Microbiology and Immunology最新文献

RETRACTION: Chlamydia Pneumoniae Induces Interleukin-6 and Interleukin-10 in Human Gingival Fibroblastsle. 撤回：肺炎衣原体诱导人牙龈成纤维细胞中白细胞介素-6和白细胞介素-10。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-04-08 DOI: 10.1111/1348-0421.13218

引用次数: 0

Issue Information – Cover 发行资料-封面

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-04-07 DOI: 10.1111/1348-0421.13137

引用次数: 0

FTO Aggravates the Infiltration of Inflammatory Cells and Pulmonary Fibrosis in Silicosis Though Inducing the Imbalance of Macrophages Polarization. FTO通过诱导巨噬细胞极化失衡，加重矽肺炎症细胞浸润和肺纤维化。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-04-01 DOI: 10.1111/1348-0421.13216

Jian-Min Fan, Xu Zhang

{"title":"FTO Aggravates the Infiltration of Inflammatory Cells and Pulmonary Fibrosis in Silicosis Though Inducing the Imbalance of Macrophages Polarization.","authors":"Jian-Min Fan, Xu Zhang","doi":"10.1111/1348-0421.13216","DOIUrl":"https://doi.org/10.1111/1348-0421.13216","url":null,"abstract":"Silicosis is a lung disease that is very harmful. This makes the disease worse. This study looks at how the fat mass and obesity associated (FTO) gene affects macrophage M1/M2 polarisation and pulmonary fibrosis in silicosis. Macrophages were isolated from alveolar lavage fluid in silicosis and bronchiectasis (BE) patients. Gene expression was detected by reverse transcription-PCR (RT-PCR). Pulmonary fibrosis was assessed by CTFLV/TLV% using 3D CT and Masson staining assay. Enzyme-linked immunosorbent assay was applied to assess inflammatory factor level. The macrophage M1/M2 polarization characteristics (iNOS, CD206) was quantified by Immunofluorescence and Flow cytometry assays. Silicosis patients alveolar lavage macrophages polarized towards M1 type, and the expression level of M1 polarization-related chemokines also increased. More importantly, FTO gene downregulation promotes macrophage polarization to M1 type and the secretion of pro-inflammatory factor TNF-α and IL-6. And FTO knockdown can strengthen the glycolysis of macrophages, especially anaerobic glycolysis, thus inducing macrophages M1 polarization. Moreover, downregulation of FTO ameliorates silicosis pulmonary fibrosis. And FTO upregulation is associated with the M2 polarization of macrophage and the deterioration of pulmonary fibrosis in silicosis patients. FTO downregulation facilitates the infiltration of inflammatory cells by promoting M1 polarization of macrophages in silicosis.","PeriodicalId":18679,"journal":{"name":"Microbiology and Immunology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Expression of Small RNAs of Bordetella Pertussis Colonizing Murine Tracheas. 缩回：百日咳杆菌定植小鼠气管小rna的表达。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-31 DOI: 10.1111/1348-0421.13214

引用次数: 0

RETRACTION: Current Understanding of Bordetella-Induced Cough. 撤回：目前对博德泰拉引起的咳嗽的理解。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-25 DOI: 10.1111/1348-0421.13215

引用次数: 0

Correction to "Bordet-Gengou Agar Medium Supplemented With Albumin-Containing Biologics for Cultivation of Bordetellae". 对“博德-根沟琼脂培养基中添加含白蛋白生物制剂培养博德菌”的修正。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-24 DOI: 10.1111/1348-0421.13212

引用次数: 0

Correction to "Identification of the Minimum Region of Bordetella pertussis Vag8 Required for Interaction With C1 Inhibitor". 更正“百日咳杆菌Vag8与C1抑制剂相互作用所需的最小区域的鉴定”。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-24 DOI: 10.1111/1348-0421.13213

引用次数: 0

Exploring miR-577 and miR-494-3p as Emerging Biomarkers in Sepsis-Associated Acute Kidney Injury: Diagnostic and Prognostic Perspectives. 探索miR-577和miR-494-3p作为脓毒症相关急性肾损伤的新兴生物标志物：诊断和预后观点

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-16 DOI: 10.1111/1348-0421.13210

Lixia Xu, Jingpo Li, Li Li, Qiushuang Zhang, Qiuju Feng, Lijie Bai

{"title":"Exploring miR-577 and miR-494-3p as Emerging Biomarkers in Sepsis-Associated Acute Kidney Injury: Diagnostic and Prognostic Perspectives.","authors":"Lixia Xu, Jingpo Li, Li Li, Qiushuang Zhang, Qiuju Feng, Lijie Bai","doi":"10.1111/1348-0421.13210","DOIUrl":"https://doi.org/10.1111/1348-0421.13210","url":null,"abstract":"Sepsis-associated acute kidney injury (AKI) poses a severe threat to patients' lives and health, making early predictions, intervention, and treatment crucial. This study aims to preliminarily explore the clinical role of miR-577 and miR-494-3p in sepsis-associated AKI. The study included 70 sepsis patients with AKI, 65 sepsis patients without AKI, and a healthy control group (HC, n = 67) to set baseline miRNA levels. Urinary miR-577 and miR-494-3p levels were measured using qRT-PCR. ROC curves evaluated their diagnostic value for sepsis-associated AKI. Logistic regression analyzed AKI risk factors, while Pearson correlation explored miRNA-clinical indicator links. Cox regression models and KM curves assessed the prognostic value of miRNAs in sepsis-associated AKI patients. Sepsis-associated AKI patients showed heightened inflammatory markers, renal indicators, and APACHE II scores compared to those without AKI. However, their urinary miR-577 and miR-494-3p levels were notably lower, distinguishing them with high diagnostic value. These miRNAs inversely correlated with inflammatory markers, renal indicators, and severity scores. Logistic regression showed lactate, PCT, BUN, Scr, Cys-C, NGAL, KIM-1, and APACHE II, as risk factors, while miR-577 and miR-494-3p were protective. In deceased sepsis-associated AKI patients, these miRNAs were lower, with higher inflammatory markers, renal indicators, and severity scores. miR-577 and miR-494-3p independently predicted mortality, with lower expressions linked to higher death rates. miR-577 and miR-494-3p are closely related to sepsis-associated AKI and can serve as potential biomarkers for diagnosis and prognostic assessment.","PeriodicalId":18679,"journal":{"name":"Microbiology and Immunology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of C-Type Lectins and Recognition of Pathogens. c型凝集素的分类与病原菌的识别。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-12 DOI: 10.1111/1348-0421.13211

Yasunobu Miyake

{"title":"Classification of C-Type Lectins and Recognition of Pathogens.","authors":"Yasunobu Miyake","doi":"10.1111/1348-0421.13211","DOIUrl":"https://doi.org/10.1111/1348-0421.13211","url":null,"abstract":"C-type lectins are calcium-dependent glycan-binding proteins that play key roles in the innate immune response by recognizing pathogens. Soluble C-type lectins agglutinate and neutralize pathogens, activate the complement system, and promote pathogen clearance via opsonization. Membrane-bound C-type lectins, also known as C-type lectin receptors (CLRs), internalize pathogens and induce their degradation in lysosomes, presenting pathogen-derived antigens to MHC-II molecules to activate adaptive immunity. CLRs also have signaling capabilities. Some contain the immunoreceptor tyrosine-based activation motif (ITAM), which induces inflammatory responses by activating transcription factors, such as NF-κB and NFAT. Others contain the immunoreceptor tyrosine-based inhibitory motif (ITIM), which suppresses activating signals by activating phosphatases, such as SHP-1. This creates a balance between activation and inhibition. C-type lectins are classified into 17 groups based on their structural domains, with Groups II and V members being particularly important for pathogen recognition. In this review, we present the accumulated and recent information on pathogen recognition by C-type lectins, along with their classification and basic functions.","PeriodicalId":18679,"journal":{"name":"Microbiology and Immunology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Inactivation of Airborne Viruses by Low-Concentration Ozone With High Humidity and Temperature. 低浓度高湿高温臭氧协同灭活空气传播病毒的研究。

IF 1.9 4区医学

Microbiology and Immunology Pub Date : 2025-03-11 DOI: 10.1111/1348-0421.13204

Hidekazu Nishimura, Soichiro Sakata, Isolde Dapat, Masayuki Segawa, Yuki Mizutani, Junya Imaizumi, Kazuya Shirato, Suguru Ohmiya, Masanori Katsumi, Takahiro Yokoyama

{"title":"Synergistic Inactivation of Airborne Viruses by Low-Concentration Ozone With High Humidity and Temperature.","authors":"Hidekazu Nishimura, Soichiro Sakata, Isolde Dapat, Masayuki Segawa, Yuki Mizutani, Junya Imaizumi, Kazuya Shirato, Suguru Ohmiya, Masanori Katsumi, Takahiro Yokoyama","doi":"10.1111/1348-0421.13204","DOIUrl":"https://doi.org/10.1111/1348-0421.13204","url":null,"abstract":"Ambient humidity, temperature, and ozone influence the viability of airborne viruses, but their synergistic effects are poorly understood, particularly regarding ozone with humidity/temperature changes. Therefore, we examined the inactivation of airborne influenza viruses and coronaviruses under combinations of low ambient ozone concentrations, relative humidity (RH) levels, and temperatures typical of daily life. Viral fluid was atomized in a closed chamber conditioned with different combinations of these factors. The atomized aerosol particles containing the virus were exposed to ambient air and then sampled for titration. Active virus levels in ambient air at 50%-85% RH with 15, 35, and 55 ppb ozone significantly decreased compared with those in ambient air with 0 ppb ozone, whereas those in ambient air at < 40% RH decreased only slightly, even with 100 ppb ozone. Viral gene copy numbers, assayed via quantitative real-time polymerase chain reaction, remained similar across all conditions. Inactivation increased with higher temperatures, although not at 15°C. These findings suggest that low concentrations of ambient ozone, when combined with high humidity and temperature, effectively inactivate airborne viruses, potentially influencing viral transmission in real-world environments.","PeriodicalId":18679,"journal":{"name":"Microbiology and Immunology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0