Microbial drug resistance最新文献_第10页

A Message from the Editor-in-Chief. 总编辑寄语。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-10-01 DOI: 10.1089/mdr.2023.29007.igb

引用次数: 0

Prevalence of fosA3 Gene in Fosfomycin-Resistant Proteus mirabilis in the Autonomous Community of Madrid (Spain) and Characterization of Two Positive Strains. 西班牙马德里自治区耐磷霉素奇异变形杆菌中fosA3基因的患病率和两株阳性菌株的特征。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-10-01 Epub Date: 2023-04-06 DOI: 10.1089/mdr.2022.0269

Cristina Loras, María Pérez-Vázquez, Andrea González Prieto, Jesús Oteo-Iglesias, Juan-Ignacio Alós

引用次数: 1

Colonization of Residents and Staff of an Italian Long-Term Care Facility and an Adjacent Acute Care Hospital Geriatrics Unit by Multidrug-Resistant Bacteria. 意大利一家长期护理机构和邻近的急性护理医院老年科的居民和工作人员被耐多药细菌定殖。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-10-01 Epub Date: 2023-06-30 DOI: 10.1089/mdr.2023.0019

Maria Teresa Nitti, Ferisa Sleghel, Malgorzata Kaczor, Richard Aschbacher, Elena Moroder, Angela Maria Di Pierro, Francesca Piscopiello, Melissa Spalla, Aurora Piazza, Roberta Migliavacca, Elisabetta Pagani

{"title":"Colonization of Residents and Staff of an Italian Long-Term Care Facility and an Adjacent Acute Care Hospital Geriatrics Unit by Multidrug-Resistant Bacteria.","authors":"Maria Teresa Nitti, Ferisa Sleghel, Malgorzata Kaczor, Richard Aschbacher, Elena Moroder, Angela Maria Di Pierro, Francesca Piscopiello, Melissa Spalla, Aurora Piazza, Roberta Migliavacca, Elisabetta Pagani","doi":"10.1089/mdr.2023.0019","DOIUrl":"10.1089/mdr.2023.0019","url":null,"abstract":"In 2022, we undertook a point prevalence screening study for Enterobacterales with extended-spectrum β-lactamases (ESBLs), high-level AmpC cephalosporinases and carbapenemases, and also methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) in a long-term care facility (LTCF) and the associated acute-care hospital Geriatrics unit in Bolzano, Northern Italy. Urine samples and rectal, inguinal, oropharyngeal, and nasal swabs were plated on selective agar plates. Metadata of the patients, including demographic data, were collected, and risk factors for colonization were determined. ESBL, AmpC, carbapenemase, and quinolone resistance genes were investigated by the HybriSpot 12 PCR AUTO System. The following colonization percentages by multidrug-resistant (MDR) bacteria have been found in LTCF residents: all MDR organisms, 59.5%; ESBL producers, 46.0% (mainly CTX-M-type enzymes); carbapenemase producers, 1.1% (one Klebsiella pneumoniae with KPC-type); MRSA, 4.5%; VRE, 6.7%. Colonization by MDR bacteria was 18.9% for LTCF staff and 45.0% for Geriatrics unit patients. Peripheral vascular disease, the presence of any medical device, cancer, and a Katz Index of 0 were significant risk factors for colonization of LTCF residents by MDR bacteria in univariate and/or multivariate regression analysis. To conclude, the ongoing widespread diffusion of MDR bacteria in the LTCF suggests that efforts should be strengthened on MDR screening, implementation of infection control strategies, and antibiotic stewardship programs targeting the unique aspects of LTCFs. ClinicalTrials.gov ID: 0530250-BZ Reg01 30/08/2022.","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":" ","pages":"477-484"},"PeriodicalIF":2.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocides in the Hospital Environment: Application and Tolerance Development. 医院环境中的杀菌剂：应用和耐受性发展。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-10-01 Epub Date: 2023-08-29 DOI: 10.1089/mdr.2023.0074

Catarina Geraldes, Luís Tavares, Solange Gil, Manuela Oliveira

引用次数: 0

Clinical and Epidemiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Infections in a Tertiary Hospital in China. 某三级医院耐碳青霉烯肺炎克雷伯菌感染的临床及流行病学特征

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2022.0280

Zhiwen Cui, Lirui Wang, Min Feng

{"title":"Clinical and Epidemiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Infections in a Tertiary Hospital in China.","authors":"Zhiwen Cui, Lirui Wang, Min Feng","doi":"10.1089/mdr.2022.0280","DOIUrl":"https://doi.org/10.1089/mdr.2022.0280","url":null,"abstract":"Purpose: Infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-KP) are an important public health problem. This study aimed to evaluate the clinical characteristics of patients with CR-KP. Methods: A retrospective cohort study was conducted of all patients with CR-KP infection. A total of 615 patients with CR-KP infection were identified and 135 patients who did not meet the eligibility criteria were excluded. Clinical characteristics, antimicrobial regimens, and patient outcomes were analyzed. Results: The overall mortality rate of CR-KP infections was 37.3% and the mortality rate in patients with bloodstream infections was 66.2%. Survival analysis revealed that there were statistically significant differences between patients with bloodstream infections and those with pulmonary and drainage fluid infections. Logistics regression analysis showed that hemopathy, age >60 years, solid tumors, diabetes, septic shock, acute kidney injury, and stroke were independent predictors of 30-day mortality rate. The chi-square test showed that treatment with a combination of carbapenems, tigecycline, and polymyxin B was superior to treatment with carbapenems with polymyxin B, without tigecycline. Conclusions: CR-KP infections, especially bloodstream infections, have a high mortality rate. The outcome is strongly dependent on patients' clinical conditions. Antimicrobial regimens combining carbapenems, tigecycline, and polymyxin B might be a better choice.","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":"29 9","pages":"401-406"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy. 一株引起菌血症的耐利奈唑胺头炎葡萄球菌的基因组分析:来自意大利中部一所大学医院的报告。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2022.0330

Lucia Brescini, Simona Fioriti, Sonia N Coccitto, Marzia Cinthi, Marina Mingoia, Oscar Cirioni, Andrea Giacometti, Eleonora Giovanetti, Gianluca Morroni, Andrea Brenciani

引用次数: 0

Whole Genome Sequencing of an Extensively Drug-Resistant Raoultella planticola Isolate Containing bla_KPC-2, bla_NDM-1, and bla_CTX-M-15. 含有blaKPC-2、blaNDM-1和blaCTX-M-15的广泛耐药的planticola Raoultella分离物全基因组测序

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2022.0229

Paulo Victor Batista Marini, Eliandro Reis Tavares, Cintia Werner Motter, Letícia Busato Migliorini, Romário Oliveira de Sales, Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Mariangela Hungria, Sueli Fumie Yamada-Ogatta, Maria Cristina Bronharo Tognim

{"title":"Whole Genome Sequencing of an Extensively Drug-Resistant Raoultella planticola Isolate Containing blaKPC-2, blaNDM-1, and blaCTX-M-15.","authors":"Paulo Victor Batista Marini, Eliandro Reis Tavares, Cintia Werner Motter, Letícia Busato Migliorini, Romário Oliveira de Sales, Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Mariangela Hungria, Sueli Fumie Yamada-Ogatta, Maria Cristina Bronharo Tognim","doi":"10.1089/mdr.2022.0229","DOIUrl":"https://doi.org/10.1089/mdr.2022.0229","url":null,"abstract":"Raoultella planticola harboring genes that confer resistance to antimicrobials, such as carbapenems, have been associated with severe infections in immunocompromised patients. In this study, we reported the first whole genome sequence of a Brazilian isolate of R. planticola and the genomic context of antibiotic resistance markers. By whole-genome sequencing (WGS) of a carbapenem-resistant R. planticola isolate, RpHUM1, we found 23 resistance-encoding genes belonging to 9 classes of antibiotics (aminoglycosides, β-lactams, fluoroquinolones, fosfomycin, macrolides, phenicols, sulfonamides, tetracycline, and diaminopyrimidine derivatives) and 3 plasmids (RpHUM1pEaer-4382s, RpHUM1_pFDAARGOS_440, and RpHUM1pRSF1010). This isolate coharbored the genes blaKPC-2, which is carried by the plasmid RpHUM1pEaer-4382s, and blaNDM-1 and blaCTX-M-15 all located in the accessory genome. In addition, these genes were associated with, at least, one mobile genetic element. This comprehensive knowledge is of great importance for implementation of control measures to prevent the rapid dissemination of this neglected microorganism and their genetic resistance background.","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":"29 9","pages":"392-400"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Letter from the Editor-in-Chief. 总编辑的来信。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2023.29006.igb

引用次数: 0

Cellular Attributes of Candida albicans Biofilm-Associated in Resistance Against Multidrug and Host Immune System. 白色念珠菌生物膜与多药耐药及宿主免疫系统相关的细胞特性

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2022.0347

Dushyant Kumar, Awanish Kumar

{"title":"Cellular Attributes of Candida albicans Biofilm-Associated in Resistance Against Multidrug and Host Immune System.","authors":"Dushyant Kumar, Awanish Kumar","doi":"10.1089/mdr.2022.0347","DOIUrl":"https://doi.org/10.1089/mdr.2022.0347","url":null,"abstract":"One of the ubiquitous hospital-acquired infections is associated with Candida albicans fungus. Usually, this commensal fungus causes no harm to its human host, as it lives mutually with mucosal/epithelial tissue surface cells. Nevertheless, due to the activity of various immune weakening factors, this commensal starts reinforcing its virulence attributes with filamentation/hyphal growth and building an absolute microcolony composed of yeast, hyphal, and pseudohyphal cells, which is suspended in an extracellular gel-like polymeric substance (EPS) called biofilms. This polymeric substance is the mixture of the secreted compounds from C. albicans as well as several host cell proteins. Indeed, the presence of these host factors makes their identification and differentiation process difficult by host immune components. The gel-like texture of the EPS makes it sticky, which adsorbs most of the extracolonial compounds traversing through it that aid in penetration hindrance. All these factors further contribute to the multidrug resistance phenotype of C. albicans biofilm that is spotlighted in this article. The mechanisms it employs to escape the host immune system are also addressed effectively. The article focuses on cellular and molecular determinants involved in the resistance of C. albicans biofilm against multidrug and the host immune system.","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":"29 9","pages":"423-437"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Enterococcus faecium Isolated from Bovine Feces in Italy Shares optrA- and poxtA-Carrying Plasmids with Enterococci from Switzerland. 从意大利牛粪便中分离的一种粪肠球菌与瑞士的肠球菌具有携带optrA和poxta的质粒。

IF 2.6 4区医学

Microbial drug resistance Pub Date : 2023-09-01 DOI: 10.1089/mdr.2023.0055

Marzia Cinthi, Sonia Nina Coccitto, Serena Simoni, Carla Vignaroli, Andrea Brenciani, Eleonora Giovanetti

{"title":"An Enterococcus faecium Isolated from Bovine Feces in Italy Shares optrA- and poxtA-Carrying Plasmids with Enterococci from Switzerland.","authors":"Marzia Cinthi, Sonia Nina Coccitto, Serena Simoni, Carla Vignaroli, Andrea Brenciani, Eleonora Giovanetti","doi":"10.1089/mdr.2023.0055","DOIUrl":"https://doi.org/10.1089/mdr.2023.0055","url":null,"abstract":"To investigate the occurrence of oxazolidinone resistance genes, 18 florfenicol-resistant enterococci were isolated from 66 fecal samples collected from several cattle farms in central Italy. The PCR screening indicated that only a bovine florfenicol-resistant isolate, Enterococcus faecium 249031-C, was positive for the presence of optrA and poxtA genes. The strain was tested for its susceptibility to florfenicol, chloramphenicol, linezolid, tedizolid, tetracycline, erythromycin, and vancomycin. Whole Genome Sequencing analysis showed that E. faecium 249031-C, belonging to the ST22 lineage, harbored two plasmids: the optrA-carrying p249031-S (179 kb) and the poxtA-carrying p1818-c (23 kb). p249031-S, containing a new optrA-carrying Tn7695 transposon, was closely related to the plasmid pF88_1 of E. faecium F88, whereas p1818-c had already been detected in a human E. faecium, both enterococci were from Switzerland. The linezolid resistance genes were cotransferred to the E. faecium 64/3 recipient. Circular forms from both optrA- and poxtA-carrying genetic contexts were obtained. The occurrence of oxazolidinone resistance genes in a bovine E. faecium isolate and their localization on conjugative and mobilizable plasmids pose a risk for public health.","PeriodicalId":18701,"journal":{"name":"Microbial drug resistance","volume":"29 9","pages":"438-442"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0