D</i> genes was detected in 35 (100%) and 29 (82.85%) of <i>S. pseudintermedius</i> strains, respectively. <b><i>Conclusion:</i></b> The high rates of antimicrobial resistance and biofilm production ability among <i>S. pseudintermedius</i> isolates, emphasize the urgent need to use more effective infection control policies and guidelines for antimicrobial use.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49679701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Colistin Dependence-Developing <i>Acinetobacter baumannii</i> with Antibiotic Combinations at Subinhibitory Concentrations.","authors":"Jeongwoo Jo,&nbsp;Ji Young Lee,&nbsp;Hongbaek Cho,&nbsp;Kwan Soo Ko","doi":"10.1089/mdr.2022.0205","DOIUrl":"10.1089/mdr.2022.0205","url":null,"abstract":"<p><p>Recent studies have revealed that colistin dependence frequently develops in colistin-susceptible <i>Acinetobacter baumannii</i> isolates. Despite resistance in parental strains, colistin-dependent mutants showed increased susceptibility to several antibiotics, which suggests the possibility of developing strategies to eliminate multidrug-resistant (MDR) <i>A. baumannii</i>. We investigated <i>in vitro</i> and <i>in vivo</i> efficacy of combinations of colistin and other antibiotics using MDR <i>A. baumannii</i> strains H08-391, H06-855, and H09-94, which are colistin-susceptible but develops colistin dependence upon exposure to colistin. An <i>in vitro</i> time-killing assay, a checkerboard assay, and an antibiotic treatment assay using <i>Galleria mellonella</i> larvae were performed. Although a single treatment of colistin at a high concentration did not prevent colistin dependence, combinations of colistin with other antibiotics at subinhibitory concentrations, especially amikacin, eradicated the strains by inhibiting the development of colistin dependence, in the <i>in vitro</i> time-killing assay. Only 40% of <i>G. mellonella</i> larvae infected by <i>A. baumannii</i> survived with colistin treatment alone; however, all or most of them survived following treatment with the combination of colistin and other antibiotics (amikacin, ceftriaxone, and tetracycline). Our results suggest the possibility of the combination of colistin and amikacin or other antibiotics as one of therapeutic options against <i>A. baumannii</i> infections by eliminating colistin-dependent mutants.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"448-455"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Activity of Cefiderocol Against Carbapenem-Resistant <i>Enterobacterales</i> and <i>Pseudomonas aeruginosa</i>.","authors":"Lucia Malisova, Iveta Vrbova, Katarina Pomorska, Vladislav Jakubu, Helena Zemlickova","doi":"10.1089/mdr.2023.0090","DOIUrl":"10.1089/mdr.2023.0090","url":null,"abstract":"<p><p>The objective of this study was to assess the susceptibility of cefiderocol against multidrug-resistant carbapenemase-producing and nonproducing bacteria. The panel comprised 182 isolates of the order <i>Enterobacterales</i>, and 40 strains of <i>Pseudomonas aeruginosa</i>. Antimicrobial susceptibility testing has been performed using broth microdilution method according to the European Committee on Antimicrobial Susceptibility Testing recommendations. Mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry and carbapenemase-producing test were used to verify the presence of carbapenemases in clinical isolates. The genetic expression of single carbapenemases (<i>bla</i>_KPC, <i>bla</i>_OXA-48, <i>bla</i>_NDM, <i>bla</i>_VIM, <i>bla</i>_IMP, <i>bla</i>_GES) was determined by real-time polymerase chain reaction. Cefiderocol exhibited a good activity against the majority of strains tested in this study. Altogether, growth of 81.9% (<i>n</i> = 149) strains of the order <i>Enterobacterales</i> and 77.5% (<i>n</i> = 31) of <i>P. aeruginosa</i> isolates were inhibited at minimal inhibitory concentration (MIC) ≤2 mg/L. Values MIC₅₀/MIC₉₀ were 0.5/8 mg/L for enterobacteria, and 1/8 mg/L for <i>P. aeruginosa</i>. One isolate (<i>Klebsiella pneumoniae</i>) harboring two carbapenemases (<i>bla</i>_OXA-48, <i>bla</i>_NDM) had cefiderocol MIC 0.5 mg/L. In enterobacteria resistant to cefiderocol, <i>bla</i>_NDM carbapenemase prevailed (43.3%, <i>n</i> = 29), followed by <i>bla</i>_OXA-48 (31.3%, <i>n</i> = 21) and <i>bla</i>_KPC (4.5%, <i>n</i> = 3). <i>bla</i>_IMP (<i>n</i> = 8) and <i>bl</i>a_VIM (<i>n</i> = 1) metallo-β-lactamases dominated in cefiderocol-resistant <i>P. aeruginosa</i> (<i>n</i> = 9) isolates. Very good susceptibility (100%) to this drug showed <i>bla</i>_GES-positive strains of <i>P. aeruginosa</i> (<i>n</i> = 8) and isolates resistant to meropenem without confirmed carbapenemase gene (<i>n</i> = 10). In this study, cefiderocol demonstrated potent activity against important nosocomial pathogens, therefore, therapeutic options of this drug against multidrug-resistant bacteria should be considered.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"485-491"},"PeriodicalIF":2.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10115359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Klebsiella quasipneumoniae</i> subsp. <i>similipneumoniae</i> ST1859 O5:KL35 from Soil: First Report of <i>qnrE1</i> in the Environment.","authors":"Ralf Lopes,&nbsp;João Pedro Rueda Furlan,&nbsp;Micaela Santana Ramos,&nbsp;Lucas David Rodrigues Dos Santos,&nbsp;Rafael da Silva Rosa,&nbsp;Eliana Guedes Stehling","doi":"10.1089/mdr.2023.0075","DOIUrl":"10.1089/mdr.2023.0075","url":null,"abstract":"<p><p>A <i>Klebsiella quasipneumoniae</i> subsp. <i>similipneumoniae</i> strain, named S915, belonging to the ST1859 O5:KL35, and harboring the plasmid-mediated quinolone resistance <i>qnrE1</i> gene, was isolated from a soil sample cultivated with lettuce in Brazil. The core genome multilocus sequence typing analysis revealed that S915 strain was most related to a clinical strain of Brazil. Comparative genomic analysis showed that ST1859 O5:KL35 strains have been circulating in clinical settings and are closely related to multidrug resistance and multimetal tolerance. Strain S915 presented a plasmid contig co-harboring the <i>qnrE1</i> gene and tellurite tolerance operon. The region harboring the <i>qnrE1</i> gene (IS<i>Ecp1</i>-<i>qnrE1</i>-<i>araJ</i>-<i>ahp</i>) shared high similarity with others from infected humans, ready-to-eat dish, and food-producing animals in Brazil. This is the first report of the plasmid-mediated <i>qnrE1</i> gene in the environment. Our findings evidence the initial dissemination of the <i>qnrE1</i> gene in the environment by the introduction of a clinical strain, which may be spread to different sectors, representing a One Health challenge.</p>","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"492-496"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Message from the Editor-in-Chief.","authors":"","doi":"10.1089/mdr.2023.29007.igb","DOIUrl":"10.1089/mdr.2023.29007.igb","url":null,"abstract":"","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":"29 10","pages":"443"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}